Article
Chemistry, Multidisciplinary
Yuxuan Xiong, Zhengtao Yong, Chen Xu, Qingyuan Deng, Qiang Wang, Shiyou Li, Chong Wang, Zhijie Zhang, Xiangliang Yang, Zifu Li
Summary: A multifunctional cascade bioreactor (HCG) based on self-assembly of pH-responsive hydroxyethyl starch prodrugs, copper ions, and glucose oxidase (GOD) combined with hyperbaric oxygen (HBO) shows efficient cooperative therapy against aggressive breast cancers. The HCG releases cargoes in response to the tumor microenvironment and HBO activates the oxidation of glucose, promoting drug release and tumor penetration. The combined strategy suppresses tumor growth, inhibits metastasis, and shows translational potential for GOD-based therapies.
Article
Chemistry, Multidisciplinary
Zhiguo Li, Xiaotong Fan, Zheng Luo, Xian Jun Loh, Yedong Ma, Enyi Ye, Yun-Long Wu, Chaobin He, Zibiao Li
Summary: The authors developed a multifunctional nanoenzyme-chitosan hydrogel complex to improve the microenvironment of diabetic wounds and provide continuous oxygen delivery. By reducing glucose and reactive oxygen species concentrations and promoting cell proliferation, migration, and angiogenesis, the complex significantly accelerated diabetic wound healing.
Article
Cardiac & Cardiovascular Systems
Romain Guenneugues, Anne Henckes, Vincent Mansourati, Jacques Mansourati
Summary: This study evaluated the effects of hyperbaric oxygen therapy on implantable cardioverter-defibrillators (ICD) and found no mechanical or electronic damage. These findings may lead to a reconsideration of the contraindication of emergency hyperbaric oxygen therapy for ICD recipients.
Article
Biotechnology & Applied Microbiology
Shuting Zuo, Zhenyu Wang, Liping Zhao, Jing Wang
Summary: In this study, gold nanocages (GNCs) loaded with a hyperpyrexia-sensitive nitric oxide (NO) donor (thiolate cupferron) were constructed to integrate extrinsic radiosensitization, local photothermal therapy, and near-infrared-activated NO gas therapy. The resulting nanoplatform (GNCs@NO) showed excellent effects as a combination therapy for triple-negative breast cancer (TNBC), with high photothermal conversion efficiency and synergistic enhancement of anticancer efficacy through the production of reactive nitrogen species.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Oncology
Katarina Kopcalic, Ivana Z. Matic, Irina Besu, Vesna Stankovic, Zoran Bukumiric, Tatjana P. Stanojkovic, Aleksandar Stepanovic, Marina Nikitovic
Summary: This study aimed to investigate the possible relations between serum concentrations of IL-6 and TGF-beta 1 and adverse effects of radiotherapy in prostate cancer patients. The results showed significant positive associations between diabetes mellitus and changes in acute genitourinary toxicity grades, as well as between smoking and maximum fatigue levels. Furthermore, there were positive correlations between IL-6 and TGF-beta 1 concentrations and genitourinary toxicity grades and fatigue levels.
Article
Biochemistry & Molecular Biology
Clement Leveque, Simona Mrakic Sposta, Sigrid Theunissen, Peter Germonpre, Kate Lambrechts, Alessandra Vezzoli, Gerardo Bosco, Morgan Levenez, Pierre Lafere, Francois Guerrero, Costantino Balestra
Summary: Hyperbaric oxygen therapy (HBOT) is a treatment method that exposes the body to pure oxygen at increased atmospheric pressure. This study investigated the metabolic responses to hyperbaric hyperoxia exposures at 1.4 and 2.5 ATA for 1 hour. The results showed that both mild and high hyperbaric hyperoxia led to a significant increase in the production of reactive oxygen species (ROS) and antioxidant reactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Justyna Podgorska-Bednarz, Lidia Perenc
Summary: The review found that hyperbaric oxygen therapy (HBOT) is not significantly effective in treating autism spectrum disorder (ASD). Most literature reviews and intervention study results do not recommend the use of this therapy in children with ASD.
Article
Biochemistry & Molecular Biology
Vivian Doerr, Ryan N. Montalvo, Branden L. Nguyen, Franccesco P. Boeno, Michael D. Sunshine, Victoria E. Bindi, David D. Fuller, Ashley J. Smuder
Summary: DOX chemotherapy can lead to cardiorespiratory dysfunction, while HBO therapy may increase muscle antioxidant expression. However, HBO therapy is not sufficient to prevent DOX-induced cardiorespiratory dysfunction.
Review
Pharmacology & Pharmacy
Yu Zhang, Ruizhe Huang, Yunchun Jiang, Wenhao Shen, Hailong Pei, Guanglin Wang, Pei Pei, Kai Yang
Summary: Bacteria-mediated anti-tumor therapy has attracted attention due to its tumor-targeting ability and immune-activation characteristics. It has made significant progress in overcoming the limitations of monotherapy and eradicating tumors, especially when combined with traditional therapy like radiotherapy. Bacteria and their derivatives can improve the sensitivity of tumor radiotherapy and protect normal tissues. Genetically engineered bacteria and bacteria-based biomaterials have expanded their applications in radiotherapy.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Engineering, Environmental
Puze Li, Yuzhu Yao, Xue Chen, Cheng Song, Meichan Wu, Jinzhao Huang, Dongdong Wang, Xuyu Li, Ban Luo, Xiangliang Yang, Jun Hu
Summary: A hyperbaric oxygen-strengthened nanoadjuvant platform has been developed to enhance the efficacy of immune checkpoint blockade therapy against breast cancer. By providing essential fuels and inducing immunogenic cell death, this nanosystem enhances the immunogenicity of tumor cells and promotes the maturation of dendritic cells and priming of cytotoxic T cells.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Medicine, General & Internal
Diogo Alpuim Costa, Pedro Modas Daniel, Joao Vieira Branco
Summary: Pneumatosis cystoides intestinalis (PCI) is a rare condition characterized by gas-filled cysts in the gastrointestinal tract wall, with varying degrees of severity and potential complications. Treatment options range from conservative approaches to surgery, with hyperbaric oxygen therapy (HBOT) showing promising results in selected cases. Further research is needed to fully understand the pathophysiology and optimal management strategies for PCI.
FRONTIERS IN MEDICINE
(2021)
Review
Oncology
Diogo Alpuim Costa, J. Guilherme Goncalves-Nobre, Mafalda Sampaio-Alves, Nuno Guerra, Joana Arana Ribeiro, Carla Espiney Amaro
Summary: Neuroblastoma is a common cancer in infants with diverse clinical presentations and prognostic factors. Multimodal therapy approaches include chemotherapy, radiotherapy, immunotherapy, and surgical resection. Hyperbaric oxygen therapy is used as a complementary measure to overcome tumor hypoxia.
FRONTIERS IN ONCOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jia Liu, Wei An, Qian Zhao, Zhen Liu, Ying Jiang, Huiqing Li, Di Wang
Summary: The combined exposure of IR and HBO significantly enhanced the cytotoxicity of OSCC cells and re-sensitized radio-resistant OSCC cells to IR through GPX4/ferroptosis regulation. Clinical data suggested a correlation between high GPX4 levels and poor chemo-radiotherapy outcome.
Article
Chemistry, Multidisciplinary
Xianya Qin, Conglian Yang, Hongbo Xu, Runzan Zhang, Dan Zhang, Jingyao Tu, Yuanyuan Guo, Boning Niu, Li Kong, Zhiping Zhang
Summary: The biosynthesis of nanomedicine using tumor cells as a basis has shown potential for enhancing radiotherapy sensitivity and promoting immune responses. Au@MC38's intracellular biomineralization and exocytosis process can be regulated by cellular metabolites and other factors, potentially leading to effective immune responses through radio-sensitization. Additionally, the strategy has demonstrated an effective inhibition of primary and metastatic tumors, as well as improving survival benefits when combined with immune checkpoint blockade.
Article
Respiratory System
Xiucheng Liu, Hao Qin, Zheng Li, Yin Lv, Shoujie Feng, Wei Zhuang, Xiaoyu Quan, Chen Guo, Chang Chen, Hao Zhang
Summary: Inspiratory hyperoxia has special significance for the malignant phenotype of lung cancer cells, inhibiting metastasis and improving long-term survival by inducing significant intracellular metabolic changes.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Oncology
Juan Lopez-Tarjuelo, Virginia Morillo-Macias, Ana Bouche-Babiloni, Carlos Ferrer-Albiach, Agustin Santos-Serra
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2016)
Article
Health Care Sciences & Services
Alfonso Gomez-Iturriaga, Jon Cacicedo, Arturo Navarro, Virginia Morillo, Patricia Willisch, Claudia Carvajal, Eduardo Hortelano, Jose Luis Lopez-Guerra, Ana Illescas, Francisco Casquero, Olga Del Hoyo, Raquel Ciervide, Ana Irasarri, Jose Ignacio Pijoan, Pedro Bilbao
BMC PALLIATIVE CARE
(2015)
Article
Oncology
Juan Lopez-Tarjuelo, Virginia Morillo-Macias, Ana Bouche-Babiloni, Enrique Boldo-Roda, Rafael Lozoya-Albacar, Carlos Ferrer-Albiach
RADIATION ONCOLOGY
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jon Cacicedo, Alfonso Gomez-Iturriaga, Arturo Navarro, Virginia Morillo, Patricia Willisch, Jose Luis Lopez-Guerra, Ana Illescas, Francisco Casquero, Olga Del Hoyo, Raquel Ciervide, Lorea Martinez-Indart, Pedro Bilbao, Dirk Rades
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2018)
Review
Oncology
O. Leaman Alcibar, D. Candini, F. Lopez-Campos, M. Albert Antequera, V Morillo Macias, A. J. Conde, A. Rodriguez Perez, A. Hervas Moron, J. Contreras Martinez, C. Ferrer Albiach, S. Navarro Aguilar, M. E. Rodriguez-Ruiz
CLINICAL & TRANSLATIONAL ONCOLOGY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jon Cacicedo, Juan Pablo Ciria, Virginia Morillo, Lorea Martinez-Indart, Alfonso Gomez-Iturriaga, Olga del Hoyo, David Buchser, Andere Frias, Inigo San Miguel, Fernan Suarez, Francisco Casquero
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2020)
Letter
Oncology
Pilar M. Samper Ots, Jose Zapatero Ortuno, Sara Pedraza Fernandez, Esther Mayrata Canellas, Carmen Gonzalez San Segundo, Maider Campo Vargas, Begona Caballero, Monica Ramos Albiac, Gonzalo Vazquez Masedo, Beatriz Alvarez, Silvia Rodriguez Villalba, Teresa Munoz Miguelanez, Patricia Diezhandino Garcia, Gemma Sancho, Laura Guzman Gomez, Juana Tripero, Mikel Rico Rico Oses, Carmen Ibanez Villoslada, Ana Maria Soler Soler Rodriguez, Maria Luisa Chust, Adriana Fondevilla Soler, Eva Maria Lozano Martin, Virginia Morillo Macias, Claudio Fuentes Sanchez, Laura Torrado Moya, Jesus Fernandez Lopez, Josep Maria Sole, Marcos Guijarro Verdu, Moises Mira Flores, Amadeo Wals, Jose Exposito Hernandez
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Encarnacion Fernandez-Camacho, Carlos Ferrer-Ramos, Virginia Morilllo-Macias, Marta Rodriguez-Cordon, Angel Sanchez-Iglesias, Inmaculada Beato-Tortajada, Alicia Frances-Munoz, Rodrigo Muelas-Soria, Teresa Piquer-Camanes, Ana Isabel Santafe-Jimenez, Vanessa Aznar-Tortonda, Carlos Ferrer-Albiach
Summary: This study aimed to analyze the impact of frailty screening questionnaires on treatment decision making in elderly patients receiving radiation oncology. The study found that the therapeutic modification rate increased to 21% after frailty analysis, and frail patients were 5.8 times more likely to have their radiotherapy modified, suggesting that the frailty screening test is a reliable and efficient aid in treatment approach.
Article
Biochemistry & Molecular Biology
Rodrigo Muelas-Soria, Rafael Garcia-Molla, Virginia Morillo-Macias, Jorge Bonaque-Alandi, Patricia Sorribes-Carreras, Francisco Garcia-Pinon, Carlos Ferrer-Albiach
Summary: The aim of this study was to develop an offline adaptive radiotherapy (ART) protocol based on deformable image registration (DIR), which can identify significant dosimetric changes in the initial treatment fractions. The study found that the rectal dose in some patients exceeded the dose limitation, and there were significant variations in the planned rectal volume in the first, third, and fifth treatment fractions. Furthermore, a variation rate of D50 in the third fraction could reliably identify dose changes that exceeded the rectal dose constraint.
Article
Oncology
Angel Sanchez Iglesias, Virginia Morillo Macias, Alfonso Pico Peris, Almudena Fuster-Matanzo, Anna Nogue Infante, Rodrigo Muelas Soria, Fuensanta Bellvis Bataller, Marcos Domingo Pomar, Carlos Casillas Melendez, Raul Yebana Huertas, Carlos Ferrer Albiach
Summary: In this study, imaging biomarker profiles extracted from MRI images were found to be able to discriminate prostate cancer patients according to their risk and the occurrence of biochemical recurrence. The predictive value of the imaging biomarkers was further improved when combined with clinical data.
Article
Surgery
A. Mayol Oltra, E. Boldo Roda, R. Lozoya Albacar, V. Morillo Macias, N. Nobleja Quiles
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2020)
Article
Oncology
Juan Lopez-Tarjuelo, Ana Bouche-Babiloni, Virginia Morillo-Macias, Agustin Santos-Serra, Carlos Ferrer-Albiach
REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY
(2017)