Article
Oncology
Chao Liu, Kai Wang, Min Zhang, Xiaoyu Hu, Tian Hu, Yumei Liu, Qinyong Hu, Shikai Wu, Jinbo Yue
Summary: The study found that patients with colorectal cancer have higher expression levels of ACE2 and TMPRSS2, and are more likely to exhibit clinical characteristics associated with COVID-19, indicating a potentially higher susceptibility to SARS-CoV-2 infection. Further mechanistic studies are needed to confirm these findings.
NPJ PRECISION ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ao Cheng, Honghao Ren, Zeyao Ma, Naqash Alam, Linying Jia, Enqi Liu
Summary: The new coronavirus has caused a worldwide pandemic and its impact on the cardiovascular system is significant. This study analyzed the relationship between COVID-19 and cardiovascular diseases through bibliometrics and visualization techniques. The findings suggest that SARS-CoV-2 has a higher infectivity rate and a higher incidence of cardiovascular diseases compared to SARS-CoV-1. The research focus has shifted from ACE2 and inflammation to the treatment of myocarditis and complications.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Tatjana Meister, Heti Pisarev, Raivo Kolde, Ruth Kalda, Kadri Suija, Lili Milani, Liis Karo-Astover, Marko Piirsoo, Anneli Uuskula
Summary: This retrospective cohort study analyzed nationwide e-health databases in Estonia to identify risk factors for SARS-CoV-2 infection and severe COVID-19. The study found that women, individuals with comorbid conditions or obesity, were more likely to be infected. Male sex, increasing age, and comorbid burden were significantly associated with more severe COVID-19 outcomes. Renal disease, previous myocardial infarction, and obesity were the strongest contributors to critical illness, while renal disease, cancer, liver disease, and cerebrovascular disease were the strongest contributors to a lethal outcome.
Article
Genetics & Heredity
Matheus Negri Boschiero, Camila Vantini Capasso Palamim, Manoela Marques Ortega, Fernando Augusto Lima Marson
Summary: The study aimed to compare the COVID-19 death rate among hospitalized patients with Down syndrome in Brazil and tease apart the unique effects of COVID-19 and Down syndrome through comparing disease characteristics.
Article
Gastroenterology & Hepatology
Monique Freire Santana, Mateus T. Guerra, Melanie A. Hundt, Maria M. Ciarleglio, Rebecca Augusta de Araujo Pinto, Bruna Guimaraes Dutra, Mariana Simao Xavier, Marcus Vinicius Guimaraes Lacerda, Anderson Jose Ferreira, David Campos Wanderley, Israel Junior Borges do Nascimento, Roberto Ferreira de Almeida Araujo, Sergio Veloso Brant Pinheiro, Stanley de Almeida Araujo, M. Fatima Leite, Luiz Carlos de Lima Ferreira, Michael H. Nathanson, Paula Vieira Teixeira Vidigal
Summary: The study revealed pathological changes in liver tissues of deceased patients with COVID-19, showing that most patients had liver injury not caused by vascular events. The injury may result from inflammation, metabolic abnormalities, and potentially direct viral damage.
HEPATOLOGY COMMUNICATIONS
(2022)
Review
Nutrition & Dietetics
Sj Shen, Muxue Gong, Gang Wang, Kamal Dua, Jincheng Xu, Xiaoyue Xu, Gang Liu
Summary: COVID-19-induced gut injury is a common symptom, and the mechanism is mainly due to the binding of SARS-CoV-2 to the ACE2 receptor in host cells. Antiviral drugs and monoclonal antibodies can reduce viral load and shorten the recovery time of the disease. Probiotics, ACE2 inhibitors, and nutrients are promising options for treating COVID-19-induced gut injury.
Article
Medicine, General & Internal
Mariano Duarte, Facundo Pelorosso, Liliana N. Nicolosi, M. Victoria Salgado, Hector Vetulli, Analia Aquieri, Francisco Azzato, Marcela Castro, Javier Coyle, Ignacio Davolos, Ignacio Fernandez Criado, Rosana Gregori, Pedro Mastrodonato, Maria C. Rubio, Sergio Sarquis, Fernando Wahlmann, Rodolfo P. Rothlin
Summary: This study in Argentina investigated the potential treatment of Covid19-induced lung inflammation using telmisartan. Results showed that patients treated with telmisartan had better CRP levels and shorter time to discharge compared to standard care alone.
Article
Medicine, General & Internal
J. Park, M-Y Park, Y. Kim, Y. Jun, U. Lee, C-M Oh
Summary: This study found that [Pyr1]-Apelin-13 can protect cells from viral infection by inhibiting the binding of ACE2 to the SARS-CoV-2 spike protein. It also regulates inflammatory responses by inhibiting the nuclear factor kappa B pathway. These findings suggest that Apelin may be a potential therapeutic candidate against SARS-CoV-2 infection.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Priscilla S. Briquez, Sherin J. Rouhani, Jovian Yu, Athalia R. Pyzer, Jonathan Trujillo, Haley L. Dugan, Christopher T. Stamper, Siriruk Changrob, Anne Sperling, Patrick C. Wilson, Thomas F. Gajewski, Jeffrey A. Hubbell, Melody A. Swartz
Summary: Patients with COVID-19 may develop autoantibodies against AngII, which correlates with blood pressure dysregulation, lower blood oxygenation, and increased disease severity. The presence of these autoantibodies suggests potential epitope mimicry between AngII and SARS-CoV-2 proteins.
Article
Public, Environmental & Occupational Health
Chunli Wang, Bing Fang, Aksara Regmi, Yoshifumi Yamaguchi, Ling Yang, Yuyang Cai
Summary: The global COVID-19 pandemic has caused significant social and economic burden, with misinformation and disinformation on social media platforms contributing to psychosocial issues. A study on Sina Weibo found 82 posts spreading disinformation about ACEI/ARB drugs and their relation to COVID-19, and 44 posts dispelling this misinformation. The dissemination of false information harmed COVID-19 prevention efforts and caused confusion and panic among patients.
JOURNAL OF GLOBAL HEALTH
(2023)
Review
Medicine, General & Internal
Nikhil T. Awatade, Peter A. B. Wark, Andrew S. L. Chan, S. M. Abdullah Al Mamun, Nurul Yaqeen Mohd Esa, Kazuto Matsunaga, Chin Kook M. Rhee, Philip M. Hansbro, Sukhwinder Singh Sohal
Summary: Chronic obstructive pulmonary disease (COPD) is a major contributor to illness and death worldwide. While COPD patients appear to be at higher risk for severe COVID-19 outcomes, it is still uncertain if they are more susceptible to acquiring SARS-CoV-2 infection. This comprehensive review examines the relationship between COPD and COVID-19, exploring the evidence on susceptibility to infection and disease severity. The review also considers factors such as smoking, corticosteroid use, socioeconomic factors, and genetics that may influence this association. The importance of managing COPD patients during the pandemic to minimize the risk of severe COVID-19 outcomes is highlighted.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Kiran Iqbal Masood, Maliha Yameen, Javeria Ashraf, Saba Shahid, Syed Faisal Mahmood, Asghar Nasir, Nosheen Nasir, Bushra Jamil, Najia Karim Ghanchi, Iffat Khanum, Safina Abdul Razzak, Akbar Kanji, Rabia Hussain, Martin E. Rottenberg, Zahra Hasan
Summary: Studying the host protective mechanisms against SARS-CoV-2 infection may lead to improved treatment for COVID-19. Differences in severity of COVID-19 were associated with changes in antigen presentation, inflammatory pathways, and interferon-stimulated genes (ISGs). Upregulation of ISGs in asymptomatic cases suggests a potential role in controlling early responses against the virus, supporting the hypothesis that early treatment with type I interferons may limit disease progression.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Mankgopo Magdeline Kgatle, Ismaheel Opeyemi Lawal, Gabriel Mashabela, Tebatso Moshoeu Gillian Boshomane, Palesa Caroline Koatale, Phetole Walter Mahasha, Honest Ndlovu, Mariza Vorster, Hosana Gomes Rodrigues, Jan Rijn Zeevaart, Siamon Gordon, Pedro Moura-Alves, Mike Machaba Sathekge
Summary: Severe cases of COVID-19 may be influenced by metabolic and epigenetic mechanisms, including DNA methylation and histone/chromatin alterations. These epigenetic phenomena may lead to enhanced viral replication, resulting in severe symptoms and fatalities.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ivan J. Nunez-Gil, Ivan Olier, Gisela Feltes, Maria C. Viana-Llamas, Charbel Maroun-Eid, Rodolfo Romero, Inmaculada Fernandez-Rozas, Aitor Uribarri, Victor M. Becerra-Munoz, Emilio Alfonso-Rodriguez, Marcos Garcia-Aguado, Javier Elola, Alex Castro-Mejia, Martino Pepe, Juan Fortunato Garcia-Prieto, Adelina Gonzalez, Fabrizio Ugo, Enrico Cerrato, Elvira Bondia, Sergio Raposeiras-Roubin, Jorge L. Jativa Mendez, Carolina Espejo, Alvaro Lopez-Masjuan, Francisco Marin, Javier Lopez-Pais, Mohammad Abumayyaleh, Miguel Corbi-Pascual, Christoph Liebetrau, Harish Ramakrishna, Vicente Estrada, Carlos Macaya, Antonio Fernandez-Ortiz
Summary: The study found that among COVID-19 patients, those who used RASi had better outcomes during hospitalization, with lower mortality rates and fewer in-hospital complications. However, there was no association between the use of RASi and the development of heart failure in patients with pre-existing heart failure.
AMERICAN HEART JOURNAL
(2021)
Article
Cell Biology
Rocio Diaz Escarcega, Pedram Honarpisheh, Gabriela Delevati Colpo, Hilda W. Ahnstedt, Lucy Couture, Shivanki Juneja, Glenda Torres, Guadalupe J. Ortiz, James Sollome, Natalie Tabor, Bhanu P. Ganesh, H. Alex Choi, Fudong Liu, Louise D. McCullough, Andrey S. Tsvetkov
Summary: The study finds sex differences in metabolism and sexual dimorphism in the correlations between clinical parameters and metabolic profiles in severe COVID-19 patients, providing important knowledge for the development of sex-associated biomarkers and druggable targets for COVID-19 patients.
CELL DEATH & DISEASE
(2022)