Article
Cell Biology
Tamara T. Lah, Metka Novak, Milagros A. Pena Almidon, Oliviero Marinelli, Barbara Zvar Baskovic, Bernarda Majc, Mateja Mlinar, Roman Bosnjak, Barbara Breznik, Roby Zomer, Massimo Nabissi
Summary: Among primary brain tumors, glioblastoma is the most aggressive and modern therapies have not significantly improved patient survival rates. Recent studies have shown that cannabigerol (CBG) may be a promising alternative to THC for treating glioblastoma, as it has similar anti-tumor effects without the psychoactive side effects. CBG has been found to effectively impair the progression of glioblastoma and destroy therapy-resistant cancer stem cells, suggesting it may have potential as a new adjuvant treatment strategy for this lethal cancer.
Article
Pharmacology & Pharmacy
Paraskevi Kyriaki Monou, Anastasia Maria Mamaligka, Emmanuil K. Tzimtzimis, Dimitrios Tzetzis, Souzan Vergkizi-Nikolakaki, Ioannis S. Vizirianakis, Eleftherios G. Andriotis, Georgios K. Eleftheriadis, Dimitrios G. Fatouros
Summary: In this study, drug carrier nanoparticles containing cannabidiol (CBD) or cannabigerol (CBG) were developed for wound healing. The nanoparticles showed enhanced wound healing effects in the first 6 hours of application. The developed 3D-printed films hold promise for wound healing applications.
Article
Pharmacology & Pharmacy
Joseph L. Damstra-Oddy, Eleanor C. Warren, Christopher J. Perry, Yann Desfougeres, John-Mark K. Fitzpatrick, Judith Schaf, Lisa Costelloe, William Hind, Eric J. Downer, Adolfo Saiardi, Robin S. B. Williams
Summary: The study found that both CBD and CBG regulate mTORC1 signaling through a mechanism dependent on the activity of the upstream IPMK signaling pathway. This has potential relevance for the treatment of mTOR-related disorders, including multiple sclerosis.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Materials Science, Composites
Francisco Sebastian Navarro Oliva, Leo Picart, Christopher Y. Leon-Valdivieso, Ahmed Benalla, Luc Lenglet, Alejandro Ospina, Jacques Jestin, Fahmi Bedoui
Summary: Nanoreinforced polymers have gained popularity for their enhanced properties in various applications, but dispersion of nanoparticles into polymeric matrices remains a challenge. This study proposes a method using coaxial electrospinning to disperse NPs in PVDF, showing that NP size affects fiber size. Transmission electron microscopy confirms good NP dispersion in the polymer.
POLYMER COMPOSITES
(2021)
Article
Biochemistry & Molecular Biology
Michael J. Viereckl, Kelsey Krutsinger, Aaron Apawu, Jian Gu, Bryana Cardona, Donovan Barratt, Yuyan Han
Summary: CBD and CBG are non-psychedelic components extracted from cannabis that have shown anti-proliferative potential in cholangiocarcinoma (CCA). Both cannabinoids inhibit proliferation in CCA, with CBG being more active at lower doses. They induce apoptosis and inhibit mitosis in CCA cells through different mechanisms.
Review
Biochemistry & Molecular Biology
Cristina Ferreira Almeida, Natercia Teixeira, Georgina Correia-da-Silva, Cristina Amaral
Summary: Cannabinoids have shown promising potential for diverse pathological conditions such as multiple sclerosis, epilepsy, pain relief, and cancer treatment. Studies have demonstrated their ability to modulate cancer cell proliferation and death, as well as angiogenesis, making them attractive as agents for cancer therapy. Research on the effects of cannabinoids on breast cancer subtypes, particularly ER- and ER+ cells, has been increasing in recent years, showing potential for future therapeutic applications.
Article
Physiology
Victoria L. Vernail, Sarah S. Bingaman, Yuval Silberman, Wesley M. Raup-Konsavage, Kent E. Vrana, Amy C. Arnold
Summary: Cannabigerol, a compound synthesized by Cannabis sativa, has been found to lower blood pressure by activating alpha 2-adrenoreceptors and inhibiting norepinephrine release. These findings suggest that cannabigerol could be potentially used as a therapeutic for hypertension.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Deepak Kumar Khajuria, Vengadeshprabhu Karuppagounder, Irena Nowak, Diana E. Sepulveda, Gregory S. Lewis, Christopher C. Norbury, Wesley M. Raup-Konsavage, Kent E. Vrana, Fadia Kamal, Reyad A. Elbarbary
Summary: Bone fractures are common musculoskeletal injuries that require effective pain management. This study found that both cannabidiol (CBD) and cannabigerol (CBG) have potent analgesic effects and promote bone healing in a mouse model for tibial fracture. Therefore, CBD and CBG have the potential to be alternative therapeutic agents for managing postfracture pain.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Ester Pagano, Fabio A. Iannotti, Fabiana Piscitelli, Barbara Romano, Giuseppe Lucariello, Tommaso Venneri, Vincenzo Di Marzo, Angelo A. Izzo, Francesca Borrelli
Summary: This study found that the combination of fish oil and phytocannabinoids has a significant anti-inflammatory effect on the intestine, supporting a novel strategy for the potential treatment of inflammatory bowel disease by combining these substances.
PHYTOTHERAPY RESEARCH
(2021)
Book Review
Clinical Neurology
Arn H. Eliasson
Summary: The book extensively examines the topic of cannabinoids and sleep in 13 chapters, providing clinicians and researchers with in-depth descriptions of neurobiology and pathophysiology. It serves as a valuable reference, especially for researchers in the field.
SLEEP AND BREATHING
(2022)
Article
Chemistry, Medicinal
Yarden Lavi, Natalya M. Kogan, Louise M. Topping, Caojie Liu, Fiona E. McCann, Richard O. Williams, Aviva Breuer, Zhanna Yekhtin, Aviva Friedman Ezra, Ruth Gallily, Marc Feldmann, Raphael Mechoulam
Summary: There is growing interest in non-psychoactive phytocannabinoids, such as CBD, CBG, and CBC, as potential therapeutic agents. This study developed new derivatives by methylating positions of olivetol and evaluated their anti-inflammatory effects. The CBD derivative, 2, and the CBG derivative, 11, showed significant reduction in cytokine levels and were as potent as dexamethasone in inhibiting IL-1 beta. These new derivatives have potential as novel drug candidates for inflammatory conditions.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Vaclav Trojan, Leos Landa, Alexandra Sulcova, Jiri Sliva, Radovan Hrib
Summary: The use of cannabinoids, particularly THC and CBD, for therapeutic purposes has gained attention. THC has limitations due to its psychotropic effects and potential for dependence. CBD, on the other hand, is highlighted for its therapeutic properties without the risk of dependence.
Review
Biochemistry & Molecular Biology
Carmen Navarrete, Adela Garcia-Martin, Alain Rolland, Jim DeMesa, Eduardo Munoz
Summary: Preclinical evidence suggests that cannabinoids like CBD may have potential in treating demyelinating diseases, but further research is needed. Current studies on the use of CBD and other cannabinoids as future potential treatments are ongoing. Collaboration between researchers, clinicians, and pharmaceutical companies is crucial in bringing novel therapies to patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Orrin Devinsky, Angelica Marmanillo, Theresa Hamlin, Philip Wilken, Daniel Ryan, Conor Anderson, Daniel Friedman, George Todd
Summary: This study examined the safety and efficacy of medical cannabis formulations containing CBD and THC for the treatment of epilepsy. The results showed that there was no significant difference in seizure frequency, duration, postictal duration, or use of rescue medication compared to baseline. There was also no improvement in behavioral disorders or sleep duration. The study found that the medication was generally well tolerated, with few adverse events. However, the doses of CBD used in the study were lower than in previous studies. Larger randomized trials are needed to further investigate the efficacy of CBD:THC products for epilepsy, sleep, and behavior.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Materials Science, Multidisciplinary
Si-Heng Chen, Ting-Ting Zhang, Dong-Yang Zhu, Ning Wang, Sheng Xu, Seeram Ramakrishna, Yun-Ze Long
Summary: This study systematically characterizes the microstructure, elements distribution, and crystallinity of La0.6Sr0.4Co0.2Fe0.8O3-delta (LSCF) and BaZr0.8Y0.2O3-delta (BZY) nanofibers prepared by electrospinning. The electrochemical performance of the single cell with nanofiber cathode is significantly improved compared to traditional powder materials. The nanofiber cathode exhibits excellent permeability and faster charge transfer rate, leading to increased stability and electrochemical performance of individual cells.
ADVANCED ENGINEERING MATERIALS
(2022)
Article
Computer Science, Cybernetics
Sofia Segkouli, Dimitrios Giakoumis, Konstantinos Votis, Andreas Triantafyllidis, Ioannis Paliokas, Dimitrios Tzovaras
Summary: This study emphasizes the potential of personalized ICT solutions in improving the workability and well-being of older workers, and the need to present the risks from an ethical standpoint. The SmartFrameWorK ethics framework is proposed to address the uncertainties of workplace digitization and promote trust in digital technologies through its five-dimensional approach. Risk analysis highlights the importance of ethically aware practices for monitoring older workers' activities and behavior. Applying the SmartFrameWorK methodology in a case study provides evidence that personalized digital services can foster trust in users.
UNIVERSAL ACCESS IN THE INFORMATION SOCIETY
(2023)
Article
Computer Science, Cybernetics
Georgia Peleka, Dimitrios Sarafis, Ioannis Mariolis, Dimitrios Tzovaras
Summary: In this paper, a framework for generating photorealistic synthetic datasets using HDRI is proposed, containing all kinds of information required by computer vision algorithms. Furthermore, the framework demonstrates cross-domain knowledge transfer in a semantic segmentation scenario. It is found that deep neural networks trained with synthetic images or a combination of real and synthetic images perform equally or even better than those trained only on real images. This is the first work to successfully transfer knowledge from the synthetic domain to the real world using HDRI.
CYBERNETICS AND SYSTEMS
(2023)
Article
Computer Science, Cybernetics
Andreas Triantafyllidis, Anastasios Alexiadis, Dimosthenis Elmas, Georgios Gerovasilis, Konstantinos Votis, Dimitrios Tzovaras
Summary: Childhood obesity is a significant public health challenge that is aggravated by lifestyle changes caused by the COVID-19 pandemic. A social robot-based platform shows potential in addressing childhood obesity by implementing an interactive motivational strategy and collecting behavioral data. Preliminary results from an experimental study demonstrate children's acceptance of the platform and its effectiveness in achieving recommended health goals.
UNIVERSAL ACCESS IN THE INFORMATION SOCIETY
(2023)
Article
Pharmacology & Pharmacy
Afroditi Kapourani, Konstantina Chachlioutaki, Eleftherios G. Andriotis, Dimitrios G. Fatouros, Panagiotis Barmpalexis
Summary: This article extends previous studies by examining the processes and mechanisms involved in the preparation of HDASDs using in situ thermal crosslinking. ATR-FTIR spectroscopy revealed that the crosslinking reaction follows a different pattern at different temperatures. TGA results were consistent with the ATR-FTIR findings regarding crosslinking density and annealing temperature, but they disagreed on the progress of the annealing process. Additionally, the rheological behavior and elastic mechanical properties of the systems were investigated using molecular dynamics simulation models.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Nikolaos Kladovasilakis, Ioannis Kostavelis, Paschalis Sideridis, Eleni Koltzi, Konstantinos Piliounis, Dimitrios Tzetzis, Dimitrios Tzovaras
Summary: Soft robotic systems have been widely used in commercial applications over the last decade, particularly in tasks involving intense human-robot interaction, such as human exoskeleton applications. In this study, a fully functional soft robotic hand exoskeleton system was developed using innovative air-pressurized soft actuators manufactured via additive manufacturing technologies. The system consists of a control glove that copies the motion from the healthy hand and passes the finger configuration to the soft exoskeleton glove on the affected hand, which can move each finger independently.
APPLIED SCIENCES-BASEL
(2023)
Review
Crystallography
Rashwan Alkentar, Nikolaos Kladovasilakis, Dimitrios Tzetzis, Tamas Mankovits
Summary: Architected materials in the form of lattice structures are increasingly used in biomedical implant design to optimize biomechanical properties. The design-related parameters, such as pore size and strut thickness, of the unit cells for strut-architected materials are still under investigation for the osseointegration process and tissue regeneration. This study provides a comprehensive review of research on the optimum unit cell parameters for generating suitable lattice structures in orthopedic applications, based on in vivo and in vitro experiments, and discusses recommendations and research gaps to improve the selection process.
Article
Automation & Control Systems
Savvas Koltsakidis, Vasiliki Koidi, Angelos Lappas, Eleni Heracleous, Dimitrios Tzetzis
Summary: In this study, 3D printing method robocasting was used to manufacture woodpile monolith catalysts based on ZSM-5 zeolite. The effect of different binder concentrations on rheological, physicochemical, and mechanical properties was examined. The results showed that the printed monoliths had high surface areas, porosity, and retained the porous structure and crystalline structure of ZSM-5 crystals.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Eleni Mavrokefalou, Paraskevi Kyriaki Monou, Dimitrios Tzetzis, Nikolaos Bouropoulos, Ioannis S. Vizirianakis, Dimitrios G. Fatouros
Summary: There is currently a significant research interest in wound dressings that promote skin injury healing. These dressings protect wounds from infections and accelerate the healing process. In this study, wound healing films were created using electrospinning, a one-step process suitable for developing fibrous films that protect wounds and allow oxygenation. Sodium Alginate (SA) and Gelatin (Gel) were used as known biopolymers for their wound healing properties, and Betamethasone (Beta) was added as an anti-inflammatory agent. Imaging revealed smooth and nanosized fibers in the produced films, and physicochemical characterization confirmed the amorphous state of Beta within the polymer matrix. The wound healing properties of the films were evaluated through scratch assays, while the biocompatibility of the films was confirmed through hemolysis assays when applied to open wounds. Lastly, the hemostatic assay demonstrated the promotion of blood cell coagulation, a crucial stage in the wound healing process.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Nikolaos Kladovasilakis, Paschalis Charalampous, Apostolos Boumpakis, Theodora Kontodina, Konstantinos Tsongas, Dimitrios Tzetzis, Ioannis Kostavelis, Panagiotis Givissis, Dimitrios Tzovaras
Summary: In the past decade, the development of customizable biodegradable scaffolds and implants has gained scientific attention. Additive manufacturing technologies enable rapid production of complex implants using biodegradable polymers. This study introduces innovative designs of tibial scaffolds using architected materials and bio-inspired diffusion canals. Finite element analysis and experimental testing were conducted to evaluate the mechanical behavior of additively manufactured scaffolds. The proposed scaffold design with SD&FCC lattice structure made of PLA material exhibited the most promising performance and is recommended for further investigation and commercialization.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Multidisciplinary
Nikolaos Kladovasilakis, Theologos Bountourelis, Konstantinos Tsongas, Dimitrios Tzetzis
Summary: This paper analyzes the topology optimization (TO) processes for a tibial implant designed for additive manufacturing. Two different approaches, namely density-based and discrete-based, were compared and evaluated through finite element analysis (FEA). The study concludes that the discrete-based approach achieved a mass reduction of around 45% and offers comprehensive advantages for biomechanical application.
Article
Pharmacology & Pharmacy
Afroditi Kapourani, Katerina Kirimkiroglou, Konstantina Chachlioutaki, Maria Koromili, Christos Ritzoulis, Andreana N. Assimopoulou, Dimitrios A. Andreadis, Dimitrios G. Fatouros, Panagiotis Barmpalexis
Summary: Buccally administrated pilocarpine can be effectively controlled for xerostomia management by using in situ thermoresponsive hydrogel. The optimized sol-gel formulations formed a strong gel at temperatures in the buccal cavity, demonstrating good drug release and mucoadhesion properties.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Konstantina Chachlioutaki, Anastasia Iordanopoulou, Nikolaos Bouropoulos, Thomas Meikopoulos, Helen Gika, Christos Ritzoulis, Dimitrios Andreadis, Christina Karavasili, Dimitrios G. Fatouros
Summary: Buccal foams containing omeprazole have been developed as a potential drug delivery system for individuals with swallowing difficulties. The foams are formulated with different polymers to optimize their properties and enhance drug delivery. The study found that the foam composed of hydroxypropyl methylcellulose and alginate exhibited moderate hardness and high mucoadhesion, resulting in increased drug permeability across porcine buccal tissue.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Engineering, Environmental
Zoi Terzopoulou, Alexandra Zamboulis, Nikolaos D. Bikiaris, Antigoni Margellou, Miguel Angel Valera, Ana Mangas, Savvas Koltsakidis, Konstantinos Tsongas, Dimitrios Tzetzis, Konstantinos Triantafyllidis
Summary: This study synthesized poly(lactic acid) by the ring-opening polymerization of L-lactide using oligo(butylene succinate) as a macroinitiator. The properties of the copolymers were extensively studied, and it was found that the introduction of flexible PBSu chains affected the crystallinity and thermal stability of the copolymer. Nanoindentation results showed that the PLA-PBSu copolymers with 2.5% PBSu content had higher elasticity modulus and strength compared to other compositions. These copolymers showed promise for production using continuous reactive extrusion.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Materials Science, Composites
Michel Theodor Mansour, Konstantinos Tsongas, Dimitrios Tzetzis
Summary: The aim of this paper is to investigate the mechanical behavior of FFF 3D-printed specimens of PLA, PLA/uDiamond, and PLA/CF under various tests. It also aims to design and fabricate hierarchical honeycombs using the investigated materials and perform examination tests of their dynamic behavior. The results show that the incorporation of nanodiamonds enhances the mechanical properties of the specimens, and the second order of the PLA/uD honeycomb structure exhibits increased strength and modulus compared to the zeroth and first hierarchies.
JOURNAL OF COMPOSITES SCIENCE
(2023)
Article
Polymer Science
Johan Stanley, Eleftheria Xanthopoulou, Matjaz Finsgar, Lidija Fras Zemljic, Panagiotis A. Klonos, Apostolos Kyritsis, Savvas Koltsakidis, Dimitrios Tzetzis, Dimitra A. Lambropoulou, Diana Baciu, Theodore A. Steriotis, Georgia Charalambopoulou, Dimitrios N. Bikiaris
Summary: Poly(ethylene 2,5-furandicarboxylate) (PEF)-based nanocomposites containing Ce-bioglass, ZnO, and ZrO2 nanoparticles were synthesized via in situ polymerization, and their structures, thermal properties, and antimicrobial abilities were extensively characterized.
