Journal
BIOSENSORS-BASEL
Volume 10, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/bios10090122
Keywords
SERS; silver; adenine; plasmon; Raman scattering; copper; pH
Funding
- Ministry of Science and Technology, Taiwan [MOST-106-2221-E-006-173-MY3, MOST-105-2221-E-006-057-MY3, MOST-108-2119-M-010-001-]
- Ministry of Science and Technology (MOST), Taiwan
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Adenine is an important molecule for biomedical and agricultural research and applications. The detection of low concentration adenine molecules is thus desirable. Surface-enhanced Raman scattering (SERS) is a promising label-free detection and fingerprinting technique for molecules of significance. A novel SERS sensor made of clusters of silver nanostructures deposited on copper bumps in valleys of an etched silicon substrate was previously reported to exhibit a low and reproducible detection limit for a 10(-11) M neutral adenine aqueous solution. Reflection of laser illumination from the silicon surface surrounding a valley provides additional directions of laser excitation to adenine molecules adsorbing on a silver surface for the generation of enhanced SERS signal strength leading to a low detection limit. This paper further reports a concentration dependent shift of the ring-breathing mode SERS adenine peak towards 760 cm(-1) with decreasing concentration and its pH-dependent SERS signal strength. For applications, where the pH value can vary, reproducible detection of 10(-12) M adenine in a pH 9 aqueous solution is feasible, making the novel SERS structure a desirable pico-molar adenine sensor.
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