Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 29, Issue -, Pages 17-22Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2016.03.008
Keywords
ULK1; Interferon Signal transduction; Immune signaling; Innate immunity
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Funding
- NCI NIH HHS [P30 CA060553, R01 CA155566, R01 CA121192, R01 CA077816, T32 CA080621] Funding Source: Medline
- CSRD VA [I01 CX000916] Funding Source: Medline
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The human serine/threonine kinase ULK1 is the human homolog of the Caenorhabditis elegans Unc-51 kinase and of the Saccharomyces cerevisiae autophagy-related protein kinase Atgl. As Unc-51 and Atg1, ULK1 regulates both axon growth and autophagy, respectively, in mammalian cells. However, a novel immunoregulatory role of ULK1 has been recently described. This kinase was shown to be required for regulation of both type I interferon (IFN) production and induction of type I IFN signaling. Optimal regulation of IFN production is crucial for generation of effective IFN-immune responses, and defects in such networks can be detrimental for the host leading to uncontrolled pathogen infection, tumor growth, or autoimmune diseases. Thus, ULK1 plays a central role in IFN-dependent immunity. Here we review the diverse roles of ULK1, with special focus on its importance to type I IFN signaling, and highlight important future study questions. Published by Elsevier Ltd.
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