Article
Biochemistry & Molecular Biology
Sarah E. J. Kamli-Salino, Paul A. J. Brown, Timo N. Haschler, Lihuan Liang, Denis Feliers, Heather M. Wilson, Mirela Delibegovic
Summary: This study compared the effects of freshly prepared STZ and anomer-equilibrated STZ on kidney damage in mice and found that anomer-equilibrated STZ caused more severe kidney tubule structural damage, while freshly prepared STZ only caused mild changes. Therefore, anomer-equilibrated STZ provides a reliable mouse model for diabetes and early-stage diabetic nephropathy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Rhiannon E. Hawkes, Lisa M. Miles, David P. French
Summary: This study found that various behavior change theories were used by providers in the National Health Service Diabetes Prevention Programme, but there was a lack of explicit logic models describing how interventions are expected to work. This resulted in discrepancies between the behavior change techniques selected in intervention design and the theory described.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2021)
Article
Psychology, Clinical
Rhiannon E. Hawkes, Lisa M. Miles, Ben Ainsworth, Jamie Ross, Rachel Meacock, David P. French
Summary: The National Health Service Digital Diabetes Prevention Programme (NHS-DDPP) is a nine-month digital behavior change intervention offered to adults in England at high risk of developing type 2 diabetes. The study found that user engagement with the program decreased over time, but support from a health coach may promote engagement with specific intervention features.
INTERNET INTERVENTIONS-THE APPLICATION OF INFORMATION TECHNOLOGY IN MENTAL AND BEHAVIOURAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Marie Williams, Louise Thomson, Elizabeth Butcher, Richard Morriss, Kamlesh Khunti, Chris Packham
Summary: The uptake of NHS Health Checks in prison settings is limited due to poor accessibility to healthcare departments, stigma, and fear. Participants generally lack awareness and have common misconceptions regarding the health check program. Ways to increase uptake include group-based approaches and improved healthcare accessibility.
JOURNAL OF PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
David Reeves, Adrine Ablitt Woodham, David French, Peter Bower, Fiona Holland, Evangelos Kontopantelis, Sarah Cotterill
Summary: This study aims to identify demographic, health, and psychosocial factors associated with the uptake of the NHS Diabetes Prevention Programme (NHS-DPP) in order to improve participation and address inequities. The results show that factors such as age, beliefs about personal vulnerability to type 2 diabetes, self-efficacy for reducing diabetes risk, and perceptions of the effectiveness of the NHS-DPP are the main predictors of uptake.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Endocrinology & Metabolism
Sridharan Raghavan, Kathleen Jablonski, Linda M. Delahanty, Nisa M. Maruthur, Aaron Leong, Paul W. Franks, William C. Knowler, Jose C. Florez, Dana Dabelea
Summary: The study found that individuals with lower diabetes GRS and those who achieved the ILS goals were associated with lower incidence of diabetes. Additionally, the study revealed significant additive interactions between GRS and achievement of weight loss, physical activity, and all three ILS goals for diabetes risk. The findings suggest that genetic risk can help identify high-risk subgroups who may benefit more from successful lifestyle modifications in reducing the risk of incident diabetes.
DIABETES OBESITY & METABOLISM
(2021)
Review
Sport Sciences
Samantha M. Gray, Heather A. McKay, Lindsay Nettlefold, Douglas Race, Heather M. Macdonald, Patti-Jean Naylor, Joanie Sims-Gould
Summary: The review found that older adult physical activity intervention studies reported implementation indicators and frameworks, but lacked specific indicators for scale-up evaluation. There is a relationship between implementation indicators and individual health outcomes, but further research is needed to explore influencing factors.
BRITISH JOURNAL OF SPORTS MEDICINE
(2021)
Article
Sport Sciences
Tess Saad, Lauren Davies, Michelle Smith
Summary: The implementation of the Netball KNEE programme in community netball is low, especially in activities related to strength, balance/landing, and agility. Feedback on technique during training sessions is required for improvement, yet it is frequently not provided. This lack of proper implementation and feedback is concerning for injury prevention and improving movement patterns among players.
JOURNAL OF SPORTS SCIENCES
(2021)
Article
Psychology, Clinical
Rhiannon E. Hawkes, Elaine Cameron, Lisa M. Miles, David P. French
Summary: The study found that commercial providers of the NHS-DPP may not be training staff with fidelity to intervention plans, with some providers showing inconsistencies between the content delivered in training and what was outlined in the intervention plans.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2021)
Article
Veterinary Sciences
Rudolf Dupak, Jana Hrnkova, Nikoleta Simonova, Jan Kovac, Eva Ivanisova, Anna Kalafova, Monika Schneidgenova, Marta Soltesova Prnova, Jan Brindza, Katarina Tokarova, Marcela Capcarova
Summary: Sea buckthorn, known for its antioxidant effects, can effectively suppress hyperglycemia, reduce water intake, and lower sorbitol levels in the lens of the eyes in diabetic rats.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Avni Gupta, Jiyuan Hu, Shengnan Huang, Laura Diaz, Radhika Gore, Natalie Levy, Michael Bergman, Michael Tanner, Scott E. Sherman, Nadia Islam, Mark D. Schwartz
Summary: This study examines the implementation fidelity and moderators of a health coaching intervention led by community health workers. The findings suggest that fidelity to the intervention components varied between implementation sites, highlighting the challenges of implementing complex interventions in different contexts.
Article
Psychology, Multidisciplinary
David P. French, Rhiannon E. Hawkes, Peter Bower, Elaine Cameron
Summary: The study compared the fidelity of delivery of Behavior Change Techniques (BCTs) in the NHS Diabetes Prevention Programme to the design specification and programme manuals, revealing a discrepancy between the two. Despite the design specification indicating 19 BCTs to be delivered, only seven were actually delivered, highlighting a lack of fidelity to the evidence base.
ANNALS OF BEHAVIORAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Lisa M. Miles, Rhiannon E. Hawkes, David P. French
Summary: This study examines the fidelity of the NHS Digital Diabetes Prevention Programme (DDPP) compared to the service specification, describes its delivery features, and explores developers' views on the programme's structural components. The findings reveal variation in the delivery of support services across providers, which may impact the effectiveness of the programme.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Medicine, General & Internal
Aileen Callanan, Diarmuid Quinlan, Susanne O'Sullivan, Colin P. Bradley, Patricia M. Kearney, Aileen Murphy, Claire Mary Buckley
Summary: Atrial fibrillation (AF) is a major risk factor for stroke and is often asymptomatic. Early detection of AF can significantly reduce stroke risk. International experts recommend AF screening, but there are multiple screening methods.
Article
Multidisciplinary Sciences
Nicola L. Hawley, Anna C. Rivara, Joshua Naseri, Kitiona Faumuina, Noelle Potoa'e-Solaita, Francine Iopu, Mata'uitafa Faiai, Eminoni Naveno, Susie Tasele, Temukisa Lefale, Ryan Lantini, Jenna C. Carlson, Tracy L. Rabin, Penny Semaia, Phyllis Mugadza, Rochelle K. Rosen
Summary: This study aims to intervene Samoan adolescents to improve glycemic control and self-care practices of their family members with diabetes, thus reducing the spread of diabetes in the Pacific Islanders community. The findings of this study can provide a replicable model for other minority groups with similar characteristics.
Review
Endocrinology & Metabolism
Tamla S. Evans, Pooja Dhir, Duncan Radley, Cristiana Duarte, Chris Keyworth, Catherine Homer, Andy J. Hill, Rhiannon Hawkes, Jamie Matu, James McKenna, Louisa J. Ells
Article
Health Care Sciences & Services
Lisa M. Miles, Rhiannon E. Hawkes, David P. French
Summary: This study aimed to evaluate participants' understanding and use of behavior change content in the NHS-DDPP, investigate the role of health coaches in supporting behavior change, and examine variations across providers. The results showed that health coaches played a pivotal role in delivering key components of the program, and additional human support is needed to improve the understanding and use of behavior change content in digital interventions.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Psychiatry
David Saxon, Michael Barkham, Penny Bee, Judith Gellatly, Cintia Faija, Peter Bower
Summary: This study concludes that offering telephone assessments does not negatively affect the uptake of assessment and may improve the efficiency and accessibility of mental healthcare services. The findings can have significant implications for the development and future reconfiguration of psychological therapy services.
Article
Oncology
Lorna McWilliams, Helen Ruane, Fiona Ulph, Victoria G. Woof, Fiona Harrison, D. Gareth Evans, David P. French
Summary: Risk-stratified breast screening is being considered for national breast screening programmes. This study aimed to explore the psychological impact of undergoing risk-stratified screening within England's NHS Breast Screening Programme. The findings suggest that risk-stratified breast screening is generally accepted but issues related to risk communication and access to care pathways need to be considered for implementation.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
David P. French, Lorna McWilliams, Sarah Bowers, Victoria G. Woof, Fiona Harrison, Helen Ruane, Alice Hendy, D. Gareth Evans
Summary: Adding risk stratification to the NHS Breast Screening Programme allows additional prevention and screening options for high-risk women, but may also increase cancer worry. This study found that offering risk stratification did not increase anxiety or cancer worry, even for women informed of being at high risk.
BRITISH JOURNAL OF CANCER
(2023)
Article
Primary Health Care
Gail Davidge, Lindsey Brown, Moira Lyons, Charlotte Blease, David French, Tjeerd van Staa, Brian McMillan
Summary: This study aims to explore the views and experiences of primary care staff regarding patients' online access to their health records, and how this service can be supported and improved. Most staff agreed with the principle of patient access but had mixed feelings about the potential benefits and drawbacks. They identified opportunities to enhance patient engagement and health literacy while also expressing concerns about maintaining clinical integrity and ensuring safety and wellbeing. Participants recognized the transformative potential of online access and emphasized the need for additional training and support to adapt practice and enhance patient understanding.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Correction
Health Care Sciences & Services
Mary Pegington, Alan Davies, Julia Mueller, Rachel Cholerton, Anthony Howell, D. Gareth Evans, Sacha J. Howell, David P. French, Michelle Harvie
JMIR RESEARCH PROTOCOLS
(2023)
Article
Geography
Christine Camacho, Roger T. Webb, Peter Bower, Luke Munford
Summary: This paper examines the relationship between economic resilience in English regions and the allocation of the government's Community Renewal Fund (CRF). Economic resilience is measured using indicators such as productivity, skills, unemployment, population density, and household income. The study finds that the current allocation of CRF funding may widen existing inequalities rather than addressing them. There is no significant correlation between resilience values and CRF allocations.
REGIONAL STUDIES REGIONAL SCIENCE
(2023)
Article
Medicine, General & Internal
Peter Knapp, Thirimon Moe-Byrne, Jacqueline Martin-Kerry, Rebecca Sheridan, Jenny Roche, Elizabeth Coleman, Peter Bower, Steven Higgins, Catherine Stones, Jonathan Graffy, Jenny Preston, Carrol Gamble, Bridget Young, Daniel Perry, Annegret Dahlmann-Noor, Mohamed Abbas, Payal Khandelwal, Siobhan Ludden, Augusto Azuara-Blanco, Emma McConnell, Nicky Mandall, Anna Lawson, Chris A. Rogers, Helena J. M. Smartt, Rachael Heys, Simon R. Stones, Danielle Horton Taylor, Sophie Ainsworth, Jenny Ainsworth
Summary: By comparing multimedia information (MMI) and printed participant information sheets (PIS), the study found that MMI can increase the recruitment rate of trials, but has no effect on the quality of decision-making. MMI is a useful tool for recruiting children and young people in trials.
Review
Endocrinology & Metabolism
Peter Bower, Claudia Soiland-Reyes, Simon Heller, Paul Wilson, Sarah Cotterill, David French, Matt Sutton
Summary: The NHS Diabetes Prevention Programme (NHS DPP) has successfully achieved significant reductions in diabetes incidence through a large-scale behaviour change programme. Despite encountering barriers during implementation, such as low engagement and fidelity issues, the programme has shown effectiveness in reducing diabetes incidence at both individual and population levels. By closely collaborating with the NHS DPP team, valuable insights have been provided for improving communication, supporting primary care referral, enhancing provider relationships, increasing patient choice, improving behavior change techniques, and enriching educational and health coaching content.
Article
Health Care Sciences & Services
Jamie Ross, Rhiannon E. Hawkes, Lisa M. Miles, Sarah Cotterill, Peter Bower, Elizabeth Murray
Summary: This study aimed to understand engagement with the NHS-digital-DPP and found that almost all participants started using the apps, but there were differences in engagement levels across providers. The findings could inform the design of other digital behavior change interventions.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Psychology, Multidisciplinary
Sophie M. C. Green, Louise H. Hall, David P. French, Nikki Rousseau, Catherine Parbutt, Rebecca Walwyn, Samuel G. Smith, ROSETA investigators
Summary: In an online study, we found that detailed side effect information had a negative impact on patients' beliefs about adjuvant endocrine therapy (AET) compared to quotes from other women with breast cancer. Therefore, we decided to remove this section from the information leaflet. The use of a stepped approach to optimize the leaflet proved to be efficient and effective in changing patients' beliefs about AET.
ANNALS OF BEHAVIORAL MEDICINE
(2023)
Article
Psychology, Clinical
Victoria G. Woof, Lorna McWilliams, Anthony Howell, D. Gareth Evans, David P. French
Summary: This study aimed to gain an in-depth understanding of women's lived experiences of receiving an increased breast cancer risk. The findings suggest that providing risk predictions has little impact on women's beliefs about breast cancer risk, and discussions with healthcare professionals are needed to help women form more accurate appraisals and make informed decisions.
BRITISH JOURNAL OF HEALTH PSYCHOLOGY
(2023)
Article
Primary Health Care
Gail Davidge, Lindsey Brown, Moira Lyons, Charlotte Blease, David French, Tjeerd van Staa, Brian McMillan
Summary: This study examined the views and experiences of primary care staff in England regarding patients' online access to their health records. Most staff supported the principle of patient access, but had mixed feelings about the potential benefits and drawbacks in practice. They identified opportunities to improve patient engagement, health literacy, and administrative efficiencies, but also expressed concerns about maintaining clinical integrity and ensuring safety and wellbeing.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)