Article
Medicine, Research & Experimental
Zhijun Meng, Hongping Liang, Jianli Zhao, Jia Gao, Caihong Liu, Xinliang Ma, Jing Liu, Bin Liang, Xiangying Jiao, Jimin Cao, Yajing Wang
Summary: Through unbiased bioinformatics analysis, we identified the crucial roles of ferroptosis and HMOX1 gene in diabetic atherosclerotic vascular disease. Experimental evidence showed that the ferroptosis inhibitor Ferrostatin-1 effectively attenuated diabetic atherosclerosis, indicating the causative role of ferroptosis in the development of diabetic atherosclerosis.
Article
Medicine, Research & Experimental
Juma El-Awaisi, Dean P. J. Kavanagh, Marco R. Rink, Chris J. Weston, Nigel E. Drury, Neena Kalia
Summary: Elderly patients have a poorer prognosis after MI, possibly due to increased susceptibility of coronary microvessels to injury. The IL-36/IL-36R pathway may play a crucial role in this process. Targeting this pathway in elderly hearts could be a potential therapy for MI.
Article
Microbiology
Alanna Kelly, John Leech, Sarah Doyle, Rachel McLoughlin
Summary: During nasal colonisation, Staphylococcus aureus creates an immunosuppressive microenvironment by inducing the production of IL-27 and IL-10, which dampens protective T cell responses and facilitates its persistence.
Article
Multidisciplinary Sciences
Alanna Kelly, John Leech, Sarah Doyle, Rachel McLoughlin
Summary: Our study reveals that Staphylococcus aureus manipulates the host immune response in the nasal cavity by promoting immunosuppression, allowing for bacterial survival. Regulatory cytokines IL-10 and IL-27 play a central role in this suppressive response, resulting in reduced protective T cell responses. Furthermore, S. aureus induces IL-27 production to enhance IL-10 production and prolong bacterial colonisation, showcasing a complex host-pathogen interaction during nasal colonisation.
Article
Multidisciplinary Sciences
Xinhao Liu, Hui Chen, Zhibing Yan, Lei Du, Dou Huang, Wei Dong Gao, Zhaoyang Hu
Summary: This study evaluated the protective effects of liver ischemic preconditioning (RLIPC) on I/R injury in streptozotocin-induced type 1 diabetic rats. RLIPC significantly reduced infarct size and cardiac tissue damage, inhibited apoptosis, improved cardiac functions, and preserved cardiac morphology in diabetic hearts post I/R. Western blotting showed that RLIPC stimulated phosphorylation of ventricular GSK-3 beta and STAT-5, indicating its strong cardioprotective properties against myocardial I/R injury in diabetic hearts.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Shuai Wang, Yubin Shi, Yanqi Zhang, Fengyun Yuan, Mintao Mao, Jun Ma
Summary: This study investigated the potential of Tregs in inhibiting the activation of astrocytes after focal cerebral infarction. The depletion of Tregs in the tMCAO mouse model protected against astrocyte activation and decreased expression levels of FSP1, IL-6, IL-2, and NLRP3, while partially reversing the changes in Tregs. Mechanistically, Tregs depletion attenuated renal fibrosis by modulating IL-10/GPX4 following cerebral infarction.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Han Feng, Hao Shen, Matthew J. Robeson, Yue-Han Wu, Hong-Kun Wu, Geng-Jia Chen, Shuo Zhang, Peng Xie, Li Jin, Yanyun He, Yingfan Wang, Fengxiang Lv, Xinli Hu, Yan Zhang, Rui-Ping Xiao
Summary: The E3 ligase-dead mutant MG53-C14A, a variant of the mitsugumin 53 (MG53) protein, not only protects the heart from acute myocardial injury but also counteracts metabolic stress, making it a potentially important treatment for acute myocardial injury in metabolic disorders, including diabetes and obesity.
Article
Biochemistry & Molecular Biology
Mengdie Li, Fengrun Sun, Jinfeng Qian, Lanting Chen, Dajin Li, Songcun Wang, Meirong Du
Summary: Establishing maternal-fetal tolerance and successful placentation are crucial for a successful pregnancy, as disruption of immune balance and inadequate placental perfusion can lead to pregnancy-related complications. Extravillous trophoblasts play a key role in regulating decidual immune cells for fetal tolerance. Blocking Tim-3 and CTLA-4 pathways can lead to abnormal interaction between decidual immune cells and extravillous trophoblasts, resulting in poor placental development and increased fetal loss. IL-4 and IL-10 treatment may rescue the adverse effects of targeting Tim-3 and CTLA-4 on pregnancy outcomes, suggesting them as potential therapeutic strategies to prevent pregnancy loss induced by checkpoint inhibition.
Article
Immunology
Fang Zhang, Ye Liu, Shiqi Wang, Xin Yan, Yue Lin, Deyan Chen, Qian Tan, Zhiwei Wu
Summary: In this study, we found that interleukin 25 (IL-25) can promote diabetic wound healing by mediating IL-17RB signaling. IL-25 improves angiogenesis and collagen deposition, thus improving the wound healing process. Additionally, IL-25 protects endothelial cells from high glucose damage, promoting cell migration and tube formation. This study provides a new therapeutic strategy for treating poor healing diabetic wounds.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Bazgha Gul, Rukhsana Anwar, Mohammad Saleem, Afifa Noor, Muhammad Ihsan Ullah
Summary: The current study evaluated the anti-arthritic activity of n-hexane and aqueous extracts of Cassia absus seeds. The extracts showed significant inhibition of paw edema and reduction in paw size and joint diameter. The extracts also improved the levels of inflammatory and oxidative biomarkers. Polymerase chain reaction investigation revealed the modulation of various inflammatory factors by the extracts. In conclusion, Cassia absus can effectively alleviate arthritis symptoms by modulating oxidative and inflammatory biomarkers.
INFLAMMOPHARMACOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Robert A. Saxton, Kenan Christopher Garcia
Summary: IL-10 is an immunomodulatory cytokine with important roles in terminating inflammatory responses and preventing tissue damage from autoimmunity. However, its pleiotropic nature and ability to elicit proinflammatory effects in vivo have hindered therapeutic efforts utilizing IL-10.
Article
Plant Sciences
Jing Ni, Yuanmin Li, Yawei Xu, Rong Guo
Summary: Salidroside has been found to significantly improve diabetes-induced cardiac dysfunction, hypertrophy, and fibrosis by up-regulating HO-1 expression through activation of the AKT signaling pathway. This demonstrates the cardio-protective effect of salidroside in diabetic mice, which is dependent on AKT signaling activation.
Article
Dentistry, Oral Surgery & Medicine
Sitong Hu, Yihui Zhu, Shujia Yu, Yanchuan Guo, Yihu Wang, Menghao Lv, Wei Bai, Pan Ma
Summary: The study aimed to investigate the effect of IL-10 on the phenotype polarization of macrophages and osteogenesis in T2DM rat jaw defects. The results showed that IL-10 can stably induce macrophages to M2 type and improve bone regeneration in jaw defects.
Article
Immunology
Qiang Li, Xiaohui Li, Hongkun Quan, Yihui Wang, Guanggang Qu, Zhiqiang Shen, Cheng He
Summary: The study revealed that IL-10(-/-) mice and IL-10 inhibitor mice showed higher survival rates during C. psittaci infection, while mice with DC depletion had lower survival rates. IL-10(-/-) upregulated the function of deficient DCs by activating OX40-OX40L, T cells, and the NLPR3 inflammasome, and inhibiting IDO and regulatory T cells, leading to enhanced clearance of C. psittaci.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Dorsaf Bouzazi, Wael Mami, Amor Mosbah, Naziha Marrakchi, Melika Ben Ahmed, Erij Messadi
Summary: Snake natriuretic peptide (NP) Lebetin 2 (L2) has anti-inflammatory effects by regulating the release of inflammatory cytokines and promoting M2 macrophage polarization through activation of IL-10 signaling. L2 increases IL-10 release in a sustained manner and promotes downstream M2 macrophage polarization, while reducing TNF-alpha and IL-6 release in lipopolysaccharide (LPS)-activated cells. The effect of L2 is mediated by stimulating NP receptors.
Article
Cardiac & Cardiovascular Systems
Zaid Ammari, Mohammad Al-Sarie, Anthony Ea, Rajveer Sangera, Jon C. George, Vincent Varghese, Pamela S. Brewster, Yanmei Xie, Tian Chen, Zhen Sun, Rajesh Gupta
Summary: This study aimed to predict reduced cardiac index in patients with acute submassive pulmonary embolism, finding that brain natriuretic peptide, tricuspid annular plane systolic excursion, and right ventricular:left ventricular diameter ratio were associated with reduced cardiac index. These markers may aid in clinical decision-making and risk stratification for patients with acute submassive PE.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Review
Cardiac & Cardiovascular Systems
Rajesh Kumari, Prabhat Ranjan, Zainab Gbongbo Suleiman, Sumanta Kumar Goswami, Jing Li, Ram Prasad, Suresh Kumar Verma
Summary: m(6)A methylation is a highly studied RNA modification that plays a crucial role in cellular functions during development, differentiation, and disease. It is found in different RNA species and is regulated by various enzymes and proteins. In cardiovascular diseases, m(6)A methylation is associated with cardiac hypertrophy, myocardial infarction, and atherosclerosis.
CARDIOVASCULAR RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Prabhatchandra Dube, Armelle DeRiso, Mitra Patel, Dhanushya Battepati, Bella Khatib-Shahidi, Himani Sharma, Rajesh Gupta, Deepak Malhotra, Lance Dworkin, Steven Haller, David Kennedy
Summary: Vascular calcification (VC) is a major cause of cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD), resembling bone metabolism and driven by factors such as hyperphosphatemia and Ca/Pi imbalance. The process involves various cell types and signaling pathways. In-depth analysis of VC types, therapies, and cellular mechanisms aims to aid in the development of preventive, diagnostic, and therapeutic strategies for CKD patients burdened with this disease.
Article
Pharmacology & Pharmacy
Sumanta Kumar Goswami, Prabhat Ranjan, Roshan Kumar Dutta, Suresh Kumar Verma
Summary: Cardiovascular disease is the leading cause of morbidity and mortality worldwide, with inflammation playing a key role in its development. Immune cells and cytokines are crucial in regulating cardiac inflammation, with IL-10 playing a significant role in reducing cardiovascular inflammation and protecting the cardiovascular system.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
John Henderson, Praveen K. Dubey, Mallikarjun Patil, Sarojini Singh, Shubham Dubey, Rajasekaran Namakkal Soorappan, Ramaswamy Kannappan, Palaniappan Sethu, Gangjian Qin, Jianyi Zhang, Prasanna Krishnamurthy
Summary: The study revealed that miR-377 plays a significant role in DOX-induced cardiomyocyte cell death. Inhibition of miR-377 in cell lines can protect against DOX-induced cell death and oxidative stress. However, in vivo administration of AAV9-anti-miR-377 leads to accelerated mortality and enhanced myocardial remodeling in DOX-treated mice.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Mallikarjun Patil, Sherin Saheera, Praveen K. Dubey, Asher Kahn-Krell, Prem Kumar Govindappa, Sarojini Singh, Sultan Tousif, Qinkun Zhang, Hind Lal, Jianyi Zhang, Gangjian Qin, Prasanna Krishnamurthy
Summary: The study demonstrates that mesenchymal stem cell-derived exosomes enhance macrophage engulfment of apoptotic cardiac cells, leading to improved cardiac repair and function after injury.
CIRCULATION RESEARCH
(2021)
Article
Cell Biology
Sarojini Singh, John Henderson, Mallikarjun Patil, Praveen K. Dubey, Shubham Dubey, Ramaswamy Kannappan, Jianyi Zhang, Prasanna Krishnamurthy
Summary: The study revealed that miR-181c-5p plays a crucial role in macrophage phagocytosis, potentially regulating cytoskeletal arrangement to improve the efficiency of cell ingestion. Targeting macrophage miR-181c-5p in injured tissues could lead to better clearance of dead cells and more effective resolution of inflammation.
INFLAMMATION RESEARCH
(2022)
Article
Cell Biology
Shubham Dubey, Praveen K. Dubey, Channakeshava S. Umeshappa, Yohannes T. Ghebre, Prasanna Krishnamurthy
Summary: Pathological fibrosis contributes to the progression of various diseases. This study identified the role of the RUNX1 gene in idiopathic pulmonary fibrosis (IPF) and demonstrated that increased expression of RUNX1 promotes the differentiation of fibroblasts into collagen-synthesizing myofibroblasts, leading to lung fibrosis. The study suggests that targeting RUNX1 could potentially limit the progression of organ fibrosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Xiaoming Fan, Xiaolu Zhang, Lijun C. Liu, Annes Y. Kim, Sean P. Curley, Xiaohuan Chen, Lance D. Dworkin, Christopher J. Cooper, Rajesh Gupta
Summary: This study investigates the mechanisms underlying acute kidney injury (AKI) after myocardial infarction (MI) in diabetic patients. It reveals dysregulation of heme clearance pathways in the kidneys of diabetic mice before and after MI. The study also demonstrates the renal protective effects of interleukin 10 (IL-10) treatment in diabetic MI.
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)
Article
Cell Biology
Praveen K. Dubey, Mallikarjun Patil, Sarojini Singh, Shubham Dubey, Paras Ahuja, Suresh Kumar Verma, Prasanna Krishnamurthy
Summary: Endotoxemia-induced m6A methylation in the myocardium is associated with increased expression of inflammatory cytokine genes and reduced cardiac function, suggesting a potential role of m6A methylation in regulating myocardial inflammation and dysfunction during endotoxemia.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Rajesh Gupta
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Urology & Nephrology
Xiaoming Fan, Xiaolu Zhang, Lijun C. Liu, Shungang Zhang, Cole B. Pelger, Haroon Y. Lughmani, Steven T. Haller, William T. Gunning III, Christopher J. Cooper, Rujun Gong, Lance D. Dworkin, Rajesh Gupta
Summary: In acute kidney injury, the accumulation of hemopexin in the kidneys worsens kidney injury by increasing hemoglobin deposition on proximal tubular cells to exaggerate hemoglobin-induced cell injury.
KIDNEY INTERNATIONAL
(2022)
Review
Neurosciences
Prabhat Ranjan, Karen Colin, Roshan Kumar Dutta, Suresh Kumar Verma
Summary: The article introduces the concept of exosomes and their applications in disease treatment. Current technological advances provide better ways for monitoring exosomes, but further research is needed to ensure effective clinical applications.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Cardiac & Cardiovascular Systems
Robert W. Ariss, Rajesh Gupta
Summary: Comprehensive medical therapy has a substantial effect on improving residual cardiovascular risk.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2022)