Article
Health Care Sciences & Services
Michael Strug, Lusine Aghajanova
Summary: The uterus is a homeostatic organ that responds to ovarian steroid hormones and prepares the endometrium for embryo implantation. Dysfunction in endometrial repair and regeneration can lead to infertility and abnormal menses. Mesenchymal stem cells have regenerative and immunomodulatory properties and have been investigated for therapeutic purposes in abnormal endometrium.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Hyun-Ji Park, Jessica R. Hoffman, Milton E. Brown, Sruti Bheri, Olga Brazhkina, Young Hoon Son, Michael E. Davis
Summary: Small extracellular vesicles (sEVs) play a critical role in cardiac cell therapy by delivering molecular cargo and mediating cellular signaling. Knocking down miR-192-5p and miR-432-5p in cardiac c-kit+ cell-derived sEVs enhances their therapeutic capabilities and improves cardiac function, reducing fibrosis and necrotic inflammatory responses. This study suggests that targeting deleterious miRNAs in sEVs could be a promising therapeutic strategy for chronic myocardial infarction.
Article
Cell & Tissue Engineering
Francesco Da Ros, Luca Persano, Dario Bizzotto, Mariagrazia Michieli, Paola Braghetta, Mario Mazzucato, Paolo Bonaldo
Summary: This study investigates the mechanisms involved in the regulation of the bone marrow microenvironment through cell-cell and cell-matrix contacts. The researchers identified Emilin-2 as an important component of the extracellular matrix in the bone marrow. Emilin-2 expression and secretion by bone marrow mesenchymal stem cells were found to inhibit adipogenic differentiation. Additionally, the deficiency of Emilin-2 was found to impair the frequency of hematopoietic stem/progenitor cells in the bone marrow. These findings provide new insights into the role of the bone marrow extracellular matrix microenvironment in the regulation of stem cell niches and hematopoietic progenitor differentiation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Health Care Sciences & Services
Cheng-Feng Chu, Shih-Hsuan Mao, Victor Bong-Hang Shyu, Chih-Hao Chen, Chien-Tzung Chen
Summary: The study found that allogeneic BMSCs can promote bone regeneration to some extent and gradually match the efficacy of autologous BMSCs after a period of time. In terms of immune response, allogeneic BMSCs caused a weaker immune response in vivo and the bone regeneration effects gradually matched those of autologous BMSCs.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Health Care Sciences & Services
Suncica Kapor, Milica Vukotic, Tijana Suboticki, Dragoslava Dikic, Olivera Mitrovic Ajtic, Milica Radojkovic, Vladan P. Cokic, Juan F. Santibanez
Summary: The study found that HU inhibits the growth of BMMSC, causing senescence-like changes and affecting cellular differentiation and immunoregulatory functions.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Pascal Fichtel, Malte von Bonin, Robert Kuhnert, Kristin Moebus, Martin Bornhaeuser, Manja Wobus
Summary: Aging of the hematopoietic system is characterized by an expansion of hematopoietic stem and progenitor cells (HSPCs) with reduced capacity for engraftment, self-renewal, and lymphoid differentiation, resulting in myeloid-biased hematopoiesis.
The communication between HSPCs and MSCs is mediated by direct cell-cell contacts or extracellular vesicles (EVs) that carry bioactive substances. Aging MSCs secrete fewer miRNAs, but aged MSC-EVs contain higher levels of specific miRNAs such as miR-29a and miR-34a. Young EVs enhance the cell number and viability of HSPCs, while aged MSC-EVs promote the differentiation of HSPCs into erythroid and erythroid-megakaryocytic progenitor cells. The therapeutic relevance of MSC-derived EVs in modulating HSPC characteristics needs further investigation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Tiemei Li, Xiaotao Su, Pinglan Lu, Xinmei Kang, Mengyan Hu, Chunyi Li, Shisi Wang, Danli Lu, Shishi Shen, Huipeng Huang, Yuxin Liu, Xiaohui Deng, Wei Cai, Lei Wei, Zhengqi Lu
Summary: Pneumonia is a common cause of death in patients with acute ischemic stroke (AIS), and antibiotics are not effective in improving the prognosis due to the negative impact on the immune system. However, a recent study found that bone marrow mesenchymal stem cells (BM-MSC) can reduce bacterial load in the lungs of stroke mice, and this is achieved by modulating the activities of pulmonary macrophages. The study also identified that BM-MSC releases migrasomes, which contain the antibacterial peptide dermcidin (DCD) and enhance the phagocytosis of macrophages.
Article
Cell & Tissue Engineering
Jeroen van de Peppel, Gerben J. Schaaf, Adriana Arruda Matos, Yuan Guo, Tanja Strini, Wenda Verschoor, Amel Dudakovic, Andre J. van Wijnen, Johannes P. T. M. van Leeuwen
Summary: This research suggests that the cell surface glycoprotein CD24 could serve as a selective biomarker for identifying subpopulations of BMSCs with varying osteogenic potential. CD24(pos) cells have increased expression of genes related to cell adhesion, motility, and extracellular matrix, while also showing reduced proliferation compared to CD24(neg) cells.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Cell & Tissue Engineering
Shan Yang, Yingying Su, Xiaoyan Li, Hao Wang, Juan Du, Jie Feng, Yongmei Xie, Zhenhua Luo, Junji Xu, Lijia Guo, Yi Liu
Summary: The decline of hydrogen sulfide (H2S) levels in bone marrow mesenchymal stem cells (BMMSCs) with age leads to cell senescence. However, increasing H2S levels can inhibit cell aging and prevent bone loss in vivo, providing new insights for stem cell therapies in elderly people.
Article
Biotechnology & Applied Microbiology
Anri Koyanagi, Iichiroh Onishi, Karin Muraoka, Ikue Sato, Shingo Sato, Tsuyoshi Kimura, Akio Kishida, Kouhei Yamamoto, Masanobu Kitagawa, Morito Kurata
Summary: Hematopoiesis is maintained by the interaction of hematopoietic stem cells and bone marrow mesenchymal stem cells in bone marrow microenvironments. Certain genetic mutations in the mesenchymal stem cells can lead to hematopoietic neoplasms. This study used a specific gene mutation in human mesenchymal stem cells and a bone scaffold to create an in vivo bone marrow microenvironment model, providing insights into these interactions and disease onset.
BIOENGINEERING-BASEL
(2022)
Retraction
Biochemistry & Molecular Biology
Sabine Wislet-Gendebien, Emerence Laudet, Virginie Neirinckx, Philippe Alix, Pierre Leprince, Aneta Glejzer, Christophe Poulet, Benoit Hennuy, Lukas Sommer, Olga Shakhova, Bernard Rogister
Summary: A correction to this paper has been published.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biophysics
Zimo Zhou, Da Liu
Summary: Porous tantalum-based biomaterials have been widely used in bone defect repair due to their unique properties and excellent biocompatibility. BMSCs, as an important type of stem cells, have shown great potential in regulating the effects of porous tantalum. This study reviews the characteristics of porous tantalum-based biomaterials and the regulatory mechanisms on BMSCs, and discusses the feasibility of seeding BMSCs in porous tantalum-based biomaterials for tissue repair.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Cell & Tissue Engineering
K. Futrega, E. Music, P. G. Robey, S. Gronthos, R. Crawford, S. Saifzadeh, T. J. Klein, M. R. Doran
Summary: The study characterized ovine BMSC and evaluated their ability to repair cartilage defects, concluding that micro-pellets manufactured from ovine articular chondrocytes were more effective than those from ovine BMSC. While ovine BMSC could form cartilage-like tissue in vitro, their effective application in cartilage repair will require successful mitigation of hypertrophy and tissue integration issues.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, General & Internal
Hideaki Kagami, Minoru Inoue, Hideki Agata, Izumi Asahina, Tokiko Nagamura-Inoue, Masataka Taguri, Arinobu Tojo
Summary: By optimizing the cell-processing protocol, stable bone regeneration can be achieved with comparable quality and less fluctuation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Wen-Ya Lin, Kang-Hsi Wu, Chun-Yu Chen, Bei-Cyuan Guo, Yu-Jun Chang, Tai-An Lee, Mao-Jen Lin, Han-Ping Wu
Summary: Pediatric traumatic brain injury is a significant cause of mortality, and stem cell therapy has emerged as a potential treatment option. However, further research is needed to understand the mechanisms, types, optimal timing, combination with concurrent medical treatment, and patient selection criteria of effective stem cell therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Elaine R. Garvican, Mazdak Salavati, Roger K. W. Smith, Jayesh Dudhia
CONNECTIVE TISSUE RESEARCH
(2017)
Article
Veterinary Sciences
R. E. Edmonds, E. R. Garvican, R. K. W. Smith, J. Dudhia
EQUINE VETERINARY JOURNAL
(2017)
Article
Medicine, Research & Experimental
Salvatore Santamaria, Oleg Fedorov, John McCafferty, Gillian Murphy, Jayesh Dudhia, Hideaki Nagase, Kazuhiro Yamamoto
Editorial Material
Biochemical Research Methods
Janina Burk, Walter Brehm, Roger K. Smith, Jayesh Dudhia
Article
Cell & Tissue Engineering
Mohammad R. Khan, Jayesh Dudhia, Frederic H. David, Roberta De Godoy, Vedika. Mehra, Gillian Hughes, Stephanie G. Dakin, Andrew J. Carr, Allen E. Goodship, Roger K. W. Smith
STEM CELL RESEARCH & THERAPY
(2018)
Article
Orthopedics
Mohammad R. Khan, Roger K. Smith, Frederic David, Richard Lam, Gillian Hughes, Roberta DeGodoy, Andrew J. Carr, Allen E. Goodship, Jayesh Dudhia
JOURNAL OF ORTHOPAEDIC RESEARCH
(2020)
Article
Cell & Tissue Engineering
Mohammad R. Khan, Nicola Mordan, Mohamed Parkar, Vehid Salih, Nikolaos Donos, Peter M. Brett
STEM CELLS INTERNATIONAL
(2019)
Editorial Material
Veterinary Sciences
E. Kelly, R. Smith, J. Dudhia, R. G. A. Faragher
EQUINE VETERINARY JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Roger Smith, Patrik Onnerfjord, Kristin Holmgren, Shacko di Grado, Jayesh Dudhia
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Mustafa Rashid, Jayesh Dudhia, Stephanie G. Dakin, Sarah J. B. Snelling, Roberta De Godoy, Pierre-Alexis Mouthuy, Roger K. W. Smith, Mark Morrey, Andrew J. Carr
SCIENTIFIC REPORTS
(2020)
Article
Dermatology
Samuel C. Bizley, Jayesh Dudhia, Roger K. W. Smith, Adrian C. Williams
Summary: The study compared the structural composition and barrier properties of equine skin and found anatomical location differences in skin structure and small molecule permeability, which can aid in the development of transdermal therapies for horses.
VETERINARY DERMATOLOGY
(2023)
Article
Biochemical Research Methods
Luke C. Dutton, Sophie A. V. Church, Hannah Hodgkiss-Geere, Brian Catchpole, Anthony Huggins, Jayesh Dudhia, David J. Connolly
Article
Biochemistry & Molecular Biology
Mark Fields, Nicholas Spencer, Jayesh Dudhia, Paul F. McMillan