Article
Polymer Science
Kinga Biedrzycka, Agnieszka Marcinkowska
Summary: In this study, the hot melt extrusion method was used to obtain an amorphous dispersion of an active pharmaceutical ingredient (API) that is sparingly soluble in water. The extrusion conditions included a screw rotation speed of 250 rpm, temperature above 100°C, and two mixing zones. The use of Eudragit EPO as a polymer matrix and ibuprofen as an API was investigated. The addition of the plasticizer Compritol 888 ATO improved processing parameters and modified the release profile of ibuprofen. The obtained solid dispersions showed good stability and released about 40% to 63% of the API within 180 minutes.
Review
Pharmacology & Pharmacy
Arun Butreddy, Dinesh Nyavanandi, Sagar Narala, Fischer Austin, Suresh Bandari
Summary: The misuse, abuse, and illicit use of prescription opioid analgesics is a global public health concern. Development of Abuse Deterrent Formulations (ADFs) using techniques like Hot-Melt Extrusion (HME) may help combat opioid abuse while ensuring safe and effective pain management.
CURRENT DRUG DELIVERY
(2021)
Article
Pharmacology & Pharmacy
Yaser Mansuroglu, Jennifer Dressman
Summary: Hot-melt extrusion is widely used in the pharmaceutical industry to increase the solubility of poorly soluble drugs. This study investigated the release of flurbiprofen from sustained-release hot-melt extrudates with different Eudragit polymers. The choice of polymer and particle size reduction by milling were found to be key factors influencing the release profile, while drug loading and hydrodynamics had minimal impact. Hot-melt extrusion allows for tailored drug release through particle size and polymer selection, with robustness under various hydrodynamic conditions.
Article
Polymer Science
Gilberto S. N. Bezerra, Tielidy A. de M. de Lima, Declan M. Colbert, Joseph Geever, Luke Geever
Summary: This study aimed to demonstrate the feasibility of using hot-melt extrusion to develop extended-release formulations of Fenbendazole dispersed in PEO/PCL blend-based matrices. The results showed that the drug converted to its amorphous state after thermal treatment, and the release rate of the drug could be controlled by adjusting the content of PCL in the blend.
Article
Engineering, Biomedical
Sama Rastpeiman, Zahra Panahi, Mohammad Akrami, Ismaeil Haririan, Maryam Asadi
Summary: The objective of this study was to use additive manufacturing to fabricate extended-release tablets of Ticagrelor for heart failure therapy. The tablets were printed using hot melt extrusion and showed good physical properties and drug release. The 3D printed tablets had a decreased release rate compared to the commercial tablets, and the drug release mechanism was affected by diffusion and swelling. Overall, this method has the potential to provide personalized medicine and improve patient adherence.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Pharmacology & Pharmacy
Siddhant Palekar, Pavan Kumar Nukala, Ketan Patel
Summary: COVID19 has caused a significant socioeconomic burden worldwide, and the opioid crisis has been further intensified in the past few years. The Food and Drug Administration (FDA) has been working tirelessly to prevent the misuse and abuse of prescription opioids, with one strategy being the development of abuse deterrent formulations (ADF). This study aimed to develop a novel 3D printed drug releasing capsule shell filled with an aversion liquid (3D-RECAL). The results showed that the capsule shell allowed for immediate release of the drug and had a deterrent effect against abuse.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Abdulmajeed A. Althobaiti, Eman A. Ashour, Mashan Almutairi, Ahmed Almotairy, Mohammed Al Yahya, Michael A. Repka
Summary: Curcumin, derived from turmeric, has various biological activities. This study successfully prepared curcumin-piperine solid dispersion using the hot-melt extrusion technique, resulting in significant improvement in the release profile of curcumin.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Leyla Rezaei, Saikishore Meruva, Maureen D. Donovan
Summary: The study evaluates different manufacturing processes for developing abuse-deterrent oral drug products and their retention of abuse-deterrent features. Direct compression showed non-uniform drug distribution, wet granulation improved drug distribution after grinding, and hot melt extrusion exhibited excellent drug content uniformity and strength. The retention of abuse-deterrent properties is influenced by product design, formulation components, and manufacturing processes.
Article
Chemistry, Medicinal
Ummarah Kanwal, Shahid Mukhtar, Muzzamil Waheed, Arifa Mehreen, Nasir Abbas, Rahat Shamim, Khalid Hussain, Fatima Rasool, Amjad Hussain, Nadeem Irfan Bukhari
Summary: The optimized fixed dose tablet formulation based on quality by design and risk assessment approach achieved differential release of AML-B and SIM over 8 hours, meeting the study objective.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Dinesh Nyavanandi, Preethi Mandati, Sagar Narala, Abdullah Alzahrani, Praveen Kolimi, Adwait Pradhan, Suresh Bandari, Michael A. Repka
Summary: The development of three-dimensional cocrystal printlets of hydrochlorothiazide (HCTZ) using hot-melt extrusion and fused deposition modeling techniques was successfully achieved. Nicotinamide was identified as a suitable coformer and cocrystal filaments were developed using polymeric carriers. Experimental results showed improved dissolution and permeability compared to pure drug.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Indrajeet Karnik, Ahmed Adel Ali Youssef, Poorva Joshi, Siva Ram Munnangi, Sagar Narala, Corinne Varner, Sateesh Kumar Vemula, Soumyajit Majumdar, Michael Repka
Summary: The study aimed to develop and evaluate a hot-melt extruded bioadhesive ophthalmic insert containing a fixed-dose combination of Prednisolone Sodium Phosphate (PSP) and Sulfacetamide Sodium (SA) for the treatment of ocular bacterial infections. The inserts were prepared using FDA-approved biocompatible polymers, and their physicochemical characteristics, drug release, permeation, and stability were assessed. The developed inserts showed prolonged release of the drugs and exhibited good bioadhesive strength and stability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Instruments & Instrumentation
Arvind Bagde, Nilkumar Patel, Ketan Patel, Ebony Nottingham, Mandip Singh
Summary: The study successfully developed a sustained release formulation of noscapine HCl using Eudragit RLPO, citric acid, and hot melt extrusion technique to achieve pH-independent drug release. The formulation showed high drug recovery, improved bioavailability, and sustained plasma concentration compared to the solution form. The findings suggest that hot melt extrusion can enhance the bioavailability and solubility of weakly basic drugs like noscapine HCl.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Phuong H. L. Tran, Beom-Jin Lee, Thao T. D. Tran
Summary: Hot-melt extrusion is a promising method for the preparation of drug delivery systems on an industrial scale, but there is still a lack of research on its recent progress and influencing factors. This review discusses the effects of hot-melt extrusion on various factors in solid dispersion systems and describes the use of molecular interactions to improve drug stability.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Sooyeon Chung, Priyanka Srinivasan, Peilun Zhang, Suresh Bandari, Michael A. Repka
Summary: This study aims to print ibuprofen tablets with high release rate by using Polyox WSR N80 as the main matrix and adding release modifiers. It is found that soluble Kollidon grades, such as Kollidon VA64 and Kollidon 12PF, can enhance the drug release rate. The tablet design with a high surface-to-mass ratio is beneficial for increasing the drug release rate.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Saurabh M. Mishra, Margarethe Richter, Luis Mejia, Andreas Sauer
Summary: The downstream processing of hot-melt extruded amorphous solid dispersions (ASDs) into tablets is challenging. This study systematically investigates the milling and tableting processes of an extruded ASD of itraconazole with hypromellose acetate succinate (HPMCAS) as a carrier polymer. The study shows that the critical quality attributes (CQAs) of the milled ASD, such as yield, mean particle size, tablet compaction characteristics, and tablet dissolution, are affected by sizing technology, milling speed, and screen size.
Article
Pharmacology & Pharmacy
Pavan Kumar Nukala, Siddhant Palekar, Manali Patki, Ketan Patel
Article
Pharmacology & Pharmacy
Siddhant Palekar, Pavan Kumar Nukala, Saurabh M. Mishra, Thomas Kipping, Ketan Patel
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Pharmacology & Pharmacy
Pavan Kumar Nukala, Siddhant Palekar, Manali Patki, Yige Fu, Ketan Patel
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Pharmacology & Pharmacy
Hemanth K. Mamidi, Siddhant Palekar, Pavan Kumar Nukala, Saurabh M. Mishra, Manali Patki, Yige Fu, Piyush Supner, Gautam Chauhan, Ketan Patel
Summary: This study aimed to optimize the melt granulation process of fenofibrate using twin-screw granulator. By utilizing a factorial design, the optimal processing conditions for high yield and low friability of granules were determined. The solid-state characterization of the optimized granules showed a transition of the drug from crystalline to amorphous state during the melt granulation process, leading to >85% drug release within 60 min in a 0.75% SLS solution.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Siddhant Palekar, Pavan Kumar Nukala, Ketan Patel
Summary: COVID19 has caused a significant socioeconomic burden worldwide, and the opioid crisis has been further intensified in the past few years. The Food and Drug Administration (FDA) has been working tirelessly to prevent the misuse and abuse of prescription opioids, with one strategy being the development of abuse deterrent formulations (ADF). This study aimed to develop a novel 3D printed drug releasing capsule shell filled with an aversion liquid (3D-RECAL). The results showed that the capsule shell allowed for immediate release of the drug and had a deterrent effect against abuse.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Srushti Tambe, Divya Jain, Sai Kishore Meruva, Gopinath Rongala, Abhishek Juluri, Girish Nihalani, Hemanth Kumar Mamidi, Pavan Kumar Nukala, Pradeep Kumar Bolla
Summary: Amorphous solid dispersions (ASDs) are widely studied techniques for enhancing solubility. The formulation development of ASDs has progressed significantly since the 1960s, with advancements in preparation methods and characterization techniques. Multiple carriers and plasticizers are now used to improve the stability and performance of ASDs. Modern techniques such as nano-tomography and transmission electron microscopy aid in understanding the microstructure of ASDs.
Review
Biochemistry & Molecular Biology
Vrinda Gote, Pradeep Kumar Bolla, Nagavendra Kommineni, Arun Butreddy, Pavan Kumar Nukala, Sushesh Srivatsa Palakurthi, Wahid Khan
Summary: mRNA vaccines have emerged as a powerful alternative to traditional vaccines, showing high potency, safety, and efficacy. The advancements in nanotechnology for delivery vehicles have played a significant role in the development of mRNA vaccines. This article provides a comprehensive summary of mRNA vaccines, including their structure, pharmacological function, lipid nanoparticles (LNPs), manufacturing process, and clinical trials. Future perspectives on mRNA vaccines, such as freeze-drying, delivery systems, and LNPs targeting antigen-presenting cells and dendritic cells, are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Siddhant Palekar, Pavan Kumar Nukala, Richa Vartak, Ketan Patel
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)