Article
Biochemistry & Molecular Biology
Chen Su, Tao Gan, Zhulan Liu, Yan Chen, Qia Zhou, Jianyu Xia, Yunfeng Cao
Summary: By using LiCl/DMSO solvent fractionation, the functional groups of lignin and LCC were increased, the molecular weight was reduced, and the antioxidant activity was improved.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Byulhana Kim, Young Kim, Yoonho Lee, Joomin Oh, Youngmee Jung, Won-Gun Koh, Justin J. Chung
Summary: Chronic wounds are difficult to repair due to continuous inflammatory response, which inhibits the normal wound healing mechanism. An antioxidant hydrogel has been developed to scavenge reactive oxygen species (ROS) and promote chronic wound healing.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Chen Dong, Xuehua Ma, Yi Huang, Yujie Zhang, Xiang Gao
Summary: This study demonstrates the synthesis of carbon dots nanozyme with excellent scavenging activity of reactive oxygen species (ROS) for anti-inflammatory therapy, indicating its potential in the treatment of inflammation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Wei Chen, Tengteng Dong, Feitian Bai, Jinlong Wang, Xusheng Li
Summary: This paper reviews the fractionation, characterization, and applications of lignin-carbohydrate complexes (LCCs) in healthcare materials, highlighting their various properties. The compiled information can encourage the development of advanced healthcare materials through LCC-based innovations.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Barry Halliwell
Summary: The field of oxygen free radicals, antioxidants, and reactive oxygen species (ROS) has seen significant growth, with ROS playing important roles in living organisms. However, many studies lack mechanistic meaning. Detailed understanding of the molecular mechanisms of ROS and appropriate measurement methods for both ROS and oxidative damage are necessary for progress.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
James H. Schofield, Zachary T. Schafer
Summary: The relationship between mitophagy and ROS production is complex and not fully understood. This review discusses mtROS generation and their detrimental effects on cellular viability, along with the cellular defense mechanisms against oxidative stress. Furthermore, the prominent mechanisms governing mitophagy induction that bear on oxidative stress are explored.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Agricultural Engineering
Jingze Sun, Jianan Wang, Yun Jia, Shujuan Zhuang, Yujiao Xie, Xiaoyan Yin, Yuan Zhang, Rongrong Zhao, Hongzi Tan, Lihong Wang, Feng Song, Hongyou Cui
Summary: This study investigated the free radical depolymerization of lignin using three model compounds and peroxymonosulfate (PMS). The results showed that the reaction pathway and selectivity of monomer products can be regulated by adjusting the pH value and temperature. The presence of hydroxyl and methoxy groups can enhance the reactivity of lignin model compounds and promote the directional generation of monomer products.
BIOMASS & BIOENERGY
(2023)
Review
Chemistry, Analytical
Hao Yu, Binjie Chen, Huiming Huang, Zhentao He, Jiangman Sun, Guan Wang, Xinggui Gu, Ben Zhong Tang
Summary: Photodynamic therapy is a non-invasive approach for tumor elimination that is gaining increasing attention. The development of aggregation-induced emission (AIE) active photosensitizers has opened up new possibilities for overcoming the limitations of traditional photodynamic therapy.
Article
Biochemistry & Molecular Biology
Andrew P. Bischer, Timothy M. Baran, Andrew P. Wojtovich
Summary: Environmental surveillance-mediated behavior in Caenorhabditis elegans integrates multiple cues and is coordinated by neurons through signaling cascades. Despite lacking eyes, C. elegans is able to perceive and react to the color blue. This study explains this color perception by showing that internally-generated reactive oxygen species (ROS), in response to light, add to exogenous sources of ROS. Multiple sub-threshold sources of ROS are integrated to coordinate behavioral responses with internal cues. Blue light affects C. elegans behavior through ROS generation by endogenous flavins, mediated by the neuronal gustatory photoreceptor like protein, LITE-1. Overall, this study demonstrates that ROS and LITE-1 play central roles in C. elegans foraging behavior through integration of multiple inputs, including light.
Article
Biochemistry & Molecular Biology
Zhefan Stephen Chen, Mingqi Yan, Wenhui Pei, Bowen Yan, Caoxing Huang, Ho Yin Edwin Chan
Summary: In this study, the potential therapeutic effect of lignin-carbohydrate complexes (LCCs) on polyglutamine diseases was investigated. LCCs isolated from bamboo and poplar were found to effectively eliminate protein aggregation and rescue photoreceptor degeneration. Mechanistically, LCCs were shown to upregulate proteasomal activity, which was crucial for their beneficial effects on polyglutamine neurotoxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Plant Sciences
Yan Wang, Yaoxing Niu, Lixia Ye, Yubing Shi, Anwei Luo
Summary: The results of this study demonstrate that ozone treatment reduces respiration rate, maintains fruit hardness and storage quality, and inhibits the ripening and senescence of kiwifruit. Ozone treatment activates antioxidant enzymes and the ascorbate-glutathione cycle to prevent the accumulation of reactive oxygen species. Furthermore, ozone treatment is also related to hormone signaling, playing an important role in regulating ROS in kiwifruit.
JOURNAL OF PLANT PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Swati Sachdev, Shamim Akhtar Ansari, Mohammad Israil Ansari, Masayuki Fujita, Mirza Hasanuzzaman
Summary: Climate change has devastating effects on plants, leading to the production of reactive oxygen species (ROS) as byproducts of oxygen consumption. While excessive ROS can disrupt cellular homeostasis, moderate levels can activate growth and stress responses in plants, though the exact mechanisms are not fully understood. Advancements in modern techniques like molecular priming and crop modeling offer potential solutions for managing ROS levels in plants under stress.
Article
Biochemistry & Molecular Biology
Ziwen Lv, Ziyi Bai, Liyuan Su, Jun Rao, Yajie Hu, Rui Tian, Siyu Jia, Ying Guan, Baozhong Lu, Feng Peng
Summary: In this study, the chemical linkage variations of lignin and lignin-carbohydrate complex (LCC) between different bamboo cell walls were investigated using FT-IR, 2D HSQC NMR, and 31P NMR techniques. The results showed that bamboo fibers and parenchyma cells had different substructures in their lignin, and there were also differences in the main chemical linkages of lignin and LCC. These findings can provide a reference for further research on biomass utilization and biorefining of bamboo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Food Science & Technology
Heui Min Lim, See-Hyoung Park
Summary: Cancer and diabetes mellitus are life-threatening diseases that share common risk factors. Conventional treatments for these diseases have limitations such as side effects, economic burdens, and patient compliance. Phytochemicals from edible plants, with their antioxidant and pro-oxidant properties, have emerged as alternative therapeutic options. These naturally occurring compounds have beneficial effects and can regulate cell proliferation, differentiation, cell cycle arrest, and apoptosis, offering preventive and therapeutic effects against cancer and diabetes. This article summarizes recent studies on the antioxidant or pro-oxidant effects and underlying mechanisms of flavonoids, alkaloids, and saponins in cancer or diabetic models.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Wenhui Pei, Junping Deng, Peng Wang, Xucai Wang, Liming Zheng, Yangheng Zhang, Caoxing Huang
Summary: Lignin and its derivatives have potential therapeutic effects in treating degenerative orthopaedic diseases, as their excellent biological activities can regulate inflammation and bone remodeling, providing new strategies for clinical treatments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Medicine, Research & Experimental
Xingyue Chen, Li Zhang, Liming Zheng, Biguang Tuo
Summary: Non-alcoholic fatty liver disease (NAFLD) is a clinically progressive illness that requires a novel treatment to prevent its progression. Calcium (Ca2+) channels play a role in regulating intracellular Ca2+ homeostasis during the development of NAFLD, making them potential targets for preventing NAFLD development.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ying An, Zhefan S. Chen, Ho Yin Edwin Chan, Jacky Chi Ki Ngo
Summary: Polyglutamine diseases are neurodegenerative disorders caused by gene expansion. Researchers discovered that the interaction between expanded CAG RNA and nucleolin protein leads to cell death. They used crystal structure and simulation models to reveal the mechanism of this interaction and identified key residues involved in RNA-protein binding. This study provides new molecular insights into the pathogenic mechanism of polyglutamine diseases.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Cell Biology
Ho Yin Edwin Chan, Zhefan Stephen Chen
Summary: This study investigates the prognostic significance of Hh-related genes INTU and IFT88 in different types of cancer, and reveals multiple mechanisms leading to the downregulation of INTU and IFT88 levels in tumor samples. The results demonstrate the importance of these genes in lung adenocarcinoma and uterine corpus endometrial carcinoma and contribute to a better understanding of their roles in cancer.
Article
Biochemistry & Molecular Biology
Zhefan Stephen Chen, Mingqi Yan, Wenhui Pei, Bowen Yan, Caoxing Huang, Ho Yin Edwin Chan
Summary: In this study, the potential therapeutic effect of lignin-carbohydrate complexes (LCCs) on polyglutamine diseases was investigated. LCCs isolated from bamboo and poplar were found to effectively eliminate protein aggregation and rescue photoreceptor degeneration. Mechanistically, LCCs were shown to upregulate proteasomal activity, which was crucial for their beneficial effects on polyglutamine neurotoxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Medicine, Research & Experimental
Shun Yao, Zhen Tu, Xingyue Yang, Li Zhang, Yuling Zhong, Liming Zheng, Hui Wang, Zhiqiang Yi, Jiaxing An, Hai Jin, Guorong Wen, Biguang Tuo
Summary: Integrins play a crucial role in cell adherence and formation of focal adhesion sites, influencing cell structure and various biological functions. Hic-5, a member of the Paxillin family, acts as an adhesive plaque scaffolding protein involved in vascular remodeling, fibrotic diseases, and invasive metastasis of cancer. It also plays a role in transcriptional regulation and signaling pathways. Inhibiting Hic-5 functions may have therapeutic implications for several diseases, including cancer.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Jacquelyne Ka-Li Sun, Deng Wu, Genper Chi-Ngai Wong, Tsun-Ming Lau, Meigui Yang, Ronald P. Hart, Kin-Ming Kwan, Ho Yin Edwin Chan, Hei-Man Chow
Summary: Chronic binge-like drinking is a risk factor for age-related dementia, potentially due to its lasting and irreversible impact on the brain. Ethanol exposure leads to pro-ageing changes in brain cortices, particularly in neurons, by affecting the ethyl alcohol oxidation and folate metabolism. This disrupts DNA repair pathways, forces post-mitotic cells to re-enter a cell cycle-like process, and ultimately results in irreversible senescence response. Supplementation of bioactive 5-methyl tetrahydrofolate during alcohol exposure can prevent these effects, highlighting the connection between binge drinking and dementia.
Review
Medicine, Research & Experimental
Liming Zheng, Li Zhang, Yi Zheng, Jiaxing An, Guorong Wen, Hai Jin, Biguang Tuo
Summary: In addition to causing SARS, SARS-coronavirus 2 (SARS-CoV-2) also harms the digestive system. It has been shown that SARS-CoV-2 can damage organs such as the gastrointestinal tract, liver, and pancreas, leading to worsened conditions or poor prognosis in patients with existing digestive illnesses. This review discusses the molecular structure of SARS-CoV-2, its mechanism of entry into the human body through ACE2 and TMPRSS2, and the clinical manifestations of SARS-CoV-2 infection in the digestive system. Furthermore, the expression characteristics of ACE2 and TMPRSS2 in the main target organs of the digestive system are described.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Xin-feng Wang, Qian Li, Xia Sun, Li-ming Zheng, Shao-li Cheng, Yan-he Zhu
Summary: This study investigated the role of vitamin D in cardiac fibroblast (CFs) growth via the integrin signaling pathway. The results showed that vitamin D suppressed CFs proliferation by downregulating the integrin beta 3/FAK/Akt pathway, leading to a reduction in fibronectin and hydroxyproline release.
CURRENT MEDICAL SCIENCE
(2023)
Correction
Engineering, Biomedical
Lei Zhang, Zhiguo Qin, Han Sun, Xiang Chen, Jian Dong, Siyu Shen, Liming Zheng, Ning Gu, Qing Jiang
BIOACTIVE MATERIALS
(2023)
Article
Energy & Fuels
Chengjun Wang, Jun Ni, Shaojing Jiang, Yiwen Gao, Weibo Wang, Yuan Xue, Lei Zhang, Liming Zheng
Summary: Before implementing enhanced oil recovery (EOR) techniques in an oilfield, it is important to evaluate the potential and economic feasibility of the techniques for each reservoir. A rapid and reliable evaluation model for the applicability of EOR techniques is proposed, considering the complex distribution of scattered small reservoirs in a fluvial delta oilfield. The model combines fraction theory with auxiliary equations to account for formation heterogeneity and the effect of different EOR techniques on fractional flow rate.
JOURNAL OF PETROLEUM EXPLORATION AND PRODUCTION TECHNOLOGY
(2023)
Article
Energy & Fuels
Bingfan Li, Bo Qi, Manping Yang, Liming Zheng, Guanghui Li, Ziyuan Guo
Summary: In this paper, rheological experiments were performed on crude oil using a high-pressure rheometer. The effects of temperature, static pressure, and methane dissolution on crude oil viscosity were quantified using a new model of combined shift factor. The results showed that higher temperature, lower static pressure, and lower methane dissolution reduce crude oil viscosity. The combined effect of saturation pressure led to an optimum condition of methane dissolution for viscosity reduction. The predicted shift factors using the new model had average deviations of 3.35% and 2.16% for Shengli and Nanyang crude oil, respectively. The predicted and tested values were in good agreement.
ENERGY SOURCES PART A-RECOVERY UTILIZATION AND ENVIRONMENTAL EFFECTS
(2023)
Review
Medicine, Research & Experimental
Xingyue Yang, Hu Wang, Li Zhang, Shun Yao, Jing Dai, Guorong Wen, Jiaxing An, Hai Jin, Qian Du, Yanxia Hu, Liming Zheng, Xingyue Chen, Zhiqiang Yi, Biguang Tuo
Summary: Hepatocellular carcinoma is a common and highly deadly liver cancer, posing a major threat to global human health. The molecular mechanism underlying its progression remains unclear, although KPNA2 has been identified as a marker of poor prognosis and early recurrence in hepatocellular carcinoma patients. Further research is needed to determine the role of KPNA2 in hepatocellular carcinoma development.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Nanoscience & Nanotechnology
Wenhui Pei, Yalikun Yusufu, Yifei Zhan, Xucai Wang, Jian Gan, Liming Zheng, Peng Wang, Kai Zhang, Caoxing Huang
Summary: This study proposes a bio-enzyme approach to synthesize lignin-dehydrogenated polymers and hybridize them with hyaluronic acid to prepare hydrogel composites for promoting cartilage defect repair. The composites exhibit similar properties to articular cartilage and can promote the regeneration of hyaline cartilage with excellent biocompatibility and chondrogenic differentiation abilities.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Francis M. Chen, Huixian Li, Dittman Lai-Shun Chung, Angel T. L. Mak, Fung Ping Leung, Ho Yin Edwin Chan, Wing Tak Wong
Summary: This study reveals that SCA3 patient-specific induced neural progenitor cells (iNPCs) exhibit proliferative defects and reduced autophagic expression compared to control. Furthermore, these SCA3 iNPCs undergo rapid senescence and do not survive subsequent passages. However, exposure to interleukin-4 (IL-4) can increase autophagic programs and reduce the proliferation defect in SCA3 iNPCs.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)