The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

(2020) Zunyou Wu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma

(2020) Chenguang Shen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

(2020) Linlin Bao et al.   NATURE

Covid-19 in Critically Ill Patients in the Seattle Region — Case Series

(2020) Pavan K. Bhatraju et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effectiveness of convalescent plasma therapy in severe COVID-19 patients

(2020) Kai Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19

(2020) Mingxing Huang et al.   National Science Review

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

(2020) Jia Liu et al.   Cell Discovery

Baicalein administered in the subacute phase ameliorates ischemia-reperfusion-induced brain injury by reducing neuroinflammation and neuronal damage

(2019) Shilun Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Baicalein and baicalin as Zika virus inhibitors

(2018) Adrian Oo et al.   ARCHIVES OF VIROLOGY

Baicalein exerts anti-neuroinflammatory effects to protect against rotenone-induced brain injury in rats

(2017) Xue Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Baicalein Exerts Beneficial Effects in d-Galactose-Induced Aging Rats Through Attenuation of Inflammation and Metabolic Dysfunction

(2017) Dan-dan Duan et al.   REJUVENATION RESEARCH

Multiple-Ascending-Dose Pharmacokinetics and Safety Evaluation of Baicalein Chewable Tablets in Healthy Chinese Volunteers

(2016) Hongxian Pang et al.   CLINICAL DRUG INVESTIGATION

Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis

(2015) Shuai Ji et al.   JOURNAL OF ETHNOPHARMACOLOGY

Safety, tolerability, and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjects

(2014) Min Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Baicalin, a metabolite of baicalein with antiviral activity against dengue virus

(2014) Ehsan Moghaddam et al.   Scientific Reports

Extract of Scutellaria baicalensis inhibits dengue virus replication

(2013) Keivan Zandi et al.   BMC Complementary and Alternative Medicine

Baicalein, Ethyl Acetate, and Chloroform Extracts ofScutellaria baicalensisInhibit the Neuraminidase Activity of Pandemic 2009 H1N1 and Seasonal Influenza A Viruses

(2013) Mann-Jen Hour et al.   Evidence-based Complementary and Alternative Medicine

Baicalein Prevents 6-Hydroxydopamine-Induced Mitochondrial Dysfunction in SH-SY5Y Cells via Inhibition of Mitochondrial Oxidation and Up-Regulation of DJ-1 Protein Expression

(2013) Yue-Hua Wang et al.   MOLECULES

Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virus-infected cells

(2012) Patchima Sithisarn et al.   ANTIVIRAL RESEARCH

Novel antiviral activity of baicalein against dengue virus

(2012) Keivan Zandi et al.   BMC Complementary and Alternative Medicine

Pharmacokinetic study of baicalein after oral administration in monkeys

(2012) Shuo Tian et al.   FITOTERAPIA

Antiviral Activity of Baicalein and Quercetin against the Japanese Encephalitis Virus

(2012) Jefree Johari et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An Official American Thoracic Society Workshop Report: Features and Measurements of Experimental Acute Lung Injury in Animals

(2011) Gustavo Matute-Bello et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Synergistic activity of baicalein with ribavirin against influenza A (H1N1) virus infections in cell culture and in mice

(2011) Lili Chen et al.   ANTIVIRAL RESEARCH

Effects of baicalein on Sendai virus in vivo are linked to serum baicalin and its inhibition of hemagglutinin-neuraminidase

(2011) Jie Dou et al.   ARCHIVES OF VIROLOGY

Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice

(2011) Xin Mu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Inhibitory Effects of Baicalein on the Influenza Virus in Vivo Is Determined by Baicalin in the Serum

(2010) Ge Xu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Computational investigation of the Anti-HIV activity of Chinese medicinal formula Three-Huang Powder

(2010) Jack Z. Hu et al.   Interdisciplinary Sciences-Computational Life Sciences

Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro

(2009) Xin Mu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Baicalein protects rat brain mitochondria against chronic cerebral hypoperfusion-induced oxidative damage

(2008) Xiao-Li He et al.   BRAIN RESEARCH

Neuroprotective effect of baicalein against MPTP neurotoxicity: Behavioral, biochemical and immunohistochemical profile

(2008) Yinxia Cheng et al.   NEUROSCIENCE LETTERS