Article
Endocrinology & Metabolism
Tomas P. Griffin, Paula M. O'Shea, Andrew Smyth, Md Nahidul Islam, Deirdre Wall, John Ferguson, Esther O'Sullivan, Francis M. Finucane, Sean F. Dinneen, Fidelma P. Dunne, David W. Lappin, Donal N. Reddan, Marcia Bell, Timothy O'Brien, Damian G. Griffin, Matthew D. Griffin
Summary: The study aimed to determine the prevalence of diabetic kidney disease (DKD) and rapid renal function decline among adults in a diabetes center in Northern Europe. Results showed a high prevalence of DKD and rapid decline for adults with type 2 diabetes, with several clinical predictors identified.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Review
Urology & Nephrology
Carolina S. Vengrus, Vinicius D. Delfino, Paulo R. Bignardi
Summary: A systematic review and meta-analysis found a significant association between long-term PPI use and increased risk of CKD and ESRD, emphasizing the need for caution and adherence to FDA guidelines when prescribing these drugs.
MINERVA UROLOGY AND NEPHROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei Mao, Yuqin Ding, Xiaoqiang Ding, Caixia Fu, Bohong Cao, Bernd Kuehn, Thomas Benkert, Robert Grimm, Jianjun Zhou, Mengsu Zeng
Summary: IVIM-DWI and ASL can be used to detect underlying pathologic injury in early CKD patients with normal eGFR.
EUROPEAN RADIOLOGY
(2023)
Article
Urology & Nephrology
Sho Hasegawa, Akira Okada, Shotaro Aso, Ryosuke Kumazawa, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Masaomi Nangaku
Summary: Diabetes is significantly associated with major bleeding complications of PRBs, and the severity of diabetes is associated with an increased risk of major bleeding complications.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Endocrinology & Metabolism
Ga Young Heo, Hee Byung Koh, Hyung Woo Kim, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Jayoun Kim, Soo Wan Kim, Yeong Hoon Kim, Su Ah Sung, Kook-Hwan Oh, Seung Hyeok Han
Summary: This study found that higher levels of glycated hemoglobin (HbA1c) were associated with an increased risk of major adverse cardiovascular events (MACEs) and mortality in patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM). The risk was significantly higher for HbA1c levels of 7.0% to 7.9% and ≥8.0% compared to HbA1c <7.0%.
DIABETES & METABOLISM JOURNAL
(2023)
Article
Surgery
Yu-Chen Liao, Chuen-Chau Chang, Chien-Yu Chen, Chih-Chung Liu, Chien-Chang Liao, Yu-Ru Vernon Shih, Chao-Shun Lin
Summary: Patients with preoperative renal insufficiency have an increased risk of postoperative 30-day mortality and complications. Those with current dialysis, lower estimated glomerular filtration rate, or concomitant anemia are at a higher risk of postoperative mortality.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Endocrinology & Metabolism
Qi Yang, Yan Liu, Juan Peng, Jinting Pan, Li Chen, Jing Cui, Bin Yi
Summary: This study examined the relationship between C-peptide and progression of renal function in patients with type 2 diabetes. The results showed that higher levels of 2hPCP, ?CP, and PCGR were associated with a decreased risk of renal progression. Specifically, among patients with male sex, age <65 years old, disease course <10 years, glycosylated hemoglobin value =7%, or a history of hypertension, levels of 2hPCP <2.92 ng/mL, ?CP <1.86 ng/mL, and PCGR <1.11 significantly increased the risk of kidney function progression.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Hematology
Hui Yin Lim, Brandon Lui, Mark Tacey, David Barit, Geoffrey Donnan, Harshal Nandurkar, Louise M. Burrell, Prahlad Ho
Summary: Despite cardiovascular diseases and thrombosis being major causes of death in patients with CKD, there remains no effective biomarker to predict thrombotic risk in this population. This study evaluated global coagulation assays in CKD patients and correlated the biomarkers to various clinical outcomes. The results showed that CKD patients have increased coagulation function and potential thrombotic risk factors.
THROMBOSIS RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Penghui Cheng, Rending Wang, Shasha He, Pengpeng Yan, Hongfeng Huang, Jianghua Chen, Jia Shen, Kanyi Pu
Summary: We report the development of Artificial bioMarker Probes (AMPros) for sensitive urinalysis of Acute renal allograft rejection (ARAR) in murine models. AMPros specifically react with immune biomarkers in the kidneys and activate their fluorescence signals to detect rejection. The urinalysis using AMPros is noninvasive, sensitive, and can detect ARAR earlier than current diagnostic methods.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Peripheral Vascular Disease
Young Su Joo, Hyung Woo Kim, Ki Heon Nam, Jee Young Lee, Tae Ik Chang, Jung Tak Park, Tae-Hyun Yoo, Joongyub Lee, Soo Wan Kim, Yun Kyu Oh, Kook-Hwan Oh, Yong-Soo Kim, Curie Ahn, Shin-Wook Kang, Seung Hyeok Han
Summary: In this longitudinal study on CKD, individuals with an increasing SBP trajectory had a significantly higher risk for adverse kidney outcomes compared to those with a stable SBP trajectory, while those with a decreasing SBP trajectory showed a similar risk of adverse kidney outcomes as the stable group.
Article
Peripheral Vascular Disease
Eun Hui Bae, Sang Yeob Lim, Bongseong Kim, Tae Ryom Oh, Su Hyun Song, Sang Heon Suh, Hong Sang Choi, Eun Mi Yang, Chang Seong Kim, Seong Kwon Ma, Kyung-Do Han, Soo Wan Kim
Summary: This study found that higher blood pressure is associated with an increased risk of end-stage renal disease (ESRD) in patients with diabetes. The risk is particularly higher in younger individuals. Age, sex, use of antihypertensive medication, and history of chronic kidney disease have different effects on the risk of ESRD.
Article
Transplantation
Kirsten S. Dorans, Hua He, Jing Chen, Mirela Dobre, Alan S. Go, L. Lee Hamm, Bernard G. Jaar, Rupal C. Mehta, Mahboob Rahman, Ana C. Ricardo, Sylvia E. Rosas, Anand Srivastava, Jiang He
Summary: The study revealed a U-shaped association between changes in ABI and all-cause mortality in patients with chronic kidney disease. Both larger decreases and increases in average annual changes in ABI (>0.04/year) were associated with higher mortality risk, suggesting that monitoring changes in ABI over time may help in risk stratification for mortality among individuals with CKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Endocrinology & Metabolism
Joao Pedro Ferreira, Diana Ferrao, Patrick Rossignol, Faiez Zannad, Abhinav Sharma, Francisco Vasques-Novoa, Adelino Leite-Moreira
Summary: In patients with type 2 diabetes and high cardiovascular risk, more than 10% experience worsening kidney function, independently associated with subsequent cardiovascular events. Preventing serious kidney function deterioration and transition from kidney function worsening to heart failure or cardiovascular death is a crucial objective for future trials.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Ophthalmology
Lanhua Wang, Ling Jin, Wei Wang, Xia Gong, Yuting Li, Wangting Li, Xiaoling Liang, Wenyong Huang, Yizhi Liu
Summary: There is a strong association between renal function and vision-threatening diabetic retinopathy (VTDR) and diabetic macular oedema (DMO) in diabetic patients. The association between glomerular filtration rate (GFR) and VTDR is significant, while the association with any DR depends on the presence of microalbuminuria. High microalbuminuria and chronic kidney disease (CKD) are significantly associated with DMO.
Article
Medical Laboratory Technology
Thuy Pham Vu, Mao Can Van, Chung Dang Thanh, Tuan Nguyen Minh, Kien Nguyen Trung, Toan Nguyen Duy, Quyet Do, Tien Tran Viet, Thang Le Viet
Summary: In kidney transplant recipients, serum adiponectin levels are lower and leptin levels are higher in NODAT patients compared to non-NODAT patients. Meanwhile, in the renal insufficiency group, both adiponectin and leptin levels are higher than in the non-renal insufficiency group. Both adiponectin and leptin levels are related to BMI in all subject groups.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Hiroki Mizuno, Junichi Hoshino, Masatomo So, Yuta Kogure, Takeshi Fujii, Yoshifumi Ubara, Kenmei Takaichi, Tetsuko Nakaniwa, Hideaki Tanaka, Genji Kurisu, Fuyuki Kametani, Mayuko Nakagawa, Tsuneaki Yoshinaga, Yoshiki Sekijima, Keiichi Higuchi, Yuji Goto, Masahide Yazaki
Summary: This study reported a rare case of DRA in a 41-year-old hemodialysis patient with a beta(2)-microglobulin variant (V27M) showing strong amyloidogenic propensity. The findings highlight the unique clinical manifestations and pathomechanical features of this variant compared to previously reported cases.
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2021)
Review
Urology & Nephrology
Wakako Kawarazaki, Toshiro Fujita
Summary: This review discusses the impact of adverse environmental factors such as prenatal malnutrition, obesity, and aging on salt-sensitive hypertension, as well as the underlying mechanisms. Kidney mechanisms and aberrant DNA methylation of certain genes play crucial roles in the development of this condition.
NATURE REVIEWS NEPHROLOGY
(2021)
Article
Urology & Nephrology
Makoto Fukuda, Hiroki Mizuno, Rikako Hiramatsu, Akinari Sekine, Masahiro Kawada, Eiko Hasegawa, Masayuki Yamanouchi, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Kenmei Takaichi, Keiichi Kinowaki, Kenichi Ohashi, Takeshi Fujii, Motoaki Miyazono, Yoshifumi Ubara
Summary: A 60-year-old Japanese woman with polymyositis developed hemolytic anemia, thrombocytopenia, and acute kidney injury after starting steroid therapy, leading to a diagnosis of hemolytic uremic syndrome with thrombotic microangiopathy. Despite hemodialysis and plasma exchange treatment, the patient passed away due to hemorrhagic respiratory failure. Renal involvement by polymyositis is rare, but clinicians should be aware of the potential serious renal complications such as HUS/TMA.
CLINICAL NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Kanako Terakawa, Naoki Sawa, Hiroki Mizuno, Akinari Sekine, Noriko Hayami, Daisuke Ikuma, Masahiro Kawada, Rikako Hiramatsu, Keiichi Sumida, Masayuki Yamanouchi, Eiko Hasegawa, Tatsuya Suwabe, Junichi Hoshino, Keiichi Kinowaki, Kenichi Ohashi, Takeshi Fujii, Yoshifumi Ubara
Summary: This case demonstrates a close relationship between the occurrence of squamous cell carcinoma and the development of polymyositis in a patient with ADPKD. Diagnostic imaging showed an 8 cm mass lesion and a renal stone in the right kidney.
Article
Medicine, General & Internal
Sayako Koga-Kobori, Naoki Sawa, Ryo Kido, Akinari Sekine, Hiroki Mizuno, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Keiichi Kinowaki, Kenichi Ohashi, Takeshi Fujii, Yoshifumi Ubara
Summary: Fabry disease is a genetic disorder caused by a lack of alpha-galactosidase A activity in lysosomes, leading to multi-organ involvement. Cardiac involvement is a key factor in prognosis, and peritoneal dialysis is the preferred treatment for long-term management.
Review
Biochemistry & Molecular Biology
Wakako Kawarazaki, Toshiro Fujita
Summary: High salt intake can result in increased blood pressure, especially in individuals with impaired renal sodium excretion, leading to salt-sensitive hypertension. Activation of Rho in the central nervous system and vascular smooth muscle cells plays a crucial role in this process, contributing to increased vascular resistance and tone, ultimately impacting blood pressure control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
Daigoro Hirohama, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Wakako Kawarazaki, Wataru Fujii, Shigeyoshi Oba, Shigeru Shibata, Takeshi Marumo, Toshiro Fujita
Summary: The study revealed that the activation of the Rac1-MR pathway contributes to the progression of DKD by causing hypertension and podocyte injury, highlighting MR antagonism and Rac1 inhibition as a novel strategy for DKD treatment.
Article
Urology & Nephrology
Shun Watanabe, Naoki Sawa, Hiroki Mizuno, Masayuki Yamanouchi, Tatsuya Suwabe, Junichi Hoshino, Keiichi Kinowaki, Kenichi Ohashi, Takeshi Fujii, Yutaka Yamaguchi, Yoshifumi Ubara
Summary: Three cases of acute kidney injury were observed after treatment with a SGLT2 inhibitor, showing osmotic vacuolization in tubules and positive staining for CD138 and CD10 indicating proximal tubules. Patients who are obese and have a body mass index over 30 are at higher risk for AKI due to overdose of sugar in urine and dehydration caused by SGLT2 inhibitor treatment, especially in individuals with type II diabetes mellitus.
Article
Medicine, Research & Experimental
Miho Akabane, Shusuke Haruta, Takeshi Fujii, Masayuki Urabe, Yu Ohkura, Masaki Ueno, Harushi Udagawa
Summary: The treatment strategy for idiopathic retroperitoneal mass is still unclear, while distinguishing between benign and malignant is challenging. This report presents a case of idiopathic retroperitoneal fibrosis that mimicked malignancy, in which partial resection of the mass was performed, and the final pathological findings revealed non-tumorous tissue. The patient had a good postoperative course and remained free of recurrence after 8 years.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Editorial Material
Urology & Nephrology
Daigoro Hirohama, Katalin Susztak
Summary: In 2021, significant progress was made in understanding the genetics of kidney function and disease, with key advances in genome-wide association studies and multi-omics methods identifying key genes and cell types involved in disease development.
NATURE REVIEWS NEPHROLOGY
(2022)
Review
Peripheral Vascular Disease
Atsuhisa Sato, Mitsuhiro Nishimoto
Summary: This article summarizes the latest evidence on the use of nonsteroidal MR antagonists in the treatment of diabetic kidney disease (DKD). It highlights the effectiveness of MR antagonists and suggests measures for managing hyperkalemia. The study emphasizes the importance of continuous use of MR antagonists in DKD treatment.
HYPERTENSION RESEARCH
(2022)
Article
Urology & Nephrology
Daigoro Hirohama, Amin Abedini, Salina Moon, Aditya Surapaneni, Simon T. Dillon, Allison Vassalotti, Hongbo Liu, Tomohito Doke, Victor Martinez, Zaipul Md Dom, Anil Karihaloo, Matthew B. Palmer, Josef Coresh, Morgan E. Grams, Monika A. Niewczas, Katalin Susztak
Summary: In this study, unbiased proteomics analysis was performed to identify diagnostic markers for kidney fibrosis and future kidney function decline in patients with diabetic kidney disease (DKD). It was found that matrix metalloprotease 7 (MMP7) is significantly associated with both fibrosis in renal tissue and decline in kidney function. Additionally, plasma levels of MMP7 were found to correlate with future kidney function decline.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Masaaki Nagano, Atsushi Miyamoto, Shinichiro Kikunaga, Souichiro Suzuki, Hisashi Takaya, Takeshi Fujii, Sakashi Fujimori
Summary: Surgical lung biopsy is a safe approach for interstitial lung disease, and an accurate diagnosis of idiopathic pulmonary fibrosis through SLB can aid in appropriate patient management.
ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
