Role of Kruppel-like factor 4 in atherosclerosis

Reflections on Atherosclerosis: Lesson from the Past and Future Research Directions

(2020) Sergio Minelli et al.   Journal of Multidisciplinary Healthcare

KLF4-Induced Connexin40 Expression Contributes to Arterial Endothelial Quiescence

(2019) Jean-François Denis et al.   Frontiers in Physiology

MicroRNA-92a promotes vascular smooth muscle cell proliferation and migration through the ROCK/MLCK signalling pathway

(2019) Jingyu Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Adipolin/CTRP12 protects against pathological vascular remodeling through suppression of smooth muscle cell growth and macrophage inflammatory response

(2019) Hayato Ogawa et al.   CARDIOVASCULAR RESEARCH

Targeting Mechanosensitive Transcription Factors in Atherosclerosis

(2019) Niu Niu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Absence of myeloid Klf4 reduces prostate cancer growth with pro-atherosclerotic activation of tumor myeloid cells and infiltration of CD8 T cells

(2018) David J. Barakat et al.   PLoS One

Characterization of Carotid Smooth Muscle Cells during Phenotypic Transition

(2018) Haize Goikuria et al.   Cells

Kallistatin Inhibits Atherosclerotic Inflammation by Regulating Macrophage Polarization

(2018) Bing Li et al.   HUMAN GENE THERAPY

LncRNA NKILA regulates endothelium inflammation by controlling a NF-κB/KLF4 positive feedback loop

(2018) Xinxing Zhu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Daniel Dicker et al.   LANCET

Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk

(2018) Dharini Iyer et al.   PLoS Genetics

Krüppel-like factor 4 (KLF4): What we currently know

(2017) Amr M. Ghaleb et al.   GENE

microRNA let-7g suppresses PDGF-induced conversion of vascular smooth muscle cell into the synthetic phenotype

(2017) Tzu-Ming Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Comparison of Risk Factor between Lacunar Stroke and Large Artery Atherosclerosis Stroke: A Cross-Sectional Study in China

(2016) Pu Lv et al.   PLoS One

Txnip ablation reduces vascular smooth muscle cell inflammation and ameliorates atherosclerosis in apolipoprotein E knockout mice

(2015) Chang Hyun Byon et al.   ATHEROSCLEROSIS

Lncing Epigenetic Control of Transcription to Cardiovascular Development and Disease

(2015) Gizem Rizki et al.   CIRCULATION RESEARCH

KLF4 mediates the link between TGF-β1-induced gene transcription and H3 acetylation in vascular smooth muscle cells

(2015) Ming He et al.   FASEB JOURNAL

Klf4 Expression in Conventional Dendritic Cells Is Required for T Helper 2 Cell Responses

(2015) Roxane Tussiwand et al.   IMMUNITY

Converting smooth muscle cells to macrophage-like cells with KLF4 in atherosclerotic plaques

(2015) Michael E Rosenfeld   NATURE MEDICINE

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

Development and Function of Dendritic Cell Subsets

(2014) Alexander Mildner et al.   IMMUNITY

Macrophage Polarization in Inflammatory Diseases

(2014) Yan-Cun Liu et al.   International Journal of Biological Sciences

Role of Krüppel-Like Factor 4 and its Binding Proteins in Vascular Disease

(2014) Tadashi Yoshida et al.   Journal of Atherosclerosis and Thrombosis

TGF-β/Smad3 inhibit vascular smooth muscle cell apoptosis through an autocrine signaling mechanism involving VEGF-A

(2014) X Shi et al.   Cell Death & Disease

Deletion of Krüppel‐Like Factor 4 in Endothelial and Hematopoietic Cells Enhances Neointimal Formation Following Vascular Injury

(2014) Tadashi Yoshida et al.   Journal of the American Heart Association

Key role of microRNA-15a in the KLF4 suppressions of proliferation and angiogenesis in endothelial and vascular smooth muscle cells

(2013) Xuemei Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of a Klf4-dependent upstream repressor region mediating transcriptional regulation of the myocardin gene in human smooth muscle cells

(2013) Elizebeth C. Turner et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Vaspin inhibited proinflammatory cytokine induced activation of nuclear factor-kappa B and its downstream molecules in human endothelial EA.hy926 cells

(2013) Shiwei Liu et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Transforming Growth Factor β Inhibits Platelet Derived Growth Factor-Induced Vascular Smooth Muscle Cell Proliferation via Akt-Independent, Smad-Mediated Cyclin D1 Downregulation

(2013) Abel Martin-Garrido et al.   PLoS One

The Role of PPARs in Placental Immunology: A Systematic Review of the Literature

(2013) Stefan Hutter et al.   PPAR Research

Smooth Muscle–Selective Inhibition of Nuclear Factor‐κB Attenuates Smooth Muscle Phenotypic Switching and Neointima Formation Following Vascular Injury

(2013) Tadashi Yoshida et al.   Journal of the American Heart Association

Myeloid Krüppel-Like Factor 4 Deficiency Augments Atherogenesis in ApoE −/− Mice—Brief Report

(2012) Nikunj Sharma et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cooperative Binding of KLF4, pELK-1, and HDAC2 to a G/C Repressor Element in the SM22α Promoter Mediates Transcriptional Silencing During SMC Phenotypic Switching In Vivo

(2012) Morgan Salmon et al.   CIRCULATION RESEARCH

CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling

(2012) Katrin Faber et al.   JOURNAL OF CLINICAL INVESTIGATION

Transforming growth factor-β increases vascular smooth muscle cell proliferation through the Smad3 and extracellular signal-regulated kinase mitogen-activated protein kinases pathways

(2012) Pasithorn A. Suwanabol et al.   JOURNAL OF VASCULAR SURGERY

The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation

(2012) Ryan Schmidt et al.   GENOME BIOLOGY

Micromanaging Vascular Smooth Muscle Cell Differentiation and Phenotypic Modulation

(2011) Brandi N. Davis-Dusenbery et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ATRA activates and PDGF-BB represses the SM22α promoter through KLF4 binding to, or dissociating from, its cis-DNA elements

(2011) Kun Yu et al.   CARDIOVASCULAR RESEARCH

Downregulation of the transcription factor KLF4 is required for the lineage commitment of T cells

(2011) Xiaomin Wen et al.   CELL RESEARCH

Krüppel-like factor 4 (KLF4) directly regulates proliferation in thymocyte development and IL-17 expression during Th17 differentiation

(2011) Jie An et al.   FASEB JOURNAL

Down-regulation of Krüppel-like Factor-4 (KLF4) by MicroRNA-143/145 Is Critical for Modulation of Vascular Smooth Muscle Cell Phenotype by Transforming Growth Factor-β and Bone Morphogenetic Protein 4

(2011) Brandi N. Davis-Dusenbery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Krüppel-Like Factor-4 Transcriptionally Regulates VE-Cadherin Expression and Endothelial Barrier Function

(2010) Colleen E. Cowan et al.   CIRCULATION RESEARCH

miR-146a and Krüppel-like factor 4 form a feedback loop to participate in vascular smooth muscle cell proliferation

(2010) Shao-guang Sun et al.   EMBO REPORTS

Cutting Edge: The Transcription Factor Kruppel-Like Factor 4 Regulates the Differentiation of Th17 Cells Independently of ROR t

(2010) L. Lebson et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-1 Regulates Smooth Muscle Cell Differentiation by Repressing Kruppel-Like Factor 4

(2010) Changqing Xie et al.   STEM CELLS AND DEVELOPMENT

TGF-β through Smad3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation

(2009) Shirling Tsai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

All-trans retinoic acid increases KLF4 acetylation by inducing HDAC2 phosphorylation and its dissociation from KLF4 in vascular smooth muscle cells

(2009) Fang Meng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells

(2009) Guadalupe Villarreal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Macrophage-Specific Expression of Mannose-Binding Lectin Controls Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

(2009) Robert A. Matthijsen et al.   CIRCULATION

Kruppel-like Factor 4 Is a Novel Mediator of Kallistatin in Inhibiting Endothelial Inflammation via Increased Endothelial Nitric-oxide Synthase Expression

(2009) Bo Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity

(2009) Kimberly R. Cordes et al.   NATURE

IL-23 and Th17 Cells Enhance Th2-Cell–mediated Eosinophilic Airway Inflammation in Mice

(2008) Hidefumi Wakashin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

PIAS1 Mediates TGFβ-Induced SM α-Actin Gene Expression Through Inhibition of KLF4 Function-Expression by Protein Sumoylation

(2008) Keiko Kawai-Kowase et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Conditional Deletion of Krüppel-Like Factor 4 Delays Downregulation of Smooth Muscle Cell Differentiation Markers but Accelerates Neointimal Formation Following Vascular Injury

(2008) Tadashi Yoshida et al.   CIRCULATION RESEARCH