Article
Immunology
Cuiyu Zhang, Yuping Zhou, Junjie Zheng, Nannan Ning, Haining Liu, Wenyang Jiang, Xin Yu, Kun Mu, Yan Li, Wei Guo, Huili Hu, Jingxin Li, Dawei Chen
Summary: This study demonstrates that GABA regulates intestinal stem cell apoptosis through its A receptor in chemoradiotherapy-induced intestinal injury. FDA-approved GABA(A)R antagonist flumazenil may be a promising drug for reducing the gastrointestinal side effects brought by chemoradiotherapy.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Fahimeh Salehi, Hossein Behboudi, Elaheh Salehi, Sussan K. Ardestani, Firoozeh Piroozmand, Gholamreza Kavoosi
Summary: An apple pectin-ZEO nanoemulsion (AP-ZEONE) was prepared and shown to significantly inhibit metastatic breast cancer cells by inducing apoptosis through various mechanisms such as morphological changes, DNA fragmentation, loss of mitochondrial membrane potential, and interaction with genomic DNA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Dan Liu, Ye Cheng, Zhipeng Tang, Xueying Mei, Xiangyu Cao, Jianli Liu
Summary: This study reveals that acrolein induces DNA damage and mitochondrial apoptosis in human bronchial epithelial cells, which may be the pivotal factors mediating its cytotoxicity.
Article
Biochemistry & Molecular Biology
Divya A. Shiroor, Kuang-Tse Wang, Bhargav D. Sanketi, Justin K. Tapper, Carolyn E. Adler
Summary: Stem cells acquire mutations during division, but can activate the DNA damage response network to repair or induce apoptosis. In planarian flatworms, ATM promotes radiation-induced apoptosis, which is important for long-term animal survival.
Article
Pharmacology & Pharmacy
Cen Zhao, Dawei Yang, Yuchen Ye, Zhenzhong Chen, Tifan Sun, Jiawei Zhao, Kai Zhao, Na Lu
Summary: This study demonstrated that LT-171-861 inhibits proliferation and induces apoptosis in multiple myeloma cells by promoting DNA damage repair pathway and impeding homologous recombination. The inhibition of Pim2 kinase activity by LT-171-861 leads to DNA damage and cell apoptosis, and the combination with PARP inhibitor Olaparib enhances its anti-tumor effect.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Changyong Wu, Yang Shen, Lin Shi, Junhao Zhang, Tongxuan Guo, Lingni Zhou, Wanzhou Wang, Xu Zhang, Rutong Yu, Xuejiao Liu
Summary: Glioblastoma multiforme (GBM) is a highly deadly brain tumor. UBA1 inhibition by TAK-243 can increase the sensitivity of GBM to radiotherapy by impairing DNA double-strand break repair. This study provides a new therapeutic strategy for improving the radiation sensitivity of GBM and lays a foundation for further clinical trials.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Yuming Cao, Sihan Chen, Jing Lu, Ming Zhang, Lei Shi, Juling Qin, Jing Lv, Danyang Li, Ling Ma, Yuanzhen Zhang
Summary: BPA exposure reduces the expression of SRB1, inhibits placental proliferation, and increases DNA damage, leading to FGR. These findings provide insights into the mechanism of BPA-associated developmental toxicity and potential therapeutic targets.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biology
Madeleine Hart, Sophie D. Adams, Viji M. Draviam
Summary: Nuclear atypia is a hallmark of cancer, and its immediate and long-term impact on cells can be determined through single-cell tracking studies. Multinucleation, a form of nuclear atypia, blocks cell proliferation in p53-compromised cells by increasing DNA damage and causing replication stress, suggesting potential therapeutic approaches for limiting tumor heterogeneity.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Michael Lohmueller, Bernhard F. Roeck, Tamas G. Szabo, Marina A. Schapfl, Fragka Pegka, Sebastian Herzog, Andreas Villunger, Fabian Schuler
Summary: Besides p53 status, the expression levels of SKP2 and p27 may also be important factors in predicting the responsiveness of cancer cells to CHK1 inhibitors.
MOLECULAR ONCOLOGY
(2022)
Article
Oncology
Maotuan Huang, Fuxiu Zhong, Mingyuan Chen, Lingju Hong, Weihong Chen, Xiahenazi Abudukeremu, Feifei She, Yanling Chen
Summary: Through bioinformatics analysis, five key genes of GBC were identified, among which CEP55 was found to be overexpressed in GBC and associated with advanced TNM stage, differentiation grade, and poorer survival. Inhibition of CEP55 in GBC cells resulted in decreased proliferation, cell cycle arrest, DNA damage, and increased apoptosis. CEP55 inhibition in vivo attenuated tumor growth and promoted apoptosis in GBC cells. The tumor suppressor effect of CEP55 knockdown is mechanistically associated with dysregulation of the AKT and ERK signaling networks.
FRONTIERS IN ONCOLOGY
(2023)
Article
Engineering, Environmental
Hongrui Guo, Yujuan Ouyang, Jiaqi Wang, Hengmin Cui, Huidan Deng, Xinyue Zhong, Zhijie Jian, Huan Liu, Jing Fang, Zhicai Zuo, Xun Wang, Ling Zhao, Yi Geng, Ping Ouyang, Huaqiao Tang
Summary: Copper is essential but over-exposure can lead to adverse health effects. CuSO4 was found to induce spermatogenesis disorder through oxidative stress-mediated DNA damage and apoptosis, impairing male reproductive function.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Inorganic & Nuclear
Yong Li, Xiaoxi Ji, Shuangyan Wu, Ying Zhang, Mingchang Zhu, Enjun Gao
Summary: A new metal-organic complex, Mn(L)2.4H2O, has been successfully synthesized and shows potential significance for cancer treatment. The complex exhibits good binding ability with DNA and can effectively act on cancer cells.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Food Science & Technology
Andrea Guidarelli, Andrea Spina, Mara Fiorani, Ester Zito, Orazio Cantoni
Summary: Arsenite stimulates crosstalk between IP3R and RyR by up-regulating ERO1α, leading to mitochondrial clearance of Ca2+ and triggering DNA strand scission and mitochondrial apoptosis. Inhibiting ERO1α expression can effectively counteract the geno- and cyto-toxic effects induced by arsenite.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michele Massimino, Laura Sciacca, Nunziatina Laura Parrinello, Nunzio Massimo Scalisi, Antonino Belfiore, Riccardo Vigneri, Paolo Vigneri
Summary: IR isoforms exhibit different effects on cell proliferation and survival. While both IR-A and IR-B can inhibit cell proliferation when unbound to insulin, IR-B is more effective in reducing resistance to DNA damage. In the presence of insulin, IR-A provides a selective growth advantage over IR-B, particularly at high concentrations. Insulin-bound IR-A, but not IR-B, can protect cells from cytotoxicity induced by DNA damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Oncology
Antoine Italiano
Summary: In a phase I trial, Yap and colleagues found that the ATR inhibitor BAY 1895344 is safe and induces durable responses in ATM-deficient tumors. This opens up possibilities for innovative combination regimens targeting DNA damage response defects in cancer.
Article
Engineering, Environmental
Paula Florencio Ramires, Marina dos Santos, Soraya Paz-Montelongo, Carmen Rubio-Armendariz, Diana Adamatti, Maria Laura Fiasconaro, Flavio Manoel Rodrigues da Silva Junior
Summary: This study aimed to assess and spatialize the health risk of potentially hazardous elements (PHEs) in the soil of the largest coal mining region of Brazil, Candiota, for children and adults. The results showed that Mn and Fe were the metals with the greatest contribution to human health risk. The use of HHRA associated with GIS tools provides important information for decision-making in the management of contaminated sites.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2023)
Article
Engineering, Environmental
Marcos Lorran Paranhos Leao, Linjie Zhang, Flavio Manoel Rodrigues da Silva Junior
Summary: Recife is ranked as the 16th most vulnerable city to climate change and has air pollutant levels exceeding the new limits proposed by the WHO. This study evaluates the health and economic benefits of reducing PM10 and PM2.5 concentrations to the new WHO limits, and simulates the behavior of these pollutants under increased temperatures using machine learning. The results show that meeting the new limits could prevent deaths and hospital admissions, improve life expectancy, while the temperature increase is predicted to worsen air pollution and health outcomes. Mitigation and pollution control policies are crucial for meeting the WHO air quality standards and achieving health benefits.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2023)
Article
Environmental Sciences
Fernanda Oliveira Reis, Eduarda de Moura Garcia, Lisiane Martins Volcao, Ronan Adler Tavella, Rodrigo de Lima Brum, Larissa Mueller, Erico Kunde Correa, Juliane Ventura-Lima, Flavio Manoel Rodrigues da Silva Junior
Summary: The toxicity of arsenite and arsenate on Californian earthworms was evaluated, with arsenite showing a greater impact and causing increased activity of antioxidant enzymes and enzymes related to glutathione metabolism.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Ronan Adler Tavella, Niely Galeao da Rosa Moraes, Carlos Daniel Maciel Aick, Paula Florencio Ramires, Natalia Pereira, Ana Goncalves Soares, Flavio Manoel Rodrigues da Silva Jr
Summary: This study investigated the levels of air pollutants and the weekend effect before and after the COVID-19 pandemic in four cities in Brazil. It found a positive weekend effect for almost all air pollutants in these cities, with a relationship between the weekend effect and the restriction measures adopted. In scenarios with less restrictive policies, a negative weekend effect was observed, while more stringent measures resulted in higher intensities of positive weekend effect. These findings provide insights for responsible authorities in developing strategies and policies for air quality control.
ATMOSPHERIC POLLUTION RESEARCH
(2023)
Article
Demography
Marina dos Santos, Julia Oliveira Penteado, Rodrigo de Lima Brum, Alicia da Silva Bonifacio, Paula Florencio Ramires, Diuster de Franceschi Gariboti, Ruana Michela Santos Cardoso, Flavio Manoel Rodrigues da Silva Junior
Summary: The study aimed to investigate ethnic/racial disparities in COVID-19 mortality in Brazilian federative units and their respective capitals in 2020. The mortality rate of COVID-19 by ethnicity in Brazilian states was higher among people with brown skin color, followed by indigenous and black individuals. Only in one state, in the Federal District and in the federal capital, age-standardized mortality rates were higher among white individuals. There is a high percentage of deaths from COVID-19 higher than expected among non-white individuals, especially in south-central states and capitals of the country.
SPATIAL DEMOGRAPHY
(2023)
Correction
Ecology
Krissia Aparecida de Almeida, Fernando Rafael de Moura, Juliane Ventura Lima, Edariane Menestrino Garcia, Ana Luiza Muccillo-Baisch, Paula Florencio Ramires, Julia Oliveira Penteado, Maria da Luz Mathias, Deodalia Dias, Flavio Manoel Rodrigues da Silva Junior
Article
Ecology
Krissia Aparecida de Almeida, Fernando Rafael de Moura, Juliane Ventura Lima, Edariane Menestrino Garcia, Ana Luiza Muccillo-Baisch, Paula Florencio Ramires, Julia Oliveira Pentado, Maria da Luz Mathias, Deodalia Dias, Flavio Manoel Rodrigues da Silva Junior
Summary: Small wild mammals, such as deer mice, have been used to measure the damage caused by exposure to oil-contaminated soil. However, there is currently no research on the toxic effects of crude oil using oxidative damage biomarkers in the wild rodent Calomys laucha (Vesper mouse). This study aimed to evaluate the effects of acute exposure to different concentrations of crude oil-contaminated soil on C. laucha using oxidative stress biomarkers. The results showed that acute exposure to oil-contaminated soil caused oxidative damage in C. laucha, indicating that these small mammals may be susceptible to the impacts of such contamination in their habitat, posing a threat to their survival.
Review
Chemistry, Analytical
Mayara Cristina Mombach Lorenz, Leandro Silva de Almeida, Ana Paula de Oliveira Lopes Inacio, Flavio Manoel Rodrigues da Silva Junior, Eliezer Quadro Oreste, Daiane Dias
Summary: Nowadays, the application of carbon-based materials in the development of chemically modified sensors is gaining attention due to their ability to generate methods with high sensitivity, stability, conductivity, accuracy, and low cost. As a result, these sensors have been used in environmental monitoring in an eco-friendly, sensitive, fast, efficient, inexpensive, and robust way. In this review, we first described carbon-based materials and their derivatives, followed by an overview of the manufacturing of chemically modified carbon-based sensors and their applications in environmental analytical chemistry for the determination of inorganic and organic compounds. Future perspectives on trends in the application of carbon-based materials for sensor modifications are also discussed.
Article
Food Science & Technology
Carina Molins Borba, Gabriela de Moraes Soares Araujo, Camila Ramao Contessa, Cristiana Lima Dora, Janaina Fernandes de Medeiros Burkert
Summary: The objective of this study was to investigate the influence of beta-carotene nanoemulsions on technological parameters and product stability in yogurt and gelato-type ice cream. The results showed that the addition of nanoemulsions increased the gelato yield and the syneresis index in yogurt, while reducing parameters such as firmness, consistency, cohesiveness, and viscosity index. The nanoemulsions also protected the carotenoid during storage, resulting in minimal color variation.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Gabriela de Moraes Soares Araujo, Jamile Lima Rodrigues, Virginia Campello Yurgel, Carla Silva, Artur Manuel Cavaco Paulo, Ana Isabel Sai Loureiro, Cristiana Lima Dora
Summary: Burns damage the skin and its appendages, providing a favorable environment for bacterial infections. Due to the limitations and costs of current treatments, finding more efficient alternatives for burns is necessary. This study developed curcumin nanoemulsion-impregnated dressings using nanotechnology, which demonstrated stability and controlled release of curcumin. The evaluation showed that cationized dressings released curcumin faster, while non-cationized dressings promoted a more constant release.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Editorial Material
Environmental Sciences
Flavio Manoel Rodrigues da Silva Junior, Fernando Rafael de Moura, Rodrigo de Lima Brum, Ronan Adler Tavella
INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
(2023)
Article
Soil Science
Livia da Silva Freitas, Rodrigo de Lima Brum, Alicia da Silva Bonifacio, Lisiane Martins Volcao, Flavio Manoel Rodrigues da Silva Junior, Daniela Fernandes Ramos
Summary: This study evaluated the functional profile of soil microbiota and the gut microbiota of earthworms in ceftriaxone-contaminated soil using Biolog EcoPlate. The results showed that different concentrations of the antibiotic did not significantly affect the evaluated parameters. The functional profile of soil microbiota was similar with and without earthworms, but differed from the profile of earthworms' gut microbiota.
Article
Green & Sustainable Science & Technology
Willian Cezar Nadaleti, Emanuelle Cardozo, Jones Bittencourt Machado, Peterson Maximilla Pereira, Maele Costa dos Santos, Eduarda Gomes de Souza, Paula Haertel, Erico Kunde Correa, Bruno Muller Vieira, Flavio Manoel Rodrigues da Silva Junior
Summary: This study demonstrates the potential of agricultural residues in the Southern region of Brazil, specifically rice straw and husks from rice cultivation and peach residues, for biohydrogen and energy production. The findings indicate a significant amount of bioH(2) and biogas can be theoretically obtained, which can contribute to the production of clean energy and mitigate environmental impacts. The study also highlights the potential for the implementation of a Circular Economy and the reduction of dependence on fossil fuels.
Article
Environmental Sciences
Ronan Adler Tavella, Fernanda Oliveira Reis, Alicia da Silva Bonifacio, Niely Galeao da Rosa Moraes, Carlos Daniel Maciel Aick, Willian Cezar Nadaleti, Erico Kunde Correa, Flavio Manoel Rodrigues da Silva Junior
Summary: This study evaluated the weekend effect of air pollutants in Recife, a tropical Brazilian metropolis, during a 2-year period of monitoring, including the post-COVID-19 restrictions period. The results showed no weekend effect in both annual contexts, suggesting minimal impact. However, seasonal variations were observed in the dynamics of air pollutants, which were likely influenced by factors other than meteorological parameters. The study also found an impact of the end of COVID-19 restrictions on the weekend effect in the first year, and a significant correlation between SO2, NO2, and O-3 levels, indicating a shared source for these pollutants. The findings aim to assist in the development of air pollution control policies.
WATER AIR AND SOIL POLLUTION
(2023)
Article
Integrative & Complementary Medicine
Adriano Referino da Silva Sobrinho, Maiara Bernardes Marques, Moan Jefter Fernandes Costa, Pedro Henrique Sette-de-Souza
Summary: This study investigated the use of herbal medicines in the Brazilian population and found that gender, race, healthcare sector, and health conditions have an impact on the use of herbal medicines. To reduce inequalities in the use of herbal medicines, there is a need for health education, professional training, and adjustment of public policies.
JOURNAL OF HERBAL MEDICINE
(2023)
