Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 16, Issue 16, Pages 1830-1842Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026616666160315142457
Keywords
Positron Emission Tomography; Ion Channel; gamma-Aminobutyric Acid-Benzodiazapine Receptor; Nicotinic Acetylcholine Receptor; N-Methyl-D-Aspartate Receptor
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Funding
- NIDA NIH HHS [K01 DA038000] Funding Source: Medline
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Positron emission tomography (PET) neuroimaging of ion channel linked receptors is a developing area of preclinical and clinical research. The present review focuses on recent advances with radiochemistry, preclinical and clinical PET imaging studies of three receptors that are actively pursued in neuropsychiatric drug discovery: namely the gamma-aminobutyric acid-benzodiazapine (GABA) receptor, nicotinic acetylcholine receptor (nAChR), and N-methyl-D-aspartate (NMDA) receptor. Recent efforts to develop new PET radioligands for these targets with improved brain uptake, selectivity, stability and pharmacokinetics are highlighted.
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