Article
Biochemistry & Molecular Biology
Luis Perpetuo, Antonio S. Barros, Jessica Dalsuco, Rita Nogueira-Ferreira, Pedro Resende-Goncalves, Ines Falcao-Pires, Rita Ferreira, Adelino Leite-Moreira, Fabio Trindade, Rui Vitorino
Summary: Coronary artery disease (CAD) and aortic valve stenosis (AVS) are common heart diseases with shared risk factors and pathogenesis. Urine, as a noninvasive collection method, is promising for biomarker assessment. This study identified dysregulated proteins in urine that could potentially differentiate these diseases from healthy subjects, and showed strong correlations between these proteins and a common cardiovascular risk factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Gudrun Feuchtner, Sven Bleckwenn, Leon Stoessl, Fabian Plank, Christoph Beyer, Nikolaos Bonaros, Thomas Schachner, Thomas Senoner, Gerlig Widmann, Can Gollmann-Tepekoeylue, Johannes Holfeld, Wolfgang Dichtl, Fabian Barbieri
Summary: Patients with bicuspid aortic valve stenosis have lower coronary calcium and less severe coronary stenosis compared to those with tricuspid aortic valve stenosis. Majority of bicuspid aortic valve patients have no or non-obstructive coronary artery disease, while obstructive CAD is more frequently observed in tricuspid aortic valve patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Veronika A. Myasoedova, Stefano Genovese, Laura Cavallotti, Alice Bonomi, Mattia Chiesa, Jeness Campodonico, Maurizio Rondinelli, Nicola Cosentino, Damiano Baldassarre, Fabrizio Veglia, Mauro Pepi, Francesco Alamanni, Gualtiero Colombo, Giancarlo Marenzi, Paolo Poggio
Summary: The study found that AVSc is frequently detected in high-risk CAD patients and is associated with long-term mortality. AVSc may be an underestimated marker of systemic cardiovascular risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Camilla Nordheim Solli, Sandra Chamat-Hedemand, Hanne Elming, Anh Ngo, Lasse Kjaer, Vibe Skov, Anders Lindholm Sorensen, Christina Ellervik, Andreas Fuchs, Per Ejlstrup Sigvardsen, Jorgen Tobias Kuhl, Klaus Fuglsang Kofoed, Borge G. Nordestgaard, Hans Hasselbalch, Niels Eske Bruun
Summary: This study investigated whether patients with Philadelphia-negative Myeloproliferative Neoplasms (MPNs) have an increased burden of cardiac calcification and found that MPNs patients have a higher prevalence of coronary artery calcium score (CACS) and aortic valve calcification (AVC) compared to the general population. This association remains significant after adjusting for cardiovascular risk factors.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marta Marcos-Mangas, Ana Revilla-Orodea, Teresa Sevilla, Esther Gonzalez-Bartol, Israel Sanchez-Lite, Noelia Uruena-Martinez, Roman Arnold, Itziar Gomez, J. Alberto San Roman
Summary: Coronary artery calcification is associated with cardiovascular events in patients with chest pain, while aortic valve calcification is not.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alberto Alperi, Siamak Mohammadi, Francisco Campelo-Parada, Erika Munoz-Garcia, Luis Nombela-Franco, Laurent Faroux, Gabriela Veiga, Vicenc Serra, Quentin Fischer, Isaac Pascual, Luis Asmarats, Enrique Gutierrez, Ander Regueiro, Victoria Vilalta, Henrique B. Ribeiro, Anthony Matta, Antonio Munoz-Garcia, German Armijo, Damien Metz, Jose M. de la Torre Hernandez, Eduard Rodenas-Alesina, Marina Urena, Cesar Moris, Dabit Arzamendi, Pedro Perez-Fuentes, Eduard Fernandez-Nofrerias, Diego Carter Campanha-Borges, Jules Mesnier, Pierre Voisine, Eric Dumont, Dimitri Kalavrouziotis, Josep Rodes-Cabau
Summary: This study aimed to compare clinical outcomes between transfemoral TAVR+PCI and SAVR+CABG in patients with complex CAD and severe AS. After 3 years of follow-up, both groups showed similar rates of MACCE, but TAVR+PCI group had a higher risk of new coronary revascularization.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Jorge Chavarria, Matt Sibbald, James Velianou, Madhu Natarajan, Iqbal Jaffer, Amanda Smith, Tej Sheth
Summary: This study evaluated the assessment of coronary artery disease (CAD) using computed tomographic angiography (CTA) in transcatheter aortic valve replacement (TAVR) patients. The results showed that TAVR CTA can avoid pre-TAVR invasive angiography in more than 70% of patients while rarely missing high-risk findings.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Roberto Valvo, Giuliano Costa, Corrado Tamburino, Marco Barbanti
Summary: TAVI has revolutionized the treatment of severe, symptomatic aortic stenosis and is now a proven and effective alternative to surgery. However, with the expansion towards younger patients, long-term considerations become more important. The chance of requiring future coronary interventions after TAVI increases dramatically with patients' life expectancy despite the decrease in coronary artery disease prevalence.
Article
Medicine, General & Internal
Nanruoyi Zhou, Gentian Lluri
Summary: Our study found that right dominant coronary artery circulation is predominant in patients with BAV, similar to the general population. Interestingly, left dominance is significantly associated with the occurrence of CoA in patients with BAV.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Agastya D. Belur, Naresh Solankhi, Ravi Sharma
Summary: Aortic stenosis (AS) is a common valve disorder among the elderly, often accompanied by coronary artery disease (CAD). Traditional treatment involves simultaneous surgical replacement of the aortic valve (AV) with coronary artery bypass grafting. However, with the advancement of transcatheter AV therapies, there have been significant improvements in safety and effectiveness, leading to a paradigm shift in the management approach for patients with AS and concomitant CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Natalie Glaser, Michael Persson, Anders Franco-Cereceda, Ulrik Sartipy
Summary: Patients who underwent surgical aortic valve replacement (AVR) have lower life expectancy than the general population, mainly due to the increased relative risk of cardiovascular death.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Patrick W. Serruys, Hironori Hara, Hideyuki Kawashima, Chao Gao, Rutao Wang, Kuniaki Takahashi, Neil O'Leary, Joanna J. Wykrzykowska, Faisal Sharif, Jan J. Piek, Scot Garg, Michael J. Mack, David R. Holmes, Marie-Claude Morice, Stuart J. Head, Arie Pieter Kappetein, Daniel J. F. M. Thuijs, Thilo Noack, Piroze M. Davierwala, Friedrich W. Mohr, David J. Cohen, Yoshinobu Onuma
Summary: This study investigated the impact of revascularization strategies on long-term survival and quality of life in elderly patients over 70 years old. The findings suggest that there was no significant difference in 10-year survival rate, life expectancy, 5-year MACCE, and 5-year QOL between elderly patients undergoing PCI or CABG.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kentaro Mitsui, Kensuke Takagi, Takashi Kakuta, Teruo Noguchi
Summary: This article presents a simple bailout technique for coronary obstruction after valve-in-valve transcatheter aortic valve replacement. It involves the use of specific guide wires and extension catheters to restore coronary flow.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Matthias Eberhard, Ricarda Hinzpeter, Amadea L. N. Schoenenberger, Andre Euler, Nazar Kuzo, Kelly Reeve, Barbara E. Stahli, Albert M. Kasel, Robert Manka, Felix C. Tanner, Hatem Alkadhi
Summary: The study found that coronary artery calcium score can independently predict 30-day and 1-year mortality in patients undergoing TAVR. Adding the CAC score to the EuroSCORE II provides additional prognostic value for 1-year mortality risk.
Article
Endocrinology & Metabolism
Liam Ward, Agne Laucyte-Cibulskiene, Leah Hernandez, Jonaz Ripsweden, Karolina GOING FWD Collaborators, Peter Stenvinkel, Karolina Kublickiene
Summary: Chronic kidney disease (CKD) affects the kidneys and increases the risk of heart problems. This study aimed to understand the differences in calcification development in the blood vessels and heart valves between males and females with CKD. The results showed that there were sex-specific differences, with inflammation and oxidative stress being associated with calcification in females and oxidative stress and inflammation being associated with calcification in males. These findings highlight the importance of considering sex differences in assessing cardiovascular complications and developing personalized treatments for CKD patients.
BIOLOGY OF SEX DIFFERENCES
(2023)
