Article
Clinical Neurology
Dario Arnaldi, Francesco Fama, Nicola Girtler, Andrea Brugnolo, Matteo Pardini, Pietro Mattioli, Riccardo Meli, Federico Massa, Beatrice Orso, Maria Pia Sormani, Maria Isabella Donegani, Matteo Bauckneht, Silvia Morbelli, Flavio Nobili
Summary: The study explored the feasibility of a neuroprotection trial in prodromal synucleinopathy using iRBD as the target population and I-123-FP-CIT-SPECT as a biomarker of disease progression. Results showed differences in the emergence of parkinsonism and/or dementia after 30 months between the treatment and control groups, with the treatment group having less decrease in putamen uptake on I-123-FP-CIT-SPECT.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Hilkka Soininen, Alina Solomon, Pieter Jelle Visser, Suzanne B. Hendrix, Kaj Blennow, Miia Kivipelto, Tobias Hartmann
Summary: The LipiDiDiet trial demonstrated that the specific multinutrient combination Fortasyn Connect has beneficial effects on cognition and disease progression in prodromal Alzheimer's disease, with greater benefits observed with long-term use.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
Marta Lancione, Graziella Donatelli, Eleonora Del Prete, Nicole Campese, Daniela Frosini, Matteo Cencini, Mauro Costagli, Laura Biagi, Giacomo Lucchi, Michela Tosetti, Massimiliano Godani, Dario Arnaldi, Michele Terzaghi, Federica Provini, Claudio Pacchetti, Pietro Cortelli, Enrica Bonanni, Roberto Ceravolo, Mirco Cosottini
Summary: In this study, we used QSM and 7T MRI to evaluate iron deposition in Nigrosome 1 (N1) in early PD patients, iRBD patients, and healthy controls, and investigated its correlation with disease progression. The results showed that the appearance of N1 was rated pathological in iRBD patients, and ePD patients had higher N1 chi values compared to iRBD patients and healthy controls, but with no correlation with disease duration. Additionally, N1 chi in the iRBD group increased as the disease evolved. Therefore, QSM may represent a valuable presymptomatic biomarker to assess neurodegeneration in the prodromal stages of PD.
Article
Clinical Neurology
Lucia A. A. Giannini, Harro Seelaar, Emma L. van der Ende, Jackie M. Poos, Lize C. Jiskoot, Elise G. P. Dopper, Yolande A. L. Pijnenburg, Eline A. J. Willemse, Lisa Vermunt, Charlotte E. Teunissen, John C. van Swieten, Lieke H. Meeter
Summary: The increase in serum neurofilament light chain (NfL) levels can predict whether individuals with genetic frontotemporal dementia (FTD) are approaching the prodromal conversion stage. These findings provide important guidance for patient recruitment in clinical trials.
Review
Neurosciences
Miriam Hojholt Terkelsen, Ida H. Klaestrup, Victor Hvingelby, Johanne Lauritsen, Nicola Pavese, Marina Romero-Ramos
Summary: This paper reviews the evidence of neuroinflammation and peripheral immune changes in Parkinson's disease, discusses their pathological roles, and considers factors associated with the immune response.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Neurosciences
Chenxi Pan, Yuqian Li, Jingru Ren, Lanting Li, Peiyu Huang, Pingyi Xu, Li Zhang, Wenbing Zhang, Min-Ming Zhang, Jiu Chen, Weiguo Liu
Summary: The study evaluated the frequency and clinical features of mild cognitive impairment in prodromal Parkinson's disease in elderly Chinese individuals. It found that memory, attention/working memory, and executive function were the most commonly impaired domains in pPD, and that cognitive performance was correlated with motor symptoms in this population.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Olaia Lucas-Jimenez, Naroa Ibarretxe-Bilbao, Ibai Diez, Javier Pena, Beatriz Tijero, Marta Galdos, Ane Murueta-Goyena, Rocio Del Pino, Marian Acera, Juan Carlos Gomez-Esteban, Inigo Gabilondo, Natalia Ojeda
Summary: This study aimed to characterize subtypes of synucleinopathies based on cognitive and nonmotor data, and to explore differences in brain structure and function using MRI between identified clusters. The results revealed two subtypes, mild and severe, with different motor and nonmotor symptoms as well as brain alterations. The study suggests that incorporating a comprehensive nonmotor evaluation could help characterize specific clinical patterns and brain degeneration patterns of synucleinopathies.
Article
Rehabilitation
David J. Clark, Dorian K. Rose, Katie A. Butera, Brooke Hoisington, Louis DeMark, Sudeshna A. Chatterjee, Kelly A. Hawkins, Dana M. Otzel, Jared W. Skinner, Evangelos A. Christou, Samuel S. Wu, Emily J. Fox
Summary: This study compared two post-stroke rehabilitation interventions on walking function and prefrontal cortical activity. The accurate adaptability and steady state walking interventions showed similar improvements in walking speed, but accurate adaptability training may reduce the demand on prefrontal resources during walking.
CLINICAL REHABILITATION
(2021)
Article
Neurosciences
Yan Sun, He-Ying Hu, Hao Hu, Liang-Yu Huang, Lan Tan, Jin-Tai Yu
Summary: This study comprehensively investigated the associations of cerebral small vessel disease (CSVD) burden with cognition and Alzheimer's disease (AD) pathologies. The authors found that higher CSVD burden was associated with worse cognition, lower cerebrospinal fluid (CSF) A beta levels, and increased amyloid burden. CSVD burden also contributed to accelerated rates of hippocampus atrophy, cognitive decline, and higher risk of AD dementia. The findings suggest that CSVD burden could be a prodromal predictor for clinical and pathological progression.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Mario H. Flores-Torres, Kjetil Bjornevik, Albert Y. Hung, Brian C. Healy, Michael A. Schwarzschild, Deborah Blacker, Alberto Ascherio
Summary: This study found that subjective cognitive decline (SCD) is more likely to be present in women with features suggestive of prodromal Parkinson's disease (PD). Women experiencing hyposmia, constipation, and probable rapid eye movement sleep behavior disorder, three major features of prodromal PD, had the worst SCD score and the highest odds of poor subjective cognition. SCD was also more common in women with a high probability of prodromal PD.
MOVEMENT DISORDERS
(2023)
Article
Multidisciplinary Sciences
Qing Wang, Jialing Zheng, Sven Pettersson, Richard Reynolds, Eng-King Tan
Summary: The neurovascular unit (NVU) consists of vascular cells, glial cells, and neurons. It plays an important role in maintaining the microenvironment homeostasis and the integrity of the blood-brain barrier. Disruption of the NVU and interactions among its components are involved in the pathophysiology of synucleinopathies, characterized by pathological accumulation of α-synuclein. Neuroinflammation contributes to the pathophysiology of synucleinopathies such as Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. This review summarizes the neuroinflammatory response of glial cells and vascular cells in the NVU, as well as the cross-talk between different cell types within the NVU and the influence of α-synuclein on neuroinflammation and disease progression.
Article
Clinical Neurology
Luisa Knecht, Jonas Folke, Richard Dodel, J. Alexander Ross, Alexandra Albus
Summary: Current therapeutic strategies for neurodegenerative diseases like Parkinson's disease focus on symptom management, but targeting alpha-syn by immunotherapy shows promise as a novel disease-modifying approach. Various immunotherapeutic approaches are currently being evaluated in clinical trials for the treatment of synucleinopathies, characterized by the aggregation of alpha-synuclein in the brain.
Article
Multidisciplinary Sciences
Jaeho Kim, Yuhyun Park, Seongbeom Park, Hyemin Jang, Hee Jin Kim, Duk L. Na, Hyejoo Lee, Sang Won Seo
Summary: The study developed machine learning algorithms to predict abnormal tau accumulation in prodromal AD patients, suggesting that GBM and RF are effective supervised learning methods. Different combinations of data were shown to impact the predictive ability, which could provide valuable guidance for the recruitment of clinical trial participants.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Albert Puig-Pijoan, Joan Jimenez-Balado, Aida Fernandez-Lebrero, Greta Garcia-Escobar, Irene Navalpotro-Gomez, Jose Contador, Rosa-Maria Manero-Borras, Victor Puente-Periz, Antoni Suarez, Francisco J. Munoz, Oriol Grau-Rivera, Marc Suarez-Calvet, Rafael de la Torre, Jaume Roquer, Angel Ois
Summary: This study explored the association between blood-brain-barrier permeability (BBBp) and cognitive decline progression. The results suggested that increased BBBp may contribute to clinical worsening in individuals with cognitive decline, indicating potential targeted therapies.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biotechnology & Applied Microbiology
Benjamin W. Schlichtmann, Monica Hepker, Bharathi N. Palanisamy, Manohar John, Vellareddy Anantharam, Anumantha G. Kanthasamy, Balaji Narasimhan, Surya K. Mallapragada
Summary: Synucleinopathies are debilitating neurodegenerative disorders with no clinically approved therapeutic options. Multiple synergistic pathological mechanisms and misfolding of proteins contribute to disease progression, making treatment challenging. Nanocarriers can improve brain delivery of therapeutics and enable multifunctional therapies.
CURRENT OPINION IN CHEMICAL ENGINEERING
(2021)
Article
Clinical Neurology
Vincent Planche, Vincent Bouteloup, Isabelle Pellegrin, Jean-Francois Mangin, Bruno Dubois, Pierre-Jean Ousset, Florence Pasquier, Frederic Blanc, Claire Paquet, Olivier Hanon, Karim Bennys, Mathieu Ceccaldi, Cedric Annweiler, Pierre Krolak-Salmon, Olivier Godefroy, David Wallon, Mathilde Sauvee, Claire Boutoleau-Bretonniere, Isabelle Bourdel-Marchasson, Isabelle Jalenques, Genevieve Chene, Carole Dufouil
Summary: Blood biomarkers for Alzheimer's disease can effectively discriminate AD from other neurodegenerative diseases and may serve as hallmarks of underlying pathology, but they add little to 5-year dementia risk prediction models.
Article
Clinical Neurology
Benjamin Cretin, Nathalie Philippi, Olivier Bousiges, Frederic Blanc
Summary: This study found that CSF sampling has good diagnostic value in TEA patients with characteristics suggestive of incipient degenerative diseases. It suggests that TEA may be the inaugurating feature in some cases of AD. The results also demonstrate the etiological heterogeneity in TEA.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Gabrielle Todd, Caroline D. Rae, Janet L. Taylor, Nigel C. Rogasch, Jane E. Butler, Michael Hayes, Robert A. Wilcox, Simon C. Gandevia, Karl Aoun, Adrian Esterman, Simon J. G. Lewis, Julie M. Hall, Elie Matar, Jana Godau, Daniela Berg, Christian Plewnia, Anna-Katharina Von Thaler, Clarence Chiang, Kay L. Double
Summary: Research has found that increased thickness of the substantia nigra in healthy older adults may be associated with changes in excitability of motor cortical circuitry. This finding has important implications for understanding brain changes in healthy older adults at risk of Parkinson's disease.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Letter
Clinical Neurology
Raffaele Ferri, Simon J. G. Lewis, Valerie Cochen De Cock, Naoko Tachibana, Clete A. Kushida, Carlos H. Schenck
Article
Chemistry, Multidisciplinary
Alka Rachel John, Zehong Cao, Hsiang-Ting Chen, Kaylena Ehgoetz Martens, Matthew Georgiades, Moran Gilat, Hung T. Nguyen, Simon J. G. Lewis, Chin-Teng Lin
Summary: This study utilized EEG signals to distinguish between the onset of freezing of gait (FOG) and voluntary stopping in patients with advanced Parkinson's disease (PD). By employing a convolutional neural network (CNN), the researchers achieved a high classification accuracy in identifying the transition to FOG from normal walking and voluntary stopping.
APPLIED SCIENCES-BASEL
(2023)
Article
Clinical Neurology
Alice Tisserand, Benjamin Cretin, Mary Mondino, Anne Botzung, Lea Sanna, Catherine Demuynck, Pierre Anthony, Candice Muller, Olivier Bousiges, Nathalie Philippi, Frederic Blanc
Summary: This study aimed to investigate the association between photophobia and dementia with Lewy bodies (DLB). The study found that photophobia was more frequent in DLB patients and was associated with decreased gray matter in the right precentral cortex and the eyelid motor region. This finding is important for understanding the pathological mechanism of DLB.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Manon Querry, Frederic Blanc, Olivier Bousiges, Nathalie Philippi, Benjamin Cretin, Catherine Demuynck, Candice Muller, Anne Botzung
Summary: The aim of this study was to describe the characteristics and evolution of the long-term memory profile of patients with prodromal and mild DLB and AD. The study found that DLB patients performed better than AD patients in terms of total recall, delayed total recall, recognition, and loss of information over time. The memory performance of DLB patients remained stable over 48 months, unlike that of AD patients. Four indicators were relevant to distinguish between DLB and AD patients in terms of memory performance.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Psychiatry
Candice Muller, Jeanne Merignac, Christophe Moog, Benoit Schorr, Herve Javelot, Frederic Blanc
Summary: This study describes three patients with DLB who presented with major visual hallucinations, delusion, and an orbitofrontal syndrome. They were intolerant of low-dose clozapine and were treated with a combination of pimavanserin and trazodone. After 4 to 6 weeks of treatment, a marked improvement in symptoms was observed.
GERIATRIE ET PSYCHOLOGIE NEUROPSYCHIATRIE DE VIEILLISSEMENT
(2023)
Article
Multidisciplinary Sciences
Priscilla Youssef, Laura Hughes, Woojin S. Kim, Glenda M. Halliday, Simon J. G. Lewis, Antony Cooper, Nicolas Dzamko
Summary: Objective biomarkers for Parkinson's Disease (PD) could aid early and specific diagnosis, effective monitoring of disease progression, and improved design and interpretation of clinical trials. In this study, the potential of the SIMOA neurology 4-plex-A marker panel, along with plasma alpha-synuclein, as biomarkers for PD diagnosis and prognosis was assessed. The levels of NFL and GFAP in plasma positively correlated with alpha-synuclein levels, while as disease state biomarkers, NFL and GFAP showed correlation with motor severity and stage.
SCIENTIFIC REPORTS
(2023)
Article
Computer Science, Artificial Intelligence
Kun Hu, Zhiyong Wang, Kaylena A. Ehgoetz Martens, Markus Hagenbuchner, Mohammed Bennamoun, Ah Chung Tsoi, Simon J. G. Lewis
Summary: This study proposes a multimodal learning-based FoG detection method using a graph fusion neural network (GFN) that combines footstep pressure maps and video recordings. The GFN constructs multimodal graphs to reduce redundancy among different modalities and achieves superior performance. Experimental results show promising FoG detection with an AUC of 0.882.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Review
Neurosciences
Anouk Tosserams, Bastiaan R. Bloem, Kaylena Ehgoetz A. Martens, Rick C. Helmich, Roy P. C. Kessels, James M. Shine, Natasha L. Taylor, Gabriel Wainstein, Simon J. G. Lewis, Jorik Nonnekes
Summary: In stressful situations, individuals with Parkinson's disease (PD) may experience worsening of motor symptoms, including gait impairments. However, some patients report benefits from stressful or high-arousal situations. A study with 4324 PD patients shows that they use various mental strategies to cope with gait impairments, which can either increase or decrease overall sympathetic tone. This suggests that arousal can have both detrimental and alleviating effects on gait control in PD.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Neurosciences
Franziska Knolle, Shyam S. Arumugham, Roger A. Barker, Michael W. L. Chee, Azucena Justicia, Nitish Kamble, Jimmy Lee, Siwei Liu, Abhishek Lenka, Simon J. G. Lewis, Graham K. Murray, Pramod Kumar Pal, Jitender Saini, Jennifer Szeto, Ravi Yadav, Juan H. Zhou, Kathrin Koch
Summary: Psychotic symptoms are common in schizophrenia and Parkinson's disease (PD) patients. Altered grey matter structure in various brain areas and networks may contribute to their pathogenesis. This study investigated the similarities in psychotic symptoms between schizophrenia and PD, and found significant grey matter reduction in both PD and early schizophrenia. Classification algorithms based on grey matter values within specific networks showed good accuracy in differentiating early psychosis cases and fair performance in distinguishing PD patients with and without psychotic symptoms. Results suggest some common underlying mechanisms and potential biomarkers for identifying these conditions.
NPJ PARKINSONS DISEASE
(2023)
Review
Biology
Alice Tisserand, Nathalie Philippi, Anne Botzung, Frederic Blanc
Summary: This review explores the relationship between the insula, a brain region, and the self. The insula is a multiconnected region that processes diverse information related to the self. Studies in healthy individuals and those with different conditions reveal the involvement of the insula in various aspects of the self. Damage to the insular cortex may lead to a collapse of the self across different pathologies.
Editorial Material
Anesthesiology
Elie Matar, Robert D. Sanders
Summary: Postoperative delirium is a significant complication of surgery that is linked to long-term cognitive decline, although the neural mechanisms behind this relationship are not well understood. Neuroimaging studies and network-based approaches are important tools for unraveling the link between delirium and cognitive decline. A recent study using resting state functional MRI revealed reduced global connectivity for up to 3 months after delirium, supporting current models of delirium and providing potential insight into the complex relationship between delirium and dementia.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Medical Laboratory Technology
Sylvain Lehmann, Susanna Schraen-Maschke, Jean-Sebastien Vidal, Constance Delaby, Frederic Blanc, Claire Paquet, Bernadette Allinquant, Stephanie Bombois, Audrey Gabelle, Olivier Hanon, BALTAZAR Study Grp
Summary: This study compared the clinical performance of Lumipulse and Simoa assays in predicting the conversion to dementia in patients with mild cognitive impairment (MCI). The results showed that both assays had similar abilities, but Lumipulse was less affected by comorbidities. Plasma pTau181 was associated with renal dysfunction, cardiovascular factors, nutrition, and inflammatory markers. The study suggests that Lumipulse could be used as a noninvasive diagnostic tool for the management of Alzheimer's disease.
CLINICAL CHEMISTRY
(2023)
