Journal
CYTOKINE
Volume 79, Issue -, Pages 38-44Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2015.12.016
Keywords
PBMC; L. donovani; A(2B) receptor; Adenosine; ERK1/2
Funding
- National Institute of Pharmaceutical Education and Research (NIPER), Hajipur
- Ministry of Fertiliser and Petrochemicals, Government of India
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Adenosine, an endogenous purine nucleoside is one such extracellular signalling molecule whose role in regulation of anti-inflammatory cytokines and immune pathogenicity in visceral leishmaniasis is not fully understood. Here, we investigated the relationship between Leishmania donovani infection and expression of A(2B) receptor on monocytes in VL patients in their pre and post treatment stage. We also investigated the molecular mechanisms influencing the interaction between immunopathogenicity and infection by exposing Leishmania donovani pulsed macrophages to Adenosine. A direct correlation of up-regulated A2B expression on monocytes with increased parasite load was also observed. Our results also suggested that A2B receptor activation is critically required for the stimulatory effect of adenosine on IL-10 production and suppression of nitric oxide release. The stimulatory effect of adenosine on Leishmania donovani induced IL-10 production required ERK1/2 activation and is p-38 MAPK independent. (C) 2015 Elsevier Ltd. All rights reserved.
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