Nuclear protein 1 imparts oncogenic potential and chemotherapeutic resistance in cancer

Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis

(2019) Patricia Santofimia-Castaño et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamics of the intrinsically disordered protein NUPR1 in isolation and in its fuzzy complexes with DNA and prothymosin α

(2019) José L. Neira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Trifluoperazine as an alternative strategy for the inhibition of tumor growth of colorectal cancer

(2019) Kun Qian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Proteasome inhibition creates a chromatin landscape favorable to RNA Pol II processivity

(2019) H. Karimi Kinyamu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LncRNA FAL1 promotes carcinogenesis by regulation of miR-637/NUPR1 pathway in colorectal cancer

(2018) Liqiang Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The antipsychotic agent trifluoperazine hydrochloride suppresses triple-negative breast cancer tumor growth and brain metastasis by inducing G0/G1 arrest and apoptosis

(2018) Zhanzhan Feng et al.   Cell Death & Disease

Cancer cells exploit an orphan RNA to drive metastatic progression

(2018) Lisa Fish et al.   NATURE MEDICINE

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis

(2018) Patricia Santofimia-Castaño et al.   Scientific Reports

Glucose Restriction Combined with Autophagy Inhibition and Chemotherapy in HCT 116 Spheroids Decreases Cell Clonogenicity and Viability Regulated by Tumor Suppressor Genes

(2017) Monica M. Schroll et al.   JOURNAL OF PROTEOME RESEARCH

Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B

(2017) Patricia Santofimia-Castaño et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breast Cancer Cell Line Classification and Its Relevance with Breast Tumor Subtyping

(2017) Xiaofeng Dai et al.   Journal of Cancer

Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma

(2017) José L. Neira et al.   Scientific Reports

Hexavalent Chromium (Cr(VI)) Down-Regulates Acetylation of Histone H4 at Lysine 16 through Induction of Stressor Protein Nupr1

(2016) Danqi Chen et al.   PLoS One

p8 attenuates the apoptosis induced by dihydroartemisinin in cancer cells through promoting autophagy

(2015) Sang-Sang Chen et al.   CANCER BIOLOGY & THERAPY

Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation

(2015) Daniel Grasso et al.   Scientific Reports

Comedo-DCIS is a precursor lesion for basal-like breast carcinoma: identification of a novel p63/Her2/neu expressing subgroup

(2015) Malathy PV Shekhar et al.   Oncotarget

Evidence supporting the existence of a NUPR1-like family of helix-loop-helix chromatin proteins related to, yet distinct from, AT hook-containing HMG proteins

(2014) Raul Urrutia et al.   JOURNAL OF MOLECULAR MODELING

The E2F Transcription Factors Regulate Tumor Development and Metastasis in a Mouse Model of Metastatic Breast Cancer

(2014) D. P. Hollern et al.   MOLECULAR AND CELLULAR BIOLOGY

Deciphering the Binding between Nupr1 and MSL1 and Their DNA-Repairing Activity

(2013) David Aguado-Llera et al.   PLoS One

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Trifluoperazine, an Antipsychotic Agent, Inhibits Cancer Stem Cell Growth and Overcomes Drug Resistance of Lung Cancer

(2012) Chi-Tai Yeh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lentivirus-Mediated RNAi Knockdown of NUPR1 Inhibits Human Nonsmall Cell Lung Cancer GrowthIn VitroandIn Vivo

(2012) Xiaotong Guo et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Simultaneous copy number gains of NUPR1 and ERBB2 predicting poor prognosis in early-stage breast cancer

(2012) Seung-Hyun Jung et al.   BMC CANCER

Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance

(2012) Andrew J. Vincent et al.   FEBS LETTERS

Autophagy Protects against Oxaliplatin-Induced Cell Death via ER Stress and ROS in Caco-2 Cells

(2012) Yan Shi et al.   PLoS One

Amino acid deprivation regulates the stress-inducible gene p8 via the GCN2/ATF4 pathway

(2011) J. Averous et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High Levels of Hsp90 Cochaperone p23 Promote Tumor Progression and Poor Prognosis in Breast Cancer by Increasing Lymph Node Metastases and Drug Resistance

(2010) N. E. Simpson et al.   CANCER RESEARCH

Nupr1: The Swiss-knife of cancer

(2010) Carla E. Cano et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Emerging role of nuclear protein 1 (NUPR1) in cancer biology

(2009) Uttio Roy Chowdhury et al.   CANCER AND METASTASIS REVIEWS

Nuclear protein 1 induced by ATF4 in response to various stressors acts as a positive regulator on the transcriptional activation of ATF4

(2009) Hyeon-Ok Jin et al.   IUBMB LIFE

p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage

(2009) Meritxell Gironella et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

NUPR1 Interacts with p53, Transcriptionally Regulates p21 and Rescues Breast Epithelial Cells from Doxorubicin-Induced Genotoxic Stress

(2008) David Clark et al.   CURRENT CANCER DRUG TARGETS