Using bumetanide to treat autism appears promising but further clinical trials are needed to confirm this approach

Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios

(2020) Lingli Zhang et al.   Translational Psychiatry

Effects of bumetanide on neurodevelopmental impairments in patients with tuberous sclerosis complex: an open-label pilot study

(2020) Dorinde M. van Andel et al.   Molecular Autism

Bumetanide for autism: more eye contact, less amygdala activation

(2018) Nouchine Hadjikhani et al.   Scientific Reports

Effects of bumetanide on neurobehavioral function in children and adolescents with autism spectrum disorders

(2017) E Lemonnier et al.   Translational Psychiatry

The GABA excitatory/inhibitory developmental sequence: A personal journey

(2014) Y. Ben-Ari   NEUROSCIENCE

Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital

(2011) Romain Nardou et al.   BRAIN

Neuro-archaeology: pre-symptomatic architecture and signature of neurological disorders

(2008) Yehezkel Ben-Ari   TRENDS IN NEUROSCIENCES