Review
Food Science & Technology
Michal Sienkiewicz, Andrzej Jaskiewicz, Aleksandra Tarasiuk, Jakub Fichna
Summary: Lactoferrin, a glycoprotein found in mucosal secretions, has immunomodulatory and anti-inflammatory activities and shows effectiveness against various bacteria and viruses, potentially inhibiting enveloped viruses like SARS-CoV-2. Studies have examined its functions, bioavailability, potential benefits and side effects, as well as its applications in clinical trials and potential role in inflammatory bowel disease.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Multidisciplinary
Chung-Sung Lee, Jiabing Fan, Hee Sook Hwang, Soyon Kim, Chen Chen, Minjee Kang, Tara Aghaloo, Aaron W. James, Min Lee
Summary: Extracellular vesicles, particularly exosome mimetics (EMs) with hydroxyapatite-binding moieties, have demonstrated potential as biocarriers for targeted bone regeneration. The introduction of a Smoothened agonist (SAG) greatly enhanced the osteogenic capacity of the EMs through hedgehog signaling activation. The integration of EM/SAG into a scaffold significantly improved in vivo reossification, and biodistribution studies confirmed the accumulation of systemically administered EMs in bone tissue.
Article
Chemistry, Multidisciplinary
Hae Hyun Hwang, Hyung Shik Kim, Dong Yun Lee
Summary: The conjugate of lactoferrin and heparin can attenuate angiogenic activity by binding to growth factors around the tumor tissue, and it can be orally absorbed and delivered to brain tumors through the blood-brain barrier. It inhibits angiogenesis in glioblastoma and shows potential as a new oral medication for treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Cell Biology
Yubo Shen, Daoxia Guo, Xiaoyuan Ji, Yanfeng Zhou, Shuo Liu, Jing Huang, Haiyun Song
Summary: In this study, a biomimetic nanoparticle consisting of a self-assembled CpG NP core and cell membrane shell was designed, showing advantages in modulating peripheral and central immune cells. This new strategy provides targeted delivery and immunomodulatory effects for CpG ODNs in disease treatment.
CELL PROLIFERATION
(2022)
Article
Nanoscience & Nanotechnology
Haifang Li, Dalin He, Xue Xiao, Guanliu Yu, Geng Hu, Wenqian Zhang, Xin Wen, Yun Lin, Xianyao Li, Hai Lin, Youxiang Diao, Yi Tang
Summary: N-MWCNTs enhance bone remodeling and bone cell activity, showing potential applications in bone tissue engineering.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Pharmacology & Pharmacy
Amit Kumar Tripathi, Jamboor K. Vishwanatha
Summary: The use of peptide-based drugs for cancer treatment is becoming more significant in the pharmaceutical industry. Anticancer peptides with immunomodulatory activity could be key lead molecules in designing effective cancer therapeutics.
Review
Biochemistry & Molecular Biology
Siqi Peng, Huizhen Wang, Zhengtao Wang, Qingzhong Wang
Summary: Viral DNA and RNA polymerases are crucial enzymes in synthesizing genetic materials of viruses, serving as attractive targets for antiviral drug development. Due to similarities in viral polymerases, inhibitors designed for one type of virus can be effective on others. This review discusses the development of viral polymerase inhibitors and proposes future strategies for antiviral drug development.
Article
Chemistry, Multidisciplinary
Juan Zhang, Wenjing Zhang, Mengsi Yang, Weiwei Zhu, Ming Li, Ao Liang, Hui Zhang, Ti Fang, Xian-En Zhang, Feng Li
Summary: This study explored the impact of tumor progression stages on the targeting efficiency of PEGylated viral nanoparticles using a colorectal cancer model. The results showed a decrease in tumor targeting efficiency with tumor progression.
Article
Multidisciplinary Sciences
Sukanya Ghosh, Manidipa Banerjee
Summary: By utilizing Flock House Virus-like particles as carriers and an easy chemical conjugation method, targeted delivery of hydrophobic drugs can be achieved effectively with dual functionality for improved bioavailability and reduced immune reactivity. The platform shows promising potential for biomedical applications.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Na Qi, Wenjuan Duan, Duan Gao, Ningzhu Ma, Jianguo Zhang, Jianfang Feng, Aimin Li
Summary: In this study, we developed dual-modified liposomes with lactoferrin and muscone to enhance the delivery and targeting of docetaxel to the brain. The results showed improved uptake and penetration in brain tumor cells and enhanced anti-tumor effects in vitro and in vivo.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Biomedical
Zhenhao Zhao, Chufeng Li, Yiwen Zhang, Chao Li, Yongchao Chu, Xuwen Li, Peixin Liu, Hongyi Chen, Yu Wang, Boyu Su, Qinjun Chen, Tao Sun, Chen Jiang
Summary: The poor outcomes of triple-negative breast cancer brain metastases are due to the lack of effective therapies. Immunotherapy has limitations for TNBC brain metastases due to non-immunogenicity of tumors and strong immunosuppressive environment. This study proposed a cocktail-like therapeutic strategy of microenvironment regulation-chemotherapy-immune synergistic sensitization and developed reduction-sensitive immune microenvironment regulation nano-materials (SIL@T). SIL@T showed dual immunomodulatory functions and provided a promising immune synergistic therapy strategy for breast cancer brain metastases.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Guo Chen, Shaohui Deng, Mingxiang Zuo, Jin Wang, Du Cheng, Bin Chen
Summary: By using the nonviral CRISPRa system, the expressions of TGF-81 and VEGF-A genes were activated to enhance osteogenesis in MC3T3-E1 cells. The engineered cells implanted with a tunable dual-crosslinked hydrogel also promoted the healing of mice calvarial bone defects.
MATERIALS TODAY BIO
(2022)
Article
Biotechnology & Applied Microbiology
Na Qi, Shangqian Zhang, Xiantai Zhou, Wenjuan Duan, Duan Gao, Jianfang Feng, Aimin Li
Summary: The study demonstrated the significant advantages of RGD-Lf-LP in cellular uptake and tumor spheroid penetration, with both in vitro and in vivo experiments confirming its strong targeting effects for brain orthotopic gliomas. The dual modification of RGD and Lf is a promising combination for brain targeting delivery.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yazhe Wang, Shipra Malik, Hee-Won Suh, Yong Xiao, Yanxiang Deng, Rong Fan, Anita Huttner, Ranjit S. Bindra, Vijender Singh, W. Mark Saltzman, Raman Bahal
Summary: In this study, we developed functionalized nanoparticles loaded with anti-seed s gamma PNAs to target oncomiRs 10b and 21 in tumor cells. Combined with temozolomide, these nanoparticles significantly improved the survival of orthotopic mouse models of GBM. This study provides a promising approach to personalized treatment of GBM based on tumor-specific oncomiRs.
Article
Materials Science, Biomaterials
Wei Tan, Chengde Gao, Pei Feng, Qing Liu, Congcong Liu, Zhenting Wang, Youwen Deng, Cijun Shuai
Summary: The PLLA/nHA/MET composite scaffold constructed in this study showed improved cell adhesion, appropriate porosity, good biocompatibility, and osteogenic-induced ability in vitro. MET enhanced water solubility and promoted osteogenic differentiation within the scaffold.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Review
Pharmacology & Pharmacy
Doaa M. Anwar, Mousa El-Sayed, Asmaa Reda, Jia-You Fang, Sherine N. Khattab, Ahmed O. Elzoghby
Summary: Herbal compounds have the potential to enhance the efficacy of cancer therapy by co-delivering with other anticancer treatments through intelligent design of nanomedicines. The use of multifunctional nanocarrier systems shows promise in accurately delivering anticancer drugs and minimizing the development of drug resistance. Early detection and management of adverse effects remains a key challenge.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Review
Biotechnology & Applied Microbiology
Asmaa F. Khafaga, Rehab N. Shamma, Ahmed Abdeen, Abdelmonem M. Barakat, Ahmed E. Noreldin, Ahmed O. Elzoghby, Marwa A. Sallam
Summary: COX-2 inhibitors show great potential in cancer therapy, especially when combined with nanotechnological approaches to enhance drug delivery efficiency. Celecoxib, being the most widely studied agent, demonstrates significant potential in chemoprevention and combined treatment with other drugs.
Review
Biotechnology & Applied Microbiology
Ahmed S. AbdElhamid, Dina G. Zayed, Lamia Heikal, Sherine N. Khattab, Omar Y. Mady, Sanaa A. El-Gizawy, Ahmed O. Elzoghby
Summary: Polymeric nanocapsules are vesicular drug delivery systems with an inner oily reservoir surrounded by polymeric membranes, offering controlled drug release properties and the ability to direct drugs to their target sites. Despite their productive applications, especially in cancer therapy, their clinical development is still at an early stage.
Article
Oncology
Islam A. Hassanin, Reem F. M. Salih, Marwa H. M. Fathy, Eman A. Hassanin, Dina H. Selim
Summary: The study found that inappropriate oral nutritional supplementation did not improve the quality of life of cancer outpatients and may lead to lower global health status and role functioning.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Chemistry, Multidisciplinary
Sarah Mokhtar, Sherine N. Khattab, Kadria A. Elkhodairy, Mohamed Teleb, Adnan A. Bekhit, Ahmed O. Elzoghby, Marwa A. Sallam
Summary: The study describes a hybrid carrier system for the simultaneous targeted delivery of two drugs, EXE and MTX, for the treatment of breast cancer. The findings show that the dual drug-loaded nanoparticles have excellent drug loading and cytotoxic activity, making them a promising candidate for combinational hormonal therapy/chemotherapy.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biophysics
Mai A. Atallah, Marwa A. Sallam, Mona A. Abdelmoneem, Mohamed Teleb, Kadria A. Elkhodairy, Adnan A. Bekhit, Asmaa F. Khafaga, Ahmed E. Noreldin, Ahmed O. Elzoghby, Sherine N. Khattab
Summary: The use of self-assembled nanogels for the co-delivery of therapeutic molecules offers an effective and safe strategy for breast cancer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Pharmacology & Pharmacy
Ahmed O. Elzoghby, Cristina R. Ferrone, Soldano Ferrone, Mahmoud L. Nasr
Summary: Pancreatic cancer is a highly aggressive and resistant type of cancer. This review highlights the recent advances in engineering nanomedicines to enhance the immune response against pancreatic cancer. Nanomedicines are used to increase the immunogenicity of cancer cells, deactivate cancer-associated fibroblasts, enhance the antigen-presenting capacity of dendritic cells, reverse the immunosuppressive nature of the tumor microenvironment, and improve the infiltration of cytotoxic T lymphocytes for efficient antitumor immune responses.
DRUG DISCOVERY TODAY
(2023)
Article
Polymer Science
Osama R. M. Metawea, Mohamed Teleb, Nesreen S. Haiba, Ahmed O. Elzoghby, Asmaa F. Khafaga, Ahmed E. Noreldin, Sherine N. Khattab, Hosam H. Khalil
Summary: A smart carrier, PNIPAM-MD NGs, decorated with FA, was developed for efficient delivery of RSV in breast cancer treatment. The FA-PNIPAM-MD F3 NGs displayed dual thermo-and pH-responsivities, high drug-loading capacity, and excellent stability. In vitro and in vivo evaluations demonstrated significant anti-breast cancer potency and tumor growth suppression.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Mai Salah, Marwa A. Sallam, Mona A. Abdelmoneem, Mohamed Teleb, Kadria A. Elkhodairy, Adnan A. Bekhit, Asmaa F. Khafaga, Ahmed E. Noreldin, Ahmed O. Elzoghby, Sherine N. Khattab
Summary: The study demonstrates the potential of rationally designed protein/polysaccharide nanohybrids loaded with a combination of drugs to effectively suppress breast tumors. The nanohybrids showed enhanced cellular uptake and a significant decrease in IC50 compared to the free drug combination, indicating their superiority as a treatment approach.
Article
Chemistry, Multidisciplinary
Riham M. Abdelgalil, Sherine N. Khattab, Shaker Ebrahim, Kadria A. Elkhodairy, Mohamed Teleb, Adnan A. Bekhit, Marwa A. Sallam, Ahmed O. Elzoghby
Summary: Researchers have developed a biocompatible silk-sericin-tagged inorganic nano-hybrid for the treatment and imaging of cancer cells. This nanocarrier can prevent premature release of the chemotherapeutic drug, enhance the stability of layered double hydroxides, and maintain the luminescence properties of zinc oxide quantum dots.
Article
Chemistry, Multidisciplinary
Tasneem A. Nasser, Rawan Adel, Abdelrahman Badr, Mohamed Teleb, Adnan A. Bekhit, Kadria A. Elkhodairy, Ahmed S. Abdelhamid, Ahmed O. Elzoghby
Summary: Cancer is a major cause of death worldwide, and delayed diagnosis leads to decreased survival rates. Immunotherapy has revolutionized the treatment of various cancers, but many patients do not respond and experience severe immune-related side effects. Recent advances in nanomedicine and imaging have provided new approaches to improving the safety and efficacy of immunotherapy. The field of theranostics, which integrates diagnosis and therapy, shows promising results in animal studies by using nanoparticles. This article discusses the latest developments in nanotheranostics for tumor imaging and cancer immunotherapy.
Article
Biochemistry & Molecular Biology
Yomna M. Elmorshedy, Mohamed Teleb, Marwa A. Sallam, Kadria A. Elkhodairy, Mohammed Bahey-El-Din, Doaa A. Ghareeb, Shaymaa A. Abdulmalek, Shimaa A. H. Abdel Monaim, Adnan A. Bekhit, Ahmed O. Elzoghby, Fernando Albericio, Sherine N. Khattab
Summary: Despite progress in targeted therapies, there is a need for convenient therapeutics for colorectal cancer (CRC). Lactoferrin nanoparticles (Lf NPs) show promise in cancer therapy, but their oral delivery is hindered by obstacles such as instability and premature uptake. Microencapsulation of Lf NPs provides a solution by protecting them and improving drug release in the colon.
Review
Biotechnology & Applied Microbiology
Riham M. Abdelgalil, Yomna M. Elmorshedy, Kadria A. Elkhodairy, Mohamed Teleb, Adnan A. Bekhit, Sherine N. Khattab, Ahmed O. Elzoghby
Summary: Colorectal cancer (CRC) is a devastating disease worldwide and immunotherapeutic agents have limitations due to the tumor microenvironment. Nanoparticles (NPs) can potentially reverse the immunosuppressive TME, enhance the effectiveness of immunotherapeutic agents and reduce side effects. This review summarizes recent research on nano-based immunotherapy in CRC, including its ability to remodel the TME and challenges in clinical translation.
Article
Chemistry, Multidisciplinary
Ahmed O. Elzoghby, Omar Samir, Ahmed Soliman, Sergey Solomevich, Minzhi Yu, Anna Schwendeman, Mahmoud L. Nasr
Summary: Engineering biocompatible HDL nanodiscs have gained significant interest in recent years for their applications in drug delivery and structural biology. Nanodiscs offer advantages such as small size, extended circulation time, high stability, good tolerability, and tissue targeting properties. However, there are challenges in isolating and purifying endogenous HDL as well as concerns about safety and production associated with converting HDL into nanoscale therapeutics. In addition to drug delivery, nanodiscs also have the potential for better investigation of virus-receptor interactions and characterization of membrane proteins. Recent advancements, such as using recombinant ApoA1 proteins and ApoA1 mimetic peptides, offer alternatives to endogenous HDL. Overall, nanodiscs show promise for clinical translation and future applications.
Meeting Abstract
Oncology
Ahmed Elzoghby, May Freag, Mostafa Mohammed, Krishna Maremanda, Hae Lin Jang, Shiladitya Sengupta
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.