Obesity and binge alcohol intake are deadly combination to induce steatohepatitis: A model of high-fat diet and binge ethanol intake

Inflammatory pathways in alcoholic steatohepatitis

(2019) Bin Gao et al.   JOURNAL OF HEPATOLOGY

Adipocyte Death Preferentially Induces Liver Injury and Inflammation Through the Activation of Chemokine (C‐C Motif) Receptor 2‐Positive Macrophages and Lipolysis

(2019) Seung‐Jin Kim et al.   HEPATOLOGY

How does your fat affect your liver when you drink?

(2019) Seonghwan Hwang et al.   JOURNAL OF CLINICAL INVESTIGATION

Past, present and future perspectives in nonalcoholic fatty liver disease

(2019) Arun J. Sanyal   Nature Reviews Gastroenterology & Hepatology

Report on the AASLD/EASL Joint Workshop on Clinical Trial Endpoints in NAFLD

(2019) Mary E. Rinella et al.   HEPATOLOGY

Low levels of alcohol consumption, obesity and development of fatty liver with and without evidence of advanced fibrosis

(2019) Yoosoo Chang et al.   HEPATOLOGY

Risks of light and moderate alcohol use in fatty liver disease – follow‐up of population cohorts

(2019) Fredrik Åberg et al.   HEPATOLOGY

Obesity in acute alcoholic hepatitis increases morbidity and mortality

(2019) Richard Parker et al.   EBioMedicine

γδ T cells Promote Steatohepatitis by Orchestrating Innate and Adaptive Immune Programming

(2019) Alejandro Torres‐Hernandez et al.   HEPATOLOGY

Moderate alcohol use in fatty liver disease; don’t throw the cabernet out with the bathwater

(2019) Paul Gow et al.   HEPATOLOGY

Interleukin‐22 ameliorates neutrophil‐driven nonalcoholic steatohepatitis through multiple targets

(2019) Seonghwan Hwang et al.   HEPATOLOGY

γδT cells and CD1d, novel immune players in alcoholic and nonalcoholic steatohepatitis?

(2019) Xiaolin Wang et al.   HEPATOLOGY

A Hepatocyte-Mimicking Antidote for Alcohol Intoxication

(2018) Duo Xu et al.   ADVANCED MATERIALS

Among Patients With Nonalcoholic Fatty Liver Disease, Modest Alcohol Use Is Associated With Less Improvement in Histologic Steatosis and Steatohepatitis

(2018) Veeral Ajmera et al.   Clinical Gastroenterology and Hepatology

Fibrosis Severity as a Determinant of Cause-Specific Mortality in Patients With Advanced Nonalcoholic Fatty Liver Disease

(2018) Eduardo Vilar-Gomez et al.   GASTROENTEROLOGY

Non-heavy drinking and worsening of non-invasive fibrosis markers in nonalcoholic fatty liver disease: A cohort study

(2018) Yoosoo Chang et al.   HEPATOLOGY

A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer

(2018) Takuma Tsuchida et al.   JOURNAL OF HEPATOLOGY

Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies

(2018) Angela M Wood et al.   LANCET

Effect of moderate alcohol consumption on liver enzymes increases with increasing body mass index

(2018) Päivikki I Alatalo et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effect of alcohol consumption on survival in non-alcoholic fatty liver disease: a national prospective cohort study

(2018) Kaveh Hajifathalian et al.   HEPATOLOGY

Effects of Moderate Alcohol Drinking in Patients with Nonalcoholic Fatty Liver Disease

(2018) Inbeom Kwon et al.   Gut and Liver

Mouse models of nonalcoholic steatohepatitis Towards optimization of their relevance to human NASH

(2018) Geoff Farrell et al.   HEPATOLOGY

Alcohol Use and Cardiovascular Disease Risk in Patients With Nonalcoholic Fatty Liver Disease

(2017) Lisa B. VanWagner et al.   GASTROENTEROLOGY

Is moderate alcohol use in nonalcoholic fatty liver disease good or bad? A critical review

(2017) Veeral H. Ajmera et al.   HEPATOLOGY

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Alcohol, adipose tissue and liver disease: mechanistic links and clinical considerations

(2017) Richard Parker et al.   Nature Reviews Gastroenterology & Hepatology

Chronic Alcohol Consumption Causes Liver Injury in High-Fructose-Fed Male Mice Through Enhanced Hepatic Inflammatory Response

(2016) Ming Song et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

A Mechanistic Review of Cell Death in Alcohol-Induced Liver Injury

(2016) Shaogui Wang et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Hepatic Peroxisome Proliferator-Activated Receptor Gamma Signaling Contributes to Alcohol-Induced Hepatic Steatosis and Inflammation in Mice

(2016) Wenliang Zhang et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Inflammation in Alcoholic and Nonalcoholic Fatty Liver Disease: Friend or Foe?

(2016) Bin Gao et al.   GASTROENTEROLOGY

PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD

(2016) Barbara Gross et al.   Nature Reviews Endocrinology

Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans

(2015) Ming-Jiang Xu et al.   GASTROENTEROLOGY

Short- or long-term high-fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: An important role for CXCL1

(2015) Binxia Chang et al.   HEPATOLOGY

Roles of alcohol consumption in fatty liver: A longitudinal study

(2015) Akio Moriya et al.   JOURNAL OF HEPATOLOGY

Liver Fibrosis in Alcoholic Liver Disease

(2015) Bin Gao et al.   SEMINARS IN LIVER DISEASE

Effect of multiple binge alcohol on diet-induced liver injury in a mouse model of obesity

(2015) A M P Duly et al.   Nutrition & Diabetes

Homeostatic Regulation of Blood Neutrophil Counts

(2014) S. von Vietinghoff et al.   JOURNAL OF IMMUNOLOGY

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(2014) Takahiro Minato et al.   MOLECULAR MEDICINE

Combination of Alcohol and Fructose Exacerbates Metabolic Imbalance in Terms of Hepatic Damage, Dyslipidemia, and Insulin Resistance in Rats

(2014) Salamah Mohammad Alwahsh et al.   PLoS One

Modest alcohol consumption decreases the risk of non-alcoholic fatty liver disease: a meta-analysis of 43 175 individuals

(2013) Silvia Sookoian et al.   GUT

Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: A critical role for E-selectin

(2013) Adeline Bertola et al.   HEPATOLOGY

An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis

(2013) Masahiko Matsumoto et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Influence of the CXCL1 rs4074 A Allele on Alcohol Induced Cirrhosis and HCC in Patients of European Descent

(2013) Hans Dieter Nischalke et al.   PLoS One

Ethanol administration exacerbates the abnormalities in hepatic lipid oxidation in genetically obese mice

(2012) Hannah Everitt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient elastography

(2011) Vincent Wai-Sun Wong et al.   GUT

Identification of a Cytochrome P4502E1/Bid/C1q-dependent Axis Mediating Inflammation in Adipose Tissue after Chronic Ethanol Feeding to Mice

(2011) Becky M. Sebastian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK

(2011) Jun Xu et al.   JOURNAL OF HEPATOLOGY

A cohort study of the effect of alcohol consumption and obesity on serum liver enzyme levels

(2010) Zhe Shen et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Hepatic Expression Patterns of Inflammatory and Immune Response Genes Associated with Obesity and NASH in Morbidly Obese Patients

(2010) Adeline Bertola et al.   PLoS One

Hepatic Expression of CXC Chemokines Predicts Portal Hypertension and Survival in Patients With Alcoholic Hepatitis

(2009) Marlene Dominguez et al.   GASTROENTEROLOGY

Clinical trial: pilot study of metformin for the treatment of non-alcoholic steatohepatitis

(2008) R. LOOMBA et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Modest wine drinking and decreased prevalence of suspected nonalcoholic fatty liver disease

(2008) Winston Dunn et al.   HEPATOLOGY