Article
Biology
Yanis Zekri, Romain Guyot, Ines Garteizgogeascoa Suner, Laurence Canaple, Amandine Gautier Stein, Justine Vily Petit, Denise Aubert, Sabine Richard, Frederic Flamant, Karine Gauthier
Summary: This study used transcriptome and cistrome analyses to identify direct target genes of thyroid hormone (T3) in brown adipocytes and developed a new mouse model to study the role of T3 in brown adipose tissue (BAT). The results showed that T3 plays a crucial role in regulating lipid and glucose metabolism and BAT proliferation, providing new insights into the pathways by which T3 activates energy expenditure through adaptive thermogenesis in BAT.
Article
Endocrinology & Metabolism
Tim Hollstein, Karyne Vinales, Kong Y. Chen, Aaron M. Cypess, Alessio Basolo, Mathias Schlogl, Jonathan Krakoff, Paolo Piaggi
Summary: This study found that thrifty individuals, who experience a greater decrease in 24-hour energy expenditure during short-term fasting, also have lower cold-induced brown adipose tissue activation. The reduced CIBA may explain the lower capacity for cold-induced thermogenesis and greater predisposition towards weight gain in individuals with a thrifty metabolism.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Cell Biology
Swe Mar Oo, Hein Ko Oo, Hiroaki Takayama, Kiyo-Aki Ishii, Yumie Takeshita, Hisanori Goto, Yujiro Nakano, Susumu Kohno, Chiaki Takahashi, Hiroyuki Nakamura, Yoshiro Saito, Mami Matsushita, Yuko Okamatsu-Ogura, Masayuki Saito, Toshinari Takamura
Summary: The study found that serum levels of selenoprotein P (SeP) are negatively correlated with brown adipose tissue (BAT) activity. Physiological cold exposure downregulates the expression of Selenop in BAT. Selenop knockout mice have higher rectal temperatures and UCP1 sulfenylation during cold exposure. Treatment with SeP in brown adipocytes reduces NA-induced mitochondrial reactive oxygen species (ROS) production by upregulating glutathione peroxidase 4, impairing cellular thermogenesis. A high-fat/high-sucrose diet increases serum SeP levels and diminishes NA-induced thermogenesis in BAT-Selenop knockout mice. Therefore, SeP acts as an intrinsic factor inducing reductive stress and impairing thermogenesis in BAT, making it a potential therapeutic target for obesity and diabetes.
Review
Biochemistry & Molecular Biology
Pei-Chi Chan, Po-Shiuan Hsieh
Summary: This review focuses on the role and regulatory mechanism of BAT in DIT and whether these mechanisms are applicable to human health and diseases. BAT is considered an important organ in the process of counter-regulating energy intake and lipid accumulation through DIT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Claudia Maushart, Jael R. Senn, Rahel C. Loeliger, Judith Siegenthaler, Fabienne Bur, Jonas G. W. Fischer, Matthias J. Betz
Summary: This study evaluated the effects of hyperthyroidism on energy expenditure, thermogenesis, and body composition. The results showed that energy expenditure decreased during hyperthyroidism, but thermogenesis did not increase. Hyperthyroidism led to increased skin temperature in warm conditions but did not affect core body temperature or skin temperature after cold exposure. Furthermore, weight regain and body composition were not influenced by hyperthyroidism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Claudia Irene Maushart, Jael Rut Senn, Rahel Catherina Loeliger, Marius E. Kraenzlin, Julian Muller, Anton S. Becker, Miroslav Balaz, Christian Wolfrum, Irene A. Burger, Matthias Johannes Betz
Summary: This study revealed a significant association between levels of free thyroxine (T4) and cold induced thermogenesis (CIT) as well as brown adipose tissue (BAT) activity. Variations in thyroid hormone levels within the euthyroid range may affect the ability to adapt to cool temperatures and regulate energy balance in humans.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Tao Zhu, Xu Chen, Shenglu Jiang
Summary: Transplantation of brown adipose tissue (BAT), engineered thermogenic progenitor cells, and adipocytes have been studied for their potential in improving obesity and metabolic disorders. However, the whitening of the brown fat graft and impaired metabolic function are significant challenges. This review discusses specific experiment designs, graft outcomes, and metabolic benefits, providing guidance for further investigation and innovation in BAT transplantation methods.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Jiamin Qiu, Feng Yue, Peipei Zhu, Jingjuan Chen, Fan Xu, Lijia Zhang, Kun Ho Kim, Madigan M. Snyder, Nanjian Luo, Hao-wei Xu, Fang Huang, W. Andy Tao, Shihuan Kuang
Summary: The study identifies FAM210A as a key regulator of cold-induced mitochondrial remodeling in brown adipocytes, which is crucial for thermogenesis.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Yufeng Shi, Honglei Zhai, Sharon John, Yi-Ting Shen, Yali Ran, Giang Hoang, Miao-Hsueh Chen
Summary: This study demonstrates that mouse scBAT possesses thermogenic features distinct from other adipose depots, showing sensitivity to cold exposure and reduced thermogenic effect under thermoneutrality. Additionally, a previously unknown mouse dnBAT depot was characterized, exhibiting similar thermogenic characteristics as scBAT under cold exposure and thermoneutrality. These findings highlight the potential therapeutic target of BAT in combating obesity.
Article
Cell Biology
Carsten T. Herz, Oana C. Kulterer, Marlene Prager, Rodrig Marculescu, Felix B. Langer, Gerhard Prager, Alexandra Kautzky-Willer, Alexander R. Haug, Florian W. Kiefer
Summary: This study found that the prevalence of cold-activated BAT is slightly but non-significantly higher in pre-menopausal women than men. CIT is increased in females and independently associated with estradiol, suggesting that sex hormones may play a role in different thermogenic responses between men and women.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Claudia Irene Maushart, Wenfei Sun, Alaa Othman, Adhideb Ghosh, Jael Rut Senn, Jonas Gabriel William Fischer, Philipp Madoerin, Rahel Catherina Loeliger, Robyn Melanie Benz, Martin Takes, Christoph Johannes Zech, Alin Chirindel, Felix Beuschlein, Martin Reincke, Damian Wild, Oliver Bieri, Nicola Zamboni, Christian Wolfrum, Matthias Johannes Betz
Summary: This study found that glucocorticoids affect energy expenditure in healthy men, but do not affect the activity of brown adipose tissue that generates heat in response to cold stimulation.
Article
Endocrinology & Metabolism
Martina Felder, Claudia Irene Maushart, Gani Gashi, Jael Rut Senn, Anton S. Becker, Julian Mueller, Miroslav Balaz, Christian Wolfrum, Irene A. Burger, Matthias Johannes Betz
Summary: Two weeks of treatment with fluvastatin reduced serum lipid levels but increased glucose area under the curve in young, healthy men, indicating reduced glucose tolerance. However, this change was not associated with cold-induced BAT activity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Yukimasa Takeda, Ping Dai
Summary: The study demonstrated that Capsaicin treatment directly activated adipocyte browning and a broad range of metabolic genes, including UCP1 expression, in ciBAs. The findings suggest that ciBAs could be a promising cell model for screening bioactive compounds targeting human brown adipocytes.
SCIENTIFIC REPORTS
(2022)
Review
Biology
Jan Nedergaard, Gabriella von Essen, Barbara Cannon
Summary: This article discusses whether a decrease in UCP1 activity could cause obesity in humans. Studies in mice suggest that the absence of UCP1 leads to obesity. It is still unknown if similar mechanisms exist in humans.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Subramanian Senthivinayagam, Vlad Serbulea, Clint M. Upchurch, Renata Polanowska-Grabowska, Suresh K. Mendu, Srabani Sahu, Prathiba Jayaguru, Kevin W. Aylor, Mahendra D. Chordia, Limor Steinberg, Nathaniel Oberholtzer, Seichii Uchiyama, Noriko Inada, Ulrike M. Lorenz, Thurl E. Harris, Susanna R. Keller, Akshaya K. Meher, Alexandra Kadl, Bimal N. Desai, Bijoy K. Kundu, Norbert Leitinger
Summary: By studying the activity of Panx1 channels in brown adipocytes, it was discovered that Panx1 channels play a significant role in regulating thermogenesis induced by beta 3AR, with potential therapeutic implications for thermoregulation.
MOLECULAR METABOLISM
(2021)
Article
Agriculture, Dairy & Animal Science
I. T. Rast, E. Zini, C. Wolfrum, T. A. Lutz, C. E. Reusch, E. Salesov
Summary: Obesity leads to insulin resistance and is a major risk factor for the development of diabetes mellitus in cats. ROR gamma and its target gene MMP3 play a key role in the development of large insulin-resistant adipocytes. THBA inhibits ROR gamma, reduces adipocyte size, and improves insulin sensitivity.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Tongtong Wang, Anand Kumar Sharma, Christian Wolfrum
Summary: Adipose tissue is mainly composed of adipocytes, while non-adipocytes in the stromal vascular fraction outnumber adipocytes by far. This tissue, known for energy storage, has emerged as a key regulator of systemic metabolism and recent single-cell RNA sequencing data showcased the profound diversity of cell types within adipose tissue.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joao Horvat, Varadan Sevilimedu, Anton S. Becker, Rocio Perez-Johnston, Randy Yeh, Kimberly N. Feigin
Summary: This retrospective cohort study assessed the frequency and outcomes of ipsilateral axillary adenopathy on breast MRI following COVID-19 vaccination. It found that younger patients and shorter time intervals from the second dose of the vaccine were significantly associated with the development of adenopathy. Most adenopathy resolved or decreased on follow-up, but a small percentage persisted up to 64 days after the second dose of the vaccine. Metastatic axillary carcinoma was diagnosed in three patients with a current ipsilateral breast cancer diagnosis.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Doris Leithner, Heiko Schoder, Alexander Haug, H. Alberto Vargas, Peter Gibbs, Ida Haggstrom, Ivo Rausch, Michael Weber, Anton S. Becker, Jazmin Schwartz, Marius E. Mayerhoefer
Summary: The purpose of this study was to investigate whether ComBat harmonization improves tissue classification based on 18F-FDG PET radiomics. The results showed that ComBat harmonization can enhance the accuracy of various feature classes in pooled PET/MRI and PET/CT data.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Editorial Material
Multidisciplinary Sciences
Christian Wolfrum, Zachary Gerhart-Hines
Editorial Material
Endocrinology & Metabolism
Nicole Bechmann, Andreas Barthel, Andreas Schedl, Stephan Herzig, Zsuzsanna Varga, Catherine Gebhard, Manuel Mayr, Constanze Hantel, Felix Beuschlein, Christian Wolfrum, Nikolaos Perakakis, Lucilla Poston, Cynthia L. Andoniadou, Richard Siow, Raul R. Gainetdinov, Arad Dotan, Yehuda Shoenfeld, Geltrude Mingrone, Stefan R. Bornstein
Summary: Current evidence shows that COVID-19 severity and mortality are higher in men compared to women, while women may be at a higher risk of reinfection and long-term COVID-19 development. Differences between sexes have also been observed in other infectious diseases and vaccine responses. This could be explained by sex-specific expression patterns of proteins involved in virus binding and entry, as well as divergent reactions of the immune and endocrine systems to acute stress. Understanding the role of sex hormones, comorbidities, and sex chromosome complement in COVID-19 could have implications for disease treatment, public health measures, and follow-up of patients predisposed to long COVID. Considering sex differences in future pandemic surveillance and COVID-19 patient treatment may lead to better disease stratification and improved outcomes.
LANCET DIABETES & ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Fabian Laumer, Davide Di Vece, Victoria L. Cammann, Michael Wuerdinger, Vanya Petkova, Maximilian Schoenberger, Alexander Schoenberger, Julien C. Mercier, David Niederseer, Burkhardt Seifert, Moritz Schwyzer, Rebekka Burkholz, Luca Corinzia, Anton S. Becker, Frank Scherff, Sofie Brouwers, Aju P. Pazhenkottil, Svetlana Dougoud, Michael Messerli, Felix C. Tanner, Thomas Fischer, Victoria Delgado, P. Christian Schulze, Christian Hauck, Lars S. Maier, Ha Nguyen, Sven Y. Surikow, John Horowitz, Kan Liu, Rodolfo Citro, Jeroen Bax, Frank Ruschitzka, Jelena-Rima Ghadri, Joachim M. Buhmann, Christian Templin
Summary: This cohort study established a real-time system for fully automated interpretation of echocardiogram videos and used machine learning to differentiate takotsubo syndrome (TTS) from acute myocardial infarction (AMI). The system achieved higher accuracy in echocardiography-based disease classification compared to cardiologists.
Article
Biochemistry & Molecular Biology
Alba Gonzalez-Franquesa, Pau Gama-Perez, Marta Kulis, Karolina Szczepanowska, Norma Dahdah, Sonia Moreno-Gomez, Ana Latorre-Pellicer, Rebeca Fernandez-Ruiz, Antoni Aguilar-Mogas, Anne Hoffman, Erika Monelli, Sara Samino, Joan Miro-Blanch, Gregor Oemer, Xavier Duran, Estrella Sanchez-Rebordelo, Marc Schneeberger, Merce Obach, Joel Montane, Giancarlo Castellano, Vicente Chapaprieta, Wenfei Sun, Lourdes Navarro, Ignacio Prieto, Carlos Castano, Anna Novials, Ramon Gomis, Maria Monsalve, Marc Claret, Mariona Graupera, Guadalupe Soria, Christian Wolfrum, Joan Vendrell, Sonia Fernandez-Veledo, Jose Antonio Enriquez, Angel Carracedo, Jose Carlos Perales, Ruben Nogueiras, Laura Herrero, Aleksandra Trifunovic, Markus A. Keller, Oscar Yanes, Marta Sales-Pardo, Roger Guimera, Matthias Blueher, Jose Ignacio Martin-Subero, Pablo M. Garcia-Roves
Summary: This study systematically assessed metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention, and found that there is a significant metabolic dysfunction in visceral white adipose tissue, which leads to a breakdown of metabolic plasticity.
Article
Endocrinology & Metabolism
Lucia Balazova, Natalia Palesova, Miroslav Balaz
Summary: Studies have shown that brown and white adipocytes can accept mitochondria from other cells, but this does not trigger transcriptional changes. Injecting mitochondria from brown adipocytes into mice does not increase energy expenditure or reduce weight gain, possibly due to immune response and rapid removal of the administered mitochondria.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Anton S. Becker
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniel Hoces, Jiayi Lan, Wenfei Sun, Tobias Geiser, Melanie L. Staubli, Elisa Cappio Barazzone, Markus Arnoldini, Tenagne D. Challa, Manuel Klug, Alexandra Kellenberger, Sven Nowok, Erica Faccin, Andrew J. Macpherson, Baerbel Stecher, Shinichi Sunagawa, Renato Zenobi, Wolf-Dietrich Hardt, Christian Wolfrum, Emma Slack
Summary: The intestinal microbiota can degrade indigestible food components to improve energy recovery. This study found that the energy released by the microbiota is balanced by decreased food intake in mice. Furthermore, the type of respiratory substrates used in metabolism differs between different microbiota groups, affecting energy storage and fat accumulation.
Article
Oncology
Anton S. Becker, Jeeban P. Das, Sungmin Woo, Pierre Elnajjar, Joshua Chaim, Joseph P. Erinjeri, Hedvig Hricak, Hebert Alberto Vargas
Summary: This study aimed to evaluate whether a custom programmatic workflow manager reduces reporting turnaround times for body oncologic imaging at a tertiary cancer center. The results showed that the custom software program significantly decreased the median reporting turnaround times for MRI and CT examinations, as well as increased the percentage of reports completed within 24 hours.
JCO CLINICAL CANCER INFORMATICS
(2022)
Article
Endocrinology & Metabolism
Anand Kumar Sharma, Tongtong Wang, Alaa Othman, Radhika Khandelwal, Miroslav Balaz, Salvatore Modica, Nicola Zamboni, Christian Wolfrum
Summary: Emerging evidence suggests the existence of constant basal lipolysis and re-esterification of fatty acids. In this study, the role of lipolysis coupled to re-esterification under basal conditions was investigated. The results showed that DGAT1 and DGAT2 mediated re-esterification plays a role in regulating fatty acid oxidation and mitochondrial fuel utilization.
MOLECULAR METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Melissa M. Chen, Admir Terzic, Anton S. Becker, Jason M. Johnson, Carol C. Wu, Max Wintermark, Christoph Wald, Jia Wu
Summary: Radiology plays a crucial role in cancer care, and compared to molecular assays, imaging offers advantages such as comprehensive evaluation of tumors unbiased by sampling errors. The application of Artificial Intelligence in radiology challenges the discipline to become competent in data science, allowing for the detection of previously unnoticed radiographic patterns.
EUROPEAN JOURNAL OF RADIOLOGY OPEN
(2022)
Article
Endocrinology & Metabolism
Hua Dong, Wenfei Sun, Yang Shen, Miroslav Balaz, Lucia Balazova, Lianggong Ding, Mona Loeffler, Bradford Hamilton, Nora Kloeting, Matthias Blueher, Heike Neubauer, Holger Klein, Christian Wolfrum
Summary: Dong and Sun et al. demonstrate the inhibitory role of adipogenesis regulatory cells in murine white adipose tissue through RSPO2. They show that RSPO2 regulates the maturation of early progenitor cells via Lgr4. This study highlights the importance of cellular crosstalk in adipogenesis and its impact on adipose tissue homeostasis.