Article
Biotechnology & Applied Microbiology
Pengjie Yang, Kun Liang, Weisong Wang, Dehua Zhou, Yuan Chen, Xueyan Jiang, Rong Fu, Benben Zhu, Xuefeng Lin
Summary: This study demonstrated for the first time that the long noncoding RNA SOX2-OT plays an important role in myocardial ischemia/reperfusion (MI/R) injury through regulating the miR-186-5p/YY1 axis. Inhibition of SOX2-OT attenuated cardiomyocyte dysregulation induced by oxygen-glucose deprivation/reoxygenation (OGD/R), with effects on relieving inflammation, promoting proliferation, and reducing apoptosis.
Article
Biochemistry & Molecular Biology
Huiyan Niu, Anna Qu, Chunyan Guan
Summary: The study revealed that miR-188-5p inhibits invasion and migration of lung cancer cells by regulating the MGAT3 gene, thereby suppressing the EMT process, suggesting potential therapeutic value for the management of metastatic lung cancer.
BIOMEDICAL JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Guo Yang, Yangyang Tian, Chao Li, Jiarui Xia, Yuanmeng Qi, Wu Yao, Changfu Hao
Summary: This study observed the changes and effects of UCA1 and miR-204-5p in silica-induced mouse silicosis model and in vitro EMT model of A549 cells. It was found that both models showed the presence of EMT process, and UCA1 was upregulated in the in vitro model. Silencing UCA1 inhibited EMT process, while intervention of miR-204-5p regulated EMT.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Oncology
Xin Zhao, Xiaoshi Zhang, Xinxue Zhang, Tao Jiang, Jialei Zhai, Huaguang Wang, Mengxiu Huang, Ren Lang, Qiang He
Summary: This study revealed that miR-374b-5p is downregulated in pancreatic cancer (PC) and its overexpression can inhibit the proliferation, migration, and invasion of PC cells by suppressing the expression of KDM5B, thereby reducing epithelial-mesenchymal transition (EMT) in PC. The findings suggest that miR-374b-5p could potentially serve as a prognostic biomarker and therapeutic target for EMT induced by KDM5B in PC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Cell Biology
Giorgia Centonze, Dora Natalini, Vincenzo Salemme, Andrea Costamagna, Sara Cabodi, Paola Defilippi
Summary: p130Cas/BCAR1 is an adaptor protein with various binding motifs that affects cell motility, adhesion, cytoskeleton remodeling, invasion, survival, and proliferation. p140Cap, encoded by the SRCIN1 gene, interacts with p130Cas indirectly through its interaction with Src Kinase and has been found to have a tumor suppressive role in breast cancer and neuroblastoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Zhenglei Xu, Zeming Chen, Minsi Peng, Zhuliang Zhang, Weixiang Luo, Ruiyue Shi, Lisheng Wang, Yingcai Hong
Summary: Pancreatic cancer is difficult to treat, and the main reasons for poor prognosis are cell invasion and migration. In this study, researchers found that miR-490-5p is abnormally low-expressed in pancreatic cancer and downregulation of miR-490-5p enhances the viability, migration, and invasion of pancreatic cancer cells. Additionally, miR-490-5p regulates the protein expression of MMP2, MMP9, and N-cadherin, and upregulates the protein expression of E-cadherin. The expression of MAGI2-AS3 is also associated with cell viability, migration, and invasion in pancreatic cancer. The study reveals that miR-490-5p plays an anti-cancer role in pancreatic cancer by targeting MAGI2-AS3 and regulating EMT.
Article
Medicine, Research & Experimental
Ke-Da Yang, Ying Wang, Fan Zhang, Bai-Hua Luo, De-Yun Feng, Zhi-Jun Zeng
Summary: This study found that circN4BP2L2 acts as an oncogene in CRC, promoting tumor growth and metastasis by regulating the miR-340-5p/CXCR4 axis. The authors revealed a novel mechanism in the ceRNA regulatory network for CRC progression and identified a potential therapeutic target for CRC treatment.
LABORATORY INVESTIGATION
(2022)
Article
Biotechnology & Applied Microbiology
Xiaobo He, Xiao Cheng, Jianfeng Ding, Maoming Xiong, Bo Chen, Guodong Cao
Summary: This study found that the overexpression of PFKFB3 is associated with poor prognosis in gastric cancer patients. Hyperglycemia stimulates the high expression of PFKFB3 and enhances proliferation, migration, and epithelial-mesenchymal transition in gastric cancer cells. Down-regulation of PFKFB3 by miR-26-5p inhibits the malignant phenotype of gastric cancer with hyperglycemia.
Article
Biochemistry & Molecular Biology
Wen-Wei Chang, Bing-Yen Wang, Shih-Hong Chen, Peng-Ju Chien, Gwo-Tarng Sheu, Ching-Hsiung Lin
Summary: This study found that in pemetrexed-resistant NSCLC cells, overexpression of BMI1 leads to downregulation of miR-145-5p, resulting in increased expression of Sp1 and induction of the EMT process. Increasing miR-145-5p expression could serve as a sensitizing agent for pemetrexed-resistant NSCLC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Dandan Wang, Liangyi Cui, Qing Yang, Jiao Wang
Summary: The up-regulated circZFPM2 in ectopic endometrial tissues can induce EMT through the miR-205-5p /ZEB1 signaling pathway, promoting cell proliferation, migration, and invasion. This may serve as a promising biomarker in the diagnosis and treatment of endometriosis.
CELLULAR SIGNALLING
(2021)
Article
Chemistry, Medicinal
Jia Yang, Gangdan Jiang, Kaiwen Ni, Liming Fan, Wang Tong, Junchao Yang
Summary: Emodin can attenuate pulmonary fibrosis and epithelial-mesenchymal transition (EMT) by regulating the c-MYC/miR-182-5p/ZEB2 axis, providing evidence for the application of Emodin in the treatment of pulmonary fibrosis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jinguo Zhang, Wencai Guan, Xiaolin Xu, Fanchen Wang, Xin Li, Guoxiong Xu
Summary: The study reveals that Sorcin plays a key role in chemoresistance of ovarian cancer, potentially driving PTX resistance through miR-142-5p and ZEB1. Targeting the SRI/Smad4/ZEB1/miR-142-5p loop may reverse chemoresistance.
Article
Cell Biology
Zhongjian Yu, Xiongjie Zhu, Ying Li, Min Liang, Meijun Liu, Zhile Liu, Lingyu Qin, Xiaoran Wu, Kunpeng Du, Lu Liu, Yong Wang, Yanfang Zheng
Summary: The study shows that in lung adenocarcinoma, circ-HMGA2 promotes cell metastasis through the miR-1236-3p/EMT axis, indicating that it could be a therapeutic target in LUAD.
CELL DEATH & DISEASE
(2021)
Article
Biology
Pingping Peng, Huamei Song, Chenghong Xie, Wenfei Zheng, Huigai Ma, Dandan Xin, Jingqiong Zhan, Xiaoqing Yuan, Aihua Chen, Jing Tao, Jufang Qin
Summary: This study reveals that miR-146a-5p mediates trophoblast cell proliferation and invasion by regulating the expression of Wnt2, thus influencing the development of preeclampsia.
BIOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yanzhe Wang, Yuyuan Liu, Ling Zhang, Linnan Bai, Sijia Chen, Hao Wu, Linlin Sun, Xiaoxia Wang
Summary: The study investigated the effect of miR-30b-5p targeting SNAIL on epithelial-to-mesenchymal transition (EMT) in diabetic nephropathy (DN). The findings suggest that miR-30b-5p plays a protective role by targeting SNAI1 in renal EMT in DN.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)