Review
Oncology
Xiao Cheng, Ke Cheng
Summary: Metastasis is a critical process in cancer progression that leads to the majority of cancer-related deaths. Understanding the molecular mechanisms of cancer cell extravasation is crucial for developing effective anti-metastasis strategies. Recent advances in visualization techniques provide insights into the stages of cancer extravasation, offering new opportunities for the discovery of anti-extravasation drugs and therapies to improve cancer patient prognosis.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Medicine, Research & Experimental
Hao Ji, Lujie Yuan, Yaqun Jiang, Min Ye, Zhen Liu, Xiaotian Xia, Chunxia Qin, Dawei Jiang, Yongkang Gai, Xiaoli Lan
Summary: In this study, a CK14 targeting tracer, Tc-99m-HYNIC-Anti-CK14 mAb, was successfully constructed and showed high binding ability to CK14+ tumors, indicating its potential value in immunoSPECT imaging of basal-like breast cancer (BLBC).
MOLECULAR PHARMACEUTICS
(2022)
Review
Physics, Applied
Katy Borner, Filipi Nascimento Silva, Stasa Milojevic
Summary: This Perspective discusses how visualizations help in understanding key aspects of big science projects, including productivity, impact, team evolution, big data, and cyberinfrastructure. The number, size, and complexity of big science projects are increasing, along with the value of the data sets and software services they produce. By analyzing and visualizing publications and grants in different disciplines, the study reveals trends of internationalization and interdisciplinary impact in big science projects.
NATURE REVIEWS PHYSICS
(2021)
Article
Chemistry, Analytical
Yanli Zhu, Jikai Wang, Haitao Xie, Chengxiao Fu, Jiecan Zhou, Hailing Liu, Pengfei Zeng, Yiyang Sun
Summary: This article presents a new aptasensing platform for sensitive and specific detection of malignancy-associated biomarkers. The platform utilizes alkaline-earth sulfide nanodots as fluorescent labels, which can be excited by near-infrared light, to achieve low detection limits and reliable quantification. Additionally, the platform enables visual analysis and detection of target analytes through color transformation.
ANALYTICAL CHEMISTRY
(2022)
Article
Physics, Multidisciplinary
Tal Einav, Yuehaw Khoo, Amit Singer
Summary: As experiments become larger, it is challenging to interpret the wealth of data and integrate local interactions across a dataset. The bipartite localization problem deals with pairwise distances in bipartite data. This study modifies previous algorithms and examines their behavior in the presence of noise and outliers, using antibody-virus neutralization measurements as a proof of concept.
Article
Chemistry, Medicinal
Uschi Dolfus, Hans Briem, Matthias Rarey
Summary: Reaction schemes for organic molecules play a crucial role in computer-aided drug design. This study introduces a visualization technique called ReactionViewer, which converts reaction schemes encoded as Reaction SMILES, Reaction SMARTS, or SMIRKS into visual representations. The method is demonstrated using two datasets of organic synthesis reaction schemes, highlighting its applicability and readability.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Multidisciplinary Sciences
Xueyan Feng, Mujin Zhuo, Hua Guo, Edwin L. Thomas
Summary: Periodic gyroid network materials exhibit interesting properties due to their space-group symmetries and triply continuous morphology. A study of the twin boundary in a self-assembled polymer showed that the boundary plane acts as a topological mirror, with alterations in morphology and the appearance of new types of nodes and loops. The boundary region was found to have similar properties to the adjacent ordered grain regions, suggesting it is a low-energy boundary.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Shashwat Anand, James P. Male, Chris Wolverton, G. Jeffrey Snyder
Summary: This study redefines the formation enthalpy of compounds and defective structures, visualizing defect energetics as intercepts in a two-dimensional convex-hull plot, simplifying the application-level defect thermodynamics.
MATERIALS HORIZONS
(2021)
Article
Chemistry, Analytical
Wei Du, Jiqing Wang, Haixiao Fang, Wenhui Ji, Yi Liu, Yunwei Qu, Duoteng Zhang, Tao Shao, Xiyan Hou, Qiong Wu, Lin Li
Summary: A dual-functional fluorescent probe, CQ-1, was designed for rapid and accurate detection of early cancer biomarkers. It can visualize the changes of nitroreductase and viscosity in cancer cell mitochondria while displaying mitochondrial targeting ability.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Daniel J. Rizzo, Alexander S. McLeod, Caitlin Carnahan, Evan J. Telford, Avalon H. Dismukes, Ren A. Wiscons, Yinan Dong, Colin Nuckolls, Cory R. Dean, Abhay N. Pasupathy, Xavier Roy, Di Xiao, D. N. Basov
Summary: This study reveals the spatially dependent magnetism in few-layer CrSBr using magnetic force microscopy (MFM) and simulations. It demonstrates that a single uncompensated layer in odd-layer terraces can reduce the stability of the low-temperature antiferromagnetic phase and result in multiple coexisting magnetic ground states at temperatures close to the bulk Neel temperature.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Wei Wang, Lijun Zhou, Sheng Hu, Konstantin S. Novoselov, Yang Cao
Summary: This study reports a technique for mapping piezoelectric potential on 2D materials bubbles, successfully visualizing strain-induced piezoelectric potential profiles on the bubbles. Factors affecting these piezoelectric properties are discussed, providing insights for designing piezoelectric nanodevices based on 2D nanobubbles.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Computer Science, Information Systems
Mohammad Raji, John Duggan, Blaise DeCotes, Jian Huang, Bradley Vander Zanden
Summary: The research introduces a data science system called eCamp to model and visualize student flow patterns in a university. eCamp provides insights into how students choose among different majors and courses at both campus and department levels, supporting analytical tasks related to student outcomes, retention, and curriculum design.
IEEE TRANSACTIONS ON BIG DATA
(2021)
Article
Biology
Morgan L. Pimm, Xinbei Liu, Farzana Tuli, Jennifer Heritz, Ashley Lojko, Jessica L. Henty-Ridilla
Summary: PFN1 is an important protein that regulates actin and microtubule assembly, affecting cell division, motility, and morphology. Two genetically encoded versions of tagged PFN1 have been developed and shown to behave identically to the tag-free protein. These tagged PFN1s are reliable tools for studying the interactions of PFN1 with actin or microtubules.
Article
Chemistry, Multidisciplinary
Qingqing Li, Xiaoguang Ge, Jiamin Ye, Zhi Li, Lichao Su, Ying Wu, Huanghao Yang, Jibin Song
Summary: This study introduces a novel core-satellite gold nanostructure for dual imaging, enabling precise detection and differentiation of H2O2 in inflammation/cancer-related tissues. The nanoprobe can also be used for targeted drug delivery and real-time tracking of anti-inflammatory treatment progress.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biology
Federico Claudi, Adam L. Tyson, Luigi Petrucco, Troy W. Margrie, Ruben Portugues, Tiago Branco
Summary: The study introduces brainrender, an open-source Python package for interactive visualization of multidimensional datasets registered to brain atlases. This tool facilitates the creation of complex renderings with different data types in the same visualization, accelerating the analysis, interpretation, and dissemination of brain-wide multidimensional data.
Article
Chemistry, Multidisciplinary
Vincent Mittelheisser, Pierre Coliat, Eric Moeglin, Lilian Goepp, Jacky G. Goetz, Loic J. Charbonniere, Xavier Pivot, Alexandre Detappe
Summary: Tumor-targeted antibody/fragment-conjugated nanoparticles show promise in improving local delivery of small molecules. A meta-analysis of 161 studies confirmed that targeted nanoparticles had significantly higher tumor uptake compared to naked nanoparticles. The study also found that the choice of nanoparticle type, size, and antibody moiety affected tumor uptake.
ADVANCED MATERIALS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ananthi Somasundaram, David Vallez Garcia, Elisabeth Pfaehler, Yvonne W. S. Jauw, Josee M. Zijlstra, Guus A. M. S. van Dongen, Willemien C. Menke-van der Houven Van Oordt, Marc C. Huisman, Elisabeth G. E. de Vries, Ronald Boellaard
Summary: This study investigates the impact of noise on radiomic features from Zr-89-Immuno-PET clinical images. It identifies features that are less affected by noise and can serve as potential prognostic and predictive biomarkers in Zr-89-Immuno-PET studies.
Editorial Material
Oncology
N. Cherny, U. Dafni, G. Pentheroudakis, M. Piccart, P. Zygoura, B. Gyawali, E. G. E. de Vries
Editorial Material
Oncology
Elisabeth G. E. de Vries, Lawrence H. Schwartz
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Pim P. van de Donk, Sjoukje F. Oosting, Daan G. Knapen, Anthonie J. van der Wekken, Adrienne H. Brouwers, Marjolijn N. Lub-de Hooge, Derk-Jan A. de Groot, Elisabeth G. E. de Vries
Summary: The arrival of immune checkpoint inhibitors has revitalized the field of immuno-oncology. Molecular imaging techniques can provide valuable information for treatment decision-making by visualizing tumor and immune cell characteristics, as well as drug distribution.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Lalitha K. Shankar, Erich Huang, Saskia Litiere, Otto S. Hoekstra, Larry Schwartz, Sandra Collette, Ronald Boellaard, Jan Bogaerts, Lesley Seymour, Elisabeth G. E. deVries
Summary: Currently, guidelines for PET with FDG-PET interpretation for therapy response in oncology involve visual evaluation of FDG-PET/CT scans. However, quantitative measurements of metabolic activity in tumors may be more useful. Guidelines based on such measurements have been proposed, but more analysis is needed for regular use.
CLINICAL CANCER RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joyce van Sluis, Walter Noordzij, Elisabeth G. E. de Vries, Iris C. Kok, Derk Jan A. de Groot, Mathilde Jalving, Marjolijn N. Lub-de Hooge, Adrienne H. Brouwers, Ronald Boellaard
Summary: This study explores the influence of using manual segmentations versus an AI-based automated segmentation tool on calculating whole-body effective doses. The results show that using AI-based segmentations can save time and achieve higher similarity coefficients compared to manual segmentations. The whole-body effective doses show minimal differences for the six patients.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ananthi Somasundaram, David Vallez Garcia, Elisabeth Pfaehler, Joyce van Sluis, Rudi A. J. O. Dierckx, Elisabeth G. E. de Vries, Ronald Boellaard
Summary: One major challenge in PET radiomics is its sensitivity to noise. This phantom study aims to identify the radiomic features that are robust to noise in terms of precision and accuracy and to explore some methods that might help to correct noise-induced bias.
Article
Oncology
S. F. Oosting, J. Barriuso, A. Bottomley, M. Galotti, B. Gyawali, B. Kiesewetter, N. J. Latino, F. Martinelli, M. Pe, G. Pentheroudakis, F. Roitberg, H. Vachon, E. G. E. de Vries, M. Piccart, N. I. Cherny
Summary: This article discusses the importance of quality of life (QoL) data and quality assurance measures in the European Society for Medical Oncology-Magnitude of Clinical Benefit Scale (ESMO-MCBS). Through field testing and revision, a checklist consisting of four items was developed to ensure the reliability and clinical relevance of QoL data. Implementation of this checklist will facilitate objective and transparent decision making in the ESMO-MCBS scoring process.
ANNALS OF ONCOLOGY
(2023)
Article
Oncology
Ramsha Iqbal, Maqsood Yaqub, Huseyyin O. Bektas, Daniela E. Oprea-Lager, Elisabeth G. E. de Vries, Andor W. J. M. Glaudemans, Philippe Aftimos, Geraldine Gebhart, Andrew P. Beelen, Robert C. Schuit, Albert D. Windhorst, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt
Summary: The purpose of this study was to investigate the use of [18F]-fluorodeoxyglucose ([18F]FDG) and [18F]-fluoro-17(3-estradiol ([18F]FES) PET/CT imaging in patients with metastatic ER-positive breast cancer undergoing treatment with rintodestrant. The study found that absence of ER expression on [18F]FES PET is a predictor for no response to rintodestrant. [18F]FES uptake during treatment and at time of progression is useful to monitor the effect of therapy and continued mode of action of SERDs.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Marianne Luyendijk, Otto Visser, Hedwig M. Blommestein, Ignace H. J. T. de Hingh, Frank J. P. Hoebers, Agnes Jager, Gabe S. Sonke, Elisabeth G. E. de Vries, Carin A. Uyl-de Groot, Sabine Siesling
Summary: This study evaluated the changes in survival of patients with de novo metastatic solid cancers over the past 30 years. The proportion of M1 disease and net survival rates varied among different cancer types. Better preventive measures and early detection are needed to reduce the incidence of metastatic disease.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Editorial Material
Multidisciplinary Sciences
Elena Garralda, Scott A. Laurie, Lesley Seymour, Elisabeth G. E. de Vries
Summary: Early detection of immunotherapy-induced tumor response is crucial, but therapy-induced pseudoprogression can make it complicated. A consensus guideline called iRECIST, a modification of RECIST version 1.1, was developed. This article explores the next steps required to test its validity and proposes novel approaches for response criteria.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Elisabeth G. E. de Vries, Josef Rueschoff, Martijn Lolkema, Josep Tabernero, Luca Gianni, Emile Voest, Derk Jan A. de Groot, Daniel Castellano, Gilles Erb, Julia Naab, Margarita Donica, Regula Deurloo, Michiel S. van Der Heijden, Giuseppe Viale
Summary: This study aimed to investigate tumor HER2 expression and its effects on T-DM1 treatment in patients with HER2-positive urothelial bladder cancer or pancreatic cancer/cholangiocarcinoma. The results showed that some HER2-positive bladder cancer and pancreatic cancer patients responded well to T-DM1, and it also provided insight into the prevalence of HER2 positivity and expression patterns in these three non-breast tumor types.
Article
Oncology
Avram E. Denburg, Adam Fundytus, Muhammad Saghir Khan, Scott C. Howard, Federico Antillon-Klussmann, Manju Sengar, Dorothy Lombe, Wilma Hopman, Matthew Jalink, Bishal Gyawali, Dario Trapani, Felipe Roitberg, Elisabeth G. E. De Vries, Lorenzo Moja, Andre Ilbawi, Richard Sullivan, Christopher M. Booth
Summary: Access to essential cancer medicines, especially in low-income countries, remains a challenge in childhood cancer treatment. Most medicines deemed essential by pediatric oncologists are included on WHO's Model List of Essential Medicines for Children, but their accessibility and cost are still issues.
JCO GLOBAL ONCOLOGY
(2022)
Review
Oncology
Katerina Jerabkova-Roda, Amandine Dupas, Nael Osmani, Vincent Hyenne, Jacky G. Goetz
Summary: The intravascular behavior of tumor-derived extracellular vesicles (EVs) and circulating tumor cells (CTCs) plays a crucial role in the metastatic cascade. Understanding the role of cellular adhesion molecules (CAMs) and their endothelial ligands in dictating the arrest site and exit capacity of EVs/CTCs could provide insight into novel targets for therapies. Exploring the differences and similarities between CAMs on CTCs and EVs may help in understanding their role in organotropism of different cancer types.
