Article
Microbiology
Tomoko Sumitomo, Masanobu Nakata, Satoshi Nagase, Yuki Takahara, Mariko Honda-Ogawa, Yasushi Mori, Yukako Akamatsu, Masaya Yamaguchi, Shigefumi Okamoto, Shigetada Kawabata
Summary: Influenza A virus infection increases susceptibility to secondary bacterial pneumonia, with GP96 on infected cell surfaces mediating interactions with Streptococcus pneumoniae, leading to increased bacterial adherence and translocation. Inhibition of GP96 enhances pneumococcal clearance and reduces lung pathology in infected mice, suggesting a potential therapeutic target for inhibiting bacterial colonization in an IAV-infected respiratory tract.
Article
Immunology
Sunil Palani, Md Bashir Uddin, Michael McKelvey, Shengjun Shao, Keer Sun
Summary: The susceptibility of B6 mice to pneumococcal pneumonia after mild IAV infection is primarily attributed to the type 1 immune predisposition. IFN-γ signaling inhibits neutrophil recruitment and bacterial clearance in B6 mice, leading to lethal coinfection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Liliana A. Gonzalez, Felipe Melo-Gonzalez, Valentina P. Sebastian, Omar P. Vallejos, Loreani P. Noguera, Isidora D. Suazo, Barbara M. Schultz, Andres H. Manosalva, Hernan F. Penaloza, Jorge A. Soto, Dane Parker, Claudia A. Riedel, Pablo A. Gonzalez, Alexis M. Kalergis, Susan M. Bueno
Summary: The study revealed that neutrophils are the main source of IL-10 production in the lungs during early infection with Streptococcus pneumoniae, and IL-10 can be induced in these cells by directly recognizing pneumococcal antigens. Adoptive transfer of neutrophils from WT mice into IL-10 knockout mice restored IL-10 production and reduced lung histopathology, indicating the importance of IL-10 in limiting lung injury and mediating an effective immune response for host survival.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yifan Zhu, Yingying Luo, Ling Li, Xinyi Jiang, Yi Du, Jing Wang, Huilin Li, Haiyan Gu, Daiying Li, Heng Tang, Houbing Qin, Changdi Xu, Yan Liu, Deyu Zhao, Yun Guo, Feng Liu
Summary: This study analyzed the microbiome and transcriptome of bronchoalveolar lavage fluid (BALF) from children with MPP and found that the progression of MPP is associated with the host immune response, especially the intrinsic immune response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Yulia Desheva, Galina Leontieva, Tatiana Kramskaya, Igor Losev, Andrey Rekstin, Nadezhda Petkova, Polina Kudar, Alexander Suvorov
Summary: This study examines the resistance of mice against early influenza infection and post-influenza pneumococcal pneumonia after intranasal live influenza vaccine (LAIV) administration. The results show that LAIV provides early protection against both homologous and heterologous viral infections and has a protective effect against post-influenza pneumococcal infection. These findings suggest that intranasal administration of LAIV may be valuable in preventing not only influenza, but also other acute respiratory infections.
Review
Immunology
Nobuo Okahashi, Tomoko Sumitomo, Masanobu Nakata, Shigetada Kawabata
Summary: Secondary bacterial infection following influenza type A virus (IAV) infection is a major cause of morbidity and mortality during influenza epidemics. This review explores the cooperative interactions between IAV and streptococci during co- or secondary infection. It reveals that IAV infection disrupts the host epithelial barrier and enhances streptococcal adherence and invasion.
MICROBIOLOGY AND IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Eliza M. Melo, Juliana Del Sarto, Juliana P. Vago, Luciana P. Tavares, Flavia Rago, Ana Paula F. Goncalves, Marina G. Machado, Irene Aranda-Pardos, Bruno V. S. Valiate, Geovanni D. Cassali, Vanessa Pinho, Lirlandia P. Sousa, Noelia A-Gonzalez, Maria Jose Campagnole-Santos, Michael Bader, Robson A. S. Santos, Alexandre Machado, Stephan Ludwig, Mauro M. Teixeira
Summary: Therapeutic treatment with Ang-(1-7) reduces neutrophil recruitment and lung injury, decreases viral load and morbidity after primary IAV infection, and protects against secondary bacterial infection of the lung. However, these effects are MasR-dependent, as MasR-deficient mice were highly susceptible to IAV infection and did not benefit from Ang-(1-7) treatment.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Yanyu Zhang, Song Gao, Shifei Yao, Danlin Weng, Yan Wang, Qi Huang, Xuemei Zhang, Hong Wang, Wenchun Xu
Summary: The study found that the SPY1 vaccine increased the expression of IL-27 and its specific receptor (WSX-1), promoting vaccine protection through activation of the STAT3 and NF-κB signaling pathways and production of memory CD4(+)T cells to enhance Th17 cell polarization. Additionally, the immune protection of the vaccine was independent of aerobic glycolysis.
Article
Medicine, General & Internal
Kuo-Shu Tang, Chih-Min Tsai, Ming-Chou Cheng, Ying-Hsien Huang, Chih-Hao Chang, Hong-Ren Yu
Summary: Community-acquired pneumonia (CAP) is common and potentially fatal in children. Salivary analysis shows potential as a noninvasive diagnostic tool. A study identified potential salivary biomarkers using proteomics to differentiate Streptococcus pneumoniae and influenza A pneumonia in pediatric patients, with higher levels of salivary alpha 1-antichymotrypsin in the Streptococcus pneumoniae group.
Article
Chemistry, Multidisciplinary
Anna Egorova, Martina Richter, Maria Khrenova, Elisabeth Dietrich, Andrey Tsedilin, Elena Kazakova, Alexander Lepioshkin, Birgit Jahn, Vladimir Chernyshev, Michaela Schmidtke, Vadim Makarov
Summary: Influenza infections are often worsened by bacterial infections such as Streptococcus pneumoniae. We discovered a new compound that may be useful in the development of small molecules against influenza. This compound inhibits both viral and bacterial neuraminidases, making it a promising candidate for treating influenza pneumonia complicated by bacterial infections.
Article
Biochemistry & Molecular Biology
Teppei Okabe, Yosuke Kamiya, Takeshi Kikuchi, Hisashi Goto, Masayuki Umemura, Yuki Suzuki, Yoshihiko Sugita, Yoshikazu Naiki, Yoshiaki Hasegawa, Jun-ichiro Hayashi, Shotaro Kawamura, Noritaka Sawada, Yuhei Takayanagi, Takeki Fujimura, Naoya Higuchi, Akio Mitani
Summary: This study found that the culture supernatant of Porphyromonas gingivalis accelerated inflammation in the lungs of Streptococcus pneumoniae-infected mice, and increased inflammatory cell infiltration. Compared to S. pneumoniae infection alone, PgSup synergistically increased TNF-alpha and IL-17 expression/production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Phoebe Wellmann, Christian Kromer, Ralf Siemer, Selina Klein, Johannes Mohr, Undine Lippert, Andreas Pinter, Dagmar Wilsmann-Theis, Rotraut Moessner
Summary: The pneumococcal vaccination rate is low among PsO and AD patients in Germany, with PsO patients having a slightly higher rate. Lack of recommendation from physicians is the most common reason for nonvaccination.
Review
Immunology
Claire Froneman, Peter Kelleher, Ricardo J. Jose
Summary: Infections with Streptococcus pneumoniae are a common cause of morbidity and mortality worldwide, especially affecting those at the extremes of age and immunocompromised individuals. Preventing pneumococcal disease is crucial in at-risk individuals, and pneumococcal vaccination should be offered to them.
Article
Immunology
Ellyse M. Cipolla, Molin Yue, Kara L. Nickolich, Brydie R. Huckestein, Danielle Antos, Wei Chen, John F. Alcorn
Summary: Influenza-experienced mice show increased resistance to bacterial superinfections and have altered lung environment, reducing inflammatory mechanisms and susceptibility to lung damage and subsequent bacterial colonization.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Thomas Sura, Vanessa Gering, Clemens Cammann, Sven Hammerschmidt, Sandra Maass, Ulrike Seifert, Doerte Becher
Summary: Epithelial cells are key defense mechanisms in the lung, and their disruption can lead to severe diseases. This study analyzed the protein and ubiquitin changes in lung epithelial cells infected with Streptococcus pneumoniae, influenza A virus, and both bacteria and virus. Pneumococcal infection affected the ubiquitination of proteins involved in cytoskeleton organization, while influenza A virus infection induced an antiviral state in the cells. Co-infection showed characteristics of both pathogens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.