Journal
BIOMEDICINES
Volume 8, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines8100440
Keywords
ALS; zebrafish; C9orf72; motoneuron
Categories
Funding
- Fondation Armand-Frappier
- ALS Canada-Brain Canada Career Transition Award
- Canadian Foundation for Innovation (CFI)
- Canadian Institutes of Health Research (CIHR)
- Natural Science and Engineering Research Council (NSERC)
- NSERC
- FRQS
- CERMO-FC scholarship
- Anna Sforza Djoukhadjian research chair in ALS
Ask authors/readers for more resources
A hexanucleotide repeat expansion within the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and its discovery has revolutionized our understanding of this devastating disease. Model systems are a valuable tool for studying ALS pathobiology and potential therapies. The zebrafish (Danio rerio) has particularly become a useful model organism to study neurological diseases, including ALS, due to high genetic and physiological homology to mammals, and sensitivity to various genetic and pharmacological manipulations. In this review we summarize the zebrafish models that have been used to study the pathology of C9orf72-related ALS. We discuss their value in providing mechanistic insights and their potential use for drug discovery.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
