Unveiling six potent and highly selective antileishmanial agents via the open source compound collection ‘Pathogen Box’ against antimony-sensitive and -resistant Leishmania braziliensis

A spotlight on the diagnostic methods of a fatal disease Visceral Leishmaniasis

(2020) Awanish Kumar et al.   PARASITE IMMUNOLOGY

Leishmania donovani Growth Inhibitors from Pathogen Box Compounds of Medicine for Malaria Venture

(2020) Markos Tadele et al.   Drug Design Development and Therapy

Elucidating the possible mechanism of action of some pathogen box compounds against Leishmania donovani

(2020) Wandayi Emmanuel Amlabu et al.   PLoS Neglected Tropical Diseases

Preclinical Gold Complexes as Oral Drug Candidates to Treat Leishmaniasis Are Potent Trypanothione Reductase Inhibitors

(2020) Luiza G. Tunes et al.   ACS Infectious Diseases

An Antiparasitic Compound from the Medicines for Malaria Venture Pathogen Box Promotes Leishmania Tubulin Polymerization

(2020) Imran Ullah et al.   ACS Infectious Diseases

Unpacking the Pathogen Box

(2019) Clinton Veale   ChemMedChem

Identification of potential inhibitors targeted for strengthening search of anti-leishmanial therapeutics

(2019) Anubhuti Jha et al.   BIOLOGIA

Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays

(2018) Sarah L. Berry et al.   PLoS Neglected Tropical Diseases

Intraspecies susceptibility of Leishmania (Viannia) braziliensis to antileishmanial drugs: Antimony resistance in human isolates from atypical lesions

(2018) Jeronimo N. Rugani et al.   BIOMEDICINE & PHARMACOTHERAPY

In vitro screening of the open source Pathogen Box identifies novel compounds with profound activities against Neospora caninum

(2017) Joachim Müller et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Arpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein Structures

(2017) Harry C Jubb et al.   JOURNAL OF MOLECULAR BIOLOGY

Chemotherapy of leishmaniasis: present challenges

(2017) SILVIA R. B. ULIANA et al.   PARASITOLOGY

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue

(2017) Ebere Sonoiki et al.   Nature Communications

Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening

(2017) Diana Ortiz et al.   PLoS Neglected Tropical Diseases

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Antileishmanial Activity of Compounds Derived from the Medicines for Malaria Venture Open Access Box Against Intracellular Leishmania major Amastigotes

(2016) Mozna Khraiwesh et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Screening the Pathogen Box for Identification of Candida albicans Biofilm Inhibitors

(2016) Taissa Vila et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor

(2016) Ana L. Valenciano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide

(2016) Daniel Stoessel et al.   Metabolomics

CSM-lig: a web server for assessing and comparing protein–small molecule affinities

(2016) Douglas E.V. Pires et al.   NUCLEIC ACIDS RESEARCH

A Luciferase-Expressing Leishmania braziliensis Line That Leads to Sustained Skin Lesions in BALB/c Mice and Allows Monitoring of Miltefosine Treatment Outcome

(2016) Adriano C. Coelho et al.   PLoS Neglected Tropical Diseases

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

(2016) Stephen Patterson et al.   eLife

Screening of the ‘Pathogen Box’ identifies an approved pesticide with major anthelmintic activity against the barber's pole worm

(2016) Sarah Preston et al.   International Journal for Parasitology-Drugs and Drug Resistance

In-vitro sensitivity of Pakistani Leishmania tropica field isolate against buparvaquone in comparison to standard anti-leishmanial drugs

(2015) Qaisar Jamal et al.   EXPERIMENTAL PARASITOLOGY

pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures

(2015) Douglas E. V. Pires et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei

(2014) Lori Ferrins et al.   JOURNAL OF MEDICINAL CHEMISTRY

SwissTargetPrediction: a web server for target prediction of bioactive small molecules

(2014) David Gfeller et al.   NUCLEIC ACIDS RESEARCH

Identification of novel candidate compounds targeting TrkB to induce apoptosis in neuroblastoma

(2014) Yohko Nakamura et al.   Cancer Medicine

Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

(2013) Manu De Rycker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chemical probes of a trisubstituted pyrrole to identify its protein target(s) in Plasmodium sporozoites

(2013) Tyrell Towle et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis

(2013) Lluís Ballell et al.   ChemMedChem

Molecular Basis of Differential Selectivity of Cyclobutyl-Substituted Imidazole Inhibitors against CDKs: Insights for Rational Drug Design

(2013) Soumya Lipsa Rath et al.   PLoS One

Target specific-trisubstituted pyrrole inhibits Babesia bovis erythrocytic growth

(2012) Audrey O.T. Lau et al.   EXPERIMENTAL PARASITOLOGY

Open Source Drug Discovery in Practice: A Case Study

(2012) Christine Årdal et al.   PLoS Neglected Tropical Diseases

An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages

(2012) Jair L. Siqueira-Neto et al.   PLoS Neglected Tropical Diseases

Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis

(2011) Robert T Jacobs et al.   Future Medicinal Chemistry

CYP5122A1, a Novel Cytochrome P450 Is Essential for Survival of Leishmania donovani

(2011) Smriti Verma et al.   PLoS One

Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis

(2010) B. Nare et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phospholipid and sphingolipid metabolism in Leishmania

(2009) Kai Zhang et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Detection of multiscale pockets on protein surfaces using mathematical morphology

(2009) Takeshi Kawabata   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Estimation of synthetic accessibility score of drug-like molecules based on molecular complexity and fragment contributions

(2009) Peter Ertl et al.   Journal of Cheminformatics

Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors

(2008) Clifford D. Jones et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS