Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 133, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2020.110943
Keywords
mircoRNA-217; Cancer; Target gene; oncomiR; Tumor suppressor miRNA
Funding
- Anhui Provincial Natural Science Foundation for Outstanding Youth [2008085J37]
- First Affiliated Hospital of Bengbu Medical College Science Fund for Distinguished Young Scholars [2019byyfyjq05]
- National Nature Science Foundation of China [81600452]
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miR-217 is a highly conserved non-coding RNA that regulates various tumors, with both tumor suppressor and potential oncomiR functions. Recent studies have shown that miR-217 plays an important role in tumor progression.
As highly conserved non-coding RNAs of approximately 18-24 nucleotides, microRNAs (miRNAs) regulate the expression of target genes. Multiple studies have demonstrated that miRNAs participate in the regulation of human cancer. MircoRNA-217 (miR-217) participates in the regulation of various tumors by specifically binding target genes and post-transcriptional regulation. In recent years, there have been numerous reports about miR-217 in tumor progression. MiR-217 is known mainly as a tumor suppressor, although some studies have shown that it functions as an oncomiR. Here, we review the current research related to miR-217, including its role in tumor progression and the molecular mechanisms.
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