Synthetic Approaches to Tricyclic Aminoketones in the Total Synthesis of Aspidosperma and Kopsia Alkaloids

Aspidosperma and kopsia alkaloids are significant functional molecules because of their potent biological activities. Their intricate structures present an intrinsic synthetic challenge and thus attract significant attention from synthetic organic academic community. Over the past decades, a series of elegant strategies has been developed, in particular, the Stork's original Fischer indolization of tricyclic aminoketones 1. Herein, we report a comprehensive review on various synthetic approaches access to tricyclic aminoketones 1 and provide a practical guidance to readers whose are interested in employing tricyclic aminoketones 1 as versatile building blocks in the realm of total synthesis of aspidosperma, kopsia and structurally related alkaloids.

Automated summary

Aspidosperma and kopsia alkaloids are important functional molecules with potent biological activities. Their complex structures pose a synthetic challenge but have attracted significant attention from the synthetic organic academic community. A series of elegant synthetic strategies have been developed, with Stork's original Fischer indolization being particularly noteworthy.