Review
Oncology
Kathryn Cole, Zaid Al-Kadhimi, James E. Talmadge
Summary: The establishment of primary tumor cells in distant organs, known as metastasis, is the main cause of cancer mortality and an important target for cancer treatment. Understanding the metastatic progression and the mechanisms involved is crucial for developing effective therapeutic approaches. Myeloid derived suppressor cells (MDSCs) play a role in tumor escape from immune responses and tumor progression. However, their role in dormancy and tumor recurrence needs further investigation. Assessing the impact of therapies on MDSCs is challenging due to the complexity of multimodality interventions.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Oncology
Guoqi Ya, Weihong Ren, Rui Qin, Jiao He, Shuo Zhao
Summary: Metastasis is a complex process that relies on the interaction between tumor cells and host organs, with the formation of a pre-metastasis niche being crucial. Myeloid-derived suppressor cells play a key role in this process, and targeting these cells as a therapeutic strategy may help inhibit the formation of the pre-metastasis niche and curb tumor metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Biomedical
Chunyu Xia, Wenjing Bai, Tao Deng, Ting Li, Ling Zhang, Zhengze Lu, Zhirong Zhang, Man Li, Qin He
Summary: A sponge-like neutrophil membrane-coated nano-system was developed to inhibit tumor recurrence and metastasis by inhibiting the recruitment and functions of myeloid-derived suppressor cells (MDSCs), which reinforced anti-tumor immunity and also suppressed pulmonary metastasis by inhibiting the formation of pre-metastatic niche (PMN). This nano-system not only showed natural tropism to postoperative inflammatory site but also relieved MDSCs-mediated immunosuppression. Additionally, it suppressed the formation of PMN to inhibit pulmonary metastasis.
ACTA BIOMATERIALIA
(2023)
Review
Oncology
Saraswoti Khadge, Kathryn Cole, James E. Talmadge
Summary: Metastasis is the primary cause of cancer mortality, understanding its pathology is crucial. Timing of tumor dissemination and release from dormancy is important, regulated by tumor-microenvironment interactions, angiogenesis, and CTL responses. Immunosuppressive mechanisms like MDSC expansion contribute to tumor progression and metastasis, inhibiting MDSC may delay metastatic relapse and prolong patient survival.
CLINICAL & EXPERIMENTAL METASTASIS
(2021)
Article
Oncology
Honglin Li, Feiran Yang, Lei Zhang, Ruohan Zhao, Xiurong Li, Huijie Li
Summary: This study found that Xiaoliu Pingyi recipe (XLPYR) can inhibit tumor growth and prevent lung metastasis, and reduce the proportion of myeloid-derived suppressor cells (MDSCs). Moreover, XLPYR can also reduce the expression of S100A8, MMP9, LOX, and IL-6/STAT3 in premetastatic lung tissue. Therefore, XLPYR may be an effective drug for preventing lung metastasis.
INTEGRATIVE CANCER THERAPIES
(2023)
Article
Chemistry, Multidisciplinary
Fan Tang, Yan Tie, Tian-Xia Lan, Jing-Yun Yang, Wei-Qi Hong, Si-Yuan Chen, Hou-Hui Shi, Long-Qing Li, Hao Zeng, Li Min, Yu-Quan Wei, Chong-Qi Tu, Xia-Wei Wei
Summary: The major challenge in treating osteosarcoma patients is the metastatic disease, particularly in the lungs. However, the underlying mechanism of recurrence and metastasis after surgical resection of primary tumor is unclear. This study investigates the association between pulmonary metastases in osteosarcoma and surgical treatment, finding that surgery contributes to the formation of a pre-metastatic niche in the lung tissue. It is demonstrated that circulating tumor cells, neutrophils, and myeloid cells contribute to this niche formation through molecular patterns released from surgical resection.
Article
Medicine, Research & Experimental
Yi Wang, Yuqiu Li, Junpei Zhong, Miao Li, Youjia Zhou, Qing Lin, Siwen Zong, Wenting Luo, Jiayang Wang, Keqin Wang, Jie Wang, Lixia Xiong
Summary: Cav-1 in exosomes derived from breast cancer cells promotes lung metastasis by regulating intercellular communication and PMN formation.
Article
Oncology
Ru Li, Mousumi Beto Mukherjee, Jun Lin
Summary: In this review, the effects of cytokines and chemokines on myeloid-derived suppressor cells in cancer metastasis are summarized. Cytokines and chemokines in the tumor microenvironment alter the functional properties of MDSCs and are involved in their production, infiltration, and immunosuppressive functions. The manipulation of MDSCs by tumors through cytokine and chemokine signaling is discussed, as well as potential treatment strategies targeting these signaling pathways to combat the immunosuppressive activities of MDSCs and improve disease outcomes.
Article
Medicine, Research & Experimental
Xinxin Yuan, Niansong Qian, Shukuan Ling, Yuheng Li, Weijia Sun, Jianwei Li, Ruikai Du, Guohui Zhong, Caizhi Liu, Guotao Yu, Dengchao Cao, Zizhong Liu, Yinbo Wang, Zhihong Qi, Yingpeng Yao, Fang Wang, Jingjing Liu, Shanshan Hao, Xiaoyan Jin, Yinlong Zhao, Jianqi Xue, Dingsheng Zhao, Xingcheng Gao, Shuai Liang, Youyou Li, Jinping Song, Shuyang Yu, Yingxian Li
Summary: Exosomes derived from breast cancer cells, particularly SCP28 cells, play a crucial role in promoting osteoclast differentiation and activation, contributing to the accelerated formation of a microenvironment favorable for bone metastasis. Specifically, the exosomal miR-21 from SCP28 cells regulates PDCD4 protein levels to facilitate osteoclastogenesis, indicating its potential as a diagnostic and therapeutic target for breast cancer bone metastasis.
Article
Oncology
Yunzhi Dang, Jiao Yu, Shuhong Zhao, Long Jin, Ximing Cao, Qing Wang
Summary: This study reveals a novel role of GOLM1 in promoting CRC metastasis, with its overexpression promoting immune escape and metastasis by recruiting MDSCs. The specific inhibitor of CCR2, PF-04136309, can effectively suppress GOLM1-mediated CRC metastasis, suggesting GOLM1 as a prognostic biomarker in human CRC.
Review
Oncology
Sitaram Harihar, Danny R. Welch
Summary: Current therapeutic approaches for metastatic cancers are ineffective at targeting dormant tumor cells, which are non-proliferative, growth-arrested, or resistant to therapy. The understanding of tumor dormancy has been limited, hindering progress in developing effective approaches. However, recent studies have identified KISS1 as a metastasis suppressor gene that keeps tumor cells in a dormant state. This review explores the mechanisms and potential application of KISS1 as a therapeutic for metastatic cancers by eliminating quiescent cells or inducing long-term dormancy.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Maximilian Geissler, Weiyi Jia, Emine Nisanur Kiraz, Ida Kulacz, Xiao Liu, Adrian Rombach, Vincent Prinz, Daniel Jussen, Konstantinos D. Kokkaliaris, Hind Medyouf, Lisa Sevenich, Marcus Czabanka, Thomas Broggini
Summary: Metastasis, especially brain metastasis, is still a mystery to researchers, and studying its molecular basis may lead to breakthroughs in combating this lethal cancer. The focus of recent research has shifted to understanding the early steps of metastasis formation, including how the primary tumor influences distant organ sites before tumor cells arrive. The concept of pre-metastatic niche encompasses various factors that affect future metastasis sites, such as immunological modulation and ECM remodeling. Although the mechanisms of brain metastasis are still elusive, studying the earliest steps in metastasis formation provides insights into these processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Heejin Lim, Taewoo Yang, Wongeun Lee, Sung-Gyoo Park
Summary: The study demonstrates that MDSCs are a source of MFGE8, which plays a role in tumor metastasis. TME positively regulates MFGE8 production by MDSCs through TGF-beta, suggesting MFGE8 as an important effector molecule for MDSCs to promote tumor metastasis.
Article
Oncology
Yunzhi Dang, Jiao Yu, Shuhong Zhao, Ximing Cao, Qing Wang
Summary: This study reveals that elevated expression of HOXA7 is associated with metastasis and poor prognosis in KRAS mutant colorectal cancer (CRC) patients. HOXA7 overexpression enhances the metastatic ability of KRAS mutant cells and promotes the infiltration of myeloid-derived suppressor cells (MDSCs). Furthermore, blocking MDSC infiltration can effectively suppress the metastasis of KRAS mutant CRC. Therefore, interrupting the HOXA7-mediated loop may provide a promising strategy for the treatment of this disease.
CANCER CELL INTERNATIONAL
(2022)
Review
Oncology
Jin Cheng, Kun Zhang, Chunhui Qu, Jinwu Peng, Lifang Yang
Summary: Metastasis is a critical stage of tumor progression, and recent studies have shown that extracellular vesicles (EVs) play an important role in the formation of the pre-metastatic niche (PMN).
Article
Cardiac & Cardiovascular Systems
Ryan J. Adam, Zhiqiu Xia, Kristina Pravoverov, Juan Hong, Adam J. Case, Harold D. Schultz, Steven J. Lisco, Irving H. Zucker, Han-Jun Wang
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2019)
Article
Cell Biology
Kristina Pravoverov, Katherine Whiting, Slesha Thapa, Trevor Bushong, Karen Trang, Pamela J. Lein, Vidya Chandrasekaran
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2019)
Editorial Material
Immunology
James E. Talmadge
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Immunology
Kathryn E. Cole, Quan P. Ly, Michael A. Hollingsworth, Jesse L. Cox, Ingunn M. Stromnes, James C. Padussis, Jason M. Foster, Luciano M. Vargas, James E. Talmadge
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Review
Oncology
Saraswoti Khadge, Kathryn Cole, James E. Talmadge
Summary: Metastasis is the primary cause of cancer mortality, understanding its pathology is crucial. Timing of tumor dissemination and release from dormancy is important, regulated by tumor-microenvironment interactions, angiogenesis, and CTL responses. Immunosuppressive mechanisms like MDSC expansion contribute to tumor progression and metastasis, inhibiting MDSC may delay metastatic relapse and prolong patient survival.
CLINICAL & EXPERIMENTAL METASTASIS
(2021)
Article
Cell Biology
Saiprasad Gowrikumar, Mark Primeaux, Kristina Pravoverov, Chao Wu, Bryan C. Szeglin, Charles-Etienne Gabriel Sauve, Ishwor Thapa, Dhundy Bastola, Xi Steven Chen, J. Joshua Smith, Amar B. Singh, Punita Dhawan
Summary: Identifying a molecular signature based on claudin-1 and claudin-7 can help predict patient survival and response to treatment in colorectal cancer. This signature is associated with poor prognosis and characteristics of treatment-resistant CRC.
Review
Oncology
Kathryn Cole, Zaid Al-Kadhimi, James E. Talmadge
Summary: The establishment of primary tumor cells in distant organs, known as metastasis, is the main cause of cancer mortality and an important target for cancer treatment. Understanding the metastatic progression and the mechanisms involved is crucial for developing effective therapeutic approaches. Myeloid derived suppressor cells (MDSCs) play a role in tumor escape from immune responses and tumor progression. However, their role in dormancy and tumor recurrence needs further investigation. Assessing the impact of therapies on MDSCs is challenging due to the complexity of multimodality interventions.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Immunology
Kathryn Cole, Zaid Al-Kadhimi, James E. Talmadge
Summary: Immunotherapy is a revolutionary addition to traditional cancer treatments, and has rejuvenated the field of tumor immunology. Different types of immunotherapies, such as adoptive cellular therapy and checkpoint inhibitors, can have long-lasting clinical responses, although their efficacy varies. This review discusses the history, current approaches, and future directions of immunotherapy, emphasizing the need for personalized interventions to address the limitations.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Correction
Oncology
Saraswoti Khadge, Geoffrey M. Thiele, John Graham Sharp, Timothy R. McGuire, Lynell W. Klassen, Paul N. Black, Concetta C. DiRusso, Leah Cook, James E. Talmadge
CLINICAL & EXPERIMENTAL METASTASIS
(2023)
Meeting Abstract
Oncology
Kathryn Cole, Quan Ly, Jesse L. Cox, Michael A. Hollingsworth, James C. Padussis, Jason M. Foster, Luciano M. Vargas, James E. Talmadge