Journal
CHEMICAL RECORD
Volume 21, Issue 1, Pages 17-28Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/tcr.202000042
Keywords
chitosan; stealth strategy; drug delivery; immune response; diagnostics
Categories
Funding
- [LPR_273/2019]
- [NANOCSDOXO 306/2018/FaF]
- [CA LTC18002]
Ask authors/readers for more resources
Polysaccharide nanoparticles have great potential in various disciplines, with non-toxicity, biodegradability, and easy preparation. The protein corona formed around polysaccharide nanoparticles in biofluids plays a crucial role in the overall response of the organism. Studying their applications in theranostics can improve the design of drug delivery systems.
Polysaccharide nanoparticles are promising materials in the wide range of disciplines such as medicine, nutrition, food production, agriculture, material science and others. They excel not only in their non-toxicity and biodegradability but also in their easy preparation. As well as inorganic particles, a protein corona (PC) around polysaccharide nanoparticles is formed in biofluids. Moreover, it has been considered that the overall response of the organism to nanoparticles presence depends on the PC. This review summarises scientific publications about the structural chemistry of polysaccharide nanoparticles and their impact on theranostic applications. Three strategies of implementation of the PC in theranostics have been discussed: I) Utilisation of the PC in therapy; II) How the composition of the PC is analysed for specific disease markers; III) How the formed PC can interact with the immune system and enhances the immunomodulation or immunoelimination. Thus, the findings from this review can contribute to improve the design of drug delivery systems. However, it is still necessary to elucidate the mechanisms of nano-bio interactions and discover new connections in nanoscale research.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available