A newly identified NES sequence present in spastin regulates its subcellular localization and microtubule severing activity

Spastin is a dual-function enzyme that severs microtubules and promotes their regrowth to increase the number and mass of microtubules

(2019) Yin-Wei Kuo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural prerequisites for CRM1-dependent nuclear export signaling peptides: accessibility, adapting conformation, and the stability at the binding site

(2019) Yoonji Lee et al.   Scientific Reports

BMP- and neuropilin 1-mediated motor axon navigation relies on spastin alternative translation

(2018) Nicolas Jardin et al.   DEVELOPMENT

Functional differences of short and long isoforms of spastin harboring missense mutation

(2018) Clément Plaud et al.   Disease Models & Mechanisms

Truncating mutations of SPAST associated with hereditary spastic paraplegia indicate greater accumulation and toxicity of the M1 isoform of spastin

(2017) Joanna M. Solowska et al.   MOLECULAR BIOLOGY OF THE CELL

Hereditary spastic paraplegia: Clinicogenetic lessons from 608 patients

(2016) Rebecca Schüle et al.   ANNALS OF NEUROLOGY

Hereditary spastic paraplegia SPG4: what is known and not known about the disease

(2015) Joanna M. Solowska et al.   BRAIN

Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia

(2015) Hans Zempel et al.   Molecular Neurodegeneration

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

(2015) Marina Vietri et al.   NATURE

Identification of non-Ser/Thr-Pro consensus motifs for Cdk1 and their roles in mitotic regulation of C2H2 zinc finger proteins and Ect2

(2015) Kazuhiro Suzuki et al.   Scientific Reports

LocNES: a computational tool for locating classical NESs in CRM1 cargo proteins

(2014) Darui Xu et al.   BIOINFORMATICS

Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons

(2014) S. Havlicek et al.   HUMAN MOLECULAR GENETICS

The Global Epidemiology of Hereditary Ataxia and Spastic Paraplegia: A Systematic Review of Prevalence Studies

(2014) Luis Ruano et al.   NEUROEPIDEMIOLOGY

Spastin-Interacting Protein NA14/SSNA1 Functions in Cytokinesis and Axon Development

(2014) Uma Goyal et al.   PLoS One

An ESCRT–spastin interaction promotes fission of recycling tubules from the endosome

(2013) Rachel Allison et al.   JOURNAL OF CELL BIOLOGY

Computer Simulation of Assembly and Co-operativity of Hexameric AAA ATPases

(2013) Doan Tuong-Van Le et al.   PLoS One

Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics

(2012) Y Kanda   BONE MARROW TRANSPLANTATION

Subunit Interactions and Cooperativity in the Microtubule-severing AAA ATPase Spastin

(2012) Thomas Eckert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Terminal Phosphorylation of p60 Katanin Directly Regulates Microtubule Severing

(2012) Evan Whitehead et al.   JOURNAL OF MOLECULAR BIOLOGY

Toward a Comprehensive Characterization of a Human Cancer Cell Phosphoproteome

(2012) Houjiang Zhou et al.   JOURNAL OF PROTEOME RESEARCH

Normal Spastin Gene Dosage Is Specifically Required for Axon Regeneration

(2012) Michelle C. Stone et al.   Cell Reports

A Mechanism for the Evolution of Phosphorylation Sites

(2011) Samuel M. Pearlman et al.   CELL

A Novel Role for the AAA ATPase Spastin as a HOXA10 Transcriptional Corepressor in Ishikawa Endometrial Cells

(2011) Gaurang S. Daftary et al.   MOLECULAR ENDOCRINOLOGY

Cortical Constriction During Abscission Involves Helices of ESCRT-III-Dependent Filaments

(2011) J. Guizetti et al.   SCIENCE

System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation

(2011) K. T. G. Rigbolt et al.   Science Signaling

Evaluation of loss of function as an explanation for SPG4-based hereditary spastic paraplegia

(2010) J. M. Solowska et al.   HUMAN MOLECULAR GENETICS

Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network

(2010) Seong H. Park et al.   JOURNAL OF CLINICAL INVESTIGATION

SPG20 Protein Spartin Is Recruited to Midbodies by ESCRT-III Protein Ist1 and Participates in Cytokinesis

(2010) Benoît Renvoisé et al.   MOLECULAR BIOLOGY OF THE CELL

Quantitative and Functional Analyses of Spastin in the Nervous System: Implications for Hereditary Spastic Paraplegia

(2008) J. M. Solowska et al.   JOURNAL OF NEUROSCIENCE

The Microtubule-severing Proteins Spastin and Katanin Participate Differently in the Formation of Axonal Branches

(2008) Wenqian Yu et al.   MOLECULAR BIOLOGY OF THE CELL

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

(2008) Antonina Roll-Mecak et al.   NATURE

Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B

(2008) Dong Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spastin Couples Microtubule Severing to Membrane Traffic in Completion of Cytokinesis and Secretion

(2008) James W. Connell et al.   TRAFFIC

Nuclear Export Signal Consensus Sequences Defined Using a Localization-Based Yeast Selection System

(2008) Shunichi Kosugi et al.   TRAFFIC