Article
Chemistry, Multidisciplinary
Liping Dong, Jinsong Ding, Lemei Zhu, Yujun Liu, Xiang Gao, Wenhu Zhou
Summary: Macromolecular drugs have significant potential for treating previously untreatable diseases, but they face challenges in terms of stability and penetration. In this study, biocompatible transition metals were screened for biomineralization with carbonate to load macromolecules. Copper carbonate nanoparticles were prepared to co-load glucose oxidase (GOx) and a HIF-alpha DNAzyme (DZ), achieving high loading capacity. The nanoparticles could accumulate in tumors, penetrate cell membranes, and release their payloads to exert anti-tumor effects. The combination of GOx and DZ resulted in synergistic tumor growth inhibition.
CHINESE CHEMICAL LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Qixiong Zhang, Shanshan Li, Lin He, Xueting Feng
Summary: Polysialic acid (PSA) is a straight-chain homoglycan that can be used in various applications in the pharmaceutical field due to its non-immunogenicity and biodegradability. It can be employed as a biomaterial for protein polysialylation and tissue engineering, as well as a component in multifunctional drug delivery systems. This article provides an overview of the bioproduction, biofunction, and chemical modification strategies of PSA, as well as the advancements in PSA-based drug delivery systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Sheng-Yan Yin, Yingcai Hu, Jing Zheng, Jishan Li, Ronghua Yang
Summary: In this study, a tannic acid-assisted biomineralization strategy was developed for the encapsulation and intracellular delivery of protein drugs, which can activate multiple therapeutic pathways and achieve efficient cancer therapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Kaixin Zhang, Jicheng Wu, Xiaoxiong Zhao, Jiale Qin, Yi Xue, Weizeng Zheng, Lixiu Wang, Haoran Wang, Hong Shen, Tianye Niu, Yan Luo, Ruikang Tang, Ben Wang
Summary: This lung cancer imaging and treatment strategy focuses on tumor iron mineralization, enabling early and differential diagnosis while inhibiting malignant behaviors of tumor cells. It integrates detection and prevention of tumor metastasis at early stages without the need for toxic drugs, offering a potential solution for precise management of lung cancer.
Article
Chemistry, Multidisciplinary
Shuxin Xu, Menghuan Zhao, Zikuan Gu, Haifeng Lu, Zhen Liu
Summary: This study reports the construction of polySia-targeting nanomissiles via molecular imprinting for the photothermal therapy of neuroblastoma. The nanomissiles specifically recognize polySia and target neuroblastoma cells with overexpressed polySia, showing promising potential for targeted therapy of neuroblastoma.
Article
Biology
Philippe Ganot, Guillaume Loentgen, Frederic Marin, Laurent Plasseraud, Denis Allemand, Sylvie Tambutte
Summary: In this study, a straightforward and alternative method for analyzing coral skeleton is presented with the aim to improve the quality of the extracted organic matrix. By directly demineralizing the entire skeleton and further rinsing and melting the material, higher quality organic matrix can be obtained compared to the standard method. The advantages and limitations of both methods are discussed in this paper.
Article
Chemistry, Multidisciplinary
Yue Sun, Sze Yi Lau, Zhi Wei Lim, Shi Chieh Chang, Farid Ghadessy, Anthony Partridge, Ali Miserez
Summary: This study reports the development of conjugated peptides that can form coacervate microdroplets through liquid-liquid phase separation. These microdroplets have the ability to easily cross the cell membrane and can recruit and release macromolecular therapeutic agents, making them promising for treating various diseases.
Article
Environmental Sciences
Bryce D. Stewart, Stuart R. Jenkins, Charlotte Boig, Catherine Sinfield, Kevin Kennington, Andrew R. Brand, William Lart, Roland Kroger
Summary: Metal pollution has been found to significantly weaken shell strength in marine bivalves, leading to increased mortality and predation risk. This study highlights the importance of reevaluating currently accepted critical contamination levels for the survival of organisms exposed to contaminants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Sergio Vargas, Thorsten Zimmer, Nicola Conci, Martin Lehmann, Gert Woerheide
Summary: While many coral reef species are threatened by overfishing, some octocorals show resilience to anthropogenic environmental changes and may replace stony corals in the future. Research has found that the molecular mechanisms of octocorals, such as Pinnigorgia flava, exhibit resilience to heat and seawater acidification stress. This provides insights into their adaptive responses to anthropogenically driven environmental changes.
Article
Engineering, Biomedical
Qixiong Zhang, Shanshan Li, Kun Guo, Xuemei Yin, Rongsheng Tong
Summary: CD22 is up-regulated in B-cell lymphoma, and a polysialic acid-modified nanocarrier was designed to target B-cell lymphoma. It enhances the immune response, suppresses tumor growth, and improves survival rate.
ACTA BIOMATERIALIA
(2022)
Article
Plant Sciences
Gerald Langer, Alison R. Taylor, Charlotte E. Walker, Erin M. Meyer, Oz Ben Joseph, Assaf Gal, Glenn M. Harper, Ian Probert, Colin Brownlee, Glen L. Wheeler
Summary: The development of coccolithophores' calcification had a significant impact on ocean carbon cycling. Holococcoliths and heterococcoliths are formed in different life cycle stages but share similar characteristics. Holococcoliths represent an ancestral form of calcification in coccolithophores.
Article
Limnology
Yong Zhang, Zhengke Li, Kai G. Schulz, Yingyu Hu, Andrew J. Irwin, Zoe V. Finkel
Summary: The study reveals that increasing light, pH, and CO2 can enhance the growth rate of Emiliania huxleyi, leading to higher RNA and protein content, while increasing temperature may decrease RNA content. Additionally, different conditions influencing growth rate can result in varying changes in carbohydrate and organic carbon ratios.
LIMNOLOGY AND OCEANOGRAPHY
(2021)
Article
Polymer Science
Boyang Jia, Weichen Sun, Wenhao Duan, Xiangbo Ma, Yong Wang, Chengyan Zhou, Jianglei Qin
Summary: Self-healing hydrogels prepared from biopolymers have great advantages in bioengineering and bioscience as drug delivery carriers due to their biocompatibility and biodegradability. In this research, a biodegradable hydrogel was constructed using poly(amino acid) and pectin for in vivo antitumor applications as a carrier for DOX release. The hydrogel exhibited regulatable mechanical strength and excellent biocompatibility, and it was biodegradable both by enzyme and in vivo due to the pectin backbone and the poly(amino acid). The hydrogel inhibited tumor growth and reduced in vivo toxicity of DOX, presenting great potential as a sustained drug delivery vehicle in biomedical areas.
JOURNAL OF POLYMER RESEARCH
(2023)
Article
Environmental Sciences
Garfield T. Kwan, Martin Tresguerres
Summary: Splitnose rockfish exposed to high levels of carbon dioxide can regulate the pH of both blood and endolymph, but with different pH setpoints. The higher pH setpoint in the endolymph leads to increased pCO2 diffusion and higher concentrations of bicarbonate ions, which promotes otolith overgrowth. The results suggest that species with stronger pH regulatory mechanisms will experience more pronounced otolith overgrowth in response to ocean acidification.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Paolo Rosa, Sofia Scibetta, Giuseppe Pepe, Giorgio Mangino, Luca Capocci, Sam J. Moons, Thomas J. Boltje, Francesco Fazi, Vincenzo Petrozza, Alba Di Pardo, Vittorio Maglione, Antonella Calogero
Summary: This study investigated the effect of PSA inhibition on GBM cells under low oxygen concentrations and found that it could inhibit GBM cell migration and differentiation. This finding suggests that PSA may be a potential target for developing therapies for GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Hao Shou, Jicheng Wu, Ning Tang, Ben Wang
Summary: Calcium deposition is a common biological process in mammals shaping mechanical structures and causing calculi formation. Tumor calcification has been proven to be a benign prognostic factor in various types of cancer. Inducing bionic calcification around cancer cells shows excellent effects in inhibiting tumor growth and metastases, as well as improving early-stage diagnosis accuracy.
Article
Chemistry, Multidisciplinary
Weijing Kong, Qiaolin Du, Yinan Qu, Changyu Shao, Chaoqun Chen, Jian Sun, Caiyun Mao, Ruikang Tang, Xinhua Gu
Summary: It is known that crosslinking agents can improve the mechanical properties of dentin by crosslinking collagen. This study focused on the influence of tannic acid (TA) crosslinking on the collagen-mineral interface and found that TA crosslinked collagen fibers can induce dentin biomineralization and improve the mechanical and anti-enzyme properties of dentin.
Review
Materials Science, Biomaterials
Jie Wang, Qiqi Liu, Zhengxi Guo, Haihua Pan, Zhaoming Liu, Ruikang Tang
Summary: Biomineralization is the natural process of regulating crystal growth in organisms, resulting in hierarchical structured biominerals with excellent properties. Repairing bones and teeth in a biomimetic way is crucial for hard tissue regeneration, and this review discusses the progress in biomimetic mineralization and materials for collagen mineralization. Recent achievements in bone and tooth repair are summarized, providing insights from materials science and biological science for future research in hard tissue repair techniques. The review concludes with a discussion on existing problems and future directions in hard tissue regeneration.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Materials Science, Biomaterials
Changyu Shao, Zhisen Zhang, Wenjing Jin, Zhan Zhang, Biao Jin, Shuqin Jiang, Haihua Pan, Ruikang Tang, James J. De Yoreo, Xiang Yang Liu
Summary: Designing a collagen-like peptide can generate self-assembled fibrils resembling the structure of collagen-I fibrils, with oriented mineralization forming a bone-like material. Unlike collagen-I fibrils, the peptide fibrils do not contain gap spaces. Molecular simulation results show that the molecular field generated by the peptide can confine the orientation of the mineralization, providing insights for the design of synthetic biopolymer scaffolds for bone-like material fabrication.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Yadong Yu, Kangren Kong, Ruikang Tang, Zhaoming Liu
Summary: Inspired by bone structure, a highly tough nanocomposite laminate is developed by integrating ultrasmall inorganic building units into an organic-inorganic hierarchical structure. The resulting laminate exhibits ultrahigh bending strain and toughness, surpassing natural and synthetic laminates. The mechanics of this material can be tunable by changing the water content.
Article
Multidisciplinary Sciences
Qingqing Wang, Haoli Wang, Huige Yan, Hongsen Tian, Yining Wang, Wei Yu, Zhanqiu Dai, Pengfei Chen, Zhaoming Liu, Ruikang Tang, Chao Jiang, Shunwu Fan, Xin Liu, Xianfeng Lin
Summary: In multinucleated osteoclasts, regulation through circular RNA circBBS9 can restrict mononuclear cell multinucleation, providing a new strategy for addressing osteolytic diseases such as osteoporosis.
Article
Nanoscience & Nanotechnology
Kaiyu Liang, Chenchen Zhao, Chenxin Song, Lan Zhao, Pengcheng Qiu, Shengyu Wang, Jinjin Zhu, Zhe Gong, Zhaoming Liu, Ruikang Tang, Xiangqian Fang, Yueqi Zhao
Summary: The combination of biomimetic hydrogels and nano-HAP is a promising way to solve critical-sized bone defects. In this study, bone-like nano-HAP was in situ mineralized in hydrogels through cross-linking periosteum-decellularized extracellular matrix and calcium phosphate oligomers. The resulting biomimetic osteogenic hydrogel demonstrated acceleration of osteogenesis and achieved large sized bone defect regeneration and remodeling.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Congcong Yu, Wentao Yang, Linjun Yang, Lin Ye, Rongtai Sun, Tianyuan Gu, Xiaozhang Ying, Monian Wang, Ruikang Tang, Shunwu Fan, Shasha Yao
Summary: Magneto-mechanical bioengineered cells consisting of magnetic silica nanoparticles (MSNPs) and mesenchymal stem cells (MSCs) have the capability of spatial localization, cell retention, and directional tracking. They can activate the YAP/β-catenin signaling pathway to promote osteogenesis, mineralization, and angiogenesis, thus improving osteoporosis.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Qingyan Zhang, Pengkai Wu, Jicheng Wu, Hao Shou, Xinliang Ming, Shuqi Wang, Ben Wang
Summary: Classical chemotherapeutic drugs can induce immunogenic cell death (ICD) and activate CD8+ T cells, but the continuous stimulation of tumor antigens exhausts these cells, hindering effective tumor suppression. This study introduces a chemo-gene combinational nanomedicine approach that bridges chemotherapy and immunotherapy. The nanomedicine induces ICD in tumor cells and reverses the antitumor effects of exhausted CD8+ T cells. In a mouse model of breast cancer and melanoma, this approach enhances cancer immunotherapy and inhibits tumor growth and metastasis.
Article
Multidisciplinary Sciences
Weifeng Fang, Zhao Mu, Yan He, Kangren Kong, Kai Jiang, Ruikang Tang, Zhaoming Liu
Summary: This study successfully integrates organic covalent bonds and inorganic ionic bonds within one molecule to create an organic-inorganic hybrid molecule, which can be used for synthesizing hybrid materials. The resulting hybrid material, poly(TA-CCO), exhibits a unique combination of ceramic-like, rubber-like, and plastic-like behaviors, offering a new class of materials called "elastic ceramic plastic".
Editorial Material
Materials Science, Biomaterials
Ruikang Tang, Michio Suzuki
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Engineering, Biomedical
Congcong Yu, Xiaozhang Ying, Mohammad-Ali Shahbazi, Linjun Yang, Zaiqiang Ma, Lin Ye, Wentao Yang, Rongtai Sun, Tianyuan Gu, Ruikang Tang, Shunwu Fan, Shasha Yao
Summary: Conductive nano-materials and electrical stimulation can be used for synergetic therapy in ordinary excitable tissue repair. In this study, a novel nano-conductive hydrogel was synthesized for electro-inspired bone tissue regeneration. The hydrogel demonstrated excellent electroactivity, biocompatibility, and osteoinductivity, and had the potential to enhance cellular functionality by activating the TGF-beta/Smad2 signaling pathway. In vivo experiments showed that the nano-conductive hydrogel with electrical stimulation significantly promoted electro-inspired bone defect regeneration.
Article
Engineering, Biomedical
Songzhe Shan, Zhenhang Tang, Kaida Sun, Wenjing Jin, Haihua Pan, Ruikang Tang, Wei Yin, Zhijian Xie, Zhuo Chen, Changyu Shao
Summary: This study proposes a new pathway for collagen fibril mineralization via particle-mediated phase transformation, deepens the understanding of its mechanism, and offers a new strategy for hard tissue repair.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Biomaterials
Zhenyu Liu, Jiake Lin, Benke Li, Yuemin Zhou, Chen Li, Yihao Cui, Fengchao Tian, Ruikang Tang, Xiaoyu Wang
Summary: This study presents a method for using manganese-mineralized tumor cells as whole-cell cancer vaccines, which improves the immunogenicity of tumor cells and overcomes immune suppression in solid tumors, leading to effective anti-tumor immune therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Wenjing Jin, Yeli Jin, Pengqiang Duan, Haiyan Wu, Leiqing Zhang, Qiaolin Du, Haihua Pan, Ruikang Tang, Changyu Shao
Summary: This study found that succinic acid can significantly promote the mineralization of collagen fibers and accelerate the process of mineralization by interacting with collagen molecules. Demineralized dentin pretreated with succinic acid can be completely remineralized in a shorter time and shows improved mechanical properties.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
