Article
Nursing
Larissa Castelo Guedes Martins, Marcos Venicios de Oliveira Lopes, Camila Maciel Diniz, Natalia Cabrera Matos, Leticia de Carvalho Magalhaes, Marilia Alves Furtado
Summary: This study aimed to verify the clinical validity of clinical indicators and etiological factors of sedentary lifestyle in individuals with arterial hypertension. Results showed that 57.8% of the participants met the diagnostic criteria for sedentary lifestyle. Out of 27 etiological factors, 22 were significantly associated with sedentary lifestyle.
JOURNAL OF CLINICAL NURSING
(2021)
Article
Cardiac & Cardiovascular Systems
Gert J. H. Snel, Maaike van den Boomen, Katia Hurtado-Ortiz, Riemer H. J. A. Slart, Vincent M. van Deursen, Christopher T. Nguyen, David E. Sosnovik, Rudi A. J. O. Dierckx, Birgitta K. Velthuis, Ronald J. H. Borra, Niek H. J. Prakken
Summary: This study aimed to investigate the impact of sedentary lifestyle-related risk factors (overweight, hypertension, and type 2 diabetes) on cardiac morphology, function, and tissue characteristics in young adults. The results showed subclinical alterations in cardiac structure and function associated with these risk factors, highlighting the importance of considering these factors in clinical decision making based on cardiac MRI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Daniel P. Andersson, Alastair G. Kerr, Ingrid Dahlman, Mikael Ryden, Peter Arner
Summary: Insulin sensitivity for antilipolysis and lipogenesis is decreased in sedentary individuals, but only the association between antilipolysis sensitivity and physical activity remains significant. Fatty acid levels decrease following hyperinsulinemia, but remain higher in sedentary women. mRNA expression of insulin receptor and its substrates 1 and 2 is decreased in sedentary individuals.
Article
Mathematics, Applied
Edna Manda, Farai Chirove
Summary: The paper presents a theoretical mathematical model of within-host hepatitis B virus infection in the chronic phase of liver cancer, considering suboptimal adherence and drug resistance. The study highlights that natural drug resistance has a stronger impact on increasing the virus burden compared to suboptimal adherence. Combination therapies are more effective in reducing virus infection than monotherapies.
MATHEMATICAL METHODS IN THE APPLIED SCIENCES
(2021)
Article
Immunology
Yiyan Ou, Ruiling Chen, Qiwei Qian, Nana Cui, Qi Miao, Ruqi Tang, Zhengrui You, Xiong Ma, Qixia Wang
Summary: TSPAN1 expression is increased and correlated with disease severity in AIH patients. TSPAN1+ B cells secrete inflammatory cytokines and exhibit chemotactic movement towards the liver in AIH. CXCR3 and CXCL10 may contribute to the migration of TSPAN1+ B cells to the liver.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Si Xie, Liu Yang, Xiaoyue Bi, Wen Deng, Tingting Jiang, Yanjie Lin, Shiyu Wang, Lu Zhang, Ruyu Liu, Min Chang, Shuling Wu, Yuanjiao Gao, Hongxiao Hao, Ge Shen, Mengjiao Xu, Xiaoxue Chen, Leiping Hu, Yao Lu, Rui Song, Yao Xie, Minghui Li
Summary: The activation of CD8+ T lymphocytes is associated with the occurrence of acute and chronic hepatitis B. CD8+ T lymphocytes play an important role in the development of hepatitis B, and their activation status is correlated with the progression of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Camilla Rodrigues de Almeida Ribeiro, Nathalia Alves Araujo de Almeida, Katrini Guidolini Martinelli, Marcia Amendola Pires, Carlos Eduardo Brandao Mello, Jose J. Barros, Vanessa Salete de Paula
Summary: In this study, cytokine levels were examined in patients with HBV occult infection and chronic hepatitis C. The results showed that there were higher levels of cytokines in OBI/HCV patients compared to the control group and HBV monoinfected patients. IL-17A was found to be high in the HBV monoinfected group, while TNF-alpha, IL-10, IL-6, IL-4, and IL-2 were elevated in OBI/HCV patients.
Review
Immunology
Wen Hou, Xiaoli Wu
Summary: This study investigates the roles of gamma delta T cells in HBV and HCV infections, discussing the different roles they play in the progression of liver diseases at various stages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Karin Kan, Danny Ka-Ho Wong, Rex Wan-Hin Hui, Wai Kay Seto, Man-Fung Yuen, Lung-Yi Mak
Summary: Low plasma levels of IP-10 are associated with subsequent HBsAg seroclearance, suggesting potential clinical utilities of measurement of IP-10 in predicting HBsAg seroclearance, especially among patients with low HBsAg.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
Minghui Li, Yuanjiao Gao, Liu Yang, Yanjie Lin, Wen Deng, Tingting Jiang, Xiaoyue Bi, Yao Lu, Lu Zhang, Ge Shen, Ruyu Liu, Shuling Wu, Min Chang, Mengjiao Xu, Leiping Hu, Rui Song, Yuyong Jiang, Wei Yi, Yao Xie
Summary: This study investigated the kinetic changes of serum, virological, and immunological markers during entecavir (ETV) antiviral therapy in HBeAg-positive chronic hepatitis B (CHB) patients. Findings suggest that baseline HBV DNA load, HBeAg, and IL-10 levels were significantly associated with ALT normalization after 48 weeks of ETV treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xiaoqing Liu, Xicheng Pang, Huimin Wang, Jinjie Du, Hong Ren, Peng Hu
Summary: Hepatitis B surface antigen (HBsAg) seroclearance is an optimal therapeutic endpoint in chronic hepatitis B (CHB) patients. The mechanisms contributing to HBsAg reduction remain unclear. In this study, HBsAg reduction was associated with decreased levels of certain cytokines and changes in adaptive immune cells. With HBsAg reduction, T-cell subsets imbalance was partially corrected, immune activity of T cells was enhanced, and immune exhaustion was alleviated to some extent.
Article
Immunology
Alexandra Johnson Valiente, Kin Seng Liem, Kathleen B. Schwarz, Philip Rosenthal, Karen F. Murray, Douglas Mogul, Jeffery Teckman, Norberto Rodriguez-Baez, Sarah Jane Schwarzenberg, Jordan J. Feld, David K. Wong, Lia L. Lewis-Ximenez, Georg Lauer, Bettina E. Hansen, Simon C. Ling, Harry L. A. Janssen, Adam J. Gehring
Summary: Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient serum. Different stages of the disease have distinct inflammatory profiles, with more inflammatory markers detected in chronic patients and elevated concentrations of cytotoxic effectors in chronic hepatitis B patients with liver damage.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Fergus Hamilton, Ruth E. Mitchell, Andrei Constantinescu, David Hughes, Aubrey Cunnington, Peter Ghazal, Nicholas J. Timpson
Summary: Through Mendelian Randomization (MR) analysis using the genetic variant rs2228145, it was found that decreasing IL-6 signaling does not have an effect on the development of severe malaria. This suggests that IL-6 may not be causal for severe outcomes in malaria, and therapeutic manipulation of IL-6 is unlikely to be a suitable treatment for severe malaria.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Gastroenterology & Hepatology
Leyla de Avila, Linda Henry, James M. Paik, Naila Ijaz, Ali A. Weinstein, Zobair M. Younossi
Summary: This study assessed the independent associations of nonalcoholic fatty liver disease (NAFLD) with all-cause and cause-specific mortality in older community-dwelling adults. The results showed that NAFLD is associated with increased risk of all-cause, cardiac, and cancer mortality. The study highlights the importance of NAFLD and calls for measures to reduce the burden of NAFLD and associated mortality.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Xin Jin, Zhi-han Yan, Lingna Lu, Shengjia Lu, Guoping Zhang, Wei Lin
Summary: The study revealed that patients with chronic hepatitis B (CHB) exhibit various immune cell disorders and functional impairments, particularly in NK and T cells. These cells showed exhaustion, and the increase in regulatory B cells may contribute to this phenomenon.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Nsoh G. Anabire, Maria del Pilar Quintana, Michael F. Ofori, Lars Hviid
Summary: Infected erythrocytes that sequester in the placenta via parasite-encoded VAR2CSA-type PfEMP1 are selectively eliminated following delivery as their cognate adhesion receptor in the placenta is lost. Parasitemia among pregnant women with protective immunity to Plasmodium falciparum malaria is often dominated by VAR2CSA-positive infected erythrocytes (IEs). VAR2CSA mediates sequestration of IEs in the placenta. We hypothesized that the previously observed spontaneous postpartum clearance of parasitemia in such women is related to the expulsion of the placenta, which removes the sequestration focus of VAR2CSA-positive IEs. We assessed parasitemias and gene transcription before and shortly after delivery in 17 Ghanaian women. The precipitous decline in parasitemia postpartum was accompanied by selective reduction in transcription of the gene encoding VAR2CSA. Our findings provide a mechanistic explanation for the earlier observation.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Manas Kotepui, Aongart Mahittikorn, Nsoh Godwin Anabire, Frederick Ramirez Masangkay, Kwuntida Uthaisar Kotepui
Summary: This systematic review investigates the association between ascorbic acid levels and malaria pathogenesis. The findings indicate that malaria patients have lower levels of ascorbic acid, while levels are similar between severe and nonsevere malaria, as well as between Plasmodium falciparum and Plasmodium vivax infected patients.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Infectious Diseases
Nsoh Godwin Anabire, Belinda Aculley, Abigail Pobee, Eric Kyei-Baafour, Gordon A. Awandare, Maria del Pilar Quintana, Lars Hviid, Michael F. Ofori
Summary: This study evaluated the impact of adherence to malaria control measures on asymptomatic malaria and anaemia outcomes among pregnant women in hospitals in the Central region of Ghana. The results showed that despite high adherence to ANC protocols, asymptomatic P. falciparum infection was common and contributed to the high burden of maternal anaemia. Therefore, improved control measures are needed to clear asymptomatic/sub-microscopic P. falciparum infection and protect pregnant women against malaria-induced anaemia.
Article
Hematology
Gideon K. K. Helegbe, Paul Aryee, Baba Sulemana Mohammed
Summary: This study aimed to investigate the prevalence of preterm delivery and neonatal deaths among anaemic pregnant women in the Bolgatanga Regional Hospital in Ghana. The results showed that over half of the anaemic women had preterm deliveries and the neonatal mortality rate was 8.5%. The study concluded that anaemia in pregnancy increases the risk of preterm delivery and neonatal death.
Review
Infectious Diseases
Manas Kotepui, Thitinat Duangchan, Aongart Mahittikorn, Chusana Mekhora, Nsoh Godwin Anabire, Kwuntida Uthaisar Kotepui
Summary: This systematic review examined the variations in interleukin-5 (IL-5) levels in patients with malaria. The results showed heterogeneity in IL-5 levels between different severities of malaria and uninfected controls. Most studies found no significant difference in IL-5 levels between malaria cases and uninfected controls.
Editorial Material
Virology
Nsoh Godwin Anabire, Osbourne Quaye, Gideon Kofi Helegbe
Summary: This study characterized the HBV genotypes in pregnant women seeking prenatal treatment in northern Ghana, revealing the presence of genotypes A, D, and E, with mixed infections observed in some cases. These findings have clinical implications for the management of chronic HBV infection among pregnant women in this region.
Review
Multidisciplinary Sciences
Manas Kotepui, Aongart Mahittikorn, Nsoh Godwin Anabire, Kwuntida Uthaisar Kotepui
Summary: This meta-analysis study found that blood levels of GPx were significantly decreased in malaria patients, especially in those with P. falciparum malaria. This finding provides important insights for further investigation into the role of GPx depletion in malaria pathogenesis.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Gideon Kofi Helegbe, Anthony Wemakor, Evans Paul Kwame Ameade, Nsoh Godwin Anabire, Frank Anaba, Jose M. M. Bautista, Bruno Gonzalez Zorn
Summary: This study aimed to assess the prevalence of the co-occurrence of G6PD deficiency and sickle cell trait (SCT) among pregnant women and the impact on anemia outcomes. The study found a higher proportion of SCT in pregnant women with G6PD deficiency than those without. The interaction between malaria and SCT was associated with anemia outcomes among G6PD deficient women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Onchuma Mueangson, Aongart Mahittikorn, Nsoh Godwin Anabire, Wanida Mala, Manas Kotepui
Summary: This study examined the relationship between malondialdehyde (MDA) concentrations and Plasmodium infections. The results showed that MDA concentrations were significantly elevated in patients with malaria compared to uninfected controls, indicating an increase in oxidative stress and lipid peroxidation. MDA levels can be a valuable biomarker for evaluating these processes in individuals with malaria.
Article
Biology
Nsoh Godwin Anabire, George Doopaar Billak, Gideon Kofi Helegbe
Summary: Objective lifestyle choices, such as alcohol intake, smoking, and self-medication, among traders in the Tamale Central market in Ghana were evaluated, and their association with anaemia was examined. Results showed that while alcohol intake and smoking were uncommon, self-medication was prevalent among the participants. Anaemia was a common condition, particularly among females, and was associated with self-medication.
BMC RESEARCH NOTES
(2023)
Article
Medicine, Research & Experimental
Gloria Asantewaa, Nsoh Godwin Anabire, Michael Bauer, Sebastian Weis, Sophie Neugebauer, Osbourne Quaye, Gideon Kofi Helegbe
Summary: Co-infection of Plasmodium falciparum and hepatitis B virus is increasing among pregnant women in northern Ghana. These co-infections result in unique metabolic alterations, including decreased concentrations of sphingolipids, amino acids, phospholipids, and hexoses, and alterations in pathways related to redox homeostasis. The metabolite PC ae C40:1 shows promise as a discriminatory marker for co-infection, and can potentially be used for diagnosis and treatment of malaria and chronic hepatitis B co-morbidity.