Article
Oncology
Rima Patel, Malin Hovstadius, Melanie W. Kier, Erin L. Moshier, Brittney S. Zimmerman, Krystal Cascetta, Shabnam Jaffer, Joseph A. Sparano, Amy Tiersten
Summary: There is no significant correlation between Ki67 and Oncotype DX RS in early-stage hormone receptor-positive breast cancer patients, although there is fair agreement between high Ki67 values and high RS values.
Article
Oncology
Michelle Zhang, Meredith Sadinski, Dana Haddad, Min Sun Bae, Danny Martinez, Elizabeth A. Morris, Peter Gibbs, Elizabeth J. Sutton
Summary: The study revealed an association between BPE metrics in the non-tumor breast and tumor Oncotype Dx recurrence score, suggesting a potential relationship between the breast microenvironment and likelihood of recurrence and response to chemotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Rachel M. Layman, Heather Lin, Angelica M. Gutierrez Barrera, Meghan S. Karuturi, Clinton Yam, Banu K. Arun
Summary: BRCA-associated early-stage hormone receptor-positive breast cancers have distinctive features compared to those without mutations. However, BRCA status does not significantly impact relapse-free survival and overall survival.
Article
Oncology
Valeria Romeo, Renato Cuocolo, Luca Sanduzzi, Vincenzo Carpentiero, Martina Caruso, Beatrice Lama, Dimitri Garifalos, Arnaldo Stanzione, Simone Maurea, Arturo Brunetti
Summary: In this study, a machine learning model was developed to predict the Oncotype DX score using DCE-MRI images of breast cancer patients. The model achieved an accuracy of 60% in the training set and 63% (AUC = 0.66) in the test set. These findings support the use of radiomics and machine learning for prognostic data prediction in breast cancer, with potential clinical applications.
Article
Oncology
Ran Cheng, Zhongzhao Wang, Xiangyi Kong, Jing Wang, Yi Fang, Liqiang Qi
Summary: In this study, a method was developed to provide a single score for patients with hormone receptor-positive, HER2-negative, node-negative breast cancer and midrange Oncotype DX breast recurrence scores, aiming to individualize chemotherapy treatment decisions. The analysis showed that chemotherapy benefit was associated with specific tumor characteristics for patients with RS = 16-25, suggesting personalized chemotherapy recommendations can be made based on these factors.
Article
Oncology
Joshua A. Bloom, Yurie Sekigami, Rebekah Young, Lisa Macera, Christy A. Russell, Yu Cao, Rachel J. Buchsbaum, Stephen P. Naber, Abhishek Chatterjee
Summary: This study demonstrates that a clinically significant rate of discordance in Oncotype DX results among patients with bilateral breast cancer may impact discussions regarding chemotherapy treatment.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Richard Buus, Ivana Sestak, Ralf Kronenwett, Sean Ferree, Catherine A. Schnabel, Frederick L. Baehner, Elizabeth A. Mallon, Jack Cuzick, Mitch Dowsett
Summary: The molecular features driving Oncotype DX, Prosigna PAM50, EndoPredict, and Breast Cancer Index are identified, with varying degrees of correlation between the molecular scores. While RS is more influenced by estrogen-related features, EP, BCI, and ROR scores are largely determined by proliferative features.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Luca Licata, Giulia Viale, Mario Giuliano, Giuseppe Curigliano, Mariana Chavez-MacGregor, Julia Foldi, Oluchi Oke, Joseph Collins, Lucia Del Mastro, Fabio Puglisi, Filippo Montemurro, Claudio Vernieri, Lorenzo Gerratana, Sara Giordano, Alessia Rognone, Lorenzo Sica, Oreste Davide Gentilini, Stefano Cascinu, Lajos Pusztai, Antonio Giordano, Carmen Criscitiello, Giampaolo Bianchini
Summary: This study evaluates whether Oncotype DX improves confidence and agreement among oncologists in adjuvant chemotherapy recommendations for ER+/HER2- early-stage breast cancers. The study found that using Oncotype DX significantly reduces discordance and uncertainty among oncologists, and improves agreement in adjuvant chemotherapy recommendations for patients.
Article
Oncology
Ran Song, Dong-Eun Lee, Eun-Gyeong Lee, Seeyoun Lee, Han-Sung Kang, Jai Hong Han, Keun Seok Lee, Sung Hoon Sim, Heejung Chae, Youngmee Kwon, Jaeyeon Woo, So-Youn Jung
Summary: This retrospective study identified clinicopathological factors that can predict the Oncotype DX (ODX) risk group in early breast cancer patients, providing alternative options to the costly and time-consuming ODX test. The factors predicting the ODX risk group differ according to age, and can help guide decision-making on adjuvant chemotherapy.
Review
Oncology
Shiliang Zhang, Kasey C. Fitzsimmons, Sara A. Hurvitz
Summary: In the past 20 years, there has been a shift in the use of multigene expression assays in guiding treatment decisions for early-stage hormone receptor-positive, HER2-negative breast cancer. While there is evidence supporting the use of Oncotype DX Recurrence Score (RS) in postmenopausal women, its application in premenopausal women remains unclear. Further research is needed to understand the reliability and interpretation of RS in this subgroup.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Shiling Zhong, Fan Wang, Zhiying Wang, Minghui Zhou, Chunli Li, Jiandong Yin
Summary: This study aimed to establish and validate multiregional radiomic signatures (RSs) based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for preoperative identification of estrogen receptor (ER) and progesterone receptor (PR) status in breast cancer. The results showed that multiregional RSs achieved the best discriminative performance for predicting ER and PR status, demonstrating promising results for preoperative evaluation in breast cancer patients.
Article
Oncology
Xiaofu Zhu, Susan Dent, Lise Paquet, Tinghua Zhang, Daniel Tesolin, Nadine Graham, Olexiy Aseyev, Xinni Song
Summary: Canadian medical oncologists preferentially use the ODX assay to avoid unnecessary chemotherapy for breast cancer patients, especially those with intermediate clinical and pathologic features.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Zhang, Jeon-Hor Chen, Yezhi Lin, Siwa Chan, Jiejie Zhou, Daniel Chow, Peter Chang, Tiffany Kwong, Dah-Cherng Yeh, Xinxin Wang, Ritesh Parajuli, Rita S. Mehta, Meihao Wang, Min-Ying Su
Summary: This study aimed to differentiate three breast cancer molecular subtypes on MRI using deep learning algorithms, with the recurrent CNN achieving higher accuracy in the training dataset. Transfer learning was effective in improving classification accuracy, particularly for datasets acquired in different settings.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Caitlin Taylor, Jane Meisel, Aimee J. Foreman, Christy Russell, Dipankar Bandyopadhyay, Xiaoyan Deng, Lisa Floyd, Amelia Zelnak, Harry Bear, Ruth O'Regan
Summary: This study evaluated the clinical and pathologic complete response rates among early-stage HR + breast cancer patients who had been randomized to neoadjuvant endocrine therapy or neoadjuvant chemotherapy. Results showed that patients with intermediate RS results did not have significant differences in pathologic outcomes based on treatment type, suggesting that women with RS 0-25 may be able to omit chemotherapy without compromising outcomes.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Vikram R. Shaw, Christopher I. Amos, Chao Cheng
Summary: In this study, a machine learning method is applied to determine the optimal threshold for using the Oncotype DX score to guide chemotherapy treatment. The results show that more lymph-node-negative and lymph-node-positive patients may benefit from chemotherapy at a lower Oncotype DX score than current guidelines suggest. Additionally, the study reveals a racial difference in chemotherapy benefit, providing evidence for tailored treatment for specific patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Apurva A. Bonde, Mayur Virarkar, Mohd Zahid, Sriram Jaganathan, Manuel J. Menendez, Luis Calimano, Bryan R. Foster, Danielle Fritze, Courtney L. Thomas, Pankaj Gupta
Summary: This article describes the common and uncommon appearances of gallbladder adenomyomatosis on multimodality imaging, helping differentiate it from non-benign gallbladder abnormalities, and providing important clinical and surgical management information.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Dheeman Futela, Suryansh Bajaj, Mihir Khunte, Xiao Wu, Seyedmehdi Payabvash, Dheeraj Gandhi, Ajay Malhotra
Article
Radiology, Nuclear Medicine & Medical Imaging
Renhui Cai, Juan Xu, Chaoqun Yan, Jie Wang, L. I. Wang, Leizhi Ku, Di Zhou, L. I. Zhu, Chunli He, Xinxiang Zhao, Xiaojing Ma
Summary: This paper analyzes the correlation between imaging features and ECG features in patients with coronary artery fistula (CAF). The study finds significant differences in ECG characteristics between coronary-cameral fistula (CCF) and coronary-pulmonary artery fistula (CPAF). Surgical treatment can improve ECG findings in some patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jordan Bozer, Kevin Peng, Melissa Magyer, Marilyn Niedermeier, Mina S. Makary
Summary: This study aimed to examine the impact of an educational website on patient understanding of Interventional Radiology (IR). The results showed that the use of an educational website can effectively improve patients' understanding of IR and familiarity with common interventional procedures.
Article
Radiology, Nuclear Medicine & Medical Imaging
Siavash Zamirpour, Marko T. Boskovski, James P. Pirruccello, William A. Pace, Alan E. Hubbard, Joseph R. Leach, Liang Ge, Elaine E. Tseng
Summary: This study evaluated sex-specific temporal changes in aortic size and sex differences in aortic reporting. The results showed that women had significantly higher aortic growth rates compared to men, and aortic dimensions were much less frequently reported in women than men.
Article
Radiology, Nuclear Medicine & Medical Imaging
Monica Miranda-Schaeubinger, Hermon Miliard Derbew, Alexandra Ramirez, Maretta Smith, Mohammad Jalloul, Savvas Andronikou, Hansel J. Otero
Summary: The prevalence of abnormal chest radiographs in patients with positive purified protein derivative (PPD) test was very low in a tertiary pediatric center in the United States. No cases of severe disease were identified, and patients with abnormal findings did not require a change in treatment according to current WHO guidelines.
Article
Radiology, Nuclear Medicine & Medical Imaging
A. Sailer, K. Fitzgerald, J. F. B. Chick, D. S. Shin, E. J. Monroe
Summary: This manuscript describes an approach to successful common femoral arterial access and arteriography in infants, highlighting common pearls and pitfalls.
Article
Radiology, Nuclear Medicine & Medical Imaging
Apurva Bonde, Alice W. Fung, Skye C. Mayo, Peter Li, Brett S. Walker, Sriram Jaganathan, Nadine Mallak, Elena K. Korngold
Summary: Hepatic arterial infusion pumps allow selective administration of chemotherapy to the liver, maximizing its effects while minimizing systemic toxicity. Radiologists play a crucial role in pre-operative planning, treatment response assessment, and evaluation of potential complications. This article aims to familiarize radiologists with various aspects of HAI pumps.
Article
Radiology, Nuclear Medicine & Medical Imaging
Huseyin Bilgin, Ercan Ayaz
Summary: By examining radiographs of children with mucopolysaccharidosis, early diagnosis can be achieved before clinical symptoms become prominent. Therefore, X-ray screening of children in endemic regions of mucopolysaccharidosis is feasible.
