Article
Chemistry, Physical
Sauradipta Banerjee
Summary: Protein glycation, induced by a-dicarbonyl compound glyoxal in diabetic conditions, results in the formation of advanced glycation end products (AGEs) and structural alteration in proteins. The study on myoglobin incubated with glyoxal for 30 days revealed aggregation with amyloidal features and modification of specific residues to AGE adducts. This research provides insight into the mechanisms of AGE-induced protein modification and subsequent conformational disorders.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Nutrition & Dietetics
Marco Mouanness, Zaher Merhi
Summary: Advanced glycation end products (AGEs), formed by the reaction between protein and reducing sugars, can impact reproductive health and fertility through inducing inflammation and oxidative stress. This review summarizes the recent data on the pathogenesis of dietary AGEs and their potential impact on female reproductive health and offspring reproduction.
Article
Food Science & Technology
Hee-Weon Lee, Min Ji Gu, Jee-Young Lee, Seungju Lee, Yoonsook Kim, Sang Keun Ha
Summary: The study found that MOLD significantly increases RAGE expression in mouse mesangial cells, leading to ROS production and mitochondrial dysfunction. MOLD activates PI3KB and NF-kappa B signaling pathways, triggering inflammatory responses.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hee-Weon Lee, Min Ji Gu, Yoonsook Kim, Jee-Young Lee, Seungju Lee, In-Wook Choi, Sang Keun Ha
Summary: This study evaluated the impact of glyoxal-lysine dimer (GOLD) on oxidative damage and inflammatory response in SV40 MES 13 mesangial cells. GOLD increased RAGE expression, reactive oxygen species production, and regulated NRF2 and GLO1 expression. Additionally, GOLD induced mitochondrial deterioration and inflammation through oxidative stress, and regulated MAPK and proinflammatory cytokines release. Inhibition of RAGE using RAGE siRNA suppressed the oxidative stress and inflammatory responses triggered by GOLD, highlighting the importance of the interaction between GOLD and RAGE in mesangial cell function.
Article
Chemistry, Applied
Hyun Hee L. Lee, Sang Keun Ha, Yoonsook Kim, Jinyoung Hur
Summary: A new pre-column derivatization method based on dansylation is proposed to overcome the analytical challenges in identifying and quantifying advanced glycation end products (AGEs). The method allows for the separation of different structural isomers of AGEs with low detection limits and wide linear ranges. The developed method shows potential applicability in various fields of food chemistry and biochemistry.
Article
Cell Biology
Lei Yang, Baozhu Liang, Jingxin Li, Xiaoyan Zhang, Hong Chen, Jia Sun, Zhen Zhang
Summary: Excessive accumulation of AGEs can impair autophagy on podocytes, while the SGLT2 inhibitor dapagliflozin effectively mitigates AGE-induced podocyte injury by promoting autophagy and regulating the AMPK-mTOR signal pathway.
CELLULAR SIGNALLING
(2022)
Article
Food Science & Technology
Qin Li, Leibing Li, Hanjian Zhu, Fan Yang, Ke Xiao, Lin Zhang, Menglin Zhang, Yongsheng Peng, Chao Wang, Dongsheng Li, Qian Wu, Mengzhou Zhou
Summary: This study investigated the inhibitory activity of lactic acid bacteria (LAB) on advanced glycation end-products (AGEs) during vinegar fermentation. The results showed that LAB strains can inhibit the formation of AGEs by accelerating substrate consumption, improving antioxidant activities, and inhibiting enzyme activities. Moreover, there was a negative correlation between fluorescent AGEs and carboxymethyl lysine (CML)/carboxyethyl lysine (CEL) with antioxidant activities, while enzyme activities were positively correlated with total phenolic content and total flavonoids.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Biochemistry & Molecular Biology
Fengmao An, Ruyi Zhao, Xinran Xuan, Tianqi Xuan, Guowei Zhang, Chengxi Wei
Summary: Growing evidence suggests that calycosin may have therapeutic effects on Alzheimer's disease, especially in Alzheimer's disease related to diabetes. Experimental results show that calycosin can promote neuronal survival, improve learning and memory abilities, down-regulate certain disease-related protein activities, reduce the production of amyloid protein, and repair mitochondrial dysfunction.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Article
Biochemistry & Molecular Biology
Sauradipta Banerjee
Summary: The study characterized MG-modified myoglobin in a time-dependent manner, with mass spectrometric studies indicating modifications at Lys-87 and Lys-133. Far-UV CD studies revealed alterations in protein structure and surface hydrophobicity as a result of MG modification. These findings suggest that MG-derived AGE adducts significantly impact the structure of Mb.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Karolina Kazmierczak, Pawel Zuchowski, Katarzyna Lapinska-Duczmal, Katarzyna Zabel, Zofia Sikorska, Magdalena Pol, Malgorzata Seredyka-Burduk, Bartosz L. Sikorski, Grazyna Malukiewicz
Summary: This study evaluated the correlation between diabetes mellitus and retinal vein occlusion using skin autofluorescence measurement of advanced glycation end products, especially in central retinal vein occlusion. The results showed a significant association between retinal vein occlusion and diabetes mellitus, particularly in the central form. Further studies with a larger sample size are recommended for future research.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Fengmao An, Ruyi Zhao, Xinran Xuan, Tianqi Xuan, Guowei Zhang, Chengxi Wei
Summary: This study explores the effects of calycosin on neurodegenerative changes induced by advanced glycation end products (AGEs) in DM-related AD. The results suggest that calycosin can improve cell viability and enhance learning and memory abilities in DM-related AD models. The molecular mechanisms involve down-regulation of GSK-3 beta activity, inhibition of RAGE and BACE-1 protein expression, reduction in beta-amyloid production, and regulation of the PGC-1 alpha/TFAM signaling pathway to repair mitochondrial dysfunction.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Chemistry, Medicinal
Amna Parveen, Razia Sultana, Seung Min Lee, Tae Hun Kim, Sun Yeou Kim
Summary: Research shows that advanced glycation end products play a crucial role in diabetes and its related complications, while natural products rich in bioactive constituents can control and prevent these diseases through various signaling cascades.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Biology
Andrew J. Smith, Jayshree Advani, Daniel C. Brock, Jacob Nellissery, Jessica Gumerson, Lijin Dong, L. Aravind, Breandan Kennedy, Anand Swaroop
Summary: We identified a mitochondrial protein, GATD3A, with bacterial evolutionary affinities, that functions as a deglycase and restricts the formation of AGEs in mitochondria. GATD3A may play a role in maintaining the integrity of important biomolecules.
Article
Food Science & Technology
Yue Luo, Jianan Zhang, Chi-Tang Ho, Shiming Li
Summary: This review examines the antiglycation effect and mechanism of tea and tea polyphenols. The findings suggest that tea polyphenols, particularly catechins, have a significant antiglycation effect by trapping alpha-dicarbonyl compounds and impeding the formation of advanced glycation end products (AGEs). Additionally, tea polyphenols alleviate aging, diabetes, and collagen-related diseases or complications through the regulation of receptor for advanced glycation end products (RAGE) expression and subsequent MAPK and TGF-beta pathways.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Neurosciences
Jiankun Zang, Dan Lu, Anding Xu
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Neurosciences
Dan Lu, Lingling Shen, Hongcheng Mai, Jiankun Zang, Yanfang Liu, Chi-kwan Tsang, Keshen Li, Anding Xu
Review
Clinical Neurology
Yousheng Wu, Dan Lu, Anding Xu
JOURNAL OF CLINICAL NEUROSCIENCE
(2019)
Article
Neurosciences
Dan Lu, Eric S. Ho, Hongcheng Mai, Jiankun Zang, Yanfang Liu, Yufeng Li, Bing Yang, Yan Ding, Chi Kwan Tsang, Anding Xu
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Clinical Neurology
Wan-Yong Yang, Yu-Feng Li, Zi-Ran Wang, Tian-Xia Yu, Dong-Juan Xu, Nan Yang, Xiao-Yuan Niu, Xue-Li Cai, Wen-Yan Zhuo, Xue-Mei Wu, Min Yan, Jun-Shan Zhou, Hao-Wen Zhang, Zhi-Gang Liang, Wen-Jun Wu, Jian-Hua Cheng, Li-An Huang, Yu-Sheng Zhang, Ying Guan, Ze-Feng Tan, Dan Lu, Niu He, Da-Wei Dong, Hui-Li Zhu, Bing Yang, Qing-Yu Shen, An-Ding Xu
Summary: The study showed that intensive statin therapy did not significantly improve clinical outcomes compared to low-dose statin therapy in patients with acute ischemic stroke undergoing intravenous thrombolysis, and both treatment groups had similar safety profiles.
JOURNAL OF NEUROLOGY
(2021)
Article
Cell Biology
Jiankun Zang, Yousheng Wu, Xuanlin Su, Tianyuan Zhang, Xionglin Tang, Dan Ma, Yufeng Li, Yanfang Liu, Ze'an Weng, Xuanzhuo Liu, Chi Kwan Tsang, Anding Xu, Dan Lu
Summary: The study elucidated that microglial exosomes play a crucial role in regulating neuronal function and survival under ischemic conditions, by modulating M1 and M2 phenotype and promoting autophagic flux. The findings also suggest that PDE1-B regulates exosome biogenesis and autophagy in microglia, highlighting a novel microglia-neuron interaction mechanism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yanfang Liu, Yufeng Li, Jiankun Zang, Tianyuan Zhang, Yaojie Li, Zefeng Tan, Dan Ma, Tao Zhang, Shiyong Wang, Yusheng Zhang, Lian Huang, Yousheng Wu, Xuanlin Su, Zean Weng, Die Deng, Chi Kwan Tsang, Anding Xu, Dan Lu
Summary: CircOGDH may serve as a potential biomarker for penumbra in AIS patients and play a role in ischemic neuronal damage. CircOGDH interacts with miR-5112, enhancing COL4A4 expression and exacerbating neuron damage. Knockdown of CircOGDH enhances neuronal cell viability under ischemic conditions. Additionally, CircOGDH is enriched in neuron-derived exosomes in peripheral blood.
CIRCULATION RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Zhenguo Yang, Cheng Huang, Xueyi Wen, Wenlin Liu, Xiaoxiong Huang, Yufeng Li, Jiankun Zang, Zean Weng, Dan Lu, Chi Kwan Tsang, Keshen Li, Anding Xu
Summary: This study reveals that circular RNA circ-FoxO3 promotes autophagy through inhibiting mTORC1, thereby protecting the blood-brain barrier and alleviating damage caused by central nervous system diseases. The findings suggest that circ-FoxO3 may be a therapeutic target for neurological disorders associated with blood-brain barrier damage.
Article
Cell Biology
Daji Guo, Xiaoman Yang, Ming Gao, Xiaoqing Chen, Yanping Tang, Lingling Shen, Keshen Li, Lei Shi
Summary: This study found that ASD-like behaviors persist into late-middle age in Dock4 KO mice, with specific alterations in spatial memory and hippocampal anatomy by age.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Jiankun Zang, Xionglin Tang, Xuanlin Su, Tianyuan Zhang, Dan Lu, Anding Xu
Summary: The prognosis of ischemic stroke patients is closely associated with collateral circulation. Competing endogenous RNAs (ceRNAs) generated from different compensatory supply regions may also play a role in regulating the prognosis of ischemic tissues. This study analyzed the RNA expression profiles and biological processes in two distinct compensatory regions in mice with middle cerebral artery occlusion (MCAO) and identified specific changes in ceRNAs that are potentially involved in the evolution of cerebral ischemic tissues and the unbalanced prognosis after stroke. Furthermore, specific miRNAs, mmu-miR446i-3p and mmu-miR3473d, were found to be involved in angiogenesis and cell proliferation after ischemic stroke. These findings provide evidence for the collateral compensatory effects on patients' prognosis and identify new targets for ischemic stroke therapy.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Ze-An Weng, Xiao-Xiong Huang, Die Deng, Zhen-Guo Yang, Shu-Yuan Li, Jian-Kun Zang, Yu-Feng Li, Yan-Fang Liu, You-Sheng Wu, Tian-Yuan Zhang, Xuan-Lin Su, Dan Lu, An-Ding Xu
Summary: A new nomogram was developed and validated to predict the risk of intracranial hemorrhage in patients with acute ischemic stroke after intravenous thrombolysis. The nomogram performed well in both the training and testing sets, showing higher predictive accuracy compared to other existing scoring systems. This new nomogram has the potential to be clinically useful for predicting the risk of intracranial hemorrhage in patients after intravenous thrombolysis.
FRONTIERS IN NEUROLOGY
(2022)
Meeting Abstract
Clinical Neurology
Yufeng Li, Dan Lu, Anding Xu