Article
Chemistry, Multidisciplinary
Gyounghwan Kim, Hyun-Sang Park, Paul Shin, Taeguk Eom, Jin-Hui Yoon, Yong Jeong, Wang-Yuhl Oh
Summary: Blood flow dynamics in microvascular networks play a critical role in tissue and organ health. Direct blood cell flow imaging (DBFI) is a new imaging technique that allows visualization of individual blood cell motions without using any contrast agents, with high time resolution. DBFI has the potential to analyze blood flow dynamics in various vessels and has been demonstrated in applications such as quantifying 3D vascular networks, analyzing heartbeat-induced blood flow, and studying neurovascular coupling.
Article
Biology
Y. Ben-Ami, G. W. Atkinson, J. M. Pitt-Francis, P. K. Maini, H. M. Byrne
Summary: By analyzing mathematical models, we found that the microstructural features of vascular networks, such as redundancy and differences in flow resistance, can promote the emergence of oscillatory dynamics. We used numerical simulations and stability analysis to study the dynamics of a three-node network and its multiple steady-state solutions. We constructed a stability diagram using the branch diameter ratio and inlet haematocrit rate, which delineates the regimes where flow oscillations exist.
BULLETIN OF MATHEMATICAL BIOLOGY
(2022)
Article
Mechanics
Guansheng Li, Ting Ye, Bo Yang, Sitong Wang, Xuejin Li
Summary: Hematocrit, as an important indicator of human health, shows the capability of blood to deliver oxygen. Recent studies have found that temporal-spatial heterogeneity is a major feature of hematocrit in microvascular networks. This study uses numerical simulations to investigate the temporal-spatial heterogeneity, and the results show that it is more pronounced in networks with smaller vessel diameters or more complex geometry. This research has significant clinical implications for more accurate diagnosis and treatment.
Review
Pharmacology & Pharmacy
Sorabh Sharma, Craig E. Brown
Summary: This review discusses the relationship between microvascular dysfunction caused by type 1 diabetes and cognitive impairment, aiming to synthesize the current knowledge in this field.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Lujuan Li, Shuo Wang, Keqin Han, Xiaojing Qi, Shuhao Ma, Li Li, Jun Yin, Dechang Li, Xuejin Li, Jin Qian
Summary: Platelet margination and adhesion in thrombus formation were investigated using dissipative particle dynamics (DPD) method. The shear-induced RBC-platelet collisions were found to significantly affect platelet margination. The lateral motion of individual platelets and platelet adhesive dynamics were characterized, revealing the impact of wall-induced lift force, shear-induced displacement, and fibrinogen concentration on platelet distribution and adhesion. The findings provide insights into the initial stage of thrombus formation.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Mechanics
Erfan Kosari, Kambiz Vafai
Summary: As the number of patients with neurodegenerative disorders continues to grow, finding effective therapies becomes a major concern. Utilizing magnetothermal stimulation to activate nanoparticles within brain capillaries may offer a non-invasive treatment option. This article presents a theoretical study on the transport and dynamic interactions of blood flow with magnetic nanoparticles through a brain capillary.
Article
Cardiac & Cardiovascular Systems
Paul D. Morris, Rebecca Gosling, Iwona Zwierzak, Holli Evans, Louise Aubiniere-Robb, Krzysztof Czechowicz, Paul C. Evans, D. Rodney Hose, Patricia Lawford, Andrew J. Narracott, Julian P. Gunn
Summary: The study developed and validated a novel method to predict absolute coronary blood flow and microvascular resistance in the catheter laboratory, which showed high accuracy in both in vitro and in vivo experiments.
CARDIOVASCULAR RESEARCH
(2021)
Article
Mathematics, Interdisciplinary Applications
Ansel L. Blumers, Minglang Yin, Hiroyuki Nakajima, Yosuke Hasegawa, Zhen Li, George Em Karniadakis
Summary: The study highlights the importance of mesoscopic simulations in understanding the cellular basis of diseases. A multiscale parareal algorithm is proposed to accelerate mesoscopic simulations in the time domain, demonstrating its effectiveness through case studies.
COMPUTATIONAL MECHANICS
(2021)
Article
Engineering, Multidisciplinary
Guansheng Li, Ting Ye, Zehong Xia, Sitong Wang, Ziwei Zhu
Summary: This study aims to analyze and predict the hematocrit distribution in microvascular networks using direct simulations of cellular blood flow. The results showed that the hematocrit is spatially and temporally heterogeneous in the microvascular network, with a significant effect from bifurcations. Additionally, deep learning techniques can provide a fast and efficient way to measure the hematocrit distribution in a microvascular network.
INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE
(2023)
Article
Multidisciplinary Sciences
Ehsan Khalilipur, Zahra Mahdizad, Negin Molazadeh, Hooshang Faghihi, Nasim Naderi, Mohammadreza Mehrabi Bahar, Ata Firouzi, Parham Sadeghipour, Majid Maleki, Sahel Soltani Shahgoli, Elias Khalili Pour, Hamid Riazi-Esfahani
Summary: This cross-sectional study aimed to evaluate microvascular changes in the choroidal and retinal regions of patients with Heart Failure with Reduced Ejection Fraction (HFrEF) compared to a normal population. The study found no significant differences in central macular thickness, retinal capillary plexus vascular densities, or choriocapillaris flow density, except for a decreased superficial capillary plexus vascular density in the parafoveal region. Patients with HFrEF also had a significantly lower subfoveal choroidal thickness. However, there was no significant change in choroidal vascularity index.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Annemiek de Vos, Tijn P. J. Jansen, Marcel van 't Veer, Aukelien Dimitriu-Leen, Regina E. Konst, Suzette Elias-Smale, Valeria Paradies, Laura Rodwell, Stijn van den Oord, Pieter Smits, Niels van Royen, Nico Pijls, Peter Damman
Summary: Microvascular resistance reserve (MRR), measured invasively using continuous thermodilution, is a new index for assessing coronary microvascular (dys)function. This study aimed to establish normal values for MRR and determine the optimal cutoff point. In patients with angina and no obstructive coronary artery disease, MRR was found to be a suitable index for distinguishing the presence or absence of coronary microvascular dysfunction (CMD).
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Peripheral Vascular Disease
Nisha Patel, Stella Duong, Parisa Mirbod, Jie Xu, Bruce I. I. Gaynes
Summary: This study analyzed the influencing factors of conjunctival hemorheology and found that there is variation in Vax among healthy subjects, while a high degree of statistical heterogeneity was observed when comparing Vax between healthy and disease state patients.
MICROVASCULAR RESEARCH
(2022)
Article
Clinical Neurology
Megan Mio, Anahit Grigorian, Yi Zou, Mikaela K. Dimick, Beth Selkirk, Peter Kertes, Brian W. McCrindle, Walter Swardfager, Margaret K. Hahn, Sandra E. Black, Bradley J. MacIntosh, Benjamin I. Goldstein
Summary: This study reveals an association between retinal vascular caliber and cerebral blood flow in adolescents with bipolar disorder. These findings provide important insights into the potential neurofunctional mechanisms linking retinal vascular caliber with psychiatric diagnoses.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Optics
Mate Siket, Imre Janoki, Kornel Demeter, Miklos Szabo, Peter Foldesy
Summary: The varied illumination speckle contrast imaging method introduced in this Letter allows for a larger range of flow rate coverage in a single exposure compared to constant illumination methods. This enables high dynamic range flow rate imaging, advantageous for studying larger vessels and small arteries. The method was demonstrated through simulations and measurements in ex vivo and in vivo settings.
Article
Nutrition & Dietetics
Colleen S. Deane, Ushnah S. U. Din, Tanvir S. Sian, Ken Smith, Amanda Gates, Jonathan N. Lund, John P. Williams, Ricardo Rueda, Suzette L. Pereira, Philip J. Atherton, Bethan E. Phillips
Summary: Acute curcumin supplementation enhances the effect of oral nutritional supplement on microvascular blood flow in healthy older adults, without affecting muscle glucose uptake, vascular function, or blood flow.
Article
Surgery
Andrea Weinzierl, Yves Harder, Michael D. Menger, Matthias W. Laschke
Summary: This study found that intermittent fasting can effectively prevent flap necrosis by increasing angiogenesis and reducing inflammatory responses.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Editorial Material
Physiology
Paola Bianchi, Giampaolo Minetti, Anna Bogdanova, Lars Kaestner
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Hematology
Laura Hertz, Daniel Flormann, Lutz Birnbaumer, Christian Wagner, Matthias W. Laschke, Lars Kaestner
Summary: The protein TRPC6 is present in mouse red blood cells but absent in human red blood cells. Transfusion experiments showed that TRPC6 could be restored in mice within 10 days. Mechanical stimulation experiments suggested that protein transfer to red blood cells can occur in the absence of translational machinery. This protein transfer mechanism has potential therapeutic applications for diseases involving red blood cells.
Editorial Material
Physiology
Lars Kaestner, Benoit Champigneulle, Emeric Stauffer, Michael Furian, Jeremy De Abreu, Thomas John, Elie Nader, Anja Scheller, Aurelien Pichon, Philippe Connes, Paul Robach, Julien V. V. Brugniaux, Christian Borsch, Silvia Rudloff, Heimo Mairbaeurl, Samuel Verges
Article
Multidisciplinary Sciences
Alexis Darras, Thomas John, Christian Wagner, Lars Kaestner
Summary: Erythrocyte sedimentation rate is a derived parameter used in health checks and medical diagnosis. Recent studies have shown that red blood cells exhibit similar sedimentation behavior as colloidal suspensions. This hypothesis allows for more accurate modeling of the sedimentation curve and extraction of meaningful descriptors.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Oncology
Antonios E. Spiliotis, Sebastian Hollaender, Jeannette Rudzitis-Auth, Gudrun Wagenpfeil, Robert Eisele, Spyridon Nika, Orestis Mallis Kyriakides, Matthias W. Laschke, Michael D. Menger, Matthias Glanemann, Gereon Gaebelein
Summary: Electrochemotherapy (ECT) is an effective treatment for hepatic tumors that combines the administration of chemotherapeutic agents with well-dosed electric pulses for cell membrane reversible electroporation. It reduces tumor oxygenation, increases tumor necrosis, and reduces tumor vascularization compared to reversible electroporation and chemotherapy. ECT is a valuable option for treating hepatic tumors with necrosis rates >85% five days post-treatment.
Review
Cell Biology
Yuan Gu, Maximilian A. Becker, Luisa Mueller, Katharina Reuss, Frederik Umlauf, Tianci Tang, Michael D. Menger, Matthias W. Laschke
Summary: Tumor endothelial cells (TECs) are crucial for tumor angiogenesis, growth and metastasis, and small non-coding microRNAs (miRNAs) play a significant role in regulating TEC function and blood vessel formation. This review provides an overview of the regulatory mechanisms and effects of endothelial miRNAs, highlighting their involvement in fundamental angiogenesis-related signaling pathways. Targeting endothelial miRNAs represents a potential strategy for anti-angiogenic cancer therapy, but further research is needed to understand their networks and develop specific delivery technologies.
Article
Cell Biology
Mohammed Nouaman, Alexis Darras, Thomas John, Greta Simionato, Minke A. E. Rab, Richard van Wijk, Matthias W. Laschke, Lars Kaestner, Christian Wagner, Steffen M. Recktenwald
Summary: The deformability of RBCs is crucial for blood flow in the microcirculatory system. The age of RBCs affects their physical properties and their shape in microfluidic channels. Our study reveals that older RBCs form more stable symmetric croissant shapes, while chemically rigidified RBCs show suppressed formation of this shape class. This research provides insights into the distinct effects of age-related changes in cell properties on the flow behavior of RBCs in confined flows.
Article
Cell & Tissue Engineering
Friederike C. Messner, Wolfgang Metzger, Julia E. Marschall, Caroline Bickelmann, Michael D. Menger, Matthias W. Laschke
Summary: MVF isolates generated by short-term enzymatic digestion are beneficial for tissue defect vascularization, isolates from obese mice lack connective tissue and exhibit improved in vivo vascularization.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Nutrition & Dietetics
Andrea Weinzierl, Maximilian Coerper, Yves Harder, Michael D. Menger, Matthias W. Laschke
Summary: This study demonstrates that a 30% reduction in caloric intake effectively prevents flap necrosis by maintaining microperfusion and inhibiting inflammation under ischemic stress.
Article
Chemistry, Physical
Yazdan Rashidi, Othmane Aouane, Alexis Darras, Thomas John, Jens Harting, Christian Wagner, Steffen M. Recktenwald
Summary: Bifurcations and branches in the microcirculation have a significant impact on blood flow and the distribution of red blood cells. This study investigates the flow behavior of healthy and artificially hardened red blood cells in a bifurcating microfluidic T-junction. The results reveal distinct focusing profiles and the development of asymmetric cell-free layers in the daughter vessels for different types of red blood cells.