Article
Immunology
Alicja Sadowska-Klasa, Wendy M. Leisenring, Ajit P. Limaye, Michael Boeckh
Summary: A systematic review of randomized and observational studies from 2013-2023 indicated that antiviral preemptive therapy initiated at cytomegalovirus viral load thresholds between 2 and 3 log10 IU/mL had comparable cytomegalovirus disease rates. Thus, viral thresholds within this range appeared to effectively safeguard patients who did not receive prophylaxis.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Surgery
Cristina Hernandez, Curtis Mabilangan, Catherine Burton, Karen Doucette, Jutta Preiksaitis
Summary: This study found that the risk of cytomegalovirus (CMV) transmission in solid organ transplant recipients is influenced by the type of allograft, and that the use of antiviral prophylaxis may not alter the transmission risk. Additionally, factors related to the donor may also impact the transmission outcomes.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Lawrence J. Purpura, Michelle Chang, Medini K. Annavajhala, Hiroshi Mohri, Lihong Liu, Jayesh Shah, Anyelina Cantos, Nicola Medrano, Justin Laracy, Brian Scully, Benjamin A. Miko, Marlena Habal, Marcus R. Pereira, Moriya Tsuji, David D. Ho, Anne-Catrin Uhlemann, Michael T. Yin
Summary: In immunosuppressed patients, the persistence of SARS-CoV-2 infection may be prolonged, leading to potential viral evolution. Immune response peaks around days 44-72 after diagnosis but wanes over time, allowing for increased viral genetic diversity and the emergence of variants.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Margaret R. Jorgenson, Hanna L. Kleiboeker, Brad C. Astor, Amy C. Gentry, Christopher M. Saddler, Jeannina A. Smith, Fahad Aziz, Didier Mandelbrot, Neetika Garg
Summary: This study evaluated the seasonal distribution of CMV disease in kidney transplant recipients and found that CMV disease is less common during the summer season for patients who were CMV positive at the time of transplantation. However, there was no seasonal variation in CMV disease for CMV negative recipients.
CLINICAL TRANSPLANTATION
(2023)
Article
Surgery
Katrina Bazemore, Nitipong Permpalung, Joby Mathew, Merte Lemma, Betelihim Haile, Robin Avery, Hyesik Kong, Moon Kyoo Jang, Temesgen Andargie, Shilpa Gopinath, Steven D. Nathan, Shambhu Aryal, Jonathan Orens, Hannah Valantine, Sean Agbor-Enoh, Pali Shah
Summary: This study suggests that the donor-derived cell-free DNA percentage at the time of respiratory viral infection could be a predictor of chronic lung allograft dysfunction progression in lung transplant recipients. The recipients with higher levels of %ddcfDNA experienced greater decline in lung function and had a higher risk of progression and failure within one year.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Tobias Veit, Dieter Munker, Juergen Barton, Katrin Milger, Teresa Kauke, Bruno Meiser, Sebastian Michel, Michael Zoller, Hans Nitschko, Oliver T. Keppler, Jurgen Behr, Nikolaus Kneidinger
Summary: This study assessed the therapeutic efficacy of letermovir in lung transplant recipients with difficult to treat CMV infections. Most patients responded rapidly to letermovir treatment, showing significant reduction in CMV viral load and clearance of infection. However, a small percentage of patients developed a mutation conferring resistance to letermovir.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Carlos Solano, Lourdes Vazquez, Estela Gimenez, Rafael de la Camara, Eliseo Albert, Montserrat Rovira, Ildefonso Espigado, Carmen M. Calvo, Javier Lopez-Jimenez, Maria Suarez-Lledo, Anabella Chinea, Albert Esquirol, Ariadna Perez, Aranzazu Bermudez, Raquel Saldana, Inmaculada Heras, Ana J. Gonzalez-Huerta, Tamara Torrado, Guiomar Bautista, Montserrat Batlle, Santiago Jimenez, Carlos Vallejo, Pere Barba, Maria a. Cuesta, Jose L. Pinana, David Navarro
Summary: The study found that CMV DNAemia was not associated with increased overall mortality and nonrelapse mortality in recipients of allogeneic hematopoietic stem cell transplantation. The use of preemptive antiviral therapy for CMV DNAemia was found to be associated with increased mortality in univariate models, but not in adjusted models. Further research is needed to confirm the potential impact of preemptive antiviral therapy on mortality.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Ravi Dhital, Shashi Anand, Brianna Graber, Qiang Zeng, Victoria M. Velazquez, Srinivasa R. Boddeda, James R. Fitch, Ranjana W. Minz, Mukut Minz, Ashish Sharma, Rachel Cianciolo, Masako Shimamura
Summary: Human cytomegalovirus (HCMV) infection is associated with renal allograft failure. CMV promotes allograft damage via cytokine-mediated Th1/17 cell recruitment. Pharmacologic inhibition of the Th17 cell signature cytokine, IL-17A, ameliorates CMV-associated allograft damage.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Kristen G. Valencia Deray, Kathleen E. Hosek, Divya Chilukuri, Jordan R. Dunson, David R. Spielberg, Sarah J. Swartz, Joseph A. Spinner, Daniel H. Leung, Elizabeth A. Moulton, Flor M. Munoz, Gail J. Demmler-Harrison, Claire E. Bocchini
Summary: This study aimed to determine the frequency of CMV DNAemia in pediatric solid organ transplant recipients and found associations with high-risk CMV status and lung transplantation. The study showed that universal prophylaxis is effective in preventing CMV disease after SOTR, but further research is needed to optimize prevention strategies and reduce morbidity and mortality.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Shuangjin Yu, Anil Dangi, Melanie Burnette, Michael M. Abecassis, Edward B. Thorp, Xunrong Luo
Summary: Acute CMV infection disrupts established transplantation tolerance in 50%-60% of recipients during the maintenance stage and leads to recipient allo-sensitization. This disruption reverts allo-specific T cells to a non-tolerant state and promotes their differentiation into allo-specific memory cells, resulting in accelerated rejection of a second same-donor islet allograft. Close monitoring for allo-sensitization is recommended in previously tolerant transplant recipients with disrupted tolerance maintenance due to acute CMV infection.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Wairimu Magua, Aileen C. Johnson, Geeta M. Karadkhele, Idelberto R. Badell, Payaswini Vasanth, Aneesh K. Mehta, Kirk A. Easley, Kenneth A. Newell, Joseph B. Rickert, Christian P. Larsen
Summary: Belatacept-treated high-risk kidney transplant recipients showed difficulty in sustaining viral control compared to tacrolimus-treated recipients, indicating the need for modified management protocols or avoidance of initial belatacept use in high-risk recipients.
TRANSPLANT INFECTIOUS DISEASE
(2022)
Article
Surgery
Hannah Kaminski, Nassim Kamar, Olivier Thaunat, Nicolas Bouvier, Sophie Caillard, Isabelle Garrigue, Dany Anglicheau, Jean-Philippe Rerolle, Yannick Le Meur, Antoine Durrbach, Thomas Bachelet, Helene Savel, Roxane Coueron, Jonathan Visentin, Arnaud Del Bello, Isabelle Pellegrin, Julie Dechanet-Merville, Pierre Merville, Rodolphe Thiebaut, Lionel Couzi
Summary: This study found that everolimus can decrease the incidence of CMV DNAemia and disease in CMV seropositive solid organ transplant recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Ophthalmology
Christophe Chiquet, Alain M. Bron, Mats Lundstrom, Max Maurin
Summary: Postoperative endophthalmitis is a serious complication of intraocular surgery. Recent advancements in microbial detection and identification methods have improved the accuracy and speed of identifying bacterial infections in the eye. Molecular biology techniques have further enhanced the identification rate of infectious agents and provide faster results compared to culture-based methods. Quantitative real-time PCR can determine the bacterial load in intraocular samples, aiding in distinguishing infection from contamination. Whole genome DNA sequencing technologies have the potential to increase the rate of microbiological identification.
SURVEY OF OPHTHALMOLOGY
(2022)
Article
Infectious Diseases
Yuka Torii, Ichiro Morioka, Yasumasa Kakei, Kazumichi Fujioka, Yu Kakimoto, Naoto Takahashi, Tetsushi Yoshikawa, Hiroyuki Moriuchi, Akira Oka, Yoshinori Ito
Summary: This study aimed to compare the accuracy of quantification methods for cytomegalovirus (CMV) infection using whole blood and plasma, and explored the relationship between CMV DNA levels and VGCV therapy. The results showed that plasma CMV viral loads were significantly decreased at the end of therapy, and overall, using plasma to measure CMV viral loads is a feasible approach to monitor the efficacy of CMV infection in children.
BMC INFECTIOUS DISEASES
(2023)
Article
Immunology
Anat Stern, Yiqi Su, Henry Dumke, Jiaqi Fang, Roni Tamari, Ann Jakubowski, Christina Cho, Sergio Giralt, Miguel-Angel Perales, Genovefa A. Papanicolaou
Summary: This study investigated the association between time-averaged area under the curve (AAUC) of CMV viral load and overall survival at 1-year post-HCT. Results showed that non-controllers had worse survival rates, while controllers had similar outcomes to elite-controllers or R-/D-. Further research is needed to validate the AAUC cutoff across different cohorts and CMV management strategies.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Rheumatology
Sara Monti, Chiara Fornara, Paolo Delvino, Alice Bartoletti, Federica Bergami, Giuditta Comolli, Jose Camilla Sammartino, Alessandro Biglia, Emanuele Bozzalla Cassione, Irene Cassaniti, Fausto Baldanti, Daniele Lilleri, Carlomaurizio Montecucco
Summary: This study analyzed the immune response to mRNA COVID-19 vaccines in patients with GCA. The results showed that GCA patients had weaker antibody response and impaired neutralizing activity compared to healthy individuals. Treatment with MTX significantly reduced the humoral response. About one-third of GCA patients did not develop cellular immune protection in response to the COVID-19 vaccine.
Editorial Material
Infectious Diseases
Liliana Gabrielli, Giulia Piccirilli, Evangelia Petrisli, Simona Venturoli, Eva Caterina Borgatti, Alice Balboni, Antonella Marangoni, Tiziana Lazzarotto
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Letter
Dermatology
Paola Zelini, Eugenio Isoletta, Martina Volonte, Daniele Lilleri, Irene Cassaniti, Valeria Musella, Catherine Klersy, Fausto Baldanti, Valeria Brazzelli
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Infectious Diseases
Cristina Merla, Irene Mileto, Stefano Gaiarsa, Cristian Achille, Stefano Ghirardello, Marta Corbella, Fausto Baldanti, Patrizia Cambieri
Summary: We report the isolation of a strain of Pantoea genus carrying a VIM carbapenemase, which is the first of its kind. The strain was obtained from a rectal swab of a 10-day-old newborn in a neonatal intensive care unit (NICU). Whole-genome sequencing revealed that the strain was identified as Pantoea brenneri. The strain harbored the carbapenemase gene bla(VIM-1). Immediate contact measures and isolation of the newborn prevented the dissemination of VIM-producing P. brenneri and the plasmid carrying the VIM-1 gene to other newborns.
Editorial Material
Oncology
Angioletta Lasagna, Irene Cassaniti, Paolo Sacchi, Simone Figini, Fausto Baldanti, Raffaele Bruno, Paolo Pedrazzoli
Article
Genetics & Heredity
Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang, Jeremy Manry, Yoann Seeleuthner, Yu Zhang, Alexandre Bolze, Matthieu Chaldebas, Baptiste Milisavljevic, Adrian Gervais, Paul Bastard, Takaki Asano, Lucy Bizien, Federica Barzaghi, Hassan Abolhassani, Ahmad Abou Tayoun, Alessandro Aiuti, Ilad Alavi Darazam, Luis M. Allende, Rebeca Alonso-Arias, Andres Augusto Arias, Gokhan Aytekin, Peter Bergman, Simone Bondesan, Yenan T. Bryceson, Ingrid G. Bustos, Oscar Cabrera-Marante, Sheila Carcel, Paola Carrera, Giorgio Casari, Khalil Chaibi, Roger Colobran, Antonio Condino-Neto, Laura E. Covill, Ottavia M. Delmonte, Loubna El Zein, Carlos Flores, Peter K. Gregersen, Marta Gut, Filomeen Haerynck, Rabih Halwani, Selda Hancerli, Lennart Hammarstroem, Nevin Hatipoglu, Adem Karbuz, Sevgi Keles, Christele Kyheng, Rafael Leon-Lopez, Jose Luis Franco, Davood Mansouri, Javier Martinez-Picado, Ozge Metin Akcan, Isabelle Migeotte, Pierre-Emmanuel Morange, Guillaume Morelle, Andrea Martin-Nalda, Giuseppe Novelli, Antonio Novelli, Tayfun Ozcelik, Figen Palabiyik, Qiang Pan-Hammarstroem, Rebeca Perez de Diego, Laura Planas-Serra, Daniel E. Pleguezuelo, Carolina Prando, Aurora Pujol, Luis Felipe Reyes, Jacques G. Riviere, Carlos Rodriguez-Gallego, Julian Rojas, Patrizia Rovere-Querini, Agatha Schlueter, Mohammad Shahrooei, Ali Sobh, Pere Soler-Palacin, Yacine Tandjaoui-Lambiotte, Imran Tipu, Cristina Tresoldi, Jesus Troya, Diederik van de Beek, Mayana Zatz, Pawel Zawadzki, Saleh Zaid Al-Muhsen, Mohammed Faraj Alosaimi, Fahad M. Alsohime, Hagit Baris-Feldman, Manish J. Butte, Stefan N. Constantinescu, Megan A. Cooper, Clifton L. Dalgard, Jacques Fellay, James R. Heath, Yu-Lung Lau, Richard P. Lifton, Tom Maniatis, Trine H. Mogensen, Horst von Bernuth, Alban Lermine, Michel Vidaud, Anne Boland, Jean-Francois Deleuze, Robert Nussbaum, Amanda Kahn-Kirby, France Mentre, Sarah Tubiana, Guy Gorochov, Florence Tubach, Pierre Hausfater, C. O. V. I. D. Human Genetic Effort, Isabelle Meyts, Shen-Ying Zhang, Anne Puel, Luigi D. Notarangelo, Stephanie Boisson-Dupuis, Helen C. Su, Bertrand Boisson, Emmanuelle Jouanguy, Jean-Laurent Casanova, Qian Zhang, Laurent Abel, Aurelie Cobat
Summary: Through a genome-wide rare variant burden association analysis, it was found that there is an association between at-risk variants in the TLR7 gene and rare loss-of-function variants in TLR3-dependent type I interferon immunity genes. These findings suggest that rare variants in TLR3- and TLR7-dependent type I interferon immunity genes may underlie life-threatening COVID-19 in patients under 60 years old.
Article
Immunology
Chiara Oltolini, Andrea Acerbis, Giorgio Orofino, Sara Racca, Maddalena Noviello, Stefania Dispinseri, Nicola Clementi, Simona Piemontese, Elisabetta Xue, Fabio Giglio, Maria Teresa Lupo Stanghellini, Elisa Diral, Alessandro Bruno, Elena Tassi, Valeria Beretta, Ilaria Marzinotto, Gabriella Scarlatti, Vito Lampasona, Anna Ardemagni, Michela Sampaolo, Chiara Bonini, Consuelo Corti, Jacopo Peccatori, Antonella Castagna, Fabio Ciceri, Raffaella Greco
Summary: This report describes a case of a 34-year-old patient with active SARS-CoV-2 infection and high-risk leukemia who underwent allogeneic hematopoietic stem cell transplantation. Timely anti-SARS-CoV-2 preventive therapies and prompt management of transplant-related complications resulted in a favorable outcome.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Jose Camilla Sammartino, Marta Colaneri, Cecilia Bassoli, Mariaelena Ceresini, Antonio Piralla, Alessandro Ferrari, Elena Percivalle, Fausto Baldanti, Raffaele Bruno, Mario U. Mondelli
Summary: This study aimed to verify the presence of viable virus on different surfaces exposed to droplets released by coughing in SARS-CoV-2 RNA positive patients. The results showed that droplets on common inanimate surfaces did not contain viable virus, while laboratory-propagated viruses could survive and grow on the same surfaces.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Editorial Material
Oncology
Michele Malagola, Robert Ohgami, Raffaella Greco
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Marta Colaneri, Raffaella Lissandrin, Matteo Calia, Cecilia Bassoli, Elena Seminari, Alessandro Pavesi, Francesca Rovida, Fausto Baldanti, Alba Muzzi, Guido Chichino, Angelo Regazzetti, Cecilia Grecchi, Angelo Pan, Matteo Lupi, Erica Franceschini, Cristina Mussini, Raffaele Bruno
Summary: This study aimed to assess the efficacy of steroid therapy in reducing intrahospital mortality, length of stay, and neurological sequelae in WNND patients. The results showed that steroid therapy did not significantly reduce intrahospital mortality or neurological sequelae. More prospective data are needed to demonstrate the protective effect of steroid treatment.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Letter
Biophysics
Michele Malagola, Vera Radici, Mirko Farina, Simone Pellizzeri, Filippo Spoldi, Enrico Morello, Nicola Polverelli, Eugenia Accorsi Buttini, Simona Bernardi, Federica Re, Alessandro Leoni, Liana Signorini, Arnaldo Caruso, Domenico Russo
BONE MARROW TRANSPLANTATION
(2023)
Article
Immunology
Simona Secondino, Paolo Pedrazzoli, Sabrina Basso, Paolo Bossi, Alba Bianco, Ilaria Imarisio, Anna Pagani, Marica De Cicco, Stella Muscianisi, Michela Casanova, Carlo Morosi, Cristiana Bergamini, Marco Benazzo, Maria Cossu Rocca, Cesare Perotti, Fausto Baldanti, Marco Zecca, Lisa F. Licitra, Patrizia Comoli
Summary: This study aimed to explore the efficacy of autologous EBV-specific CTL transplantation in the treatment of recurrent/metastatic EBV-NPC patients after chemotherapy. The results showed that patients who received CTL transplantation had a 5-year overall survival rate of 44% and a median overall survival of 60 months. This indicates that autologous CTL transplantation can effectively control the disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Medicine, Research & Experimental
Elisabetta Xue, Gianluca Scorpio, Annalisa Ruggeri, Daniela Clerici, Francesca Farina, Edoardo Campodonico, Andrea Acerbis, Paolo Fiore, Alessandro Bruno, G. Carrabba, Jacopo Peccatori, Raffaella Greco, Maria Teresa Lupo Stanghellini, Fabio Ciceri, Consuelo Corti
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Edoardo Campodonico, Elisabetta Xue, Simona Piemontese, Anna Chiara, Alessandro Bruno, Gianluca Scorpio, Rosamaria Nitti, Daniele Sannipoli, Giorgio Orofino, Paolo Fiore, Maria Chiara Quattrocchi, Elisa Diral, Daniela Clerici, Francesca Farina, Consuelo Corti, Francesca Lunghi, Maria Teresa Lupo-Stanghellini, Nadia Di Muzio, Fabio Ciceri, Raffaella Greco, Jacopo Peccatori
Summary: A retrospective analysis on 14 MF patients found that splenic irradiation before hematopoietic stem cell transplantation can effectively reduce spleen size and alleviate symptoms. This approach is safe and effective in the selected population and may be considered as a treatment option for MF.
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Angioletta Lasagna, Irene Cassaniti, Francesca Arena, Federica Bergami, Elena Percivalle, Giuditta Comolli, Antonella Sarasini, Alessandro Ferrari, Daniela Cicognini, Roberta Schiavo, Giuliana Lo Cascio, Paolo Pedrazzoli, Fausto Baldanti
Summary: We prospectively evaluated the long-term immunogenicity of the third dose of the SARS-CoV-2 BNT162b2 mRNA vaccine in 55 patients undergoing cancer treatment. Our findings indicate that one year after receiving the third dose, more than 67% of patients showed an immune response against the virus, with less than 20% of patients showing no response to certain variants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
