Article
Oncology
Alessandro Coppola, Vincenzo La Vaccara, Michele Fiore, Tommaso Farolfi, Sara Ramella, Silvia Angeletti, Roberto Coppola, Damiano Caputo
Summary: In patients with resectable pancreatic ductal adenocarcinoma, preoperative CA19-9 levels can predict nodal involvement and help in deciding on neoadjuvant treatments.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Laura Maggino, Giuseppe Malleo, Stefano Crippa, Giulio Belfiori, Sara Nobile, Giulia Gasparini, Gabriella Lionetto, Claudio Luchini, Paola Mattiolo, Marco Schiavo-Lena, Claudio Doglioni, Aldo Scarpa, Claudio Bassi, Massimo Falconi, Roberto Salvia
Summary: This study investigated the incidence and pattern of recurrence in patients with initially resectable and borderline resectable pancreatic ductal adenocarcinoma who received post-neoadjuvant pancreatectomy. The results showed that preoperative tumor size <20 mm, normal posttreatment CA19.9 and Delta CA19.9 > 50% were associated with longer recurrence-free survival (RFS) in these patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Biophysics
Guichun Mo, Xuanming He, Dongmiao Qin, Shuo Meng, Yusheng Wu, Biyang Deng
Summary: A new ECL immunosensor based on spatially-resolved dual-potential technology was developed for simultaneous detection of CA 19-9 and CA 242, showing high selectivity and stability in real sample analysis.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Gastroenterology & Hepatology
Sarang Hong, Ki Byung Song, Dae Wook Hwang, Jae Hoon Lee, Woohyung Lee, Eunsung Jun, Jaewoo Kwon, Yejong Park, Seo Young Park, Naru Kim, Dakyum Shin, Hyeyeon Kim, Minkyu Sung, Yunbeom Ryu, Song Cheol Kim
Summary: This study identified high CA 19-9 levels, larger tumor size, poor differentiation, and lack of adjuvant chemotherapy as significant risk factors for early recurrence in early-stage PDAC patients. Early identification of high-risk patients and recommending adjuvant chemotherapy are crucial for preventing early recurrence in PDAC.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Guopei Luo, Kaizhou Jin, Shengming Deng, He Cheng, Zhiyao Fan, Yitao Gong, Yunzhen Qian, Qiuyi Huang, Quanxing Ni, Chen Liu, Xianjun Yu
Summary: CA19-9 is a well-validated biomarker in pancreatic cancer, playing roles as a biomarker, predictor, and promoter. It has screening potential when used with symptoms and risk factors, although challenges include false results in certain conditions. It can also accelerate pancreatic cancer progression through glycosylation, binding to proteins, and enhancing angiogenesis.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Oncology
Timothy P. DiPeri, Timothy E. Newhook, Laura R. Prakash, Naruhiko Ikoma, Jessica E. Maxwell, Michael P. Kim, Jeffrey E. Lee, Matthew H. G. Katz, Ching-Wei D. Tzeng
Summary: This study compared the normalization of serum carbohydrate 19-9 (CA19-9) levels before and after surgery in patients with pancreatic adenocarcinoma (PDAC) who underwent neoadjuvant therapy (NT) versus surgery-first (SF). The results showed that normal pre/postoperative CA19-9 was associated with better recurrence-free survival (RFS) and overall survival (OS). Nearly 30% of SF patients failed to achieve postoperative CA19-9 normalization. NT should be considered for patients with elevated CA19-9 levels, and ideal SF patients may have normal CA19-9 levels at presentation.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Marton Benke, Nelli Farkas, Peter Hegyi, Benedek Tinusz, Patricia Sarlos, Balint Eross, Kata Szemes, Nora Voerhendi, Zsolt Szakacs, Akos Szuecs
Summary: This study investigated the relationship between preoperative serum carbohydrate antigen 19-9 levels and surgical resectability in pancreatic ductal adenocarcinoma patients. The results showed a significant difference in resectability between low and high carbohydrate antigen 19-9 groups. However, due to considerable heterogeneity, carbohydrate antigen 19-9 should not be used as a standalone marker in surgical decision-making.
PATHOLOGY & ONCOLOGY RESEARCH
(2022)
Article
Chemistry, Analytical
Mehmet Lutfi Yola, Necip Atar
Summary: The study focuses on the development of an electrochemical immunosensor for CA 19-9 detection using 1D-MoS2 NRs/LNO and AuNPs@POM. The immunosensor shows high selectivity, stability, and reusability, providing a novel opportunity for clinical immunoassays.
MICROCHEMICAL JOURNAL
(2021)
Article
Nutrition & Dietetics
Jae Hyun Lee, Dong-Kun Kim, Mi-Yeon Lee, Han-Sol Lim, Min-Jung Kwon, Yong-Taek Lee, Kyung Jae Yoon, Chul-Hyun Park
Summary: There is a relationship between high CA 19-9 level and low muscle mass (LMM) in healthy adults without cancer.
Article
Surgery
Timothy E. Newhook, Timothy J. Vreeland, James F. Griffin, Rebecca S. Tidwell, Laura R. Prakash, Eugene J. Koay, Ethan B. Ludmir, Brandon G. Smaglo, Shubham Pant, Michael Overman, Robert A. Wolff, Naruhiko Ikoma, Jessica Maxwell, Michael P. Kim, Jeffrey E. Lee, Matthew H. G. Katz, Ching-Wei D. Tzeng
Summary: Objective: This study aimed to characterize the associations between CA19-9 dynamics during neoadjuvant therapy (NT) and survival for patients with PDAC. It was found that the A-B-C-D-E classification of CA19-9 dynamics could predict postresection outcomes more accurately than CA19-9 normalization alone.
Review
Biochemistry & Molecular Biology
Reiko Yamada, Junya Tsuboi, Yumi Murashima, Takamitsu Tanaka, Kenji Nose, Hayato Nakagawa
Summary: Pancreatic cancer is often diagnosed at late stages, making treatment difficult. Early diagnosis is crucial, but it can be challenging due to nonspecific symptoms. Recent studies suggest that selective screening and biomarkers can improve early detection. This review discusses advancements in imaging, biomarkers, biopsies, surveillance, and machine learning for identifying high-risk individuals. These new methods and techniques have the potential to improve overall survival in pancreatic cancer patients.
Article
Surgery
Kojiro Omiya, Atsushi Oba, Yosuke Inoue, Kosuke Kobayashi, Y. H. Andrew Wu, Yoshihiro Ono, Takafumi Sato, Takashi Sasaki, Masato Ozaka, Naoki Sasahira, Hiromichi Ito, Akio Saiura, Yu Takahashi
Summary: This study explores the use of serum DUPAN-2 in predicting the progression of pancreatic cancer in CA19-9 nonsecretors. The results demonstrate that DUPAN-2 >2000U/mL serves as an independent prognostic factor for poor prognosis in CA19-9 nonsecretors, equivalent to CA19-9 >500U/mL in CA19-9 secretors, which indicates the need for enhanced neoadjuvant treatment.
Article
Oncology
Hui Li, Yuan Feng, Chang Liu, Jiawang Li, Jiaxin Li, Hong Wu, Genshu Wang, Dewei Li
Summary: The study revealed that elevated preoperative CA19-9 that normalized after surgery does not lead to a poor prognosis in ICC patients, while those with persistently elevated postoperative CA19-9 are at higher risk of recurrence and death.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Kyohei Yugawa, Takashi Maeda, Shigeyuki Nagata, Akihiro Sakai, Kenji Taketani, Shohei Yamaguchi, Kozo Konishi, Kenkichi Hashimoto
Summary: This study aimed to establish a scoring model to assess the optimal treatment in patients who underwent surgery for pancreatic ductal adenocarcinoma (PDAC). The CA19-9-LMR scoring model can predict early recurrence after surgery and help with risk stratification and assessment of patients with resectable PDAC.
Article
Oncology
Jeongin Yoo, Jeong Min Lee, Ijin Joo, Dong Ho Lee, Jeong Hee Yoon, Mi Hye Yu, Jin-Young Jang, Sang Hyub Lee
Summary: This study aimed to determine if the addition of PET/MRI and CA 19-9 to CECT can improve the accuracy of predicting resectability and prognosis in PDAC patients. The results showed that the combination of CECT, PET, and CA 19-9 increased the AUC and sensitivity for determining resectability without compromising specificity. Additionally, FDG avidity on post-NAT PET and pathologically confirmed vascular invasion predicted recurrence-free survival in PDAC patients.
Article
Biochemistry & Molecular Biology
Muhammad Majid, Anam Farhan, Muhammad Waleed Baig, Muhammad Tariq Khan, Yousaf Kamal, Syed Shams ul Hassan, Simona Bungau, Ihsan-ul Haq
Summary: This study demonstrates that 3-epifriedelinol (EFD) isolated from Ipomoea batatas can inhibit prostate cancer cell proliferation and induce apoptosis. EFD shows good binding affinity with target proteins and reduces inflammation. It also exhibits favorable physicochemical and pharmacokinetic properties, making it a potential candidate for primary or adjuvant therapy against prostate cancer.
Review
Medicine, General & Internal
Horatiu Moldovan, Robert Tiganasu, Lucian Calmac, Cristian Voica, Marian Broasca, Camelia Diaconu, Vlad Ichim, Mihai Cacoveanu, Liliana Mirea, Claudia Nica, Costin Minoiu, Irina Dobra, Daniela Gheorghia, Lucian Dorobantu, Adrian Molnar, Luminita Iliuta
Summary: The incidence of isolated iliac artery aneurysms is about 2%, while common iliac artery pseudoaneurysms are even rarer. A pseudoaneurysm is a localized hemorrhage rather than a true aneurysm, which affects the entire vascular wall. They are usually asymptomatic and can be detected accidentally. If large and symptomatic, they may cause pressure symptoms and various complications. We report two cases of common iliac artery pseudoaneurysm, one treated with endovascular repair and the other with open surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Ali Mahnavi, Mina Shahriari-Khalaji, Bahareh Hosseinpour, Mostafa Ahangarian, Amir Aidun, Simona Bungau, Syed Shams ul Hassan
Summary: Different biomaterials and methods have been used in tissue engineering for repairing damaged bones. However, the weakness in cellular activity or osteoconductivity sometimes limits their optimal use. To address this issue, surface modification techniques, such as polydopamine coating, have been employed. Polydopamine not only covers the weakness of scaffolds but also enhances their osteoconductivity. The hydrophilic layer created by polydopamine allows bone cells to anchor and adhere well to the surfaces, while the catechol and amine groups make the surfaces chemically active, resulting in increased osteoconductivity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Delia Mirela Tit, Simona Gabriela Bungau
Editorial Material
Medicine, General & Internal
Simona Gabriela Bungau
Review
Biochemistry & Molecular Biology
Sukhbir Singh, Sonam Grewal, Neelam Sharma, Tapan Behl, Sumeet Gupta, Md. Khalid Anwer, Celia Vargas-De-La-Cruz, Syam Mohan, Simona Gabriela Bungau, Adrian Bumbu
Summary: Herbal drugs have gained significant scientific interest, particularly in the past few decades, and research based on phytoconstituents is ongoing to explore their potential medicinal benefits. Daidzein (DAI), a natural phytoestrogen isoflavone found in leguminous plants like soybean and mung bean, has shown promising pharmacological properties for the treatment of various diseases. However, its limited aqueous solubility, low permeability, and poor bioavailability pose challenges for therapeutic applications. This review provides an overview of the physicochemical characteristics, pharmacokinetics, and pharmacological applications of DAI in oxidative stress, cancer, obesity, cardiovascular, neuroprotective, diabetes, ovariectomy, anxiety, and inflammation. Additionally, it discusses the recent advancements in nanotechnology-based formulations for DAI, including polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carrier, and other drug delivery systems.
Article
Clinical Neurology
Tapan Behl, Tarapati Rana, Aayush Sehgal, Neelam Sharma, Ali Albarrati, Mohammed Albratty, Hafiz A. Makeen, Asim Najmi, Raman Verma, Simona Gabriela Bungau
Summary: Depression is a major neuropsychiatric disorder and developing novel medications with fewer side effects is a critical priority. Phytoconstituents, such as alkaloids and polyphenols, have shown antidepressant effects by regulating neurotransmitters and neurotrophic factors. They can potentially be used as alternative treatments for depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Review
Oncology
Mihnea-Alexandru Gaman, Matei-Alexandru Cozma, Muhammad Romail Manan, Bahadar S. Srichawla, Arkadeep Dhali, Sajjad Ali, Ahmed Nahian, Andrew C. Elton, L. V. Simhachalam Kutikuppala, Richard Christian Suteja, Sebastian Diebel, Amelia Maria Gaman, Camelia Cristina Diaconu
Summary: Myeloproliferative neoplasms (MPNs) are clonal disorders characterized by excessive production of mature myeloid cells. Classical MPNs, such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis, have a tendency to develop thrombotic complications at unusual sites. The pathogenesis of thrombotic events in MPNs is complex and involves endothelial injury, leukocyte adhesion, genetic mutations, and other factors. In this review, we discuss the epidemiology, pathogenesis, histopathology, risk factors, classification, clinical presentation, diagnosis, and management of Budd-Chiari syndrome in Philadelphia-negative MPNs.
WORLD JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Medicine, Research & Experimental
Manisha Nigam, Abhay Prakash Mishra, Vishal Kumar Deb, Deen Bandhu Dimri, Vinod Tiwari, Simona Gabriela Bungau, Alexa Florina Bungau, Andrei-Flavius Radu
Summary: One of the most extensively studied processes in cancer development and treatment is inflammation. While acute inflammation is necessary for wound healing and tissue reconstruction, chronic inflammation may contribute to the onset and growth of cancer. Inflammatory molecules disrupt cell signaling processes that lead to cancer induction, invasion, and development. The tumor microenvironment is greatly influenced by inflammatory cells and their secretions, which also play a significant role in tumor growth, survivability, and potential migration. Targeting inflammation with various therapies can reduce the inflammatory response and potentially inhibit the proliferation of cancer cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Alexa Florina Bungau, Andrei-Flavius Radu, Simona Gabriela Bungau, Cosmin Mihai Vesa, Delia Mirela Tit, Anamaria Lavinia Purza, Laura Maria Endres
Summary: Acne vulgaris, a chronic inflammatory dermatological condition characterized by pustules, comedones, nodules, and cysts, can potentially be treated with essential oils derived from natural sources. These essential oils, such as oregano, lavender, lemon grass, myrtle, lemon, thyme, eucalyptus, rosemary, and tea tree, have anti-inflammatory, antioxidant, and antimicrobial properties that target the multiple causes of acne. Analytical methods for evaluating the antioxidant potential and optimization of the dosage and safety profiles of essential oils are crucial for their implementation in acne management.
Review
Gastroenterology & Hepatology
Vlad Alexandru Ionescu, Gina Gheorghe, Valentin Nicolae Varlas, Ana Maria Alexandra Stanescu, Camelia Cristina Diaconu
Summary: Inflammatory bowel disease (IBD) is a chronic condition with high disability. One third of IBD patients have abnormal liver biochemical tests and 5% have chronic liver disease. Various liver diseases, including primary sclerosing cholangitis, can be associated with IBD. The progress in IBD treatment has not eliminated the risk of drug-induced liver disease and reactivation of viral hepatitis.
GASTROENTEROLOGY INSIGHTS
(2023)
Review
Environmental Sciences
Arpita Arora, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Ahmed A. H. Abdellatif, Hamad Ghaleb Dailah, Saurabh Bhatia, Ahmed Al-Harrasi, Lotfi Aleya, Simona Bungau
Summary: Medicinal plants have been used for their therapeutic benefits since ancient times, particularly in the treatment of neurodegenerative disorders like Alzheimer's disease. Traditional Chinese medicine, with its multiple-target approach, shows promise in breaking the cycle of oxidative stress and improving the quality of life for patients.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Medicine, General & Internal
Raluca S. Costache, Andreea S. Dragomirica, Bogdan E. Gheorghe, Vasile D. Balaban, Silviu M. Stanciu, Mariana Jinga, Daniel O. Costache
Summary: The use of anticoagulants in patients with liver disease is challenging due to the imbalance between thrombosis and bleeding. Risk factors for both liver disease and atrial fibrillation need to be prevented, and vitamin K antagonists are currently recommended for advanced liver disease patients. Direct oral anticoagulants (DOACs) are considered efficient and safe, offering superior protection against stroke compared to warfarin.
MEDICINA-LITHUANIA
(2023)
Review
Environmental Sciences
Neelam Sharma, Shahid Nazir Wani, Tapan Behl, Sukhbir Singh, Ishrat Zahoor, Aayush Sehgal, Saurabh Bhatia, Ahmed Al-Harrasi, Lotfi Aleya, Simona Bungau
Summary: COVID-19 disease has led to a significant increase in cases of mucormycosis infection in India, primarily among individuals recovering from COVID-19. This poses a serious threat to immunocompromised COVID-19 patients and is associated with severe clinical complications and elevated death rate.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Medicine, General & Internal
Raluca S. Costache, Mihaela Georgescu, Adelina Ghilencea, Oana Feroiu, Sorin G. Tiplica, Daniel O. Costache
Summary: Psoriasis is a chronic inflammatory skin condition characterized by red plaques covered by white scales. It commonly occurs on extension areas, scalp, and intertriginous regions. The origin of psoriasis is multifactorial, involving both genetic and environmental factors.
ROMANIAN JOURNAL OF MILITARY MEDICINE
(2023)
