Review
Pediatrics
Suma Balan, Sumanth Madan
Summary: Idiopathic inflammatory myopathies (IIMs) are a diverse group of diseases characterized by muscle weakness and inflammation, with juvenile dermatomyositis (JDM) being the most common subtype in children. Significant progress has been made in understanding the pathogenesis, disease course, and treatment of JDM, leading to improved outcomes. The presence of specific autoantibodies can help predict response to therapy. A multidisciplinary approach and early referral to specialist centers are important for improving outcomes.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Review
Clinical Neurology
Rachel Zeng, Stefanie Glaubitz, Jens Schmidt
Summary: Inflammatory myopathies, or myositis, are rare diseases characterized by progressive muscle weakness, with each subtype having different autoantibody profiles, histological findings, and extramuscular manifestations. New molecular pathways for targeted therapy have been discovered due to a better understanding of the muscle inflammation's pathogenesis in myositis. Current therapies aim at different components of the immune response, and therapeutical antibodies have shown promising results in clinical trials.
Article
Rheumatology
Johan Lim, Filip Eftimov, Camiel Verhamme, Esther Brusse, Jessica E. Hoogendijk, Christiaan G. J. Saris, Joost Raaphorst, Rob J. De Haan, Ivo N. van Schaik, Eleonora Aronica, Marianne de Visser, Anneke J. van der Kooi
Summary: The study demonstrates that IVIg as first-line treatment for patients with idiopathic inflammatory myopathy resulted in at least moderate improvement in nearly half of the patients, with a fast clinical response in the majority of responders within 3 weeks. Some patients required rescue medication due to insufficient efficacy and prematurely ended the study.
Review
Immunology
Esther Guadalupe Corona-Sanchez, Erika Aurora Martinez-Garcia, Andrea Veronica Lujano-Benitez, Oscar Pizano-Martinez, Ivette Alejandra Guerra-Duran, Efrain Chavarria-Avila, Andrea Aguilar-Vazquez, Beatriz Teresita Martin-Marquez, Kevin Javier Arellano-Arteaga, Juan Armendariz-Borunda, Felipe Perez-Vazquez, Ignacio Garcia-De la Torre, Arcelia Llamas-Garcia, Brenda Lucia Palacios-Zarate, Guillermo Toriz-Gonzalez, Monica Vazquez-Del Mercado
Summary: Idiopathic inflammatory myopathies (IIMs) are rare autoimmune diseases characterized by muscle weakness and immune cell invasion into non-necrotic muscle. The presence of myositis-specific antibodies and myositis-associated antibodies is associated with various IIM phenotypes and clinical prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Anne Schaenzer, Leonie Rager, Iris Dahlhaus, Carsten Dittmayer, Corinna Preusse, Adela Della Marina, Hans-Hilmar Goebel, Andreas Hahn, Werner Stenzel
Summary: Morphological characteristics discriminate subtypes of juvenile idiopathic inflammatory myopathies, highlighting the differences in pathogenesis and the importance of individualized therapeutic strategies.
Article
Rheumatology
Ramya Janardana, S. N. Amin, Liza Rajasekhar, Benzeeta Pinto, Chanakya Kodishala, Sumithra Selvam, Vineeta Shobha
Summary: The study found that rituximab (RTX) treatment significantly improved symptoms and reduced steroid dosage in patients with refractory idiopathic inflammatory myopathy (IIM). The efficacy of two dosage regimens of RTX was comparable at 6 months and 12 months of follow-up.
Review
Clinical Neurology
Adeel S. Zubair, Sharfaraz Salam, Mazen M. Dimachkie, Pedro M. Machado, Bhaskar Roy
Summary: Idiopathic inflammatory myopathies (IIMs) are acquired muscle diseases characterized by muscle inflammation, weakness, and extra-muscular manifestations. Imaging biomarkers such as MRI, muscle ultrasound, EIM, and PET play a crucial role in the diagnosis, assessment, and management of IIMs. MRI is the most commonly used imaging biomarker, but its availability and cost are limitations. Muscle ultrasound and EIM are convenient and can be performed in clinical settings, but further validation is needed. These technologies provide objective assessment of muscle health in IIMs and contribute to improving patient care.
FRONTIERS IN NEUROLOGY
(2023)
Review
Medicine, General & Internal
Catherine Ashton, Shereen Paramalingam, Brittany Stevenson, Anna Brusch, Merrilee Needham
Summary: Idiopathic inflammatory myopathy is an umbrella term for various subtypes including dermatomyositis, polymyositis, and necrotising autoimmune myopathy, each presenting with similar clinical features but distinguishable by serum creatine kinase levels and specific muscle involvement. Treatment options are evolving, with focus on diagnosis and therapy based on clinical assessment, serology, and imaging.
INTERNAL MEDICINE JOURNAL
(2021)
Review
Immunology
Andrea Farini, Chiara Villa, Luana Tripodi, Mariella Legato, Yvan Torrente
Summary: Muscular dystrophies and inflammatory myopathies are muscular disorders characterized by progressive muscle weakness and mass loss, with shared features of inflammation and immune response. Immune mechanisms involved include complement cascade activation and auto-antibodies directed against muscular proteins.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Valerie Leclair, Angeles S. Galindo-Feria, Simon Rothwell, Olga Krystufkova, Sepehr Sarrafzadeh Zargar, Herman Mann, Louise Pyndt Diederichsen, Helena Andersson, Martin Klein, Sarah Tansley, Lars Ronnblom, Kerstin Lindblad-Toh, Ann-Christine Syvanen, Marie Wahren-Herlenius, Johanna K. Sandling, Neil McHugh, Janine A. Lamb, Jiri Vencovsky, Hector Chinoy, Marie Holmqvist, Matteo Bianchi, Leonid Padyukov, Ingrid E. Lundberg, Lina-Marcela Diaz-Galloc
Summary: In patients with idiopathic inflammatory myopathies (IIM), autoantibodies are associated with specific HLA genetic variants and clinical manifestations. Distinct HLA class II and I associations were observed for almost all autoantibody-defined subgroups, supporting the use of autoantibody profiles for classifying IIM.
Article
Rheumatology
Nelly Ziade, Marc Aoude, Ihsane Hmamouchi, R. Naveen, James B. Lilleker, Parikshit Sen, Mrudula Joshi, Vishwesh Agarwal, Sinan Kardes, Jessica Day, Ashima Makol, Marcin Milchert, Tamer Gheita, Babur Salim, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Elena Nikiphorou, Tulika Chatterjee, Ai Lyn Tan, Miguel A. Saavedra, Samuel Katsuyuki Shinjo, Johannes Knitza, Masataka Kuwana, Arvind Nune, Lorenzo Cavagna, Oliver Distler, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta
Summary: This study aimed to explore the current practice and interregional differences in the treatment of idiopathic inflammatory myopathies (IIMs). The findings revealed marked regional treatment disparities in a global cohort of IIM and emphasized the need for international consensus-driven management guidelines.
Article
Rheumatology
Khalil Bourji, Christopher A. Mecoli, Julie J. Paik, Jemima Albayda, Eleni Tiniakou, William Kelly, Thomas E. Lloyd, Andrew Mammen, Shivani Ahlawat, Lisa Christopher-Stine
Summary: This study retrospectively evaluated the prevalence of AVN and associated risk factors in patients with IIM, finding that most patients were asymptomatic. The overall prevalence of AVN was 3%, and the MRI prevalence was 4.2%. None of the established risk factors were found to be associated with AVN development in IIM patients.
Review
Immunology
Claudio Galluzzo, Ilaria Chiapparoli, Ada Corrado, Francesco Paolo Cantatore, Carlo Salvarani, Nicolo Pipitone
Summary: This review focuses on the rare localized forms of idiopathic inflammatory myopathies. These forms are often challenging to diagnose due to their localized nature and can be misdiagnosed as tumors.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Article
Rheumatology
Keith J. Chinniah, Girish M. Mody
Summary: This retrospective study of idiopathic inflammatory myopathies (IIM) in a multi-ethnic cohort in Durban, South Africa found that overlap myositis (OM) was the most frequent subtype. African blacks in the cohort were diagnosed at a younger age and had more cardiac abnormalities compared to Indians.
CLINICAL RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
Ingrid E. Lundberg, Manabu Fujimoto, Jiri Vencovsky, Rohit Aggarwal, Marie Holmqvist, Lisa Christopher-Stine, Andrew L. Mammen, Frederick W. Miller
Summary: Idiopathic inflammatory myopathies, also known as myositis, are a group of autoimmune disorders with heterogeneous clinical manifestations and organ involvement. Different subtypes have varying prognoses, treatment responses, and organ manifestations, highlighting the importance of understanding the underlying pathophysiological mechanisms.
NATURE REVIEWS DISEASE PRIMERS
(2021)
Article
Rheumatology
Akira Yoshida, Minchul Kim, Masataka Kuwana, Naveen Ravichandran, Ashima Makol, Parikshit Sen, James B. Lilleker, Vishwesh Agarwal, Sinan Kardes, Jessica Day, Marcin Milchert, Mrudula Joshi, Tamer Gheita, Babur Salim, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Albert Selva O'Callaghan, Elena Nikiphorou, Tulika Chatterjee, Ai Lyn Tan, Arvind Nune, Lorenzo Cavagna, Miguel A. Saavedra, Samuel Katsuyuki Shinjo, Nelly Ziade, Johannes Knitza, Oliver Distler, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta
Summary: The physical function of patients with idiopathic inflammatory myopathies (IIMs) is significantly poorer compared to those with non-IIM autoimmune rheumatic diseases (AIRDs) or healthy controls (HCs). Even in patients with inactive disease, physical function remains impaired. Factors such as older age, female gender, longer disease duration, and specific diagnoses were identified as independent factors contributing to lower PROMIS PF-10a scores.
Article
Rheumatology
Sasha Saadia Ali, R. Naveen, Parikshit Sen, Jessica Day, Mrudula Joshi, Arvind Nune, Elena Nikiphorou, Sreoshy Saha, Ai Lyn Tan, Samuel Katsuyuki Shinjo, Nelly Ziade, Tsvetelina Velikova, Marcin Milchert, Kshitij Jagtap, Ioannis Parodis, Abraham Edgar Gracia-Ramos, Lorenzo Cavagna, Masataka Kuwana, Johannes Knitza, Yi Ming Chen, Ashima Makol, Vishwesh Agarwal, Aarat Patel, John D. Pauling, Chris Wincup, Bhupen Barman, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio Garcia-De La Torre, Iris J. Colunga-Pedraza, Javier Merayo-Chalico, Okwara Celestine Chibuzo, Wanruchada Katchamart, Phonpen Akawatcharangura Goo, Russka Shumnalieva, Leonardo Santos Hoff, Lina El Kibbi, Hussein Halabi, Binit Vaidya, Syahrul Sazliyana Shaharir, A. T. M. Tanveer Hasan, Dzifa Dey, Carlos Enrique Toro Gutierrez, Carlo Vinicio Caballero-Uribe, James B. Lilleker, Babur Salim, Tamer Gheita, Tulika Chatterjee, Oliver Distler, Miguel A. Saavedra, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta
Review
Medicine, General & Internal
Dina Zucchi, Chiara Cardelli, Elena Elefante, Chiara Tani, Marta Mosca
Summary: Treat-to-target is a therapeutic approach that aims to achieve well-defined clinical targets by making adjustments to treatment at set intervals. This approach has shown promising results for rheumatoid arthritis, but it has been challenging to determine the most meaningful treatment targets for systemic lupus erythematosus (SLE) due to the complexity and heterogeneity of the disease. This review focuses on describing the treatment targets and methods for achieving them in SLE, and it also discusses the potential of treat-to-target as an approach for this complex disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Konstantinos Triantafyllias, Leif-Erik Thiele, Lorenzo Cavagna, Xenofon Baraliakos, George Bertsias, Andreas Schwarting
Summary: Patients with autoimmune rheumatic diseases have an increased risk of cardiovascular diseases due to systemic inflammation and the presence of traditional risk factors. The use of traditional cardiovascular screening methods may underestimate the true risk. Arterial stiffness has shown promise as a surrogate marker for cardiovascular risk in rheumatic patients.
Article
Rheumatology
Luc Pijnenburg, Margherita Giannini, Maude Bouchard-Marmen, Laurent Arnaud, Simone Barsotti, Silvia Bellando-Randone, Livio Bernardi, Paola Bini, Jelena Blagojevic, Veronica Codullo, Marion Couderc, Claire De Moreuil, Emanuelle Dernis, Luca Diamanti, Jean Jacques Dubost, Fanny Duval, Giacomo Emmi, Jean-Marc Galempoix, Bernard Geny, Jacques-Eric Gottenberg, Monica Groza, Aurelien Guffroy, Isabelle Guichard, Philippe Guilpain, Baptiste Hervier, Marie Hudson, Luca Iaccarino, Florenzo Iannone, Delphine Lebrun, Enrico Marchioni, Kuberaka Mariampillai, Francois Maurier, Marta Mosca, Aleksandra Nadaj-Pakleza, Carlotta Nannini, Jean-Maxime Piot, Sergio Prieto-Gonzalez, Nicolas Poursac, Eglantine Rouanet, Jeremie Sellam, Albert Selva-O'Callaghan, Francois Severac, Jean Sibilia, Guilhem Sole, Antoine Soulages, Benjamin Terrier, Anne Tournadre, Yves Troyanov, Nathalie Vernier, Veronique Vesperini, Jean-Francois Viallard, Rahima Ziane, Lorenzo Cavagna, Alain Meyer
Summary: Dropped head or bent spine syndrome (DH/BS) in patients with inflammatory myopathies (IM) is a marker of severity and is associated with systemic sclerosis (SSc).
Letter
Rheumatology
Mrinalini Dey, R. Naveen, Elena Nikiphorou, Parikshit Sen, Sreoshy Saha, James B. Lilleker, Vishwesh Agarwal, Sinan Kardes, Jessica Day, Marcin Milchert, Mrudula Joshi, Tamer Gheita, Babur Salim, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Albert Selva O'Callaghan, Minchul Kim, Tulika Chatterjee, Ai Lyn Tan, Ashima Makol, Arvind Nune, Lorenzo Cavagna, Miguel A. Saavedra, Samuel Katsuyuki Shinjo, Nelly Ziade, Johannes Knitza, Masataka Kuwana, Oliver Distler, Bhupen Barman, Yogesh Preet Singh, Rajiv Ranjan, Avinash Jain, Sapan C. Pandya, Rakesh Kumar Pilania, Aman Sharma, Manesh M. Manoj, Vikas Gupta, Chengappa G. Kavadichanda, Pradeepta Sekhar Patro, Sajal Ajmani, Sanat Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha Shenoy, Ajay Asranna, Keerthi Talari Bommakanti, Anuj Shukla, Arunkumar R. Pande, Kunal Chandwar, John D. Pauling, Chris Wincup, Dondu Uskudar Cansu, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio Garcia-De La Torre, Nicoletta Del Papa, Gianluca Sambataro, Atzeni Fabiola, Marcello Govoni, Simone Parisi, Elena Bartoloni Bocci, Gian Domenico Sebastiani, Enrico Fusaro, Marco Sebastiani, Luca Quartuccio, Franco Franceschini, Pier Paolo Sainaghi, Giovanni Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo Venerito, Lisa S. Traboco, Leonardo Santos Hoff, Suryo Anggoro Kusumo Wibowo, Stylianos Tomaras, Daman Langguth, Vidya Limaye, Merrilee Needham, Nilesh Srivastav, Akira Yoshida, Ran Nakashima, Shinji Sato, Naoki Kimura, Yuko Kaneko, Jesus Loarce-Martos, Sergio Prieto-Gonzalez, Albert Gil-Vila, Raquel Aranega Gonzalez, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta
Article
Rheumatology
S. Barsotti, G. Aringhieri, B. Mugellini, F. Torri, F. Minichilli, A. Tripoli, C. Cardelli, E. Cioffi, V. Zampa, G. Siciliano, D. Caramella, G. Ricci, M. Mosca
Summary: Muscular MRI can help differentiate between idiopathic inflammatory myopathies (IIM) and muscular dystrophies (MD) by identifying different patterns of muscular involvement. Oedema is more common in IIM, while adipose infiltration/substitution and muscular atrophy are more common in MD. Higher oedema scores increase the probability of IIM, while higher atrophy and intramuscular adipose infiltration/substitution scores decrease the probability of IIM.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Review
Rheumatology
E. Dourado, F. Bottazzi, C. Cardelli, E. Conticini, J. Schmidt, L. Cavagna, S. Barsotti
Summary: Idiopathic inflammatory myopathies (IIM) are a diverse group of disorders characterized by chronic inflammation of the skeletal muscle and muscle weakness. Different subtypes of IIM have been identified based on various factors such as extra-muscular manifestations, immunology, muscle histology, treatment response, and prognosis. This review focuses on the latest literature published in the past year regarding the pathogenesis, classification, treatment, and prognosis of different IIM subtypes.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Rheumatology
R. Naveen, Darpan Thakare, Masataka Kuwana, John Pauling, Jessica Day, Mrudula Joshi, Ioannis Parodis, Parikshit Sen, Kshitij Jagtap, Elena Nikiphorou, Sreoshy Saha, Vishwesh Agarwal, Tulika Chatterjee, James Lilleker, Sinan Kardes, Marcin Milchert, Tamer Gheita, Babur Salim, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Ai Lyn Tan, Arvind Nune, Lorenzo Cavagna, Miguel Saavedra, Samuel Katsuyuki Shinjo, Nelly Ziade, Johannes Knitza, Oliver Distler, Hector Chinoy, Rohit Aggarwal, Latika Gupta, Vikas Agarwal, Ashima Makol
Summary: The safety profile of COVID-19 vaccines in patients with systemic sclerosis (SSc) was compared with other rheumatic and non-rheumatic autoimmune diseases, as well as healthy controls. The study found that short-term adverse events following vaccination did not differ significantly between the different groups, and background immunosuppression and disease activity did not influence these events.
RHEUMATOLOGY INTERNATIONAL
(2023)
Meeting Abstract
Rheumatology
Giovanni Zanframundo, Sara Faghihi-Kashani, Paul Hansen, Carlo A. Scire, Garifallia Sakellariou, Lorenzo Cavagna, Rohit Aggarwal
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Giovanni Zanframundo, Davide Rozza, Sara Faghihi-Kashani, Garifallia Sakellariou, Carlo A. Scire, Rohit Aggarwal, Lorenzo Cavagna
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Rohit Aggarwal, Lorenzo Cavagna, Noriko Iikuni, Sanjay Rakhade
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Silvia Grignaschi, Lorenzo Cavagna, Minchul Kim, Vikas Agarwal, Rohit Aggarwal, Latika Gupta
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alessandro Biglia, Valentina Morandi, Giovanni Zanframundo, Danilo Donati, Francesco Maggiore, Fabio Vita, Luigi Sammarchi, Chiara Pagani, Lorenzo Cavagna, Stefano Galletti, Carlomaurizio Montecucco
Summary: Frozen shoulder is a common condition characterized by severe pain, limited range of motion, and difficulty with daily activities. It affects the soft tissues of the shoulder and is more prevalent in women and individuals in their fifth and sixth decades of life. It can be idiopathic or associated with other conditions such as metabolic disorders, diabetes, thyroid diseases, prolonged immobilization, trauma, or complications after vaccine administration known as SIRVA. The natural history of frozen shoulder progresses through three stages: freezing, frozen, and thawing.
JOURNAL OF ULTRASOUND
(2023)