Article
Oncology
Mingwei Chen, Xuedong Wei, Xiu Shi, Le Lu, Guangbo Zhang, Yuhua Huang, Jianquan Hou
Summary: The study revealed that HIF1A-AS2 was upregulated in renal carcinoma and associated with pathological features like tumor size, lymph node metastasis, and differentiation. HIF1A-AS2 and miR-30a-5p were found to affect the malignant phenotype of renal carcinoma cells by modulating the WNT/beta-catenin signaling pathway.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yue Cui, Bozhong Shi, Zijie Zhou, Bo Chen, Xiaoyang Zhang, Cong Li, Kai Luo, Zhongqun Zhu, Jinghao Zheng, Xiaomin He
Summary: A long non-coding RNA (CFRL) associated with cardiac fibrosis has been identified, which can promote the proliferation and migration of cardiac fibroblasts. Silencing CFRL significantly alleviates cardiac fibrosis and improves ventricular function. Interfering with CFRL may be considered as a multitarget strategy for treating cardiac fibrosis and heart failure.
Article
Cell Biology
Jie Yang, Guangliang Shi, Yafan Gong, Jingzeng Cai, Yingying Zheng, Ziwei Zhang
Summary: The study found that selenium deficiency upregulates ATG7 expression, while miR-17-5p inhibits cardiomyocyte autophagy by targeting ATG7. Additionally, LncRNA 0003250 regulates miR-17-5p, thereby affecting ATG7 and autophagic cell death.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chao Zhang, Jing Li, Hongjing Li, Guiling Wang, Qingqing Wang, Xin Zhang, Baiteng Li, Haixu Xu
Summary: This study demonstrates that MIR155HG promotes sepsis progression by modulating the miR-194-5p/MEF2A axis. Knockdown of MIR155HG improves cell viability, reduces apoptosis and inflammation, which can be counteracted by upregulating miR-194-5p. Additionally, overexpression of MEF2A reverses the inhibitory effect on sepsis progression induced by MIR155HG deletion.
DNA AND CELL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Xiaodong Yin, Xilan Gu, Fenjun Li, Fei Ye, Fang Liu, Wenbin Wang
Summary: This study aimed to investigate the molecular mechanism of lncRNA SNHG6 in nasopharyngeal carcinoma (NPC) progression. The findings demonstrated that SNHG6 expression was increased in NPC tissues and cells, and its depletion attenuated NPC cell viability and metastasis. SNHG6 was found to regulate NPC progression by modulating the miR-26a-5p/ARPP19 axis.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Medicine, Research & Experimental
Lei Ding, Taiyuan Liu, Yuan Qu, Zhichen Kang, Lixin Guo, Haina Zhang, Junjie Jiang, Fuling Qu, Wanbao Ge, Shanyong Zhang
Summary: In metastatic osteosarcoma, the upregulation of the abnormally expressed lncRNA MELTF-AS1 is associated with a poor prognosis in patients and may promote metastasis of osteosarcoma by regulating MMP14 expression. It could serve as a potential therapeutic and diagnostic target for osteosarcoma.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Ping Zhang, Shenghui Gong, Shuoshuo Li, Zengqiang Yuan
Summary: Endothelial dysfunction is crucial in vascular disease pathogenesis. Long noncoding RNA (lncRNA) and microRNA (miRNA) play significant roles in various cellular processes in vascular endothelial cells (VECs), including cell growth, migration, autophagy, and apoptosis. The present study investigated the role of plasmacytoma variant translocation 1 (PVT1) in regulating autophagy and apoptosis in human umbilical vein endothelial cells (HUVEC). It was found that PVT1 knockdown accelerates apoptosis and suppresses cellular autophagy. PVT1 functions as a competing endogenous RNA (ceRNA) of miR-15b-5p and miR-424-5p, promoting cellular autophagy and down-regulating apoptosis. This study suggests PVT1 as a potential therapeutic target for cardiovascular disease treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Shi Tao, Yu Chen, Min Hu, Lu Xu, Cai-Bo Fu, Xin-Bao Hao
Summary: This study found that lncRNA PVT1 promotes the progression of DLBCL by acting as a miR-34b-5p sponge to disinhibit Foxp1/β-catenin signaling, providing a new perspective on the pathogenesis of DLBCL.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Environmental Sciences
Yan Li, Wenqing Sun, Honghong Pan, Jiali Yuan, Qi Xu, Tiantian Xu, Ping Li, Demin Cheng, Yi Liu, Chunhui Ni
Summary: This study revealed that lncRNA-PVT1 activates lung fibroblasts via miR-497-5p in silica-induced pulmonary fibrosis. Additionally, FOXM1 acts as a profibrotic factor by elevating lncRNA-PVT1 transcription, contributing to pulmonary fibrosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Mingjun Jiang, Guanwen Chen
Summary: The characteristics of ncRNA in children with autism spectrum disorder (ASD) were observed, providing a theoretical basis for further research on molecular markers for early warning of ASD. The study found that the level of PVT1 was downregulated while the content of miR-21-5p was upregulated in the disease group. The expression level of serum miR-21-5p was negatively correlated with the level of PVT1. PVT1, miR-21-5p, and their combination showed potential clinical value for disease diagnosis in ASD.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Oncology
Shaorong Zhao, Teng Pan, Jinhai Deng, Lixia Cao, Jose M. Vicencio, Jingjing Liu, Guanglin Zhou, Tony Ng, Jin Zhang
Summary: This study reveals the important role of exosomal miR-181b-5p in doxorubicin resistance in breast cancer, and suggests its potential as a prognostic biomarker and therapeutic target for doxorubicin-resistant BC patients.
BRITISH JOURNAL OF CANCER
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yingzhi Gu, Yuxing Bai
Summary: This study aimed to determine whether lncRNA MALAT1 promotes the osteogenic differentiation of human PDLSCs in vitro. The results showed that MALAT1 regulates human PDLSC differentiation by regulating the miR-93-5p/SMAD5 axis.
Article
Urology & Nephrology
Wensheng Yuan, Xiaoqing Xiong, Jinlong Du, Qi Fan, Rong Wang, Xia Zhang
Summary: PVT1 knockdown promoted cell viability, suppressed inflammatory response and apoptosis by regulating miR-17-5p expression and NF-kappa B pathway in LPS-stimulated HK-2 cells. MiR-17-5p was sponged by PVT1, and its inhibition weakened the impact of PVT1 deficiency on LPS-mediated injury of HK-2 cells.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Article
Immunology
Junkui Xu, Yanjiang Pei, Jun Lu, Xiaojun Liang, Yi Li, Junhu Wang, Yingang Zhang
Summary: The study revealed that SNHG7 was downregulated in OA while miR-214-5p was upregulated. SNHG7 enhanced cell viability and suppressed apoptosis and inflammation, whereas upregulation of miR-214-5p had opposite effects on chondrocytes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Zhe Chen, Qinning Wang, Lujie Huang, Guodong Xu, Jing Hu
Summary: In this study, the researchers found that the lncRNA PVT1 is significantly upregulated in cisplatin-resistant esophageal carcinoma (ESCA) and is associated with poor patient survival. Silencing PVT1 increases cisplatin sensitivity in ESCA cells. PVT1 promotes cisplatin resistance by modulating the miR-181a-5p-GLS axis.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2023)
