Journal
CYTOMETRY PART A
Volume 89A, Issue 8, Pages 755-760Publisher
WILEY
DOI: 10.1002/cyto.a.22885
Keywords
drug discovery; antimicrobial; antiprotozoal; screening; hit identification; chemical biology
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Funding
- Singapore Ministry of Health's National Medical Research Council under its Cooperative Basic Research Grant [NMRC/CBRG/0083/2015]
- Lee Kong Chian School of Medicine, Nanyang Technological University Start-Up Grant
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Originally developed to study fundamental aspects of cellular biology, high-content imaging (HCI) was rapidly adapted to study host-pathogen interactions at the cellular level and adopted as a technology of choice to unravel disease biology. HCI platforms allow for the visualization and quantification of discrete phenotypes that cannot be captured using classical screening approaches. A key advantage of high-content screening technologies lies in the possibility to develop and interrogate physiologically significant, predictive ex vivo disease models that reproduce complex conditions relevant for infection. Here we review and discuss recent advances in HCI technologies and chemical biology approaches that are contributing to an increased understanding of the intricate host-pathogen interrelationship on the cellular level, and which will foster the development of novel therapeutic approaches for the treatment of human bacterial and protozoan infections. (C) 2016 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of ISAC
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