Article
Radiology, Nuclear Medicine & Medical Imaging
Yihao Chen, Chenchen Qin, Jianbo Chang, Yan Lyu, Qinghua Zhang, Zeju Ye, Zhaojian Li, Fengxuan Tian, Wenbin Ma, Junji Wei, Ming Feng, Jianhua Yao, Renzhi Wang
Summary: This study aimed to predict early and delayed perihematomal edema (PHE) expansion in intracerebral hemorrhage (ICH) patients using a machine learning approach. The results showed that the combined ML model performed the best in predicting both early and delayed PHE expansion, suggesting its potential for assisting in the management of neurocritical ICH patients.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Lotte Sondag, Axel Wolsink, Wilmar M. T. Jolink, Sabine Voigt, Marianne A. A. van Walderveen, Marieke J. H. Wermer, Catharina J. M. Klijn, Floris H. B. M. Schreuder
Summary: This study investigated the association between blood pressure variability and the development of perihematomal edema after intracerebral hemorrhage. The results suggest that blood pressure variability is not associated with edema development, indicating that other mechanisms such as inflammatory processes may play a more important role.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Laurent Puy, Antoine Rauch, Vincent Deramecourt, Charlotte Cordonnier, Vincent Berezowski
Summary: This study conducted a postmortem examination to investigate acute microvascular lesions (microbleeds and microinfarcts) in the perihematomal area of patients with spontaneous intracerebral hemorrhage (ICH). It was found that these lesions may contribute to secondary brain tissue damage.
Article
Clinical Neurology
Jawed Nawabi, Tobias Orth, Sophia Schulze-Weddige, Georg Lukas Baumgaertner, Anna Tietze, Christian Thaler, Tobias Penzkofer
Summary: Neoplastic intracerebral hemorrhage (ICH) can be distinguished from non-neoplastic ICH using relative perihematomal edema (relPHE) on computed tomography (CT) imaging. This study aims to evaluate the discriminatory power of relPHE in an independent cohort.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Immunology
Yihao Chen, Shengpan Chen, Jianbo Chang, Junji Wei, Ming Feng, Renzhi Wang
Summary: PHE is considered a promising therapeutic target for ICH, but existing research results are conflicting. Therefore, it is necessary to classify, compare, and summarize existing studies on PHE.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Yingfeng Wan, Katherine G. Holste, Ya Hua, Richard F. Keep, Guohua Xi
Summary: Intracerebral hemorrhage (ICH) is responsible for 10% of strokes in the USA, resulting in significant disability and mortality. It causes primary brain injury due to mechanical disruption and secondary injury through the release of clot-derived factors. ICH leads to brain edema and increased intracranial pressure, affecting patient prognosis. Currently, effective treatment methods for reducing perihematomal cerebral edema and intracranial pressure are limited. This review explores the mechanisms of edema formation, the influence of sex and age, and the progress in pharmacotherapy for ICH.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Hanwool Jeon, Moinay Kim, Wonhyoung Park, Joon Seo Lim, Eunyeup Lee, Hyeuk Cha, Jae Sung Ahn, Jeong Hoon Kim, Seok Ho Hong, Ji Eun Park, Eun-Jae Lee, Chul-Woong Woo, Seungjoo Lee
Summary: Intracerebral hemorrhage (ICH) can lead to delayed cerebral edema due to disruption of the blood-brain barrier (BBB), with perihematomal edema (PHE) considered a major factor in morbidity and mortality. The water channel AQP4 on astrocytes plays a crucial role in PHE formation, influenced by reactive oxygen species (ROS) from the hemorrhage. Modulating AQP4 may present a potential therapeutic target for alleviating delayed cerebral edema in ICH.
Article
Clinical Neurology
Maaike P. Cliteur, Lotte Sondag, Axel Wolsink, Ingeborg Rasing, F. J. A. Meijer, Wilmar M. T. Jolink, Marieke J. H. Wermer, Catharina J. M. Klijn, Floris H. B. M. Schreuder
Summary: This study found no association between cSVD burden and PHE formation, implying that mechanisms other than BBB dysfunction are involved in the pathophysiology of PHE.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Jawed Nawabi, Sarah Elsayed, Andrea Morotti, Anna Speth, Melanie Liu, Helge Kniep, Rosalie McDonough, Gabriel Broocks, Tobias Faizy, Elif Can, Peter B. Sporns, Jens Fiehler, Bernd Hamm, Tobias Penzkofer, Georg Bohner, Frieder Schlunk, Uta Hanning
Summary: This study found that patients with oral anticoagulant-associated intracerebral hemorrhage (OAC-ICH) had lower levels of perihematomal edema (PHE) in the early stages compared to those with non-oral anticoagulant-associated intracerebral hemorrhage (NON-OAC-ICH), with NOAC patients also exhibiting significantly lower levels of edema expansion distance compared to NON-OAC-ICH patients. The increase in early PHE volume did not increase the likelihood of poor outcomes in OAC-ICH, but was independently associated with poor outcomes in NON-OAC-ICH.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Audrey C. Leasure, Lindsey R. Kuohn, Kevin N. Vanent, Matthew B. Bevers, W. Taylor Kimberly, Thorsten Steiner, Stephan A. Mayer, Charles C. Matouk, Lauren H. Sansing, Guido J. Falcone, Kevin N. Sheth
Summary: Higher admission IL-6 levels in patients with spontaneous intracerebral hemorrhage are associated with worse 90-day functional outcome, larger ICH volume, and larger perihematomal edema volume.
Review
Clinical Neurology
Wendy Bautista, P. David Adelson, Nathan Bicher, Marios Themistocleous, Georgios Tsivgoulis, Jason J. Chang
Summary: Intracerebral hemorrhage can be divided into primary and secondary phases, with current treatments focusing on reducing hematoma expansion and maintaining blood pressure. However, lack of therapies targeting secondary injury and inflexible trial designs may contribute to the lack of clinical efficacy in major ICH trials.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Article
Clinical Neurology
Yu-Lun Li, Chu Chen, Li-Juan Zhang, Yi-Neng Zheng, Xin-Ni Lv, Li-Bo Zhao, Qi Li, Fa-Jin Lv
Summary: This study investigated the predictive value of nonradiomics features and machine learning for early perifrom 214 patients with spontaneous ICH. A total of 23 features were selected to establish models, and the MLP model seemed to be the best for prediction of PHE expansion. NCCT models based on radiomics features and machine learning could predict early PHE expansion and improve the discrimination of identifying spontaneous intracerebral hemorrhage patients at risk of early PHE expansion.
WORLD NEUROSURGERY
(2023)
Article
Immunology
Yihao Chen, Chenchen Qin, Jianbo Chang, Yixun Liu, Qinghua Zhang, Zeju Ye, Zhaojian Li, Fengxuan Tian, Wenbin Ma, Junji Wei, Ming Feng, Shengpan Chen, Jianhua Yao, Renzhi Wang
Summary: A deep learning model was used to automatically segment hematoma and perihematomal edema (PHE), and a new definition of delayed perihematomal edema expansion (DPE) was generated. The time course, risk factors, and clinical outcomes of DPE were analyzed. The study found that DPE was associated with worse outcomes, and larger initial hematoma volume was a significant risk factor for DPE formation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Critical Care Medicine
Neal S. Parikh, Arun Jesudian, Hooman Kamel, Daniel F. Hanley, Wendy C. Ziai, Santosh B. Murthy
Summary: This study found that a liver fibrosis score was not associated with perihematomal edema volume or growth in patients with primary intracerebral hemorrhage.
NEUROCRITICAL CARE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wenliang Guo, Lanxi Meng, Aiyu Lin, Yi Lin, Ying Fu, WanJin Chen, Shaowu Li
Summary: This study found that severe chronic-ischemia cerebral small vessel changes (sciSVC) are associated with progression of perihematomal edema (PHE) and hematoma absorption in hypertensive intracerebral hemorrhage (ICH) patients.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Guido J. Falcone, Elayna Kirsch, Julian N. Acosta, Rommell B. Noche, Audrey Leasure, Sandro Marini, Jaeyoon Chung, Magdy Selim, James F. Meschia, Devin L. Brown, Bradford B. Worrall, David L. Tirschwell, Jeremiasz M. Jagiella, Helena Schmidt, Jordi Jimenez-Conde, Israel Fernandez-Cadenas, Arne Lindgren, Agnieszka Slowik, Dipender Gill, Michael Holmes, Chia-Ling Phuah, Nils H. Petersen, Charles N. Matouk, Murat Gunel, Lauren Sansing, Derrick Bennett, Zhengming Chen, Luan L. Sun, Robert Clarke, Robin G. Walters, Thomas M. Gill, Alessandro Biffi, Sekar Kathiresan, Carl D. Langefeld, Daniel Woo, Jonathan Rosand, Kevin N. Sheth, Christopher D. Anderson
ANNALS OF NEUROLOGY
(2020)
Article
Neurosciences
Nia M. Harris, Meaghan Roy-O'Reilly, Rodney M. Ritzel, Aleah Holmes, Lauren H. Sansing, Lena M. O'Keefe, Louise D. McCullough, Anjali Chauhan
EXPERIMENTAL NEUROLOGY
(2020)
Article
Clinical Neurology
Audrey C. Leasure, Lindsey R. Kuohn, Kevin N. Vanent, Matthew B. Bevers, W. Taylor Kimberly, Thorsten Steiner, Stephan A. Mayer, Charles C. Matouk, Lauren H. Sansing, Guido J. Falcone, Kevin N. Sheth
Summary: Higher admission IL-6 levels in patients with spontaneous intracerebral hemorrhage are associated with worse 90-day functional outcome, larger ICH volume, and larger perihematomal edema volume.
Article
Clinical Neurology
Jacqueline H. Geer, Guido J. Falcone, Kevin N. Vanent, Audrey C. Leasure, Daniel Woo, Jennifer R. Molano, Lauren H. Sansing, Carl D. Langefeld, Margaret A. Pisani, Henry K. Yaggi, Kevin N. Sheth
Summary: The study found that obstructive sleep apnea (OSA) is associated with the risk of intracerebral hemorrhage (ICH). Cases with OSA were more likely to be male and have hypertension, heart disease, hyperlipidemia, and higher body mass index compared to those without OSA. Logistic regression analysis showed that OSA is a risk factor for ICH.
Letter
Dermatology
A. C. Leasure, S. E. Cowper, J. McNiff, J. M. Cohen
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Letter
Clinical Neurology
Audrey C. Leasure, Yosef M. Khan, Raakhee Iyer, Mitchell S. V. Elkind, Lauren H. Sansing, Guido J. Falcone, Kevin N. Sheth
Letter
Clinical Neurology
Audrey C. Leasure, Julian N. Acosta, Cameron Both, Natalia Szejko, Stacy C. Brown, Kevin N. Sheth, Guido J. Falcone
Article
Cardiac & Cardiovascular Systems
Julian N. Acosta, Audrey C. Leasure, Cameron P. Both, Natalia Szejko, Stacy Brown, Victor Torres-Lopez, Safa Abdelhakim, Joseph Schindler, Nils Petersen, Lauren Sansing, Thomas M. Gill, Kevin N. Sheth, Guido J. Falcone
Summary: The study evaluated the burden of cardiovascular disease in underrepresented groups participating in the All of Us project. The findings showed a higher prevalence of CVD in underrepresented groups based on race, ethnicity, age, disability, and low income. This highlights the importance of targeting research towards individuals in underrepresented groups to address these disparities.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Clinical Neurology
Julian N. Acosta, Cameron P. Both, Natalia Szejko, Audrey C. Leasure, Safa Abdelhakim, Victor M. Torres-Lopez, Stacy C. Brown, Charles C. Matouk, Murat Gunel, Kevin N. Sheth, Guido J. Falcone
Summary: Genetically elevated LDL-C levels were found to be inversely associated with the risk of intracranial aneurysms and subarachnoid hemorrhage, indicating a potential protective effect. These results were consistent across different analytical methods and suggest a causal relationship between LDL-C levels and the risk of IA/SAH.
ANNALS OF NEUROLOGY
(2022)
Letter
Dermatology
Ryan Fan, Audrey C. Leasure, Fahrisa I. Maisha, Jeffrey M. Cohen, Alicia J. Little
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Natalia Szejko, Julian N. Acosta, Cameron P. Both, Audrey Leasure, Charles Matouk, Lauren Sansing, Thomas M. Gill, Hongyu Zhao, Kevin Sheth, Guido J. Falcone
Summary: This study provides evidence through genetic instrumentalization that lower levels of vitamin D are associated with a higher risk of intracerebral hemorrhage, particularly in nonlobar cases.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Letter
Dermatology
Annika Belzer, Audrey C. Leasure, William Damsky, Jeffrey M. Cohen
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Ryan Fan, Audrey C. Leasure, William Damsky, Jeffrey M. Cohen
Summary: This cross-sectional study examined the association between atopic dermatitis (AD) and migraine among a cohort of US adults. The study found that adults with AD were 89% more likely to have a diagnosis of migraine after controlling for common comorbidities.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Clinical Neurology
Julian N. Acosta, Cameron P. Both, Zachariah S. Demarais, Carolyn J. Conlon, Audrey C. Leasure, Victor M. Torres-Lopez, Adam de Havenon, Nils H. Petersen, Thomas M. Gill, Lauren H. Sansing, Kevin N. Sheth, Guido J. Falcone
Summary: This study examines the relationship between genetic susceptibility to hypertension and blood pressure control in stroke survivors. The results show that stroke survivors with higher genetic susceptibility tend to have worse blood pressure control, with a higher prevalence of uncontrolled and resistant hypertension.
Letter
Dermatology
Gloria F. Chen, Ryan Fan, Audrey C. Leasure, Daniel F. Levey, William Damsky, Jeffrey M. Cohen
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)