Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 534, Issue -, Pages 540-546Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2020.11.047
Keywords
Silica nanoparticle; Inflammatory bowel disease; Inflamma some
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [JP18H04028]
- Japan Agency for Medical Research and Development [JP19gm1010004h0004]
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Nanoparticles, especially silicon dioxide (SiO2), are commonly used as food additives. However, ingestion of 10-nm-sized SiO2 nanoparticles exacerbates colitis, while ingestion of 30-nm-sized SiO2 nanoparticles has no effect on intestinal inflammation. The study suggests that oral intake of small SiO2 nanoparticles poses a risk for worsening intestinal inflammation through activation of the ASC inflammasome.
Nanoparticles, i.e., particles with a diameter of <= 100 nm regardless of their composing material, are added to various foods as moisturizers, coloring agents, and preservatives. Silicon dioxide (SiO2, silica) nanoparticles in particular are widely used as food additives. However, the influence of SiO2 nanoparticle oral consumption on intestinal homeostasis remains unclear. The daily intake of 10-nm-sized SiO2 nanoparticles exacerbates dextran sulfate sodium (DSS)-induced colitis, whereas the daily intake of 30-nm-sized SiO2 nanoparticles has no influence on intestinal inflammation. The exacerbation of colitis induced by consuming 10-nm-sized SiO2 nanoparticles was abolished in mice deficient in apoptosis-associated speck-like protein containing a CARD (ASC). Our study indicates that the oral intake of small SiO2 nanoparticles poses a risk for worsening intestinal inflammation through activation of the ASC inflammasome. (C) 2020 The Authors. Published by Elsevier Inc.
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