Article
Oncology
Choong-kun Lee, Jii Bum Lee, Se Jung Park, Jingmin Che, Woo Sun Kwon, Hyo Song Kim, Minkyu Jung, Seulkee Lee, Sook Ryun Park, Dong-Hoe Koo, Hyun Woo Lee, Woo Kyun Bae, Hei-Cheul Jeung, In Gyu Hwang, Hyunki Kim, Chung Mo Nam, Hyun Cheol Chung, Sun Young Rha
Summary: This study evaluated the efficacy and safety of nivolumab and paclitaxel as second-line therapy for AGC and found that they demonstrated a durable response with manageable toxicity profiles. Genomic analysis and plasma cytokine analysis may help in selecting patients who would benefit more from immunotherapy combined with chemotherapy.
Article
Genetics & Heredity
Seung Tae Kim, Jason K. Sa, Sung Yong Oh, Kyung Kim, Jung Yong Hong, Won Ki Kang, Kyoung-Mee Kim, Jeeyun Lee
Summary: The study identified a subset of GC patients with distinct clinical response to ramucirumab therapy through prospective molecular characterization. The results demonstrate the feasibility of personalized therapeutic opportunities in gastric cancer.
Article
Oncology
Yasuyuki Kawamoto, Satoshi Yuki, Kentaro Sawada, Michio Nakamura, Osamu Muto, Susumu Sogabe, Yoshiaki Shindo, Atsushi Ishiguro, Atsushi Sato, Yasushi Tsuji, Masayoshi Dazai, Hiroyuki Okuda, Takashi Meguro, Kazuaki Harada, Mari Sekiguchi, Kazufumi Okada, Yoichi M. Ito, Yuh Sakata, Naoya Sakamoto, Yoshito Komatsu
Summary: This article reports the efficacy and safety of ramucirumab plus irinotecan combination therapy as second-line treatment in previously treated advanced gastric cancer patients. Although the primary endpoint was not achieved statistically, the combination therapy showed anticancer activity and a manageable safety profile.
Article
Oncology
Akio Nakasya, Yuya Hagiwara, Tatsuki Ikoma, Yusuke Kurioka, Toshihiko Matsumoto, Yoshiyuki Yamamoto, Takao Tsuduki, Takeshi Kajiwara, Toshikazu Moriwaki, Tomohiro Nishina, Natsumi Yamashita, Ichinosuke Hyodo
Summary: This study compared the efficacy and toxicity of nab-PTX + RAM and PTX + RAM for the treatment of AGC using propensity score matching. The results showed that nab-PTX + RAM exhibited more favorable trends in terms of PFS and OS but was more myelosuppressive than PTX + RAM.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Sylvie Lorenzen, Peter Thuss-Patience, Claudia Pauligk, Eray Goekkurt, Thomas Ettrich, Florian Lordick, Michael Stahl, Peter Reichardt, Martin Soekler, Daniel Pink, Stefan Probst, Axel Hinke, Thorsten O. Goetze, Salah E. Al-Batran
Summary: This study reported the efficacy and safety analyses of FOLFIRI plus ramucirumab versus paclitaxel plus ramucirumab in patients with metastatic gastroesophageal adenocarcinoma. Although overall survival rates were similar between the two groups, FOLFIRI plus ramucirumab showed better objective response rates and progression-free survival.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Hye Sook Han, Bum Jun Kim, Hee-Jung Jee, Min-Hee Ryu, Se Hoon Park, Sun Young Rha, Jong Gwang Kim, Woo Kyun Bae, Keun-Wook Lee, Do-Youn Oh, In-Ho Kim, Sun Jin Sym, So Yeon Oh, Hyeong Su Kim, Ji-Hye Byun, Dong Sook Kim, Young Ju Suh, Hyonggin An, Dae Young Zang
Summary: This study analyzed real-world data of patients with gastric or GEJ cancer treated with ramucirumab plus paclitaxel in South Korea, showing an objective response rate of 15.1% and disease control rate of 57.7% in second-line treatment. The study also identified factors negatively associated with overall survival and demonstrated the efficacy and safety of this treatment option.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2021)
Article
Oncology
Yuka Masuda, Yoshikazu Kananazawa, Kunihiko Matsuno, Daisuke Kakinuma, Nobuyuki Sakurazawa, Fumihiko Ando, Nobutoshi Hagiwara, Tsutomu Nomura, Shunji Kato, Toshiro Yoshiyuki, Hioshi Yoshida
Summary: This study investigated the prognostic impact of the clinical response to taxanes plus ramucirumab (RAM) for AGC patients. The results showed that the response to taxanes plus RAM chemotherapy had an impact on the survival of patients with AGC.
ANTICANCER RESEARCH
(2022)
Article
Oncology
Lorenzo Fornaro, Gianna Musettini, Paola Orlandi, Irene Pecora, Caterina Vivaldi, Marta Banchi, Francesca Salani, Elisabetta Fini, Valentina Massa, Silvia Catanese, Federico Cucchiara, Monica Lencioni, Gianluca Masi, Enrico Vasile, Guido Bocci
Summary: Ramucirumab plus paclitaxel is considered standard treatment for second-line gastric carcinoma (GC) patients. This study evaluated plasma VEGF-A, VEGF-D, and sVEGFR-2 as potential markers of resistance or response to this treatment. Results showed significant increases in VEGF-A and VEGF-D levels during treatment, and early increase in sVEGFR-2 levels was associated with longer progression-free survival and overall survival.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Bum Jun Kim, Hee-Jung Jee, Sun Young Rha, Hye Sook Han, Min-Hee Ryu, Se Hoon Park, Jong Gwang Kim, Woo Kyun Bae, Keun-Wook Lee, Do-Youn Oh, Ji-Hye Byun, Dong Sook Kim, Young Ju Suh, Hyonggin An, Dae Young Zang
Summary: In patients with HER2-positive gastric or gastro-esophageal junction adenocarcinoma, second-line treatment with ramucirumab plus paclitaxel showed a significantly higher objective response rate compared to patients with HER2-negative disease. However, the increased response to treatment did not correlate with an improvement in overall survival (OS).
Article
Biochemistry & Molecular Biology
Hai-Qiang Mai, Qiu-Yan Chen, Dongping Chen, Chaosu Hu, Kunyu Yang, Jiyu Wen, Jingao Li, Ying-Rui Shi, Feng Jin, Ruilian Xu, Jianji Pan, Shenhong Qu, Ping Li, Chunhong Hu, Yi-Chun Liu, Yi Jiang, Xia He, Hung-Ming Wang, Wan-Teck Lim, Wangjun Liao, Xiaohui He, Xiaozhong Chen, Zhigang Liu, Xianglin Yuan, Qi Li, Xiaoyan Lin, Shanghua Jing, Yanju Chen, Yin Lu, Ching-Yun Hsieh, Muh-Hwa Yang, Chia-Jui Yen, Jens Samol, Hui Feng, Sheng Yao, Patricia Keegan, Rui-Hua Xu
Summary: The study is a double-blind phase 3 trial that shows the combination of toripalimab with GP chemotherapy for RM-NPC patients provides a superior PFS compared to GP alone. Most adverse events were similar between the two arms, but immune-related AEs were more frequent in the toripalimab arm.
Article
Oncology
Stefano Cascinu, Gyorgy Bodoky, Kei Muro, Eric Van Cutsem, Sang Cheul Oh, Gunnar Folprecht, Sumitra Ananda, Gustavo Girotto, Zev A. Wainberg, Maria Luisa Limon Miron, Jaffer Ajani, Ran Wei, Astra M. Liepa, Roberto Carlesi, Michael Emig, Atsushi Ohtsu
Summary: In the RAINBOW study, ramucirumab plus paclitaxel showed higher objective response rate than the control arm in previously treated advanced gastric or gastroesophageal junction adenocarcinoma patients, with longer response duration, leading to improved quality of life.
Article
Gastroenterology & Hepatology
Emeric Boisteau, Eric Francois, Thomas Aparicio, Karine Le Malicot, Rabia Boulahssass, Thierry Lecomte, Pierre Laurent-Puig, Boris Guiu, Elena Paillaud, Marie-Pierre Galais, Daniel Lopez-Trabada Ataz, David Tougeron, Louis-Marie Dourthe, Rosine Guimbaud, Emmanuelle Samalin, Marie Moreau, Christophe Louvet, Come Lepage, Astrid Lievre
Summary: The study aims to evaluate the impact of second-line Ramucirumab alone or combined with Paclitaxel on overall survival and quality of life in patients over 70 years old with advanced gastric cancer.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Oncology
Chang Gon Kim, Minkyu Jung, Hyo Song Kim, Choong-kun Lee, Hei-Cheul Jeung, Dong-Hoe Koo, Woo Kyun Bae, Dae Young Zang, Bum Jun Kim, Hyunki Kim, Un-Jung Yun, Jingmin Che, Sejung Park, Tae Soo Kim, Woo Sun Kwon, Juin Park, Sang Woo Cho, Chung Mo Nam, Hyun Cheol Chung, Sun Young Rha
Summary: Trastuzumab combined with ramucirumab and paclitaxel showed appreciable efficacy with manageable safety profiles in patients with previously treated HER2-positive G/GEJ cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Chemistry, Medicinal
M. Kimura, E. Usami, H. Teramachi, T. Yoshimura
Summary: This study found that grade ≥1 neutropenia and the number of anti-cancer drugs used were independently associated with survival in patients receiving paclitaxel plus ramucirumab as second line chemotherapy for advanced gastric cancer. Patients with grade ≥1 neutropenia had significantly prolonged treatment durations compared to those without, indicating potential benefits of this therapy for patients with initial neutropenia.
Article
Oncology
Tianshu Liu, Yuxian Bai, Xiaoyan Lin, Wei Li, Jufeng Wang, Xiaochun Zhang, Hongming Pan, Chunmei Bai, Li Bai, Ying Cheng, Jingdong Zhang, Haijun Zhong, Yi Ba, Wenwei Hu, Ruihua Xu, Weijian Guo, Shukui Qin, Nong Yang, Jianwei Lu, Kohei Shitara, Ming Lei, Mingshun Li, Nicole Bao, Tian Chen, Lin Shen
Summary: Chinese patients in the global CheckMate 649 study showed improved efficacy and safety with nivolumab plus chemotherapy as first-line treatment for GC/GEJC/EAC.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Oncology
Shuichi Hironaka
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Oncology
Kohei Shitara, Yoshitaka Honma, Yasushi Omuro, Kensei Yamaguchi, Keisho Chin, Kei Muro, Shintaro Nakagawa, Satoe Kawakami, Shuichi Hironaka, Tomohiro Nishina
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Oncology
Ken Kato, Yuichiro Doki, Takashi Ura, Yasuo Hamamoto, Takashi Kojima, Takahiro Tsushima, Shuichi Hironaka, Hiroki Hara, Toshihiro Kudo, Satoru Iwasa, Kei Muro, Hirofumi Yasui, Keiko Minashi, Kensei Yamaguchi, Atsushi Ohtsu, Yuko Kitagawa
Article
Gastroenterology & Hepatology
Shuichi Hironaka, Azusa Komori, Ryunosuke Machida, Yoshinori Ito, Hiroya Takeuchi, Gakuto Ogawa, Ken Kato, Masakatsu Onozawa, Keiko Minashi, Tomonori Yano, Kenichi Nakamura, Takahiro Tsushima, Hiroki Hara, Isao Nozaki, Takashi Ura, Keisho Chin, Haruhiko Fukuda, Yuko Kitagawa
Article
Gastroenterology & Hepatology
Takashi Ura, Shuichi Hironaka, Yasuhiro Tsubosa, Junki Mizusawa, Ken Kato, Takahiro Tsushima, Kunihiro Fushiki, Keisho Chin, Akihisa Tomori, Tatsuya Okuno, Hisayuki Matsushita, Takashi Kojima, Yuichiro Doki, Hitoshi Kusaba, Kazumasa Fujitani, Shiko Seki, Yuko Kitagawa
Summary: This study investigated the association between early tumor shrinkage (ETS) and depth of response (DpR) and clinical outcomes in patients with metastatic esophageal cancer treated with bDCF. The results showed that ETS and DpR were associated with progression-free survival and overall survival in these patients.
Article
Oncology
Kazuo Nishikawa, Shuichi Hironaka, Takashi Inagaki, Azusa Komori, Satoshi Otsu, Kenji Mitsugi, Akitaka Makiyama, Koichiro Watanabe, Shingo Tamura, Yuta Okumura, Hitoshi Kusaba, Taito Esaki, Eishi Baba, Kuniaki Shirao
Summary: The survival rates were similar between patients with cancer of unknown primary site in the unfavourable subset who received site-specific treatment and those who received empiric treatment. Performance status, number of metastatic sites, and hypoalbuminaemia were identified as independent prognostic factors for overall survival in the unfavourable subset.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Shuichi Hironaka, Ryo Sadachi, Nozomu Machida, Satoru Iwasa, Yasuhide Yamada, Mitsuru Sasako, Takaki Yoshikawa, Narikazu Boku, Masanori Terashima
Summary: The study found that lower CrCl was associated with higher incidences of severe adverse events in cisplatin plus S-1 therapy, but not in docetaxel plus cisplatin plus S-1 therapy. However, there were no significant differences in overall survival, progression-free survival, and response rates based on CrCl levels.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2022)