☆ 4.7 Article

Testing the bioaccumulation potential of manufactured nanomaterials in the freshwater amphipod Hyalella azteca

CHEMOSPHERE (2021)

Journal

CHEMOSPHERE

Volume 263, Issue -, Pages -

Publisher

PERGAMON-ELSEVIER SCIENCE LTD

DOI: 10.1016/j.chemosphere.2020.127961

Keywords

Bioaccumulation; Nanomaterials; Nanoparticles; Hyalella azteca; Risk assessment

Funding

German Federal Ministry for the Environment
Nuclear Safety within the ReFoPlan Project [FKZ 3718 67 401 0]
Fraunhofer Institute for Molecular Biology and Applied Ecology IME
Nature Conservation

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Abstract

This study investigated the suitability of the benthic freshwater amphipod Hyalella azteca for assessing the bioaccumulation potential of nanomaterials using a flow-through test system. The results showed that the released ions play a significant role in the bioavailability and bioaccumulation of metals from nanoparticles for both bioconcentration and biomagnification pathways. Additionally, data from studies with invertebrates like Hyalella azteca may be included in the proposed tiered testing strategy for engineered nanomaterials.

Standardized experimental approaches for the quantification of the bioaccumulation potential of nanomaterials in general and in (benthic) invertebrates in particular are currently lacking. We examined the suitability of the benthic freshwater amphipod Hyalella azteca for the examination of the bioaccumulation potential of nanomaterials. A flow-through test system that allows the generation of bioconcentration and biomagnification factors was applied. The feasibility of the system was confirmed in a 2-lab comparison study. By carrying out bioconcentration and biomagnification studies with gold, titanium dioxide and silver nanoparticles as well as dissolved silver (AgNO3) we were able to assess the bioaccumulation potential of different types of nanomaterials and their exposure pathways. For this, the animals were examined for their total metal body burden using inductively coupled mass spectroscopy (ICP-MS) and for the presence of nanoparticulate burdens using single-particle ICP-MS. The role of released ions was highlighted as being very important for the bioavailability and bioaccumulation of metals from nanoparticles for both examined uptake paths examined (bioconcentration and biomagnification). In 2018 a tiered testing strategy for engineered nanomaterials was proposed by Handy et al. that may allow a waiver of bioaccumulation fish studies using inter alia invertebrates. Data gained in studies carried out with invertebrates like the developed Hyalella azteca test may be included in this proposed tiered testing strategy. (C) 2020 The Author(s). Published by Elsevier Ltd.

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Bioaccumulation potential of chlorpyrifos in resistant Hyalella azteca: Implications for evolutionary toxicology

Nadhirah Johanif, Kara E. Huff Hartz, Alexandra E. Figueroa, Donald P. Weston, Devon Lee, Michael J. Lydy, Richard E. Connon, Helen C. Poynton

Summary: The non-target freshwater amphipod Hyalella azteca shows resistance to the organophosphate pesticide chlorpyrifos, with potential for bioaccumulation of the insecticide by resistant individuals. Toxicokinetic experiments revealed that resistant animals had slower uptake of chlorpyrifos but higher bioaccumulation potential compared to non-resistant organisms. Metabolite analysis indicated that between 20 and 50 % parent compound was detected in H. azteca, suggesting that bioaccumulation potential may be more significant in chlorpyrifos resistant individuals.

ENVIRONMENTAL POLLUTION (2021)