Combined onabotulinumtoxinA/atogepant treatment blocks activation/sensitization of high-threshold and wide-dynamic range neurons

Ubrogepant, an Acute Treatment for Migraine, Improved Patient‐Reported Functional Disability and Satisfaction in 2 Single‐Attack Phase 3 Randomized Trials, ACHIEVE I and II

(2020) David W. Dodick et al.   HEADACHE

Calcitonin Gene‐Related Peptide Modulators – The History and Renaissance of a New Migraine Drug Class

(2019) Richard Hargreaves et al.   HEADACHE

Efficacy, safety, and tolerability of rimegepant orally disintegrating tablet for the acute treatment of migraine: a randomised, phase 3, double-blind, placebo-controlled trial

(2019) Robert Croop et al.   LANCET

Rimegepant, an Oral Calcitonin Gene–Related Peptide Receptor Antagonist, for Migraine

(2019) Richard B. Lipton et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exploring the effects of extracranial injections of botulinum toxin type A on prolonged intracranial meningeal nociceptors responses to cortical spreading depression in female rats

(2019) Agustin Melo-Carrillo et al.   CEPHALALGIA

Migraine and the trigeminovascular system—40 years and counting

(2019) Messoud Ashina et al.   LANCET NEUROLOGY

Fremanezumab - a humanized monoclonal anti-CGRP antibody — inhibits thinly myelinated (Aδ) but not unmyelinated (C) meningeal nociceptors

(2017) Agustin Melo-Carrillo et al.   JOURNAL OF NEUROSCIENCE

Selective Inhibition of Trigeminovascular Neurons by Fremanezumab: A Humanized Monoclonal Anti-CGRP Antibody

(2017) Agustin Melo-Carrillo et al.   JOURNAL OF NEUROSCIENCE

Fremanezumab for the Preventive Treatment of Chronic Migraine

(2017) Stephen D. Silberstein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extracranial injections of botulinum neurotoxin type A inhibit intracranial meningeal nociceptors’ responses to stimulation of TRPV1 and TRPA1 channels: Are we getting closer to solving this puzzle?

(2016) XiChun Zhang et al.   CEPHALALGIA

Migraine: Multiple Processes, Complex Pathophysiology

(2015) R. Burstein et al.   JOURNAL OF NEUROSCIENCE

Selective inhibition of meningeal nociceptors by botulinum neurotoxin type A: Therapeutic implications for migraine and other pains

(2014) Rami Burstein et al.   CEPHALALGIA

Botulinum neurotoxins: genetic, structural and mechanistic insights

(2014) Ornella Rossetto et al.   NATURE REVIEWS MICROBIOLOGY

Differentiation of Nerve Fibers Storing CGRP and CGRP Receptors in the Peripheral Trigeminovascular System

(2013) Sajedeh Eftekhari et al.   JOURNAL OF PAIN

Migraine headache is present in the aura phase: A prospective study

(2012) J. M. Hansen et al.   NEUROLOGY

Activation of central trigeminovascular neurons by cortical spreading depression

(2010) XiChun Zhang et al.   ANNALS OF NEUROLOGY

OnabotulinumtoxinA for treatment of chronic migraine: Results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 1 trial

(2010) SK Aurora et al.   CEPHALALGIA

OnabotulinumtoxinA for treatment of chronic migraine: Results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 2 trial

(2010) HC Diener et al.   CEPHALALGIA

Neuronal circuitry for pain processing in the dorsal horn

(2010) Andrew J. Todd   NATURE REVIEWS NEUROSCIENCE

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL