Article
Engineering, Biomedical
En Ren, Haimin Chen, Zainen Qin, Siwen Guan, Lai Jiang, Xin Pang, Yi He, Yang Zhang, Xing Gao, Chengchao Chu, Li Zheng, Gang Liu
Summary: The genetically engineered ferritin nanocage RC-Fn, with RGD peptide and WYRGRL peptide on the surface, can efficiently bridge bone marrow mesenchymal stem cells (BMSCs) and stimulating factor kartogenin (KGN), promoting chondrocyte differentiation and cartilage repair.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Physical
Arjan Atwal, Tina P. Dale, Martyn Snow, Nicholas R. Forsyth, Pooya Davoodi
Summary: The impairment of articular cartilage poses challenges, but recent advancements in regenerative medicine, particularly the use of injectable hydrogels, offer promising prospects for cartilage regeneration. Hydrogels can mimic the characteristics of native cartilage and provide minimally invasive delivery of bioactive agents to the damaged site, accelerating cartilage healing and modulating inflammation.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Review
Chemistry, Medicinal
Brandon Vorrius, Zhen Qiao, Jonathan Ge, Qian Chen
Summary: The musculoskeletal system is composed of specialized connective tissues that provide protection, structure, and mobility to the body. However, diseases of the musculoskeletal system are increasing in burden, resulting in pain, disability, and a decrease in quality of life. Regenerative drug therapies for musculoskeletal disorders are in demand, but effective drug delivery poses challenges.
Review
Biotechnology & Applied Microbiology
David A. Hart, Norimasa Nakamura, Nigel G. Shrive
Summary: Regenerating musculoskeletal tissues faces challenges such as the heterogeneity of biological and biomechanical environments, declining anabolic factors with age, and unfavorable conditions in injured tissues. Despite the obstacles, progress has been made in repairing and regenerating MSK tissues.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Sheng-Long Ding, Xin Liu, Xi-Yuan Zhao, Ke-Tao Wang, Wei Xiong, Zi-Li Gao, Cheng-Yi Sun, Min-Xuan Jia, Cheng Li, Qi Gu, Ming-Zhu Zhang
Summary: The successful regeneration of cartilage tissue at a clinical scale has been a significant challenge. Microcarrier systems offer an attractive approach to regulate cell phenotype and tissue maturation, and have shown promise in cartilage regeneration. This review provides comprehensive guidelines for the rational design and applications of microcarriers in cartilage tissue engineering.
BIOACTIVE MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Yevgeniy Kim, Zharylkasyn Zharkinbekov, Kamila Raziyeva, Laura Tabyldiyeva, Kamila Berikova, Dias Zhumagul, Kamila Temirkhanova, Arman Saparov
Summary: Chitosan, a biopolymer derived from chitin, has great potential for tissue regeneration and controlled drug delivery. It possesses qualities such as biocompatibility, low toxicity, and antimicrobial activity, making it attractive for biomedical applications. Chitosan can be fabricated into different structures, including nanoparticles, scaffolds, hydrogels, and membranes, which can be customized for specific outcomes. It has been shown to stimulate tissue regeneration and repair in various tissues and organs, and is an efficient carrier for medications, genes, and bioactive compounds.
Review
Biochemistry & Molecular Biology
David A. Hart, Norimasa Nakamura
Summary: After injuries to musculoskeletal tissues, an inflammatory response occurs to promote endogenous repair, but it often results in functionally inferior scar tissue. Injuries in adults no longer have the anabolic processes that contribute to growth and maturation, which can lead to degenerative conditions such as osteoarthritis. Researchers have been exploring cellular therapies, such as Platelet-rich Plasma and mesenchymal stem/medicinal signaling cells, to enhance tissue repair and regeneration. However, implanting these cells or engineered constructs into an inflammatory adult environment may compromise their potential for regeneration. Therefore, it may be necessary to neutralize the inflammatory environment and create an anabolic environment for optimal outcomes.
Review
Pharmacology & Pharmacy
Long Bai, Gang Tao, Maogeng Feng, Yuping Xie, Shuyu Cai, Shuanglin Peng, Jingang Xiao
Summary: With the advancement in understanding bone regeneration mechanisms and development of bone tissue engineering, a variety of scaffold carrier materials called hydrogels have emerged. Hydrogels are biocompatible, have unique swelling properties, and are relatively easy to fabricate, making them increasingly popular in bone regeneration and tissue engineering. Hydrogel drug delivery systems consist of cells, cytokines, an extracellular matrix, and small molecule nucleotides, each with different properties based on their chemical or physical cross-linking. This paper summarizes recent research in the field of bone regeneration using hydrogels as delivery carriers, discusses their application in bone defect diseases and their mechanisms, and explores future research directions of hydrogel drug delivery systems in bone tissue engineering.
Article
Biochemistry & Molecular Biology
Xiaolu Huang, Xiao Liang, Yiwen Zhou, Haizhou Li, Hengyu Du, Yinjun Suo, Wenhui Liu, Rui Jin, Bangda Chai, Ran Duan, Haizhou Li, Qingfeng Li
Summary: This study demonstrates the crucial role of E-cadherin (CDH1) in mechanical stretch-induced skin cell regeneration and proliferation. The induction of keratinocyte dedifferentiation by Cdh1 is highlighted as a key event in mechanical stretch-mediated skin regeneration, suggesting Cdh1 as a potential therapeutic target for promoting skin regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Engineering, Biomedical
Ying Wang, Ranjith Kumar Kankala, Caiwen Ou, Aizheng Chen, Zhilu Yang
Summary: This review focuses on the application and advantages of hydrogels in tissue vascularization, including the creation of highly complex three-dimensional tissues and organs, tunable physical properties, and high similarity to physiological environments. Furthermore, the utilization of hydrogel-based vascularized tissues in various applications such as tissue regeneration, drug screening, and organ-on-chips is discussed.
BIOACTIVE MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Yaping Zhuang, Wenguo Cui
Summary: Gene therapy for tissue regeneration is promising but faces limitations in vivo due to physiological obstacles. Biomaterial-based gene delivery systems can overcome stability issues and control overexpression of therapeutic genes, contributing to local production of regulatory factors.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Biotechnology & Applied Microbiology
Kexin Nie, Sicheng Zhou, Hu Li, Jingyi Tian, Weiliang Shen, Wenwen Huang
Summary: Musculoskeletal diseases are a leading cause of chronic pain and physical disability, globally affecting millions of individuals. Advances in bone and cartilage tissue engineering using silk biomaterials have provided new possibilities for treatment. Silk biomaterials offer unique mechanical properties, versatile design options, favorable biocompatibility, and controllable degradation rates. This review highlights the latest progress in engineering natural and recombinant silk biomaterials for bone and cartilage regeneration, discussing their future potentials and challenges in musculoskeletal tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Engineering, Biomedical
Shang Lyu, Zhifei Dong, Xiaoxiao Xu, Ho-Pan Bei, Ho-Yin Yuen, Chung-Wai James Cheung, Man-Sang Wong, Yong He, Xin Zhao
Summary: Microneedles have gained widespread attention as a novel drug delivery system due to their non-invasiveness, painless administration, controllable drug delivery, and versatile cargo loading capacity. In addition to transdermal drug delivery, microneedles have shown promising results in promoting wound healing and tissue regeneration. This review provides an overview of microneedle systems, including potential cargos, structural designs, material selection, and drug release mechanisms. It also summarizes different fabrication methods and the recent progress of microneedle-assisted wound healing and tissue regeneration in various tissues and organs.
BIOACTIVE MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Yang-Hee Kim, Jonathan Dawson, Richard O. C. Oreffo, Yasuhiko Tabata, Dhiraj Kumar, Conrado Aparicio, Isha Mutreja
Summary: Musculoskeletal disorders pose a significant burden on the global economy and public health. Hydrogels, especially Gelatin methacryloyl (GelMA) hydrogel, hold great potential for enhancing the repair of damaged musculoskeletal tissues. This review provides a comprehensive overview of GelMA synthesis, hydrogel design, and its applications in regenerative medicine, particularly in the field of musculoskeletal drug delivery.
BIOENGINEERING-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Ziqi Gao, Tao Sheng, Wentao Zhang, Huiheng Feng, Jicheng Yu, Zhen Gu, Yuqi Zhang
Summary: Microneedles have emerged as a promising platform for transdermal drug delivery. Recent research has shown the potential of using microneedles in combination with cell therapy to address localized conditions and improve treatment efficacy. This study provides an overview of the recent advances, applications, challenges, and future prospects of microneedle-assisted cell delivery.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.