Curcumin Diglutaric Acid, a Prodrug of Curcumin Reduces Pain Hypersensitivity in Chronic Constriction Injury of Sciatic Nerve Induced-Neuropathy in Mice

Synthesis, pharmacological profile and 2D-QSAR studies of curcumin-amino acid conjugates as potential drug candidates

(2020) Siva S. Panda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Curcumin diethyl disuccinate, a prodrug of curcumin, enhances anti-proliferative effect of curcumin against HepG2 cells via apoptosis induction

(2019) Chawanphat Muangnoi et al.   Scientific Reports

A curcumin-diglutaric acid conjugated prodrug with improved water solubility and antinociceptive properties compared to curcumin

(2018) Chawanphat Muangnoi et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

WWL70 protects against chronic constriction injury-induced neuropathic pain in mice by cannabinoid receptor-independent mechanisms

(2018) Jie Wen et al.   Journal of Neuroinflammation

Astaxanthin ameliorates behavioral and biochemical alterations in in-vitro and in-vivo model of neuropathic pain

(2018) Kuhu Sharma et al.   NEUROSCIENCE LETTERS

Minocycline as a promising therapeutic strategy for chronic pain

(2018) Ya-Qun Zhou et al.   PHARMACOLOGICAL RESEARCH

Role of curcumin in the management of pathological pain

(2018) Jia Sun et al.   PHYTOMEDICINE

Rosmarinic acid attenuates development and existing pain in a rat model of neuropathic pain: An evidence of anti-oxidative and anti-inflammatory effects

(2018) Mahboobeh Ghasemzadeh Rahbardar et al.   PHYTOMEDICINE

Comparison of the effects of curcumin, tramadol and surgical treatments on neuropathic pain induced by chronic constriction injury in rat

(2017) Dilek Ceyhan et al.   Turkish Neurosurgery

Neuropathic pain

(2017) Luana Colloca et al.   Nature Reviews Disease Primers

Enhanced Expression of TREK-1 Is Related with Chronic Constriction Injury of Neuropathic Pain Mouse Model in Dorsal Root Ganglion

(2016) Hyo Jo Han et al.   Biomolecules & Therapeutics

Acetal-linked polymeric prodrug micelles for enhanced curcumin delivery

(2016) Man Li et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Enhancement of Curcumin Bioavailability Via the Prodrug Approach: Challenges and Prospects

(2016) Pahweenvaj Ratnatilaka Na Bhuket et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Synthesis and in vitro Toxicity ofd-Glucose andd-Fructose Conjugated Curcumin-Ruthenium Complexes

(2016) Michael Pröhl et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Repeated activation of delta opioid receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain

(2016) Nunzio Vicario et al.   Molecular Pain

Pain regulation by non-neuronal cells and inflammation

(2016) R.-R. Ji et al.   SCIENCE

Curcumin ameliorates neuropathic pain by down-regulating spinal IL-1β via suppressing astroglial NALP1 inflammasome and JAK2-STAT3 signalling

(2016) Shenbin Liu et al.   Scientific Reports

Pharmacokinetics of Curcumin Diethyl Disuccinate, a Prodrug of Curcumin, in Wistar Rats

(2015) Kunan Bangphumi et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Spinal glial activation and oxidative stress are alleviated by treatment with curcumin or coenzyme Q in sickle mice

(2015) Y. Valverde et al.   HAEMATOLOGICA

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

(2015) Nanna B Finnerup et al.   LANCET NEUROLOGY

Acidosis Mediates the Switching of Gs-PKA and Gi-PKCε Dependence in Prolonged Hyperalgesia Induced by Inflammation

(2015) Wei-Yu Huang et al.   PLoS One

Spinal glial activation and oxidative stress are alleviated by treatment with curcumin or coenzyme Q in sickle mice

(2015) Y. Valverde et al.   HAEMATOLOGICA

Effects of curcumin on pain threshold and on the expression of nuclear factor κ B and CX3C receptor 1 after sciatic nerve chronic constrictive injury in rats

(2014) Hong Cao et al.   Chinese Journal of Integrative Medicine

Curcumin modulates TLR4/NF-κB inflammatory signaling pathway following traumatic spinal cord injury in rats

(2014) Hongbin Ni et al.   JOURNAL OF SPINAL CORD MEDICINE

HDAC and HAT Inhibitors Differently Affect Analgesia Mediated by Group II Metabotropic Glutamate Receptors

(2014) Magda Zammataro et al.   Molecular Pain

Minocycline improves peripheral and autonomic neuropathy in type 2 diabetes: MIND study

(2014) Ashit Syngle et al.   NEUROLOGICAL SCIENCES

Effect of curcumin in mice model of vincristine-induced neuropathy

(2014) Anand Babu et al.   PHARMACEUTICAL BIOLOGY

Curcumin Alleviates Neuropathic Pain by Inhibiting p300/CBP Histone Acetyltransferase Activity-Regulated Expression of BDNF and Cox-2 in a Rat Model

(2014) Xiaoyan Zhu et al.   PLoS One

Curcumin Could Prevent the Development of Chronic Neuropathic Pain in Rats with Peripheral Nerve Injury

(2013) Younghoon Jeon et al.   CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL

Curcumin acts via transient receptor potential vanilloid-1 receptors to inhibit gut nociception and reverses visceral hyperalgesia

(2013) L. Zhi et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Curcumin loaded NLC induces histone hypoacetylation in the CNS after intraperitoneal administration in mice

(2012) Carmelo Puglia et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

(2012) Paul J. Austin et al.   Jove-Journal of Visualized Experiments

Synthesis, Characterization and Biological Evaluation of Succinate Prodrugs of Curcuminoids for Colon Cancer Treatment

(2011) Wisut Wichitnithad et al.   MOLECULES

Curcumin exerts antinociceptive effects in a mouse model of neuropathic pain: Descending monoamine system and opioid receptors are differentially involved

(2011) Xin Zhao et al.   NEUROPHARMACOLOGY

Interactions between the immune and nervous systems in pain

(2010) Ke Ren et al.   NATURE MEDICINE

Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid

(2009) Ramendra K. Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Curcumin Produces an Antihyperalgesic Effect via Antagonism of TRPV1

(2009) K.Y. Yeon et al.   JOURNAL OF DENTAL RESEARCH

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1 , Interleukin-6, and Tumor Necrosis Factor-  in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

(2008) Y. Kawasaki et al.   JOURNAL OF NEUROSCIENCE